CLUSTAL 2.1 multiple sequence alignment ENST00000175506.4 AGTCCTGCTCCGCCCCGGACACCCCGCGGCCCCGCCCCTGTGCGCGCTGGTTGGTCCTCG ENST00000451989.1 -GTGTGGCA----TTTGGGCCCTCTTTGGCAGCAATGATAGCCTCTCTGGTCAGCATCCG ** ** ** * * * *** * * * * ***** * ** ENST00000175506.4 CAGGCATGATGAAACTTCCCGCACGCGTTACAGGAGCCAGGTCGGTATAAG--CGCCAGC ENST00000451989.1 --AGTGCTATGAAGAT-CACACACGGGTC-CAGATGC-ATTTCGTCCTGAGAATGTCAAT * ***** * * * **** ** *** ** * *** * ** * ** ENST00000175506.4 GGCCTCGCCGCCCGTCAAGCTG---TCCACATCCCTGGCCTCAGCCCGCCACATCACCCT ENST00000451989.1 GGATACATCAGCTGCTGCTTTGGATTTCAC-CAGTTGGTCGTAGTTGACCA-GCTGTTTG ** * * * * ** * *** *** * ** *** ENST00000175506.4 GA--CCTGCTTACGCCCAGCCTGTGGACATTTTCGCGGTCCGGGTCC-CTGCGGCGG--- ENST00000451989.1 GAATCCAGCCAAT-TCAAGTGAGGAAATATCTTCATT-TGTGGCTCTGTTGCAGTGGTGA ** ** ** * * ** * * ** *** * ** ** *** * ** ENST00000175506.4 -----------ACGGGTCGG-ATCGTGC-----------TCGTGGCCAGGGCGCAGTCAG ENST00000451989.1 AATTTACAACCACAAGAAGGTATAATACCATTTTGAATTTGATTACAAGGCCAGAGTGGA ** * ** ** * * * * * *** * *** ENST00000175506.4 GTGTCGCGTGGTCCTG-ATCT--------AGGAAGAGACTGCGGC--------CTTATCA ENST00000451989.1 TGGTGACATAATCCTTCATCTTTATGACAAAGGAGGGACTG-GGCAGAAAATGTGTATGT ** * * **** **** * * ** ***** *** *** ENST00000175506.4 CCGTCTCGGTGTCTGCTTTCACCTT--CAACTGCCCCC------------CTCCTCACCT ENST00000451989.1 TGGGCTGAGTGTTTGCATTTATTTTATTAAATACTGTCAATAAGAAAGTATTCCTGGGCA * ** **** *** ** * ** ** * * * **** * ENST00000175506.4 GGACCGCTCACCCTCCTCCTCCCCTCTCACCCCGCCATCCCCACCAGTCCCCACCTGTCT ENST00000451989.1 GAAACACCTACCTAGAGAGTCATCACTGTAGAGATTAACCTCTGCATGCCCTCTATAACA * * * * *** ** * ** * ** * ** *** * * ENST00000175506.4 CTGTAGACTGCAAGACTCATCAAGTG---ACT-TGCTGAGCAAACCCTGCCGAGAAGAGA ENST00000451989.1 GTGTGGA--GAAACAGTTTTGAGATAGAAACTGTGAAGAGCAACCTCTG---------GA *** ** * ** * * * * * *** ** ****** * *** ** ENST00000175506.4 TTTTCTTCAATCACATC-TGAATAAATCACT--TGA-----AGAAAGCTTA-----TAGC ENST00000451989.1 TTCCTTTTGACAGTGCTATTAAGAAACGACTGATGACAGAGAAAAGGCTTGGATTCCAGC ** ** * * ** *** *** *** * ** **** *** ENST00000175506.4 TTCATTGC-ACCATG----TGTGGCATTTG------------------GGCGCTGTTTGG ENST00000451989.1 TTCGTTGCTGCCATTCTGTTGATGCAGCTGAAAGAGTCCCAAGTGTAAGACACTCTCTAG *** **** **** ** *** ** * * ** * * * ENST00000175506.4 -CAGTGATGATTGCCTT----TCTGTTC-AGTGT-CTGAGTGCTATGAAGATTGCACACA ENST00000451989.1 ACATTTGCGATTGGCATGAAATCAGTCCCAATGTACTGGCTGCTAGAAAGGTGGAAAATC ** * ***** * * ** ** * * *** *** ***** *** * * * * ENST00000175506.4 GAGGTCCAGATGCATTCCGTTTTGAGAATG----TCAA----TGGATACACCAACTGCTG ENST00000451989.1 ATATTGAAAGTGAACACCACTCTGAGGAAGGCATTCAGGTCCTGGATGAAATAATATTTT * * ** * ** * **** * * *** ***** * ** * ENST00000175506.4 CTTTGGAT-TTCACCGGTTGGCGGTAGTTGACCCGCT---------GTTTGGAATG---C ENST00000451989.1 