CLUSTAL 2.1 multiple sequence alignment ENST00000283109.3 GGAATAACGACCTGCCTTAC-GCTTTGCGGCTGTCGTCGGAGAGGCATCTGGGTTCGGAC ENST00000447743.1 ---------CCTCATCTAATTGCCTTGT---CATTATTAAACAGA-----GAATTCAGAC * ** * ** *** * * * ** * *** *** ENST00000283109.3 TGGGGCCGCCATGGGGAAAGTGAATGTGGCCAAGTTGCGTTACATGAGCCGAGATGACTT ENST00000447743.1 T-----TTTCAGAGATGAAGAAAATATGG----------------GAGCTA-------TT * ** * *** *** *** **** ** ENST00000283109.3 CAGGGTCTTGACCGCGGTTGAAATGGGCATGAAGAACCATGAAATTGTTCCCGGCAGTTT ENST00000447743.1 ---------------------AATCAGTAT--AGAACAA-GAA----CTCTTG--AGT-- *** * ** ***** * *** ** * *** ENST00000283109.3 GATTGCTTCTATAGCCAGCCTTAAACATGGTGGCTGTAATAAAGTTTTAAGAGAATTAGT ENST00000447743.1 -ATTACTTCTTCAGGTAGTGTTGTTAA--GTTGTT-CAACAATTCTCTG---GAACTGGT *** ***** ** ** ** * ** * * ** ** * * *** * ** ENST00000283109.3 GAAACATAAACTCATAGCTTGGGAGCGTACCAAAACTGTCCAGGGCTATCGGTTGACAAA ENST00000447743.1 GAAACAGAA-----------GGGG-------AAA------------TGTCAGTTGACAAA ****** ** *** *** * ** ********* ENST00000283109.3 TGCAGGATATGATTACCTAGCTTTGAAAACACTTTCTTCTAGGCAAGTAGTTGAGTCTGT ENST00000447743.1 -ACAGCAAA-----ACTCAGCCGTCAGA-CAT-----------CAA----------CTGC *** * * ** *** * * * ** *** *** ENST00000283109.3 TGGAAACCAGATGGGTGTTGGCAAAGAATCAGATATTTACATTGTTGCAAATGA-AGAAG ENST00000447743.1 -AGAAAGAAGA--------GGCAA------ATACACTTAC-------CAAGCAATGGAGG **** *** ***** * * * **** *** * ** * ENST00000283109.3 GACAACAATTTGCATTAAAGCTTCA--CAGACTAGGAAGAACCTCGTTTCGAAATTTGAA ENST00000447743.1 GAAAACA---TGCA--AAATATTAAGTCAAGTTTGGAAGCAACTAGCTT-----TTGGGG ** **** **** *** ** * ** * ***** * ** * ** ** * ENST00000283109.3 AAACAAACGCGATTATCATAAACATAGGCACAATGTGTCATGGCTATATTTATCTCGTCT ENST00000447743.1 AGA-----------ATGATACATTTAAG--------ATCTTGGATATGTTTAATGTATTT * * ** *** * ** * ** *** *** **** * * ENST00000283109.3 CTCTGCCATGAAGGAATTTGCCTATATGAAGGCATTGTATGAGAGGAAATTTCCAGTTCC ENST00000447743.1 TT------TAAAG----TTAC-TATA-------ATTCTTT----------TTTGAGCTCC * * *** ** * **** *** * * ** ** *** ENST00000283109.3 AAAGCCAATTGATTACAATCGTCATGCAGTGGTCATGGAACTCATAAATGGTTATCCACT ENST00000447743.1 ------------CTTTAGTCTTTTT----------TGGACC-----AAGG-----CCATT * * ** * * **** * ** * *** * ENST00000283109.3 ATGTCAGATACACCATGTTGAAGATCCTGCATCAGTATATGATGAAGCTATGGAACTAAT ENST00000447743.1 ATAT-AAATACATAA-GTAAACTCTCTTTCATC--TATTTAAAAAAAAAAAAAAAAGAAT ** * * ***** * ** * ** * **** *** * * ** * ** *** ENST00000283109.3 --TGTCAAACTTGCAAATCATGGGCTGATTCATGGAGATTTTAATGAATTTAATCTCATT ENST00000447743.1 