CLUSTAL 2.1 multiple sequence alignment ENST00000216879.4 AAGTTCCTCTTTGGAGAGGCAAGAGGGCAAAGAAGCTGAGGACCCAGAAGACAGGATTGT ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 GCCTAAGAAAGTGGCCTTGGAGCAGAGGCCCAAAGAAAGCGGGGAGAGCGCCTTGCCCAT ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 CGGTAAGGGAAAGGTGCTCCAGGCACAGAAGCAGCTAATGCAACGGCCCTGAGGCAAATG ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 CAAGATAACTGGCAAGTTCCAGGAACAGCAAGGAGGGCAAGGCGCCTGGAGCAGAGGAAG ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 CTAGCGGATCCCTTGATGAGAGGGAGGAACTGGCCCATCTCTCATGGGTCCTGCAGGCAG ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 GCCATGAGACTGTCTTTTATGCGGGGCGAGATAACGAGGCATGGACGTGTTGTGAGCGGA ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 GGCCTAGCCTGTTCAAGGTCTGAATTTTTACCCCTAGAATGTAAGAAGCATGGGAGCAGG ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 GACTTTGTTTTGCTCCCTGCCATATCCACAGCCCTAGAAAAACGTCGGGCCATTGATAGC ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 TCTCAGTAAATGCTTGACAAGTAAGTGAATGAACGAATGCACAATTAATGAAATGAGGGC ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 TGCGTCAATGAATAACTGGGAATCTGACTCCTGCAGGGAGCCTTCAGCCCACAGGTGTAT ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 GTAAGACCCGCCCCGCCTCTCATCCTTCGGGCTCCCACCCCCGCCGTTAGGCTGCGGTTC ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 GCGCCGCGGTCGCCAGAGGGCGCGGAGCGGCGGGGCTTCCCGCACGGAGGGCTTTGCGTG ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 AGGCACCGCGTGGGGCGGGGCTGCGGGCGGGCTCCCAGCTGCTGGGCCCTCATCGGCTGG ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 GCCTCGTCGACCGGCAAGCGGAACGCGGCAGCGGGGCTGGGCCTGTGCGGCGGCCGCCGG ENST00000519856.1 ------------------------------------------------------------ ENST00000216879.4 AGCGCTTTGGAAGGCGCACGGGGCGAAGATGGCGGCGGAGCGACAGGAGGCGCTGAGGGA ENST00000519856.1 -------------------------------GCAGCGGAGCAACAGAAGACGCTGAGAGA ** ******* **** ** ******* ** ENST00000216879.4 GTTCGTGGCGGTGACGGGCGCCGAGGAGGACCGGGCCCGCTTCTTTCTCGAGTCGGCCGG ENST00000519856.1 GTTCGTGGTGGTGATGGGCACTGAGCAGGACCGGGCCTGCTTCTTCCTCGAGTCGGCTAC ******** ***** **** * *** *********** ******* *********** ENST00000216879.4 CTGGGACTTGCAGATCGCGCTAGCGAGCTTTTATGAGGACGGAGGGGATGAAGACATTGT ENST00000519856.1 CTGGGACTTGCAGATTGCGCTAGCGAGCTTTTATGAGGACAGAGGGGAAGAAGACATCAT *************** ************************ ******* ******** * ENST00000216879.4 GACCATTTCGCAGGCAACCCCCAGTTCAGTGTCCAGAGGCACAGCCCCCAGTGATAATAG ENST00000519856.1 AACCATTTCACAGGCAACCCCCAGTTCAGTGTCCAGAGGCACAGCCCCTAGTGATAATAG ******** ************************************** *********** ENST00000216879.4 