CLUSTAL 2.1 multiple sequence alignment ENST00000230588.4 CTTGCAGCAATGGCTTGGATTAGATCCACTTGCATTCTCTTTTTTACCTTGCTTTTTGCC ENST00000445953.1 -AGGAGATGATGACCATAATTGGAA--AATTGC-------------CCATG--TGGTACT * *** * *** ** * **** ** ** * * * ENST00000230588.4 CACATAGCAGCTGTACCGATTAAGTATCTTCCTGAAGAAAATGTACATGATGCAGATTTT ENST00000445953.1 CAAAGAGGAACAGAAAT--TTCGCTAACTTTTCCAGG-----GCACAAAAGGCGACCCTC ** * ** * * * * ** ** *** * * * *** * ** * ENST00000230588.4 GG---TGAACAGAAGGA---TATTTCA--GAAATCAATTTAGCTGCAGGCTTGGACCTCT ENST00000445953.1 GGAACTCAACTGGGGGAATTTACCTGGATGACATCACTCTGACAGAAACCCCCTGCCCCA ** * *** * *** ** * ** **** * * * * * * ** * ENST00000230588.4 TTCAAGGG----GACA-TCC------TCTTGCAGAAATCCAGAAATGGCC-TGAGAGACC ENST00000445953.1 --CAGGGGTCTGGACAGTCCGGAATTTCTCCCAGGTCCTTGAGAACACCAGCGAAGGGGA ** *** **** *** *** *** ** * ** * ENST00000230588.4 CAAACACCAGGTGGACGTTCCCCATTCCTTACATCTTGGCTGATA--ATTTGGGGCTGA- ENST00000445953.1 CAAGCTTCAGA-----GCCCTCGATTCTACA-ATTCAGAGGGATGCGGTTTTGGGTTAAC *** * *** * * * **** * ** * *** *** *** * * ENST00000230588.4 -----------ATGCTAAAGGA-------GCCATTCTGTA--TGCCTTTGAGATGTTCCG ENST00000445953.1 TTTATACCCCCATGGCAGAGAAAGCTCTGGCTATTTGAGACTTGCTTTTCACGTGTGCAG *** * ** * ** *** * *** *** * *** * * ENST00000230588.4 TCTCAAGTCCTGTGTGGATTTCAAGC--CC--TATGAAGGAGAGAGCTCATA--TATCAT ENST00000445953.1 TGGGGAGAATGATGCTATCCTGGAGTGGCCGGTAGAAAACAGACAGGTGATAATTACCAT * ** ** * ** ** ** ** *** ** * *** ** *** ENST00000230588.4 ATTT---CAACAGTTTGATG---GGTGCTGG-----TCTGAGGTTGGTGACCA------- ENST00000445953.1 CTTCGACCAGGAGCCTGATGTCAGGAACAGGATGTCCTCAAGTTTGGTGTTCACTACCTC ** ** ** ***** ** * ** ** ****** ** ENST00000230588.4 --------ACATGT-----GGGACAGA--ACATTTCCATT-------GGCCA---AGGAT ENST00000445953.1 CAAGTTGCACATATCTCCAGCGACAAATGACACTGTCATCTGGGACAGGCCGTCCAGGGT **** * * **** * *** * *** **** *** * ENST00000230588.4 GTG--CCTATAAGGCCA----------TCATAGAA-CACGAGATCCTGC----ATGCTTT ENST00000445953.1 GGGAACCTATCATGCTGACTGTAATTGTTTTAGAAGCATTGACTTTGGCTGGAGTGGTTT * * ***** * ** * ***** ** * ** ** *** ENST00000230588.4 GGGATTTTACCACGAGCAGTCAAGGACGGACC------GGGATGATTATGTGAACAT-CT ENST00000445953.1 CATCTCCCACCAAATGCTGAAAAGGAGGAGTTTCCTGAAAAATGATGACCTCATCATGTT * **** ** * ***** * ***** * * * *** * ENST00000230588.4 GGTGGGACC---AAAT-TCTTTCAGGTTA-CCAGCACAACTTTGACACCTATGATGATAG ENST00000445953.1 TGTGGACTTTGAAAATATCACCCACCTCAGCCAGACTGAAGTTCCCACTAAAGGCAAAAG **** **** ** ** * * **** * ** *** * * * ** ENST00000230588.4 CTTAATCAC---AGACCTCAATACACCCTATGATTATGAG-------TCTTTGATGCACT ENST00000445953.1 