AGTGTCTAAATT---AACCAC-----------------TTCTACT----TCCATCTGTCT **** ** ** ** ** ** ** * * **** * ENST00000283109.3 TTGGATGAAAGTGACCATATCACCATGATTGATTTTCCACAGATGGTTTCAACTTCTCAT ENST00000447743.1 CTGAAGGA---------------------TGATTTCCTAC------TTGTGACAT---GT ** * ** ****** * ** ** ** * * ENST00000283109.3 CCCAATGCTGAGTGGTATTTTGACAGAGATGTTAAATGCATTAAAGATTTCTTTATGAAA ENST00000447743.1 CCC-----------------TAACAGAAGC----AATGCTC---AGAT---------AAA *** * ***** ***** **** *** ENST00000283109.3 CGTTTCAGCTACGAAAGTGAGCTTTTTCCAACTTTTAAGGATATCAGGAGAGAAGACACT ENST00000447743.1 ----TTAACTA---AAG----------CCAAGTCTT-----TATT----GAAAAGAT-TA * * *** *** **** * ** *** ** **** ENST00000283109.3 CTTGATGTGGAGGTTTCTGCCAGTGGCTACACAAAGGAAATGCAGGCAGATGATGAACTG ENST00000447743.1 CTTAATAGCAA------TAGCTGTGTATCCCCAAAGCCAATG-----AGA---------- *** ** * * * *** * * ***** **** *** ENST00000283109.3 CTTCATCCATTAGGTCCAGATGATAAAAATATTGAAACAAAAGAGGGATCTGAATTCTCA ENST00000447743.1 CTTTGTTT------TCCAAATCATT----TATT-------------------AATT---- *** * **** ** ** **** **** ENST00000283109.3 TTTTCAGATGGAGAAGTGGCAGAAAAAGCAGAGGTTTACGGGTCAGAAAATGAAAGTGAA ENST00000447743.1 TTTCTAAAT------------------ACCAAAATTTA---------------------- *** * ** * * **** ENST00000283109.3 CGGAACTGTCTAGAAGAATCAGAGGGCTGCTATTGCAGATCATCTGGAGACCCTGAACAA ENST00000447743.1 ---ACTCTTCTAGAAGCAT--------TGCCATTTT---CCATC-----ACCTTGAAGAA * ******** ** *** *** **** *** **** ** ENST00000283109.3 ATAAAGGAAGACAGTTTATCAGAAGAGAGTGCTGATGCACGGAGTTTTGAAATGACTGAA ENST00000447743.1 ATAAGTG----CAGTTT--------------CTAAT------AATTTGGATCTAACCACA **** * ****** ** ** * *** ** * ** * ENST00000283109.3 TTCAATCAAGCTTTAGAAGAAATAAAAGGGCAGGTTGTTGAAAACAACTCTGTAACTGAA ENST00000447743.1 CT------AGTCTTA-------TTATTCCATAC-TTGTTAAGAA-------------AAA * ** *** * * * ***** * ** ** ENST00000283109.3 TTTTCTGAGGAGAAAAACAGAACTGAAAATTACAACAGGCAAGATGGTCAGAGAGTTCAA ENST00000447743.1 TTTTGTGATGAGCTAGACAATTCTGTCATTTACCACAGCTA-------CATAAAGCC--- **** *** *** * *** *** * **** **** * ** * ** ENST00000283109.3 GGAGGAGTCCCTGCTGGCTCTGACGAGTATGAAGATGAATGCCCTCATCTAATTGCCTTG ENST00000447743.1 -----AGTTTCT-TTAACTC--ATGAA-ACAATGATGG-----------TAGCTG----- *** ** * *** * ** * * **** ** ** ENST00000283109.3 TCGTCATTAAATAGAGAATTCAGGCCTTTCAGAGATGAAGAAAATGTGGGAGCTATGAAT ENST00000447743.1 --ATCAT---------AATTC-----TTTTA-----------AATTTAGGA-------AT **** ***** *** * *** * *** ** ENST00000283109.3 CAGTATAGAACAAGAACTCTGAGTATCACTTCTTCAGGCAGTGCTGTAAGCTGTTCAACA ENST00000447743.1 C---------------------------TTTCTCTTAGTGGTACT---AGTAGATCTAAA * **** * ** ** ** * ** * * ENST00000283109.3 ATTCCTCCAGAACTGGTGAAACAGAAGGTGAAACGTCAGT-TGACAAAACAGCAAAAATC ENST00000447743.1 AGTTCTAGAGAAATGATGAT---GATGATGA----TCAGGATGATAAAA--ATAAAAGT- * * ** **** ** *** ** * *** **** *** **** **** * ENST00000283109.3 AGCTGTCAGACGTCGATTGCAGAAAGGAGAAGCAAATATATTTACCAAGCAACGTAGGGA ENST00000447743.1 ----GGCAGG--------GCACAGTGGCTCA-TGACTGTAAT--CCCAGTA-CTTTGGGA * *** *** * ** * * * ** * ** ** * * * **** ENST00000283109.3 AAACATGCAAAATATCAAATCAAGTTTGGAAGCAGCCAGCTTTTGGGGAGAATAATATAT ENST00000447743.1 GGCCA------------------------AGGCAGGCAGATCACG---AGGTCAAGAGAT ** * **** *** * * ** ** * ** ENST00000283109.3 TTAGG--ATCTTGGATATGTTTAATATATTTTTTAAAGTTACTGTAATTCCTTTTTGAGC ENST00000447743.1 CGAGACCATCCTGG------CTAACATG---------------GTGA----------AAC ** *** *** *** ** ** * * * ENST00000283109.3 CCTCATTTGTCTTTTTTGAGCCAAGGCTATCATATATTAAT-AAATAAACCCTCTTTCAT ENST00000447743.1 CC-----CGTCTCT-----ACTAAAAATACAAAAAATTAGCCAGGTGTGGTGGCACGCGC ** **** * * ** ** * * **** * * * * ENST00000283109.3 CTATAAATTTGGTCATTCAGTATGTGTCTTGCAAAGAATAATTACCTGCCAAAGCAGTCC ENST00000447743.1 CTGTAGTCCCAGCTACTCAGGA---GCCTAAGGTAGGAGAATCGCTTG--AACCCGG--- ** ** * * **** * * ** ** * *** * ** ** * * ENST00000283109.3 ATTTTTTTCAAAGTAATTTGGGTAACTACAGTTACGTAACTTTATTAGAGACATTTGCAT ENST00000447743.1 ---------GAGGT------GGAGATTGCAGTGAGCCAAGATCGT--GCGAC---TGCAC * ** ** * * **** * ** * * * *** **** ENST00000283109.3 ATTTTTAAAAATCTAAATAACATTTTTGTTGTTTTCTGTTTGTTGAGGATGATATGCTAC ENST00000447743.1 TCC------AGCCTGGGCGACA----------------------GAGCAAGA-------C * ** *** *** * ** * ENST00000283109.3 AATGCACATAAAGCAATTAGAACAATGTTTAGCACATTCTTAAGCATTCAATAAAACATG ENST00000447743.1 ACTGCTCA-AAAACA---AAAACAA------------------------AACAAAACA-- * *** ** *** ** * ***** ** ****** ENST00000283109.3 GCTATTAGAATCATAATGATTCTGAAATTCTGCTGACAATTTGGTTGCATTTTATTTGGC ENST00000447743.1 ------AAAAAAGCAACAAA---AAAACCCCAC-----ATT-------ATTTCATTCAAT * ** ** * *** * * *** **** *** ENST00000283109.3 AACTGGAGGACTTCACTGTCTTATTTTTCTTTAGAAGTAAAGATAAGCCTTTGGAAGTAA ENST00000447743.1 AAATAG-GAACTATA-TG-CTGATT-----------------ACATGCC--AGGCACTAG ** * * * *** * ** ** *** * * *** ** * ** ENST00000283109.3 AGATAAGCCAGTGATGCACAATTTGCTTAATTAATTGATTAATAATCTGTTTTGTGCCAC ENST00000447743.1 GTATAA---AATGATGAACAA--GACTTAACTATTTCTTTAA------------------ **** * ***** **** ***** ** ** **** ENST00000283109.3 TTACATTGGTAATGTGGTCATGAGAATGGAAACTTACTTGAGATAGTCTACCACAATTTT ENST00000447743.1 ---------------------------GGAA--CTACC------AGTCTGCCAA---TTA **** *** ***** *** ** ENST00000283109.3 TACAGTTGGCAGCTTGTAAGCAGGCCTGAGTAGCAGAAGAGTTAGGGGTTGGGGAAGGTG ENST00000447743.1 AACAGTCA---------AATCAGGCCAG-------------------------------- ***** ** ****** * ENST00000283109.3 GAGTAGAATGAGGAATGAAATGTTCTTTCTCATATGCTTATTATATAAGTGGGTCCGGAA ENST00000447743.1 --GTACAGTGTGG---------------CTCA--TGCCTATAAT---------CCCAG-- *** * ** ** **** *** *** ** ** * ENST00000283109.3 CATGTTCTCACCTCAAGGTTAACAAATACCTAATGCAGGAAAGAAAATACATAGCCATGG ENST00000447743.1 --------CACTCTGAGAC------------------GGTATGGTGGCATGCAACTGTAG *** ** ** * * * * * * * ENST00000283109.3 TCCCTTCCTCAAGGACTTTATAATTCAGTGAGATGTAAAGATGAGTGCTTAAGTGTATGC ENST00000447743.1 TCCC---------AACT-----ACTCGG---GAGGCTGAGGTGGGAG------------- **** *** * ** * ** * ** ** * * ENST00000283109.3 ACCTGATTATTGTCTCTTCATTGCCGCATAAGTCGGAAAAGGGGATCACTTGCAGCGAAA ENST00000447743.1 ----GATCATT----------TGC-GCCTAGG---AAGCAGAGG-----TTGCAGTGA-- *** *** *** ** ** * * ** ** ****** ** ENST00000283109.3 AATGGCCACTAGATGGCAATATCACCCCATAGTCACCAAACAGGATTACTTGCATCCCTA ENST00000447743.1 --------------GCCAAGATCACGCCACTGT--------------ACTT-CAGCCT-- * *** ***** *** ** **** ** ** ENST00000283109.3 ATTATGTTCTACCAGAGGGAATATAGTACAGACTTTTCCAAGATTGATAAAGACAGCAGA ENST00000447743.1 ---------------GGGTGACAGAGCA-AGACTGTGCCAGAA--GAAAAAAAAAA---- ** * * ** * ***** * *** * ** *** * * ENST00000283109.3 TTCCCTTTCACCTTTGCCAAATTAACTCTACTAGCTATTTGCAAGACCTGTAATTATCTA ENST00000447743.1 ------------------AAAT--------CCAG------GCAA-----------ATTCA **** * ** **** ** * ENST00000283109.3 ATAAATTGGCTTAAATATATAGAAGCTAGAAAATGCCAATTCCTCTTCCCTCAAAAGTTA ENST00000447743.1 ACATAATGAGATAAGTACTCTGA----------------------------CAGGAATAA * * * ** *** ** ** ** * * * ENST00000283109.3 CCTGACATTCAAATATTTAAATACCCTTGCTTTGCATTTTAGATATATCTTTGAATTCAG ENST00000447743.1 --TGATA---GAATGCT-----ACCCT---------------ATCCACATTCG---TCAG *** * *** * ***** ** * ** * **** ENST00000283109.3 GTATTCATTTTGTATAATCTCTCAACTTTTAAGCATTTTTATAATGTAAAGTTGAAAACA ENST00000447743.1 GCA----------------------------GGGAGTTTCA-AATG----GTTG------ * * * * *** * **** **** ENST00000283109.3 GCTTAATAGAACCACAGAATGTTTATTTTGGAGTCATTTTCTTATATTCAGAGCTATGAA ENST00000447743.1 -CTTAGAAGA----CATGACATCTCAGCTGGA-------TCCTA-----------ATGGA **** *** ** * * * **** ** ** *** * ENST00000283109.3 AGCAAATTGGGAATAAAGCCTTATCCTGCTCAGCTTTACCTAGTTGACTCAGTTGACTTT ENST00000447743.1 AGAGGAT-----------CTTTTTCCTACCTGGCTTCA---GGGTAA------------- ** ** * ** **** * **** * * * * ENST00000283109.3 