CLUSTAL 2.1 multiple sequence alignment ENST00000188403.6 ---TTCAGTGGCTGTGAATAAGCTAAGAATGGTAATGCAGTTTCAGGG--GTTAGAAAAT ENST00000452683.1 AACTTTGCTTGTTGAGATTAAAC--------ACTTTGAAATTTGAAAACTATTAGGAAAT ** * * ** ** *** * ** * *** * **** **** ENST00000188403.6 CCAATTCAAATTAGTCCTCACTGCAGCTGTACGCCGTCAGGATTTTTCATGGAAATGATG ENST00000452683.1 ----TTTGACTT----TTTAC--CATTTGTTC----------TTTTTCATGT-------- ** * ** * ** ** *** * ********* ENST00000188403.6 AGTATGAAGCCCGCGAAAGGTGTTTTAACAGAACAAGTGGCAGGTCCTCTGG--GACAGA ENST00000452683.1 --TTTAAAAACT-----AGATATTTTACCAGAACAAATTAGTTATCAGCTGCATGACACT * * ** * ** * ***** ******** * ** *** **** ENST00000188403.6 -ACCTGGAAGTGGAACCATACTCGCAATACAGCAATGTTCAGTTTCCCCAAGTTCAACCA ENST00000452683.1 CATTTTAAAAAATCACCTTATTGCCAGTATTCTATTGCTCAGTTTCCTCCAGCTT---TA * * ** *** ** * ** ** * ** ********* * ** * * ENST00000188403.6 CAGATTTCCTCGTCATCCTATTATTCCAAC-CTGG--GTTTCTACCCCCAGCAGCCTGA- ENST00000452683.1 CAGTCTGAATCTTTATAAAATCATTTCAACACTTATAGATTGGATCCACAGGACAGTGAT *** * ** * ** ** *** **** ** * ** * ** *** * *** ENST00000188403.6 -------AGAGTGG---TA-CTCTCCTGGAATATATGAACTCAGGCGTATGCCAGCTGAG ENST00000452683.1 GGTGGACAGTGTGGATTTAGTTCTCGTGAATTAAATAAACCCA--CTTATGT-GGTTG-- ** **** ** **** ** * ** ** *** ** * **** * ** ENST00000188403.6 ACTCTCTACCAGGGAGAAACTGAGGTAGCAGAGATGCCTGTAACAAAGAAGCCCCGCATG ENST00000452683.1 -CTCAT---------GATGCTGAAG--ATGGATAC-CCTGGAATAAAAAGGTCCAGACCA *** ** **** * ** * **** ** *** * * ** * ENST00000188403.6 GGCGCGTCAGCAGGGAGGATCAAAGG---GGATGAGCTGTGTGTTGTTTGTGGAGACAGA ENST00000452683.1 ACCTATTCTTCCTCGAGAAATAAGGGACAGGAAGAATTCTGTGTAGTTTGTGGTGATAAA * ** * *** * ** ** *** ** * ***** ******** ** * * ENST00000188403.6 GCCTC----TGG--ATACCACTATAATGCACTGACCTGTGAGGGGTGTAAAGGTTTCTTC ENST00000452683.1 GCATCACCATCACCATATCATTATAATGCACTTACCTGTGAAGGTTGCAA---TTTTTTC ** ** * *** ** *********** ******** ** ** ** *** *** ENST00000188403.6 AGGAGAAGCATTACCAAAAACGCTGTGTACAAGTGTAAAAACGGGGGCAACTGTGTGATG ENST00000452683.1 AAT-GTAGCATCAACAAAA-TGCAGTATATAGTTGCAGGAATGGTAGTCACTGTGAAATG * * ***** * ***** ** ** ** * ** * ** ** * ****** *** ENST00000188403.6 GATATGTACATGCGAAGAAAGTGTCAAGAGTGTCGACTAAGGAAATGCAAAGAGATGGGA ENST00000452683.1 GACATGTACATGCGTAGAAAATGTCAAGAGTGCAGACTGAAAAAGTATAAGGCAGTAGGA ** *********** ***** *********** **** * ** * ** * * *** ENST00000188403.6 ATGTTGGCTGAATGCTTGTTAACTGAAATTCAGTGTAAATCTAAGCGACT---------- ENST00000452683.1 ATGTTGGCAGA---TTTGCTCACAGAAATCCAATGTAAATTAAAGAGACTTCAAAAGAAC ******** ** *** * ** ***** ** ******* *** **** ENST00000188403.6 ------GAGAAAAAATGT---------------------------GAAGCAGCA---TGC ENST00000452683.1 TTTAAGGAGAAGAATCATTTTTACTCTAACATCAAAGTGGAAGAGGAAGGAGTAGACCAC ***** ** * **** ** * * ENST00000188403.6 