ACTGAGCCCCCAAGGCCTCATT---CTCCAAGGCCAGGAGCAGCAGGTCTCCAAAGAAGG * * * * ** ***** * * * * * * *** *** * * * ENST00000230588.4 ACCAGCCTTTCTCATTTAACAAGAA--TGCAAGTGTT---CCCACC-------ATCACAG ENST00000445953.1 TTCAGGAAAGGCCATGTTAGAGGAAGCCGTACCTGTCAGCCTCAGCCAGGGGCAGCCCAG *** *** * * * *** * * *** * ** * * * *** ENST00000230588.4 C---CAAGATCCCTGAGTTTAA------------CT------CCATTATCGG--ACAGCG ENST00000445953.1 CTGACAGAAGCCGTCAGTGAAGAACACAGGCCCCCTGAAGGACCATAACTGGCCACAGTA * ** * ** * *** * ** **** * ** **** ENST00000230588.4 CCT-GGATTTCAGTG---------CCATTG-------------ATTTA-GAGAGGCTGAA ENST00000445953.1 CTTCAGAGACCAATGTGACCCAAACCCTTGCCAAAATGATGGCATCTGTGTGAACGTGAA * * ** ** ** ** *** ** * * ** **** ENST00000230588.4 CCGAATG------TACAATTGCACCACAACTCACACTCTTTT-------GGACCACTGT- ENST00000445953.1 GGGGGTGGCGAGGTGCAGGTGCATCTCTGGACATGCTTTCTTCTAAATGGGAGCGCTGTC * ** * ** **** * * ** ** * ** *** * **** ENST00000230588.4 --ACTTTTGAG----AAGGCAAACATCTGTGGA--ATGATTCAGGGCAC--CAGAGATGA ENST00000445953.1 AGGCCATGCAGTTGCACGGCAGCGTCCTGGGCATGGTGATTGGAGGCACGGCTGGTGTGA * * ** * **** *** * * ***** ***** * * *** ENST00000230588.4 CACT---GACTGGGCCCATCAGGACAGTGCTC------AGGCTGGAGAAGTGGATCACAC ENST00000445953.1 TCTTCTTGACCTTCTCCATCATTGCCATCCTTTCCCAAAGGCCAAGGAAGTGACCTGCCT * *** ****** * * ** **** ****** * ENST00000230588.4 CTTGTTG--GGACAATGCACAGGTGCCGGCTACTTCATGCAGTTCAGCACCAGCTCGGGG ENST00000445953.1 GTTGGCATTGGCCAGACCACAG-CAGCACCTCCTCCATGCAGGCCT-TACCTTCCAATGG *** ** ** ***** * ** ** ******* * *** * ** ENST00000230588.4 TCCGCGGAA---GAGGCAGCCCTACTGG-AGTCTCGGATTCTTTA-----CCCAAAGAGG ENST00000445953.1 TCAGTGCAGTTTGGGGCAGCTTTTTTGTCAGCCTTGCTTTGGATAGGATCTCCAAGGTCT ** * * * * ****** * ** ** ** * ** ** **** * ENST00000230588.4 AAG-----CAGCA----GTG-----CCTGCAATTTTTCT-----ATAAAATG-----AC- ENST00000445953.1 AAGGCCTCCAGCCCCATGTGTGACCCTTGTCATCTTTCTGCCCCACATAATTCTGTTACT *** **** *** * ** ** ***** * * *** ** ENST00000230588.4 --GGGAAGTCCTTCAGACAGACTCGTTGT---CTGGGTCAGGAGGGATGACAGCACAG-G ENST00000445953.1 CTGCTATGTGCTCCTAATGTATCTAGTGTGTCCTGTGACAACATTCATCATACTTCATTG * * ** ** * * * *** *** * ** * ** * * ** * ENST00000230588.4 CAA------TGTTCG-----------------CAAGTTG--------GTGAAGGT--GCA ENST00000445953.1 TAAACCACTTGTTTGATTGACTGTCTTTCCTATAGACTGTAAGCCCCATGAGGGCAGGCA ** **** * * ** *** ** *** ENST00000230588.4 GACTTT-TCAAGGAG-ATGATGACCAC------AATTGGAAAATTGCC-CAT-GTGG-TG ENST00000445953.1 CATGTTGTTATTGACCATGCTGGCCACGTGCCTAGATGCATGGCTGGCACATTGTGGGCA * ** * * ** *** ** **** * ** * ** * *** **** ENST00000230588.4 CTCAA--------AGAGGAACAGAAGTTTCGCTACCT---TTTCCAGGGCACAAAAGGCG