CCTTGGAAATTTAAGACATAACAATAGTTCACACTTCAGTAGGTAGGTTTGTAATTTCCC * ***** ** * * * ***** ** * ***** *** * ENST00000175506.4 AGCCAATTCGAGTGAAGAAATAT-CCGTA-------TTTGTGG------CTCTG------ ENST00000451989.1 AGTATATTTGGAAGAACACAGATATCATAGTGATCTTCTCTAGAGAACGTTCGGATGAAA ** *** * *** * * ** * ** * * * * ** * ENST00000175506.4 TTACA-ATGGTGAAAT------CTACAA-------CCATAAGAAGATGC--AACAGCA-- ENST00000451989.1 TTACACAGGGTTACATATATTTTTACAAGACTCCTCCTCAGGAAAAAGCCAAGGAGCAGA ***** * *** * ** ***** ** * *** * ** * **** ENST00000175506.4 ---------TTTTGAA------TTTG--------AATAC---CAGACCAAAGTG------ ENST00000451989.1 GTCAGGGGCTTCTGAAGGACTCTTTGTTTTATGTAGTGTGTGCAGATTGAACTGCTGCTG ** **** **** * * **** ** ** ENST00000175506.4 -----GA---TGG--TGAGA---TAATCCTT----CATCT---------TTAT------- ENST00000451989.1 CCTGTGACCTTGAACTGAGAGTCTAATTCCTGGATCATCTGTTTTCTTCTTATTGCCTCT ** ** ***** **** * * ***** **** ENST00000175506.4 GACA----AAGGAGGAATT--------------GAGCAAACAATTTGT-------ATGTT ENST00000451989.1 GGCACCAGAAATAAGAATTCTGAAGACTGGGATAGGAAAACATCTCCTGATAAAGATATT * ** ** * ***** * ***** * * ** ** ENST00000175506.4 GGA-TGGTGTGTTTG-CATTTGT-----TTTACTGGATA-------CTGCCAATAA---G ENST00000451989.1 TGAGTACTATACCTGATACCTAAAGAAATTCTCTGGCCAAAAGAAGCCTTCAGTGATGGG ** * * * ** * * ** **** * * ** * * * ENST00000175506.4 A----------AAGTGTTCCTG------GGT---AGAGATACATATGGAG--TCAGACCT ENST00000451989.1 ATAACTTAGTTAAGAATTTCTGTTTTAGGGTTTTACAGAAATATACTGAACATCAGGTTG * *** ** *** *** * *** * *** ** **** ENST00000175506.4 TTGTT-TAA----AGCAATGACAGAAGATGGATTTTTGGCT-GTATGTTCAGAAGCTAAA ENST00000451989.1 ATGACATAATGATGGCAACTGCAACACAAAAATTTTCCTTCAGTATTCTTA-AAACTAAA ** *** **** ** * * ***** **** * * ** ***** ENST00000175506.4 -GGTCTTGTTACATTGAAGCAC---TCC---GCGACTCCCTTTTTAAAAGTGGAGCCTT- ENST00000451989.1 TAAGGCTATTACAGCAATCTACAAATTCAATGCAATTCCCATC---AAAATATCACCATC * ***** * ** * * ** * **** * *** * ** * ENST00000175506.4 -TTCTTCCTGGACACTATGAAG-------TTTTGGATTTA---AAGCCAAA-------TG ENST00000451989.1 ATTCTTCATAGA-ACTAGGAAAAAACAACCCTAAAATTCATGTGAACCAAAAAAGAGCTC ****** * ** **** *** * *** * * ***** * ENST00000175506.4 GCAAAGTT---GCAT--CCGTG-GAAATGGTTAAATAT-----CATCAC---------TG ENST00000451989.1 GCATAGCTAAAGCAAGACTAAGCAAAAAGAACAAATCTGGAGGCATCACATTACCTGATT *** ** * *** * * *** * **** * ****** * ENST00000175506.4 TCGGGATGTACCCC--TGC-ACGCCCTCTATGACAATGTGG-------------AGAAAC ENST00000451989.1 TCAAACTATACTATAATGCCACAGTCACCAAAACAGCATGGTATTGGTATAAATATAGGC ** * *** *** ** * * * *** *** * * * ENST00000175506.4 TCTT---TCCAGGTTTTGAGATAGA-AACTGTGAAG--AAC---AAC-CTCAGGATC--- ENST00000451989.1 ACATAGACCAATGGAACAGAATAGAGAACCCAGAAATAAACCCAAATACTTACAGCCAAC * * * * * ***** *** *** *** ** ** * * ENST00000175506.4 ---CTTTTTA----------------ATAATGCTGTAAAGAAACGTTTGAT--GACAGAC ENST00000451989.1 