CLUSTAL 2.1 multiple sequence alignment ENST00000259963.3 GGGGGAGGGAAACGGAGCAGTGACAGGTATCCCAGAGGGTGCTGCTGAGGCGACGATGGC ENST00000427218.1 ------------------------------------------------------------ ENST00000259963.3 CGAGGGGCCCGAGGAAGCCCGAGGCCACCCTCCCGGGCAGGACGATGGCGGAGGGGACCA ENST00000427218.1 ------------------------------------------------------------ ENST00000259963.3 CGAGCCCGTCCCTTCCCTGAGAGGCCCTCCTACCACCGCCGTCCCATGCCCCCGCGACGA ENST00000427218.1 ------------------------------------------------------------ ENST00000259963.3 CCCCCAGGCCGAACCCCAGGCCCCGGGCCGGCCCACAGCCCCGGGCCTCGCGGCTGCCGC ENST00000427218.1 ------------------------------------------------------------ ENST00000259963.3 CGCAGCCGACAAATTGGAGCCGCCGCGCGAGCTCAGGAAGCGCGGGGAGGCGGCCTCCGG ENST00000427218.1 ------------------------------------------------------------ ENST00000259963.3 CTCCGGTGCAGAGCTGCAGGAGCAGGCGGGCTGCGAGGCGCCCGAAGCCGCGGCGCCACG ENST00000427218.1 ------------------------------------------------------------ ENST00000259963.3 AGAGAGACCAGCTCGGCTGAGCGCCCGCGAGTACTCCCGGCAAGTGCACGAGTGGCTGTG ENST00000427218.1 ------------------------------------------------------------ ENST00000259963.3 GCAGTCCTACTGCGGCTACCTCACCTGGCACAGCGGCCTGGCCGCCTTCCCAGCCTACTG ENST00000427218.1 ------------------------CTGGCGCAGTGGCCCGGCTACACTCCCCGACTGCTG ***** *** **** *** * **** * ** *** ENST00000259963.3 CAGCCCCCAGCCCTCCCCGCAGAGCTTCCCTTCGGGCGGCGCTGCAGTCCCCCAGGCCGC ENST00000427218.1 TAGCCCCCAACCGTCCCGGCAGAGCTTCTCTTTGGA-GGCACTGCCGTCCCCCAGGCCGC ******** ** **** ********** *** ** *** **** ************** ENST00000259963.3 GGCGCCGCCGCCCCCGCAGCTGGGCTATTACAACCCCTTCTACTTCCTGAGCCCCGGGGC ENST00000427218.1 GGCGCCGCCATCCCCACGGCTGGGCTATTACAACCCCTTCTACTTCCTGAGCCCCAGGGC ********* **** * ************************************* **** ENST00000259963.3 CGCGGGG-CCTGACCCGCGGACAGCTGCCGGCATCAGCACCCCTGCTCCAGTCGCGGGCC ENST00000427218.1 CGCGGGGGCTTGACCCGGGGGCAGCTGCTGGCATCAGCACCCCTGCTACAGTCACGGGCC ******* * ******* ** ******* ****************** ***** ****** ENST00000259963.3 TGGGACCCCGGGCTCCTCACGTGCAGGCGTCGGTCCGGGCCACTCCAGTGACGAGGGTAG ENST00000427218.1 TGGGACCCTGGGTTCCTCATGTGCAGGCGTCAATCCGGGCCACTCCAGTGACAAAGGTAG ******** *** ****** *********** ******************* * ***** ENST00000259963.3 GATCCGCAGCCCCTTCGCGAAGCCCGAGCGAGACCGGGCGACAGGCAGGCAGAGAATATG ENST00000427218.1 GATCTGCAGCCCCTTCCCGAAGCCAGAGTGAGACCGGGCAACCGGCAGGCAAAGAATAAG **** *********** ******* *** ********** ** ******** ****** * ENST00000259963.3 TTATTCCATCCTTGGCCCACAGATTTATGGCAGAGATGGTGGATTTCTTTATTCTCTTCT ENST00000427218.1 