AGTGACATCCTTCAGAGACCTCATTCATGACCAAGATGAAGATGAGGAGGAAGAGGAAGG ENST00000519856.1 AGTGACATCCTTTAGAGATCTCACTCATGACCAAGATGAGGATGAGGAAGAGGAGGAAGG ************ ***** **** *************** ******** ** ******** ENST00000216879.4 CCAGAGGTTTTATGCTGGGGGCTCAGAGAGAAGTGGACAGCAGATTGTTGGCCCTCCCAG ENST00000519856.1 CCAGAGGTTTTATGCCGGGGCCTCAGAGAGAAGTGGACAGCAGATTGTTGGCCCTCCCAG *************** **** *************************************** ENST00000216879.4 GAAGAAAAGTCCCAACGAGCTGGTGGATGATCTCTTTAAAGGTGCCAAAGAGCATGGAGC ENST00000519856.1 AAAGAAAAGTTCCAATGAGCTGGTGGATGATCTCTTTAAAGGTGCCAAAGAGCATGGAGC ********* **** ******************************************** ENST00000216879.4 TGTAGCTGTGGAGCGAGTGACCAAGAGCCCTGGAGAGACCAGTAAACCGAGACCATTTGC ENST00000519856.1 TGTAGCTGTGGAGCGAGTGACCAACAGACCTGGAGAGACCAGTACACCAAGACCATTTGC ************************ ** **************** *** *********** ENST00000216879.4 AGGAGGTGGCTACCGCCTTGGGGCAGCACCAGAGGAAGAGTCTGCCTATGTGGCAGGAGA ENST00000519856.1 CGGAGATGGCTATGGCCTTGGGGCAGCACCAGAGGAAGAGTCTGCTTATGTGGCAGGAGA **** ****** ******************************* ************** ENST00000216879.4 AAAGAGGCAGCATTCCAGCCAAGATGTTCATGTAGTATTGAAACTCTGGAAGAGTGGATT ENST00000519856.1 AAAGAGACATCATTCCAACCAAGATGTTCATGTAGTACTGAAACTCTGCAAGAGTGGATT ****** ** ******* ******************* ********** *********** ENST00000216879.4 CAGCCTGGATAATGGAGAACTCAGAAGCTACCAAGACCCATCCAATGCCCAGTTTCTGGA ENST00000519856.1 CAGCCTGGATAATGGAGGACTCAGAAGCTACTGAGACCCATCCGATGCCCAGTTTCTGGA ***************** ************* ********** **************** ENST00000216879.4 GTCTATCCGCAGAGGGGAGGTGCCAGCAGAGCTTCGGAGGCTAGCTCACGGTGGACAGGT ENST00000519856.1 GTCTATCCACAGAAGGGAGGTGCCAGCAGAGCTGTGGAGGCTAGCTCACAGTGGACAGGC ******** **** ******************* ************** ********* ENST00000216879.4 GAACTTGGATATGGAGGACCATCGGGACGAGGACTTTGTGAAGCCCAAAGGAGCCTTCAA ENST00000519856.1 GAACTTGGATATGGAGGAACATCAGGACGAGGACTTTATGAAGTCCAAATAAGCCTTCAA ****************** **** ************* ***** ***** ********* ENST00000216879.4 AGCCTTCACTGGCGAGGGTCAGAAACTGGGCAGCACTGCCCCCCAGGTGTTGAGTACCAG ENST00000519856.1 AGCCTTCACTGGCGAGGGTCAGACACCGAGCAGCACTGCCCCCTAGGTGTTGAGTACCAT *********************** ** * ************** *************** ENST00000216879.4 CTCTCCAGCCCAACAGGCAGAAAATGAAGCCAAAGCCAGCTCTTCCATCTTAATCGACGA ENST00000519856.1 CTCTCCAGTCCAACTGGCAGAAAATGAAGCCAAAGCCAGCTCTTCCATCTTAATCGTCGA ******** ***** ***************************************** *** ENST00000216879.4 ATCAGAGCCTACCACAAACATCCAAATTCGGCTTGCAGACGGCGGGAGGCTGGTGCAGAA ENST00000519856.1 