TCACCTTCGACAAAGCAAACAAAAACATAAAGCAGAAAAGGGACACCCTATTCAACAAAT * ** * **** ** * **** ** ** *** * ENST00000175506.4 AG------AAGGATTGGCT-GCCTTTTATCAGGGGGC----TTGGACTCCAG---CTTGG ENST00000451989.1 GGTGCTGGGAGAATTGGCAAGCCACACATAGGAGAATGAAACTGGATTCTCATCTCTCAC * ** ****** *** ** * * **** ** ** ENST00000175506.4 TTGCTG-------CCACTC----TG----------TTGAA----------GCAGCTGAAA ENST00000451989.1 TTCATATAAAAATCAACTCAAGATGGATCAAGGACTTAAACGTAAGACCTGAAACTATAA ** * * **** ** ** ** * * ** ** ENST00000175506.4 GAAGCCCA-AGTACAGTATC--------CTCTCCAGACATTTGCAATTGGCATGGAA--- ENST00000451989.1 AAATTCTACAGGATAACATCAGAAAAACCCTTCTAGACATTGGCT-TCGGCAAGGAGTTC ** * * ** * * *** * ** ******* ** * **** *** ENST00000175506.4 ------GACAGCCCCGATT----TAC------------------TGGCTG---------- ENST00000451989.1 ATGACCAATAACCCAAAAGCAAATACAGTAAAAACAAAGAAAAATAGGTGGGACTTAATT * * *** * *** * * ** ENST00000175506.4 ---CTAGAAAGGT-------GGCAGA-----TCATATTGGAAGTGAACA------TTATG ENST00000451989.1 AAACTAAAGAGCTTTTGCACAGCAAAAGGAACCATCTGCAAAGTAAACAGACAACCCATA *** * ** * *** * *** * **** **** ** ENST00000175506.4 AAGT---------CCTTTTTAAC-------TCTGAGGAAGG-----CATTCAGGCTCTGG ENST00000451989.1 GAGTGGGAGAAAATCTTCACAATCTATATATCCGACAAAGGAATAATATCCAGAATCCAC *** *** ** ** ** **** ** *** ** ENST00000175506.4 ATGAAGTCATAT---TTTCCTTGGAAA---CTTATGA---CATTACAACAGTTCGTGCTT ENST00000451989.1 ATGAACTCAAACAAATTAGCAAGAAAAAGACAAACAATCCCATCA-AAAAGT--GGGCTA ***** *** * ** * * *** * * * *** * ** *** * *** ENST00000175506.4 CAGTAGGTATGTATTTAATTTCCAA----GTATATTCGGAAG---AACACAGAT---AGC ENST00000451989.1 -AGGACATGAATAGACAATTCTCAAAAGAGGATATACAAATGGCCAACAAACATGAAAAA ** * * ** **** *** * **** * * * **** * ** * ENST00000175506.4 GTGGTGATCTTCTCTGG-----AGAAGGAT-CAGATGAACTTACGCAGGGTTACATA--- ENST00000451989.1 ATGCTCAACATCACTAATGATCAGGGAAATGCAAATCAACAC-CACAATGTGATACCACC ** * * * ** ** ** ** ** ** *** * ** ** * * ENST00000175506.4 -TATTTTCACAAGGCTCCTTCTCCTGAAAAAGCCG-AGGAGGAGAG----TGAGAGGCTT ENST00000451989.1 TTATTCCCACAAGAATGGCCATAATCAAAAAATCATAAAATAATAGATGTTGGCATGGAT **** ****** * * * ***** * * * * ** ** * * * ENST00000175506.4 CTG------AGGGAACTCTATTTGTTTGATGTTCTCCGCGCAGATCGA----ACTACTGC ENST00000451989.1 GTGGTGAAAAGGGAACACTTCTACACTGCTGGTGGGAATGTAAACTAGTACGACCACTAT ** ******* ** * ** ** * * * * ** *** ENST00000175506.4 TGCCCATGGT----------CTT---GAACTGAGAGTCCCATT----TCTAGATCATCGA ENST00000451989.1 GGAAAACAGTGTAGAGATTCCTTAAAGAACTAAAAGTAGAATTATCATTTGATCCAGCAA * * ** *** ***** * *** *** * * ** * * ENST00000175506.4 TTTTCTTCCT--------------ATTAC-------------TTG--------TCTCTGC ENST00000451989.1 TCCCATTACTGAGGAAAAGAAGTCATTACACGAAAAAGATACTTGCACACACGTTTATAG * ** ** ***** *** * * * ENST00000175506.4 CACCAGAAATGAGAATTCCAAAGA-ATGG------------------------------- ENST00000451989.1 