TTATTCCATCCTTGGGCCACGGGT----GGCAAGGATGGTGGATTTCTTTATTATCTTCT *************** **** * * **** ******************* ****** ENST00000259963.3 TTATAAAAGCAACCATTGTCTTAAGCATTATGCACCTCAGTGGGATAAAGGATATCTCTA ENST00000427218.1 TTGTAAAAGCAACCATTGTCTTAAGCATTATGCACCTCAGTGGGATAAAGGATATCTCTA ** ********************************************************* ENST00000259963.3 AGTTTGCTATGCATTATATAATAGAAGAAATAGATGAAGACACATCAATGGAAGACTTGC ENST00000427218.1 AGTTTGCTATGCATTATATAATGGAAGAAATAGATGAGGACACATCAACGGAAGACTTGC ********************** ************** ********** *********** ENST00000259963.3 AGAAAATGATGGTTGTGGCACTTATATACAGATTATTAGTTTGTTTCTATGAGATAATTT ENST00000427218.1 TGAAAATGATGGTTATGGCTCTTATATACAGATTATTAGTTTGTTTTTATGAGATAATTT ************* **** ************************** ************* ENST00000259963.3 GCATTTGGGGAGCAGGTGGAGCTACCCCAGGGAAGTTCCTGCTGGGGCTTCGAGTTGTGA ENST00000427218.1 TCATTTGGGGAGCAGGTGGAGCTACCCCAGGGAAGCTCCTGGTGGGGCTTCGAGTTGTGA ********************************** ***** ****************** ENST00000259963.3 CATGTGATACATCAGTGCTTATTGCACCAAGTCGGGTTTTAGTGATTCCTTCCTCAAATG ENST00000427218.1 CATGTGATACATTAGTGCTTATTGCACTAAGTCGTGTTTTAGTGATTCCTTTTTCAAATG ************ ************** ****** **************** ******* ENST00000259963.3 TTAGCATTACAACGTCCACTATCCGAGCTTTGATCAAGAATTTTTCAATTGCTTCTTTTT ENST00000427218.1 TTAGCATTACAACGTCCACTATACGAGCTTTGATCAAGAATTTTTTGATTGCTTCTTTTT ********************** ********************** ************* ENST00000259963.3 TCCCTGCTTTCATCACACTGCTGTTTTTTCAGCATAATCGAACAGCTTATGACATTGTAG ENST00000427218.1 TCCCTGCTTTTATCACACTGTTGTTTCTTCAACATAATCGAACAGCCTATGACATTGTAG ********** ********* ***** **** ************** ************* ENST00000259963.3 CAGGAACCATTGTGGTAAAAAGAAATGGGGTCAGATGATGCCCCCC-AAAACCCTGATTT ENST00000427218.1 CAGGAACCATTGTGGTAAAAAGAAATGGGGTCAGA-GATGCCCCCCCAAAGACCTGATTT *********************************** ********** *** ******** ENST00000259963.3 CCACACACTA--------AGACTAAATTATGTATCAAGGCCATCAGTATCCCTGGGTTAC ENST00000427218.1 CCACACGCTATAATGACAAGACTAAATTATGTATCAAGGCCATCAGTATCCCTGGGTTCC ****** *** **************************************** * ENST00000259963.3 ACTAATTGATGATTTAGAAATTAAAGCAGTCACTCCAGTGTGATGCAGGTGACTACTCTG ENST00000427218.1 ACTAACTGATGATTTAGAAATTAAAGCAATCACTCCAGTGTGATGCAGCTGACTACTCTG ***** ********************** ******************* *********** ENST00000259963.3 AAAGTATTGATTATACTTGAATGCCAAAGAACTTGTCCAGAAGAAAAACCTGTTAAATTC ENST00000427218.1 AAAGTTTTGATTGTACTTGAATGCCAAA-AACTTTTCCAGAAGAAAAACCTATTAAATTC ***** ****** *************** ***** **************** ******** ENST00000259963.3 