ATCAGAGACTACCACAAACATCCAAATTCGGCTTGCAGACGGTGGGAGGCTGGTGCAGAA ******* ********************************** ***************** ENST00000216879.4 ATTTAACCACAGCCACAGGATCAGCGACATCCGACTCTTCATCGTGGATGCCCGGCCAGC ENST00000519856.1 ATTTAACCACAGCCACAGGATCAGCAACATCCAACTCTTCATTGTGGATGCCCGGCCAGC ************************* ****** ********* ***************** ENST00000216879.4 CATGGCTGCCACCAGCTTTATCCTCATGACTACTTTCCCGAACAAAGAGCTGGCTGATGA ENST00000519856.1 CATGGCTGCCACCAGCTTTATCCTCATGACTACTTTCCCAAACAAAGAGCTGGCTGACGA *************************************** ***************** ** ENST00000216879.4 GAGCCAGACCCTGAAGGAAGCCAACCTGCTCAATGCTGTCATCGTGCAGCGGTTAACATA ENST00000519856.1 GAGCTGGACCCTGAAGGAAGCCAACCTGCTCAATGCTGCCATCATGCAGTGGTGAACCTA **** ******************************** **** ***** *** *** ** ENST00000216879.4 ACCGCCCAGCCAGCTGCCTGGCCTCCCTCCTGTGTTTCCCATGGCCAGTGGCCATGCCCC ENST00000519856.1 ACTGCCCAGGCAGCTGCCTGGCCTCTCTCCTGTGTTTCTCACAGCCAGTGGCCATGCCCC ** ****** *************** ************ ** ***************** ENST00000216879.4 ATGGGGATCGCCCCTCCTGCCCCCTTGTGCACACCCAGCAGTCCAGTGCAACGTCTCCTC ENST00000519856.1 ATGGGGATCATCCCTCCTGCCCCCTTGTACACACC-AGTAGTCCAGTGTGACATCTCCTC ********* ***************** ****** ** ********* ** ******* ENST00000216879.4 CATAGCTCTGGGTTCTTAGATCTTGGTTGGACGTTTGTTTTCTCCTTAGTTGCATTTCCT ENST00000519856.1 CACAGCTCTAGGTTCTTAGGTGTTGGTTGAACATTTGTTTTCTCCTTAGTTGTATTTCCT ** ****** ********* * ******* ** ******************* ******* ENST00000216879.4 GGGTTTTTGTGATGATCAATGGACTTTAATGAAAAAAAAAATAAAAACAACCAAAAA--- ENST00000519856.1 GGGTTTTTGTGATGATCAATGGACTTTAATGAAAAAAA---TAAAAATAACCAAAAACAA ************************************** ****** ********* ENST00000216879.4 --AATTGAAGGAATATCACCAGCA-----TGTTGTACGGAAACTCTCCCACTGAAGC--- ENST00000519856.1 GTAGTGGATGTATTTTCACTAAAAAGAAATATTATATAGA--------CATAGAAACTGA * * ** * * * **** * * * ** ** ** ** *** * ENST00000216879.4 AGGCTTTAATTGCTTTAAAA--TTATATTTAT---CTTGGGGCCTGTGGGAGGAAACTTC ENST00000519856.1 AGATTGTAATTATTGCAAAAAATTCCAAACATACACATAATTCTTAT---ACAATTTTTC ** * ***** * **** ** * ** * * * * * * * *** ENST00000216879.4 -CTTCCATCTTCT----CTGCATAAAAACTTGTGGCACACAATGCTTATTCACTAGTGTG ENST00000519856.1 ACTTGTAACTTCCTAGACTCTATCAACAATT-CAACA-AGTATATTTGTTAACT-GTTTG *** * **** ** ** ** * ** ** * ** ** ** *** ** ** ENST00000216879.4 TCCCACC-CGCCAGCCCCACAGATGACTGGAGGAAGGAGGGGAAATGTGTAGAAAGAGGC ENST00000519856.1 TGCAACTACATTA--TACACA-ACATTTTGTTTTTTTTTTGCAAATACTCTACTGAATAT * * ** * * **** * * * * **** * ENST00000216879.4 TTCGCCA--CCACTTGTTCCCACGAGAATATGTCA--CTTGCCCAGA---TAAAACTG-- ENST00000519856.1 