ENST00000445953.1 CTCAACAATGGTTGAATGAATAAAA----CAATAAATGAATGAATAAGATATAGAA---- ***** * *** * ** * ** * * * * * * ** ENST00000230588.4 ACCCTCAGAACTCA-ACTGGGGG---AATTTACCTAGATGACATC---------ACTCTG ENST00000445953.1 ACTCTCA---TTTATATTGCAGATCAAATATATATT-ATGAAATTCTTATGTTGAATATG ** **** * * * ** * *** ** * **** ** * * ** ENST00000230588.4 ACAGAAAC-----CCCCTGCCCCACAGGGGTCTGGACAGTCCGGAATT--TCTCCCAAGT ENST00000445953.1 TTAGAATCAAATACTCATTTTTCATTAGACACAGTACTGTC----ATTACTCTTTTAAGA **** * * * * ** * * * ** *** *** *** *** ENST00000230588.4 CCTTG----AGAACACCAGCAAAGG-------GGACAA----GCTTCAGAGCCCTCGATT ENST00000445953.1 TCTTGTTAAAGATTTCAAATAAAGGTACTTCCAGGCAGCCCGGCTTCACAGCATTTGCTT **** *** * * ***** * ** ****** *** * * ** ENST00000230588.4 ----CTACAATTCGGAGGGATATGGTTTTGGGGTAACTTTATACCCAAATAGCAGAGAAA ENST00000445953.1 TCCTCTGAGATTCTAAGAGA---AGCCCTTTAATAAATTTAA---TAAATATT-GAGTTA ** **** ** ** * * *** **** ***** *** * ENST00000230588.4 GC------------TCTGGT----TACTTGAGACTTGCTTTTCATGTGTGCAGTG----- ENST00000445953.1 GCACCTTCTTTGTATCTGGTATTGTATGTACGTGTGGGTGTGCATGTGTGTGTTGAAGGT ** ****** ** * * * * * * ******** ** ENST00000230588.4 -GGGAG-----AACGATGCTATCCTGGAG---------TGGCCGGTAGA------AAACA ENST00000445953.1 TGGGGGTGTTCAAAAGCTCTTTCCCAGATCTTTTAAGTTTAACAGTATATTTTATAGCTA *** * ** ** *** ** * * *** * * * ENST00000230588.4 GACAGGTGATA-ATTACCATCCT--TGACCAGGAG---CCTGATGTCCGGAACAGGATGT ENST00000445953.1 TTTATGTACAACATTATCATATTAACAAACAGAAGGTATCAGAGAACTTTAAAGAAGTAT * ** * **** *** * * *** ** * ** * ** * * ENST00000230588.4 CCTCAAGCATGGTGT---TCACTACCTC------------------------------GA ENST00000445953.1 TTTTAGATATGCTTTCTTTCCATAGTTCCTAAGGAGATAAAAATCTAGCCGGGGCAAGGA * * *** * * ** ** ** ** ENST00000230588.4 AGTCGCAC-ACATCTCCAGCGATAAATGACA-------------------------CTGT ENST00000445953.1 AGTTCCAAGATAGATCAAGTGAAAAAAAAAAAAAAAAAAAAAAAAAGCTAAAGTTTCTAT *** ** * * ** ** ** *** * * ** * ENST00000230588.4 C----ATCTGGGACAGGCC-GTCCAGGG----TGGGAACC-----TATCATACGGACTGT ENST00000445953.1 ACCCAATCAGCAATGAGTCAGCTCAGGAAATTTAACAAACAAAAATATTTTAAGGATTCT *** * * * * * **** * ** * *** ** *** * * ENST00000230588.4 AATTG---TTTTAG---------------AAGCATCGACTTG--GGC-------TGGAGT ENST00000445953.1 GAGTGGTCCTTTAAGTTATAAGGTTTCCTAAGTAGAGACTTTATGACAATTTTGTAGAGT * ** **** *** * ***** * * * **** ENST00000230588.4 --GGTTTCATTTCCCACCAAATGCTGAAA--AGGAGGAGTTTCCTGAA---AAATG-ATG ENST00000445953.1 TAAAATGCACTGGAAACAAAATGA-GAGATTAACAAGAGTTTCTTTAATGCAAAGGTATG * ** * ** ***** ** * * * ******* * ** *** * *** ENST00000230588.4 