AAGTATTAAAATTTTTAGATCAAAAAGGCAAATGATTTTATAAACAATGGACAATATATA ENST00000427218.1 AAGTATTAAAATTTTTAGATCAAAAAGGCAAATGATTTTATAAACAATGAACAATATATA ************************************************* ********** ENST00000259963.3 CTTTCTTAAGATCTAAGGTACTTTCTTAAGATCTAAGAATTTGCTGAAAGCATTTTCAGC ENST00000427218.1 CTTTCTTAAGATCTAAGGTACTTTCATAAGATCTAAGAATTTGCTGAAAGCATTTTCAGC ************************* ********************************** ENST00000259963.3 TTTGAAATCTCCAAATGAAACTTTAAAATTTATTTTGGTTTATCCCAAAATAATGGAAAA ENST00000427218.1 TTTGAAATCTCCAAATGAAACTTTAAAATTGATTTTGGTTTATCCCAAAACAATGGAAAA ****************************** ******************* ********* ENST00000259963.3 TGTCCAGTTGTGTTTTGTAAACACCTATGTAACTCATCTTTTAGTTTACACTTCCTGGGG ENST00000427218.1 TGTCCAGTTGTGTTTTGTAAACATGTATGTAACTCATCTTTTAGTTCACACTTCCTGGGG *********************** ********************* ************* ENST00000259963.3 AAATTGTCTTTGGTGTTTAGAGGAGGGAATGAGAACACAAATTGGATAATCCACTGTCTC ENST00000427218.1 A-----------GCCACCAAAGAAGG-------------------------------TCC * * * ** *** * ENST00000259963.3 CCATCCCAGGAGGTGGTGAGTTGGCTACAAGAGAAAGGGACAAGTGAGGCAGGCCTAGCA ENST00000427218.1 CCAT-----------GGGAGCTAG------------GGGAC------------------- **** * *** * * ***** ENST00000259963.3 GTTCCCTTACCTGAAGTTTTCAAATCCATACTGCAGTTCCCTCTCGTAATGATGTAACTT ENST00000427218.1 ----CCTTACC-------------------------------CTCAGGA----------- ******* *** * ENST00000259963.3 TACAACTATTCTTAATGCTTGAACATGTATTTAGGGGCAAGTTTCTCATGATGATGAAAA ENST00000427218.1 -ACAGTCAGTCT-ATTACTTGGA---------AGGTCTAAATTT-------------AAA *** * *** * * **** * *** ** *** *** ENST00000259963.3 AGTATCAAGTCATATTGCTATGTTAATTGGTTTTTTTTTTTAAAAGGTAAGTTAGTGATT ENST00000427218.1 AG---------ATGTTACTGTAC--AT---------------ACAGG--AATAATTGACT ** ** ** ** * ** * *** * * * *** * ENST00000259963.3 ACTGTTAATGGTGGGGGAGTAAGTTTTCACTGTAAATTGAACTTATAATTTATGTGCAAG ENST00000427218.1 -CTGATTATACTGGAG-----------------AGATTCAA--------TTA-------- *** * ** *** * * *** ** *** ENST00000259963.3 TGTTTTCAGTGCCCTGAATCAAACTATAAATGTGGGGAGAAATCACCTCCATCAAACAGT ENST00000427218.1 -GTTATTAGTTCCTCGA-----------------------------CTCC---------T *** * *** ** ** **** * ENST00000259963.3 TGCATATTTACTGTAAAAGTATTCCCAGTATGTGTGCAGCATGAAGAAAGTATTAGTGCT ENST00000427218.1 TG---ATCTGCC---------TCCCCAA---------------GAAAAAGAATTG----- ** ** * * * **** * **** *** ENST00000259963.3 TCTCAGTGTTCTCAGTGTAAATTCTATTTATATACAGCATATTCACATACTACTTTCCTT ENST00000427218.1 -CTCAGT----------------------------------------TGTTGCTGT---- ****** * * ** * ENST00000259963.3 ATATTTTATATAGTTCTATGACTGTTGAAACATCAAGGAGTTAAAAAAATCTTAATATTT