AG----------------ATCAGACCGTGAATGAAGACAGTG----------AAGGTC-- ENST00000452683.1 AGTTTTCTATCATCCACCACTAGACCTGGAAAAGTGGCAAGGCTTTTCTTATAAAATTTG ** * ***** *** * ** * ** * ENST00000188403.6 --------------GTGACTTGC--GACAA--GTGACCTCGACA---------------- ENST00000452683.1 TTTCTTTAATTATGGTGTTTTGTTTAATAATTATGAATTCTATATTTATAATTTTCCTCC *** *** * ** *** ** * * ENST00000188403.6 -----------ACAAAGTCA------------TGCAGGGAGA----------AAACTGAA ENST00000452683.1 TATATTTTCTTATAGATTCAGGAAAGCATAGCTGCAGGAACATACAAATCCTGAACTGAG * * * *** ****** * * ****** ENST00000188403.6 CTCACCCCAGATC-----AACAG-ACTCTTCTACAT----------------TTTATTAT ENST00000452683.1 CTTTTTGCAACTCTCAGAGACAGCAGTCCTACACATACGTGGGCTAATGAATTTTACCAA ** ** ** **** * ** * **** **** * ENST00000188403.6 GGA---TTCATATAACAA-------ACAGAGGAT--------GCCTCAGGA------AAT ENST00000452683.1 GGGGCTCCCATTTGAAAATTTGGCCAATGAGGATCAAACTGCACTACAGAAGGGATCAAA ** *** * * ** * ****** * *** * ** ENST00000188403.6 AAC--AAATAA------------------AATTTTA-------AAA-------------- ENST00000452683.1 AACTGAAGTGATATTTCTCCATGGGGCCCAACTTTACAGTCAGAAACAATCAGCCTTACT *** ** * * ** **** *** ENST00000188403.6 GAAGAATTCAGTGCA------------------GAAGAA--------------------A ENST00000452683.1 GAAGAATTTATTACACACTGTTTTACTTCTACAAAAGAATGAGCAAACTTGATGTAACTA ******** * * ** ***** * ENST00000188403.6 AT-------------------------------TTTCTCATTTTG--------------- ENST00000452683.1 ATACTGAATATGCTCTGCTTGCAGCAACAATTGTTTTTTATTTTTCAGATCGTCCATGCC ** *** * ***** ENST00000188403.6 -----------------ACGGAAA-----TGGCAACCAAT----CA-----TGTACAGGT ENST00000452683.1 TTAAAAATAAGCAATATATGGAAAATTTATAAGAACCAGTTTTACAAATATTGTATAAGT * ***** * ***** * ** **** * ** ENST00000188403.6 TCT------TGTAGAATTCACAAAA----------------------------AAGC-TA ENST00000452683.1 ATTCAAAAATGTATCATCCAGAAGACCCATAGCATTTTGCCCATCTCATATGGAAGCATA * **** ** ** ** * **** ** ENST00000188403.6 CC------AGGATT---------------TCAGA----CTT------TGGACCATGAAGA ENST00000452683.1 CTGAACTGAGAACTCTGAATTATAACCATTCAGAAATACTTAGCACTTGGAAAACAAAGG * ** * * ***** *** **** * *** ENST00000188403.6 ---CCAGATTG----CTTTGCT----GAAAGG----GTCTGCG-----GTTGAAGCT--- ENST00000452683.1 ACCCCAAATTGGCTACTTTACTCTCTGAGAAGTGAAATTTGTATTCTTGCTGAAATTTTA *** **** **** ** ** * * * ** * **** * ENST00000188403.6 --ATGTTCC--TTCGTTC------------AGCTGAGATTTTCA----ATAAGA-AACTT ENST00000452683.1 GAATGTTGTAGTTTGTTTTAAACTTCCTAAATCTGAATTGTTTACCATATAGGATGACTT ***** ** *** * **** * ** * *** ** **** ENST00000188403.6 C--CGTCTGGGC--ATTCTGACCTATTGGAAGAAAGAATTCGA-AATA---GTGGTATCT ENST00000452683.1 TATCATATAGGATGACTTTATCATATAGGATGACTGATTTGGACAACATGAACGGTATTG * * * ** * * * * *** *** ** ** ** ** ** * ***** ENST00000188403.6 CTG----ATGAATATATAAC---------------ACCTATGTTTAGT----TTTTATAA ENST00000452683.1 