CAGCACAATTCACAATTGCAAAAATGTGGAACCAGACCAAATACCCATCAATCAACAAGT ** ** ** * * **** **** * *** ENST00000175506.4 -GATAGAAAAAC----ATCT-----------------------CCTGAGAGA--GACGTT ENST00000451989.1 GGATAAAGAAACTGTGATATGTGGCCGGGTGCAGTGGCTCACACCTGTAATGCCAACACT **** * **** ** * **** * ** * ENST00000175506.4 TGAGGATTCCAATCTGA------TACCCAAAG---AGATTCTCTGGC------GACCAA- ENST00000451989.1 TTGGGAGGCCAAGGCGGGTGGATCACCCGAAGTTGGGAGTTTGAGACCAGACTGACCAAT * *** **** * **** *** ** * * * * ****** ENST00000175506.4 ---AAGAAGCCTT--------CAGTGATGGAATAACTTCAGTTAAGAAT-----TCCTGG ENST00000451989.1 ATTAAGAAACCCTATCTCTACTAAAAATACAAAAAATT-AGCCAGGCATGGTGGCGCTTG ***** ** * * ** ** ** ** ** * * ** ** * ENST00000175506.4 TTTAAGATTTTA------CAGGAA--TACGTT--GAACATC-------------AGGTTG ENST00000451989.1 CCTATAATCCCAACTACTCAGGAGGCTGAGGCAGGAGAATCGCTTTAACCCGGGAGGCGG ** ** * ***** * * ** *** *** * ENST00000175506.4 ATGATGCAATGA-------TGGCA--AATGCAGCCCAG-----------------AAATT ENST00000451989.1 AGGCTGCAGTGAGCCGAGATTACACCATTGCACTCCAGCCTGGGCAACAAGAGAGAAACT * * **** *** * ** * **** **** *** * ENST00000175506.4 TCCCTTCAATACTCCTAAAACCAAAGAAG----GATAT---TACTACCGTCAAGTCTTTG ENST00000451989.1 CCATCTCAAAG------AAAGAAAAGAAACTGTGATATATATATCAC-ATCATATATATA * **** *** ****** ***** ** ** *** * * * ENST00000175506.4 AACGCC-----ATTACCCAGGCC------GGGCTGACTGGCTG--------AGCCATT-- ENST00000451989.1 TATGATGGAATACTACTCAGCCATAAAAAGGAATGAATTAATGGCATTCGCAGCAACTTG * * * *** *** * ** *** * ** *** * * ENST00000175506.4 ------ACTGGATGCC-------CAAGTGGATCAATGCC--ACTG----ACC------CT ENST00000451989.1 GTTGGGATTGGAGACTATGATTTTAAGTAAAGTAACTCAGGATTGGAAAACCAAACATCG * **** * **** * ** * * ** *** * ENST00000175506.4 TCTGCCCGCAC------------GCTGACCCAC-----TACAAG---------------- ENST00000451989.1 TATGTTCTCACTCATAAGTGGGAGCTAAGCTATGAGGATGCAAAGGCAAAAGAATAATAC * ** * *** *** * * * * *** ENST00000175506.4 --TCAGCTGTCAAAGCTTAGGTGGTCTTTATGCTGTAATGTGAAAGCAAATATTTCT--T ENST00000451989.1 AATAAACTTTGAAGACTCGGGGAAAGTTGGTGGGGGGATGAGGGATAAAAGACTACAAAT * * ** * ** ** ** ** ** * *** * * *** * * * * ENST00000175506.4 CGTGTTGGATGGGGACTGT--GGGTAGATAGGGGAAC---AAT----------------- ENST00000451989.1 TGGGTTCTGTAGATACTGCTCGAGT-GATGGGTGCACCAAAATCTCACAAATCACCACTA * *** * * **** * ** *** ** * ** *** ENST00000175506.4 GAGAGTCAACTCAGG----------CTAACT----------------TGGG--------- ENST00000451989.1 AAGAACCTACTCATGTACCCAAACACCACCTGCTCCCCAAAAACCTATAGAAACAAAAAA *** * ***** * * * ** * * ENST00000175506.4 --TGTGAAAAAAATAAA-----------AGTCCTAAAT--------------------CT ENST00000451989.1 TTTTTTAAAAAAATAAAGCATTGATTAAAAGCAAAAATAAATAAATAAATTAGCCCACCT * * *********** * * **** ** ENST00000175506.4 AAA------------------------CCATTGC----TGT----------- ENST00000451989.1 AAAAAAGAAAGACATGCTCACAGTTATTTATTGCAGGATGTTTGTATCAGAA *** ***** ***