ENST00000427218.1 -TACCTTACATAAAACTAGGA-------AGCAGCA--CAGTGAAAAGAA----------- ** *** *** *** ** * ** ** *** **** ** ENST00000259963.3 CATGATTAACTCTAAGTACTATTAATTAATAGCTTGCGAAATATTAGCAATTTTCCCATT ENST00000427218.1 CAGGA--GGCTTTG-GTAATACTAAT-----------------------------CCAGC ** ** ** * *** ** **** *** ENST00000259963.3 ATGGACTATTCTCTCTAAAGCAAGAGAGACTAGCATTCCCAGACATCATTCTAGGGTCTT ENST00000427218.1 ATG------------------AAGGG------------CCGTGCA-----CTGGGTTAAT *** *** * ** ** ** ** * * ENST00000259963.3 TAAGCTCATTTTGGGTCTGCTAAAGTTTGGGGGGAAATGTTACGCAAAGTGATACTGTGT ENST00000427218.1 CAAGT---------ATCTGACAAAA--------GACCTATT-TGCACAGTAA-------- *** **** *** ** * ** *** *** * ENST00000259963.3 ATGTTGCCATTTTGCTTTATTCTTCTGTTGAAGCAAAATTGTGGGGTTTTATTATGTGTG ENST00000427218.1 ------------------------CTATTCAGGGAAAA------GATTTT-------GAA ** ** * * **** * **** * ENST00000259963.3 TGTGCTTTTCCTAGATGTCCCAGTTAGCTGTGCTGAGATATACCTGTACTATTTATGGTT ENST00000427218.1 GGAG-------TAGA------AGATACTGGAGCTGA----TGTCTCTATTATT---GCTG * * **** ** ** * ***** * ** ** **** * * ENST00000259963.3 TAAGTTTTGATTCTTAGGTATTTTCTCCAGCTCTGACATTGTTTTCCAAAGACACACTAA ENST00000427218.1 TAAAT--CAAT-----------------GGCCCTGGCACTGGC-------------CTAA *** * ** ** *** ** ** **** ENST00000259963.3 ACTGCATTGCACAGTTCAAAATTTGATTACTTAAGGGATCAATCTAGGTGGTGTTCTTGG ENST00000427218.1 GC---------------AAAA-------------GGCATCCAT-----TGGTATTGTTGG * **** ** *** ** **** ** **** ENST00000259963.3 TCTTAAATTTAACAGCAAACACAGCACATATCTATTATCACTATATTAATTTTCAAAGGT ENST00000427218.1 -------------AGTAGGAGCTGC-------------------------CTTCAGAG-- ** * * ** **** ** ENST00000259963.3 TTTTCTTTGACGTTTAAAACTGTGACAACAGATATTCACATTTGATTATAGAAACTTAAT ENST00000427218.1 --TTCTTTGATTTT----ACCATGTCAAGGG-----------------------CTGGAT ******** ** ** ** *** * ** ** ENST00000259963.3 GTCTATTAATAATTTTAGTACAAAATTTCATAAACCGTGTTTTTCAAAATAAGTTTATGT ENST00000427218.1 G---GTCAGGAA----GGGACAA------------------------------------- * * * ** * **** ENST00000259963.3 CAAATCCAGCTTCCCAGAAACACTAATAATTAAGTACATCAATGTACTAAATAAATCATT ENST00000427218.1 ----TTCAGCCT-------------ATCATTA----CACCTAT---------------TC * **** * ** **** ** * ** * ENST00000259963.3 CAGTTGCACCCATGGGGAAGATTGTGTTACTGCCCTTCACAGTGAAAAAAAGAAAAATCT ENST00000427218.1 CTGTC-CATTTATGGGGTAGA--GACTCATTG----TAACAATGGGATGCTGAAATACCT * ** ** ****** *** * * * ** * *** ** * **** * ** ENST00000259963.3 TTCATTTTTA-AAATTAGGAGATGTTACGTAACTTGGCACTTTAGTAGTGTATACACTAG ENST00000427218.1 ---ATTCCTACGGATCAATATA------GTAA-TCG------TAGTAG-----ACA---- *** ** ** * * * **** * * ****** *** ENST00000259963.3 