CTGTGTTACCAATATATGACCGTAAAATGGACATCATCAATGCTCATCAAAATTTTATGA *** * ******* ** * * *** * * ****** * ENST00000188403.6 AAGTATTGGGGAA-------------CTGAAA-------------------ATGA----- ENST00000452683.1 AAATTTTGTGGAATATAGAACTATCACTGAGGGATATCTAGGATTCTTTTTATGATTGGA ** * *** **** **** **** ENST00000188403.6 CTCAAGAGGAGTA-----TGCTC-----TGCTTAC---------AGC-----AATTGTTA ENST00000452683.1 CTCAAAAGAAGCAAAAGTTGTTTCCTCATGTTTCCTTCAAAAGGAGCCAGAGAGTTATTA ***** ** ** * ** * ** ** * *** * ** *** ENST00000188403.6 TC-------------CTGTCTCCA--------------GATAGACAATACATAAA----- ENST00000452683.1 CCTGAAGAAGCTTCACTTTTTTCATTCAGTAAAACATTGAATGAAAATATATAAATTTAT * ** * * ** ** ** **** ***** ENST00000188403.6 GGATA---GAGAGGC--------------------------AGTAGAGAAGCTTCAG--G ENST00000452683.1 GGATATAAGAAAGGCTAGCTAGTGCAAACAGTTGTAATTGAAATAAAGAGAGTTTGGCCG ***** ** **** * ** *** ** * * ENST00000188403.6 AGC-----------CACTT-------------CTTGATGTGCTACAA-AAGTTGTGTA-- ENST00000452683.1 GGCGTGGTGGCTCACACCTGTAATCCAAACACTTTGGGAGGCTGAGGCAAGTGGAGCACC ** *** * *** *** **** * * * ENST00000188403.6 ---------AGATTCA---CCAGCCTGA-----------AAATCCT-------------- ENST00000452683.1 TGAGGTCAGGAGTTCAAGACCAGCTTGACCAACATGGCGAAACCCCGTCGCTACTAAAAA **** ***** *** *** ** ENST00000188403.6 --------------CAACACTT-------------------TGCCTGT-----------C ENST00000452683.1 TACAAAACAAAATACAAAAATTAGCCAGGCATGGTGATGCGCGCCTGTAATCCCAGCTAC *** * ** ****** * ENST00000188403.6 TCCTGGGTC----GCCTGA-------CTGAATT------ACGGACATT-CAATCATC--- ENST00000452683.1 TCCAGGGGCTGAGGCCAGAGAGTAGCTTGAATCCGGGAGGTGGAGATTGCAATGAGCCGA *** *** * *** ** ***** *** *** **** * * ENST00000188403.6 -ACCACGCTGAGATGCTGATGTCATGG-----AGAGTAAA-------------------- ENST00000452683.1 GATCACGCCATTGCTCTCCAGCCTGGGCGACAAGAGCAAAACTCCATCTCAACAACAACA * ***** ** * * ** **** *** ENST00000188403.6 -CGACCACAA-------------------GTTTAC------------------------- ENST00000452683.1 GCGACAACAACAACAACACAATAAAGAGAGTTTGTGACCTTCATTAACTAAAGCCAGACT **** **** **** ENST00000188403.6 ---------------------------CCCACTTCT-----------CTGTGAA--ATCT ENST00000452683.1 GATGGAATAAGGAGGTAACATTTTAAACCTATTCCTGTTACAGCATTTTGTGAATTATTA ** * * ** ****** ** ENST00000188403.6 GGGACGTGCAG------------------------TGATG-----------GGGATT--- ENST00000452683.1 AAGACGAGCAAAACTGTTCAAATCTTATCATTTCTTAATGCCTTAAAAAAAGAGATGCTT **** *** * *** * *** ENST00000188403.6 -------ACAGGGGAGGGGTCT---------------------------------AGCTC ENST00000452683.1 TATAAAAACAAAGTAGGAATTTTGTGATGGCAAGAATAATGAAAAATTAAAATACAGATT *** * *** * * ** * ENST00000188403.6 CTTT-----TTCTCTCTCATATTA----ATCTGATGTA--TAACTTTCCTTT-------- ENST00000452683.1 ATTAAAATATTTTAACATATATTAGGAAATTAAACATAATTTACTTCTCATTCTGGCACA ** ** * * ****** ** * ** * **** * ** ENST00000188403.6 ----ATTT---CACTTGTACC--CAGTTTCA------------------CTCAA-----G