TTCCCCATTCTATTTAATAT-ATTATGATCTTTCATACTTTATGAAACTCTAAAACTGTA *** *** * * ** * * * ** * *** *** * * ******** ENST00000216879.4 ------------GGCGGCAGCCA-GAGTTCC-CTGAAGTGGGAAGTCAGAGCTCCATGCA ENST00000519856.1 AAATAATTTTTGGGAGGGAGAGAAGAGTTCTATTGCAAAAAAAAAT----GCTTTATGCA ** ** ** * ****** ** * ** * *** ***** ENST00000216879.4 CACAGTGTCTTCAGAAGGTGAAAATAAATATTTCCCTGTGCTCCTTTTAC-----TCAAC ENST00000519856.1 CATAATTTTTTTA--TGCTAAACA-----ATTTCCTTGGAATAAACTTGCAGGCATGGAC ** * * * ** * * * ** * ****** ** * ** * * ** ENST00000216879.4 CCCTGGG----GTATCTAATCT-----------TGCCAGGTCTTG----GCCAGTT---- ENST00000519856.1 ATCTAGATTAAGTATGCAATTTCTTTTGACATTTGCTACATATTGCTATGCTAATTTCCA ** * **** *** * *** * * *** ** * ** ENST00000216879.4 --GAGATTCTGTTC-------------CACCTGCCTGCCTG-GCCCTTTC-CTCCATTAC ENST00000519856.1 AAAGAACTGTACTCAGTAAGACAATTACACATTTCAGCCTCCGCACTGTAACTCTGTCAG * * * ** *** * * **** ** ** * *** * * ENST00000216879.4 CATCCAGAC-TGCTCGCCT-------CCTGGGGATT-CTCAGGGGCT---CCATTATGGC ENST00000519856.1 CATTTGTGTGTGCACACATAATTACACATAGAGTTGACACAGACATTTTGCCAAGATATT *** *** * * * * * * * * * *** * *** ** ENST00000216879.4 TTGATTTA-CTCCACGTGCAGAAGTCTTGAG--TGGA----CCT--AGGAGGTAGGT--- ENST00000519856.1 TTAATTTAACTTTTTTTG-ATTAATAATGAGACTGAAGATTCCTTCATGAGTTGGGTTTT ** ***** ** ** * * * **** ** * *** * *** * *** ENST00000216879.4 GGGATATTTTT----------TTTCACTAGGATACAG----CTCA---TGCCAAC--CCA ENST00000519856.1 GGGCAACTTCTGAGGTGAGAATTT--TTAGGAAAAAAAACCCCCACATTGCAAGTAATGA *** * ** * *** ***** * * * ** *** * * ENST00000216879.4 TCCTAAGTGAGTTCAGAAT-CAGGGTATCTTGCCCTATAAGATAAACAGTCAAAAT-GCC ENST00000519856.1 TTATAGCTGAAATCGAAATGCAG---ATTTTACCTTC--ATCCAAACAAAAAAAATTGCT * ** *** ** *** *** ** ** ** * * ***** ***** ** ENST00000216879.4 AC---CGAGCTGTTCACTAGTG-ATG-TGT-----GGCAAATCAA-------------AT ENST00000519856.1 GTATTTGAGTTTCTTAATAATACATGCTGTTTTTAGGAGCATCAACATTTGACATGACAC *** * * * ** * *** *** ** ***** * ENST00000216879.4 CAACTGT------TGAAGAAGGGGTGAGTTTTCTGTGCTA--------CAAGCACCTGTC ENST00000519856.1 AAATTGTAGTTTCTGGATAGGGAGTGTGTGTGGTGTACAGATGTGTGTTAAGTGTGTGTC ** *** ** * * ** *** ** * *** * *** **** ENST00000216879.4 AC-----TGTTGGTACTTGCAGGAGGCTTCTGC-TG---GGTATGTTTTG---GAAGTGA ENST00000519856.1 GTGTGTGTGTGTGTGCATGTGTGTGGTATGTGCATAAGTGGTATGTGATGTGTGGTGTGT *** ** * ** * ** * *** * ******* ** * *** ENST00000216879.4 GTGTCAC-TACTTG-----GCTTTGC-TTA---GCAGGT-----TCTGCTTCACACT-TG ENST00000519856.1 GTGTCACGTATGTGTGAGTGCATCATATTATACGCATGCACACATCCACGTGCCACCATG ******* ** ** ** * *** *** * ** * * *** ** ENST00000216879.4 