CATTAGTTTATACACCACTTTTGCCGCTGGGGAATTCAAGTTGAAATGTCCCTCAATCAT ENST00000427218.1 ----AAT------------------GATGAAAAATA-----TGGGATATCACCTGG--GA * * * ** *** ** ** ** * ENST00000259963.3 ATAGGTCTGGAATACATCTTTCATTCATAATTTCTGCTCAGATAATTGAATAGTTTGCCA ENST00000427218.1 ATAGGACTAGGAAA-------------------------AGATAA--AAATGGC---CAA ***** ** * * * ****** *** * * * ENST00000259963.3 TCGAGATTATTTTCATTTATACTATAAAACAAAAGCAAACTAGTCCAGTTTAATTTTTTG ENST00000427218.1 TCAGAA-------CCTTTAGAAT-TAAA---AGGGCAAA-TAGATCGGACCAGATT---- ** * * **** * * **** * ***** *** * * * ** ENST00000259963.3 TACTTAGAATATTGCACATTTTCTATATATGAGTTATTCAGATTAGTATCTATGTAGGTT ENST00000427218.1 -----GGGGTGT----CATTTT-TAGAAGCG-GCCATC--GTTGAGCCTCT-----GGCT * * * ****** ** * * * ** * * ** *** ** * ENST00000259963.3 CAGTCAGATCCAACCATGGATTCGAGGTATTATACTGTATAACCCTACAAAATACATAGA ENST00000427218.1 C------------CCAT---TTC----TCTTGT-CTGGCTAA--CTGCCAAAC---CAG- * **** *** * ** * *** *** ** * *** ** ENST00000259963.3 AGTATTATTTGCCTTCATAATAGAACCCAAGAGTCTGTTTCAATTTATGAATTCAGTATT ENST00000427218.1 -------TTTG-------GGTGGAGC---AATGGCTGCTGAAA----------CAG---- **** * ** * * * *** * ** *** ENST00000259963.3 TGCACCGAGATTTTGATTCCCAAAGTTTGGAAAAAAATGACAAAACAACGAGGGAAGAAG ENST00000427218.1 ------GAAAAACTGG------AGGCTTTAAAAGAACTGGTACAGGAACAATTGCAAAAG ** * ** * * ** *** ** ** * * *** * * * *** ENST00000259963.3 GAACCAGACCTTAGTGCCACATATTTTTCTCTTGGGGTTGTAAGGTAGTCTCCTGCTTTC ENST00000427218.1 GGAC-ATA---TAGAGCC-TACTTTCTCCCCTTGGAATT----------CTCCTG----- * ** * * *** *** * ** * * ***** ** ****** ENST00000259963.3 CAGAACACTTTATTATATTTCACTTATAGACCTGATTTTCTGTGTCAAAGTATAATTCTC ENST00000427218.1 ---------------TATTT-----------------------GTCA------------- ***** **** ENST00000259963.3 ATGCTGAAGCTGTAGCCTAAAAAGCCAAAAGAAAGTTGTCTTCATTGTACAAACATATTC ENST00000427218.1 ----TTAAG---------AAAAAATCAGGGAAA--------------TGGAAA------- * *** ***** ** ** * *** ENST00000259963.3 ATCACTTTAACAATAAGGGAACAAAATTTAGTATTCAAGCTGAGTGAGAATACTGT--TT ENST00000427218.1 ---ACGTTAACAG-------------------ATTTAAG--GGCTGTTAATGCTGTGATT ** ****** *** *** * ** *** **** ** ENST00000259963.3 CAATGAGCATGTCCCTAAGATAAACCAGAATTGGCAGTTAATTTAGGCGTCTAGAAAATC ENST00000427218.1 CAACC--CATGGGCGCACTGCAA-CCAGGGCTGCC------------CTCCCCAACAAT- *** **** * * ** **** ** * * * * *** ENST00000259963.3 TCAGTTCCCACCAGTAAAATTATCCTGAGTAGCTAATGCACCTTGAGAAAAATCTGGCAT ENST00000427218.1 --GATCCCCA-----AATACTGGCCT------CTCATA------GTGATAGATCTAAAGG * **** ** * * *** ** ** * ** * **** ENST00000259963.3 