ENST00000452683.1 GAATATTTTAACATTTTTGCCAACATCTTTTGTGGAAAAAAACGAAGTTCTTAAAACCAG **** ** ** * ** ** ** ** ** * ENST00000188403.6 AAATCTTG--ATGAATATTTATGT----------------TGT---------------AA ENST00000452683.1 AAATCTTTCTACAAATTTTTAAGTCCTTATATGGACAGGATGTTAATATGTTAAATTAAA ******* * *** **** ** *** ** ENST00000188403.6 TTACATGTGTAAC----------------TTCCACA-----ACTGT-------AAATATT ENST00000452683.1 TTTCATGTGAAATACATGGAAGTGAGAAATTCTATGGTGGCACTATTGCTTTGGAAGACT ** ****** ** *** * *** * ** * * ENST00000188403.6 GGGCT-----AGATAGAACA-----ACTTT-------CTCTA-------CATTGTGTTTT ENST00000452683.1 GATTTTAAGTAAATAAAATATGGTAAATTTAATATAACACTAGGAGTAGCATTTTGGTTT * * * *** ** * * *** * *** **** ** *** ENST00000188403.6 ----------AAAAGG---CTCCAG--GGAATCCT-------GCA----TTCTAA----- ENST00000452683.1 TCAATAAAGAAAAAAGTGACCATAGTTGAAATTTTCACTGTTGTAAAACTTTTAAAAATA **** * * ** * *** * * * ** *** ENST00000188403.6 TTGGCA------------AGCCCTGTTTG----------CCTAATTAAATTGATTGTTAC ENST00000452683.1 TTGGGATATTAGATTTATAGCCTCAATTGAATAAAAATTTTTAATTAGATCAATTATTGC **** * **** *** ****** ** *** ** * ENST00000188403.6 TTCA---------------------------------------------ATTCTATCT-- ENST00000452683.1 CTCTGGTGGTACTTTGTGTATATTCTTAGTATCATCTCTCTGAGGGAGTATCTTATCTTT ** ** ***** ENST00000188403.6 ---------------------------------------------GTTGAACTAGG---- ENST00000452683.1 TTCAGAGTATCTAGACTCAGTTTCCCTAAATAGTAAAATGAAGGAGTTAAACTGGATCAT *** **** * ENST00000188403.6 ------------GAAAATCTCATTTTG----------------CTCATCTTACCA----- ENST00000452683.1 CCTTTACTGCTCAAAAATTTTATTTTATCGGGAATGATTGTTTCTGATTATACAAAATGA ***** * ***** ** ** *** * ENST00000188403.6 --TATT----------------------------GCATATATTTTATTA----------- ENST00000452683.1 GCTATTAAAAATATTGCTAAAGTCCTTAGAAAAAGCATCAATTATATTATGATGCCCAGA **** **** *** ***** ENST00000188403.6 AAGAGTTG-------------------TATTCAA--------------TCTTG--GC--- ENST00000452683.1 GAAAGTTGGAAAACAAAGTCAATGGTATATTCAAAATGGAGCTCATTATTTTATTGCTCA * ***** ******* * ** ** ENST00000188403.6 -AATAAAGCAA------AC----------ATAATGGC----------------------- ENST00000452683.1 AAATTAAGTAACTTAGCACTAGGATGATGATAATAGCTAGTTACTCAAGCCTGAAACCAG *** *** ** ** ***** ** ENST00000188403.6 ------------------------------------------------------------ ENST00000452683.1 GTAGTCATCTTAGACTGCTCCCTTTCTTTCACTTCTTACTACTAAAAAGTTATAAAATTC ENST00000188403.6 ------------------------------------------------------------ ENST00000452683.1 TACTAATTTTACTTCTTAAATATCTTTTACATTTGACACCTCCTCTTCACTCCACTGTCC ENST00000188403.6 ------------------------------------------------------------ ENST00000452683.1 GTGTCATAGCTCAAGTCCTCATGTCTCACCCAGGCTATTAAAACTGTCTCGCTACTCTGG ENST00000188403.6 ----------------------------- ENST00000452683.1 TCTCTTAAGCCTAAACCATTCTTCATACT