ACCTCATCATATTTGTGGACTTTGAAGATATCACCC-----------ACCTCAGCCAGAC ENST00000445953.1 AGAACA----ATTTGTAGCAAGTGAAAACAGCACCCCTGAGGGCAATACCTC--TCAAAC * ** ****** * **** * * ***** ***** ** ** ENST00000230588.4 T-GAAGT---------TCCCACTAAAGGC-------AAAAGACTG-AGCCCCCAAGGCCT ENST00000445953.1 TTGAGGTGCATCTGTATCCCAGGGAGGACTGATTAAAACAGATTACAGGGCCCCACACTT * ** ** ***** * * * ** *** * ** *** * * * ENST00000230588.4 CAT---TCTCCAAGGCCAGGAG---CAGCAGGTC--TCCGAAGAAGGTTCGGGAAAGGCC ENST00000445953.1 TACAAACCTCCACTTTCAGTAGAGCCTCCAGGTCCCTCCCAAGAGCTTCCGTAAGTCACC * ***** *** ** * ****** *** **** * ** * ** ENST00000230588.4 ATGTTAGAGGAAGCCCTACCTGTCAGCCTGAGCCAGGGGCAGCCCAGCCGACAGAAGCGG ENST00000445953.1 ACAACCCAAGAGGACCAGGGAGATTCCCTCATGCAGATGTT-CCCAGACCATGCATGTGA * * ** * ** * *** * *** * ***** * * * * * ENST00000230588.4 TCG---GTGGAGAACACAGGCCCCCTGGAGGACCATAACTGGCCACAGTA----CT---T ENST00000445953.1 TGGCATGTGGAGGGCTTC--CCACCTTGACATCTTC--CTGTCCTCTGTAGAAACTGGGT * * ****** * ** *** ** * *** ** * *** ** * ENST00000230588.4 CAG-AGACCCA---TGTGACCCAA------ACCCTTGCCAAAATGACGGCATCT------ ENST00000445953.1 CAGTAGATCTAGGGTGAGATCTAAGAATGTACATTCTTAAATGTGCCAGGATCTAACAAG *** *** * * ** ** * ** ** * ** ** * * **** ENST00000230588.4 GTGT--GAACGTG---------AAGGGGAT----GGCGA-GCTGCAGGTGC-----ATCT ENST00000445953.1 GTATAAGAATGTGCCAGAATCTAATAAGTTCTCAGGCCATGCTGCTACTGCTACTGACTC ** * *** *** ** * * *** * ***** *** * ENST00000230588.4 CTGGACATGCTTTCTTCT-----ACACG--GGGGAGCGCTG-TCAGGCCGT------GCA ENST00000445953.1 CCCCACA-ACCCCCACCTCACAGACACCTTGAGAACCACTGCTCTAGTGGATAGAAAACA * *** * * ** **** * * * * *** ** * * ** ENST00000230588.4 GGT--GCACGGCA-GTGTCCTGG--GCATGGT--GATCGGAGGCACGGCTGGC---GTGA ENST00000445953.1 AGTCTGGAAGCCAAGCATCCTGGCTGCAGGCTTGGATTGCCCATCCAGCTGGCTGGGTAA ** * * * ** * ****** *** * * *** * * ****** ** * ENST00000230588.4 TCTTCTT--GACCTTCTCCATCATCGCCATCCT--TTCCCAAAG--GCCAA--GGAAGTG ENST00000445953.1 TTTTAGTAAGAAATCATTTAAGCTCTTGATCTTAGTTTACTAACTTGTCAAATGGAAATA * ** * ** * * * ** *** * ** * ** * *** **** * ENST00000230588.4 AC------CTGCCTGCTGGCAT-TGGCCAGACCAC------AGCAGCACCTC--CTCCAT ENST00000445953.1 ATAGCTGACTATCTCCTTCCACATGACTTTACTACTTACAGAGTAGCAGAGTAATACAAT * ** ** ** ** ** * ** ** ** **** * ** ENST00000230588.4 G------CAGGCCTTAACTT-TCCCATGGTCAA-------TGCAGTTTTTATCAGCCT-T ENST00000445953.1 GGGATAATGAATATGAACCTATCTTAGAGTTTAATATGTATGAAAATATTACTATTCAAT * * *** * ** * ** * ** * * *** * * * ENST00000230588.4 GCTT----TGGATAGGA------CCT--------CCAAGGACTAAGGCCTCCAGC-CCCA ENST00000445953.1 GTTCAGACTAGATAGGAAGCTATCCTGTCACCAGCCCAGTTGTATTATCTCCAAAGTCCA * * * ******* *** ** ** ** ***** *** ENST00000230588.4 TGT-----GTG------ACCCTTGTCATCTCTCTGCCCCACATAATTCTGTTACTTTGCT ENST00000445953.1 GATTGGAAATGGATTCCAGCTTTGTT-TCTCGCTGTGCTTCACAGTCCTGCAAACCCTCC * ** * * **** **** *** * ** * * *** * * ENST00000230588.4 A-TGTGCTCCTAAT-GTATCTAGTGTGTCCTGTGAC---AACACTC--------ATCACA ENST00000445953.1 ACTAACCTCATAGTTAGGCCTAAAGAAAGCTATGCCCTTAACACTCTGCTGAGTATCTGA * * *** ** * *** * ** ** * ******* *** * ENST00000230588.4 CTTCATT-GTAAATCACTTGTTTTATTG--ACTGTCTTTCCTATAGACTGTAAGCTCCAT ENST00000445953.1 CCTCAGAAGTGAACTCTAGGCTTTGTTGCTGCTGCTGCTGTTATTGTCCTTTGGTTTTAT * *** ** ** * *** *** *** * *** * * * * * ** ENST00000230588.4 GAGGGCAGGCACATGTTGT--------TCTCATTGACCG--TGCTGGCCC----CAGTG- ENST00000445953.1 TAAA--AGGAACATGCTGTGGTCTGTCTCACATGGAAAGGTCCCTAGCCCAAACCAATGA * *** ***** *** ** *** ** * ** **** ** ** ENST00000230588.4 --------CCTAGATGCATGG--------CTGG--------------CACATT------- ENST00000445953.1 CAACATTTCTTAAATATATGAGTTTCTCTCTGGAAGAAGCAGAAGCTCAAATTTCAAAGA * ** ** *** **** ** *** ENST00000230588.4 -------GT---------TGGCACT-CAAC----AATGGTTGAATGAATAAAACAATAAA ENST00000445953.1 TAACCTAGTATTTTCATCTAGTACTGCAAATTAAAACTGCTAGGTCAAAATAATGATAAG ** * * *** *** ** * * * ** * ** **** ENST00000230588.4 T--------GAATGAA--TAA------CTAAGATATAG--------AAACTCTCA----- ENST00000445953.1 GAGGTACCAGAATGAGGGTAAAGCATTTTGATATTTATTTCTCTCTAGATTCTCAACCAG ****** *** * * ** ** * * ***** ENST00000230588.4 --------------------TTTATA----TTGCAGATTGAATAT------ATATGATGA ENST00000445953.1 TACCATGCCTACTATCTATCTTTATCACTTTTGGTGATTAATGGTCACCTCAGTTGATTA ***** *** **** * * * **** * ENST00000230588.4 A--ATT---CTTATGTTGAATATG--------------------TTAGAATCAAATACTC ENST00000445953.1 ATGATCTGGCTCACCATAAATCTGACATGGTATTCAGCTTTTCTTTGAGCCCAAACCCTC * ** ** * * *** ** ** **** *** ENST00000230588.4 ATT--TTTCATTAGATACAGTAGTGTCATCACTCTTTTAAGATCTTGT--TAAAGATTTC ENST00000445953.1 AATCATTCCAGGAGGACTAGCAGATACTTTATTCTTTTGAGGTGTTGGGATGGTGATGGC * * ** ** ** ** ** * * * ****** ** * *** * *** * ENST00000230588.4 AAA-------------------------TAAAGGT-----ACTTCTGGGCAGCCAGGCTG ENST00000445953.1 AAAGTGGGCATGTAGGATGGGGAGTGGGTAGAAATTAAGCATTTCATAATCTCTAGGCAG *** ** * * * *** * **** * ENST00000230588.4 CACAGCATTTG---CTT----------------------------TCCTCTGAGATTCTA ENST00000445953.1 TATGGAATTTGGGATTTAGATGAGCAACATGAAAAATGTGGGAAATCCTCCCTGAATCTG * * ***** ** ***** ** *** ENST00000230588.4 AGAGAAGGCCTTTAATAAATTTA-ATAA--ATATTGAGTTAGCA ENST00000445953.1 AGTGTCTGACTTCTTTAATCTTACATAGTGGGAATAAGTCA-TA ** * * *** *** *** *** * * *** * *