ACTGAATAAATAACATTAACTTGGGAGCCAAGAGCTGGGTAAGCCTTACCTTTAGACTAC ENST00000427218.1 ATTGCTTTTTTACCATTCCTTTAGCTGCCCAAGATTATGAGAAATTTGTTTTT--ACTGT * ** * ** **** ** * *** * * * * ** *** *** ENST00000259963.3 TCTGTGACTACAGA-AATAAAGCCAGCACTTTTGGAACTAATAAGCCTTCACTTGTCAGT ENST00000427218.1 TCCC--GCCATAAATAATAAAG-------------AACCAGCAGACA----------GAT ** * * * * ******* *** * * * * ENST00000259963.3 ATCAT-AAAGAGTATTGCCCAACTGAACTTTGCTCCCACTGGTTTAATAGTTACTTATTT ENST00000427218.1 ACCATTGGAAAGTACTACC--ACAAGGCAT-----------GCTAAATAGTCA------- * *** * **** * ** ** * * * * ****** * ENST00000259963.3 CTGCCTAAGCACTCACCTTCCGATTTTACCCAAGTATATATATAGGATAGAAAAAAATGC ENST00000427218.1 --GACTA-----------------TTTGTCAAACT---TATGTCGG-------------- * *** *** * ** * *** * ** ENST00000259963.3 ATTATATTTGAGAGCTACTTCGCCCAAATTACAAAATGAGTGTTTTTAGATTCAAGTGAC ENST00000427218.1 ---------GAAAGCTATTAAGCC--AGTTAGAGAACAG-----TTTAAA---AAATG-- ** ***** * *** * *** * ** **** * ** ** ENST00000259963.3 AGTAAAAGGATTTGTTCCCTTCAGTGACTTGAGTGTTTTAGTTATGCATAAGTATTTCTA ENST00000427218.1 -----------TTGTATCATCCA-TTCCATGGATGAT---ATTCTGTGT--GCAGCTGAA **** * * ** * * ** ** * ** ** * * * * * ENST00000259963.3 GCAAAGGAAGGGTAGAAAGGAATTGAAAATTAATTTACACTAGTTGCTACTTGGGAATAA ENST00000427218.1 ACTAGGGAAG-----------------AACTGAT--------GTTG-TGCT-----ACAA * * ***** ** * ** **** * ** * ** ENST00000259963.3 AGGGCTTTTTGAGGGGGGTATGGATATTAAATGTTTTCGTTATATACTTATCCCTATTAA ENST00000427218.1 A---CTGTTAGAAAAGGCTGT-------AAATGC-------------------------- * ** ** ** ** * * ***** ENST00000259963.3 AACAGGCAGTTGTTTCTTTGAATATGCCTAAATAACAGTATTCTTAAAATCTGACAGACA ENST00000427218.1 AGCAGG--GTTAATT------ATAGCCCTCGATAA------------AATCCAA------ * **** *** ** *** *** **** **** * ENST00000259963.3 AGTAACATGTCAATTACTTGATATTCCTTGTCTCCAGTACCACAGGCCACTCTTGACATC ENST00000427218.1 ---------------ACTTC-TACTCCCT---TTCAATA----AAGCCA----TGGC--T **** ** *** * * ** ** * **** ** * ENST00000259963.3 CCATGTTTGCCTGGATAAAGTTCCTCATTTCAAACAGTATACATACTTCTTTGCAGTTCA ENST00000427218.1 ACATTTTTTCAACAATGGAAT-----ATTGCCCATACTACGGGTA-TTCCACATAACTCA *** *** * ** * * *** * * * ** ** *** * *** ENST00000259963.3 TTATAGTAAGGCTTAACCTGTAAACAGTATCTGATGGCCCACCTATAAATAAAATTCAGC ENST00000427218.1 C------AAGG--------ACAAGCAATA---------------GTGGAAAGAGCT---A **** ** ** ** * * * * * ENST00000259963.3 ATTCTATTTTTAATAATTTGTATGCCACCAATTTGTATTATTTGTCTCAATAAATACTTA ENST00000427218.1 ATTGTACTTT-AAAAACTC--------------------------------AAATAC--A *** ** *** ** ** * ****** * ENST00000259963.3 GTCATCAATGCA ENST00000427218.1 A-----AAAGC- ** **