TTCTTTGACCTGCTGACT--------TGTGACTTGCAGAAACATAGGCAGTAGTCCTAG- ENST00000519856.1 GTATTTGTGTTG-TAACAAAAGAGGACAAGAAGTCAAGAGATATACGTTGTAGACCTAGT * **** ** * ** ** * *** * *** * **** ***** ENST00000216879.4 -----CCTGGTAAAG------ACCCTCCA-----------CCACCCCTATAAG------- ENST00000519856.1 TCTGCCCCAGAAAAGTTAATTACCTTTTCTGAATTTCTTTCCTCATCTGTAAGAATCTAG ** * **** *** * ** * ** **** ENST00000216879.4 TTT---GATTGCTATGCAGGT-TTGGGAGAGGAGGCC----------TAT-----TGGGC ENST00000519856.1 TTTTACGAATACCATACAGTTATCTAAAGAGGAAGTAAGAAAATAAATGTGAAAGTAGGC *** ** * * ** *** * * ****** * * * * *** ENST00000216879.4 TCTTGG---ATGGAACC--CTTTCCCGT--ATTAAAC-----AA------ACCAGAGACA ENST00000519856.1 TGAAAAGTTATGCGACTTGCTTTTTTGTCTGTTAGATGTTGTAATATGTTACTAGAGAAA * *** ** **** ** *** * ** ** ***** * ENST00000216879.4 GA-ATC---AGTGCTGACTCAGGATCTCCT---GGTT--TGGAATCGTAAT------GTG ENST00000519856.1 GATATCCAAGGTATAAAACTGGGAGTTCATCACAGTTGCCAAAATGCCAGTCTATAAGTG ** *** ** * *** ** * *** *** * * *** ENST00000216879.4 CCTCAATCCT---CTTTCCAAGCAGG--CCTCACCAGTCTCTTTCTCTTTCCTGCTTCA- ENST00000519856.1 GCACTCTCCTGGGCCCTAAAACCAAGTACCTTAA-AACTTCTACCTTCTGCATAGTTTAA * * **** * * ** ** * *** * * *** ** * * * ** * ENST00000216879.4 ----CCCCTGCAAT-GAGCCAAGAA---CCA-ACACTA----CATCCACCTAGAAC---- ENST00000519856.1 CAGCCCCCTGTAATAGAAACTAGAATAGCTAGATGCCAGGAATGTCTTGATAAAATACAG ****** *** ** * **** * * * * * ** ** ** ENST00000216879.4 -TGCAGAAG----GGCTT-GTGGTTTCAACCAAG----------ACCCA----------- ENST00000519856.1 ATGTAGAAATATAGACTTAGGGGGATCTACCATGTCTCCTGCTTACCCACCTCGTAACTA ** **** * *** * ** ** **** * ***** ENST00000216879.4 ---TCCTGAG------CA---AGGGACTTGGCTTGGTGCTTTTGAT-----CCCAAAG-- ENST00000519856.1 CACTCCCAAGAGGCTACAGACAGGAATTCCGGCCAGCATTGCAGATGCTGCCTCAAGGGC *** ** ** *** * * * * * *** * *** * ENST00000216879.4 -------TTCCCACACCGGCAG---TGGCC-------------------TGCTGGGGCAA ENST00000519856.1 TTCCGGATTTCTACAAGAACAGGAATGGCTGAGGTAGCAGAGCTAAGTGTCCAGAGGCAA ** * *** *** **** * * * ***** ENST00000216879.4 TGGCATCTGTC----------------ACGGT----GTTTTCTCCAGC-AGGTGGAGATT ENST00000519856.1 GAGGATCTGGCTAACATAACAAGCCGAAGGGCCAAAGTGTGTGTAAGCTAGCTGGGTATT * ***** * * ** ** * *** ** *** *** ENST00000216879.4 ATGGAACCTACATAT-------GGGTCTG----------------GAAAAACTGTA--CA ENST00000519856.1 TGGGAATGGACAGTTAATGAGAGGGTCTGTAGGGCCAGAGTAGTGGGAAAGCCTCAGACA **** *** * ******* * *** * * ** ENST00000216879.4 CTGTTGTC--ACCT-TGACCA--TTAAAAA---CCAGAATGA----GGACAATGGA---- ENST00000519856.1 CTCTAATCTGATCTGTAGGCAGGTGACAGAGGCCTAGAGGGATCCAGCACGACAGCCTCA ** * ** * ** * ** * * * * * *** ** * ** * * ENST00000216879.4 -- ENST00000519856.1 AT