TGAGTATCTACTACATAAAAAGCCCATTACTATTAAGAAACTCAAGACAAACATGATTTT ENST00000447743.1 ----TAGTTCCCATAT------TCTATAGTTTTCAACTGACT--AAGCAGTTATG-TTTC ** * * * ** * ** * * ** *** * ** *** *** ENST00000283109.3 TACCTTTAATAGCCTAAGATTTCTTGTGGGCCAAGGAATTAATTATTCCAATCAGAAATG ENST00000447743.1 TGTCTTT------------TTTGCT-----CCA------CAGCCGTTACTATCAATAACA * **** *** * *** * ** * **** ** ENST00000283109.3 GAGGCCTTACCTCATTTGGGCAAAGATTAGTGCTAGTTATTGAAGATTTACTAATAAATG ENST00000447743.1 AAGG-----------TTAAGAAAGCATT----CTGG--------GACTTG----TAAGTG *** ** * ** *** ** * ** ** *** ** ENST00000283109.3 ATCTGTTAAGGAATTTAGTTTTTTTTGGATATGTTGTTTTGGTTGTTGAAAACTAAGGTA ENST00000447743.1 -------------------------TGG-TACCCTCTTTTG--TGTTACAAA-------- *** ** * ***** **** *** ENST00000283109.3 TAATTATAATAGTTATTTTTTGAAGATATGTTTGGCTAGCCATCAATTAGAAGTTAGAGA ENST00000447743.1 -------AATA---------TGAAAATGAA-----------AACAACCAGA---CAGACT **** **** ** * *** *** *** ENST00000283109.3 GTTTGTCCTAACAGATAAGCTATAACCCTCACA----TTTTAAAACATGCATAGTGAACA ENST00000447743.1 GTCTCTCC-AAGAAGTAAATTA-----CTCACAGTGCCTTCAGTCTCTGAATAG--AGTC ** * *** ** * *** ** ****** ** * ** **** * ENST00000283109.3 ATGAACAAAAACAAATTCAAAATTTTACTAATGTAAAGCTGTATATTGTGATTGTTAAAA ENST00000447743.1 CTGACCAGAAGC----TGAAAGT---GCTTTTATCCAGTTG-ATA----GA--GTCGAGA *** ** ** * * *** * ** * * ** ** *** ** ** * * ENST00000283109.3 CACTTTTTTTTGCCTAGGAGTTCCAGATTTAAATCCTGGTTCTACACTTCCCAAACCTCA ENST00000447743.1 ---------TTTCTCAAATGTTTCAGA-----ATCCATGATCTG----TCCTAA------ ** * * *** **** **** * *** *** ** ENST00000283109.3 GGTACCTTCTGTGGCCTCTCTAACCTCAATTTTTTTACTTGTAAAATGGGGACATTTAAT ENST00000447743.1 -----CTCCGGTGGT-------ACATGAGTTGTT-------------------GTTTTAT ** * **** ** * * ** ** *** ** ENST00000283109.3 AGTATACCTCAGTGTCGTGAAGACTAAATGAAGTACCACTTGTAAAGAGTTTATTACAGT ENST00000447743.1 A-TATCCTTC----TC------------TGAAATA----TTTTAAAGAAAACACTTTAGT * *** * ** ** **** ** ** ****** * * *** ENST00000283109.3 GCCTGACATATACTGTATGGTTAGTACTGCTAAAATGACTTCTTAAGGTTACCAAAAGGA ENST00000447743.1 G------AAATAGT---TGTTTATTAC------AATAGTCATTTATG---ATCAAACATC * * *** * ** *** *** *** *** * * **** ENST00000283109.3 AAATTCCACAAGCTGACCACCTTTCCTATTGTGATGGTCACTGGTATTTCAGCTATGATC ENST00000447743.1 GAAT------GGTTTATAGCTT--------------GCCACTTATATCT--GTTGAA--- *** * * * * * * **** *** * * * ENST00000283109.3 CTTTGTTGTGTATTTATCCAGACTGAAAGATGTTTTTCTAGTAACCATCTTGCATCGTCT ENST00000447743.1 -TTTGCTTTATACCTACACAAA--------TATT------GCA-----CTTG-ATCA--- **** * * ** ** ** * * ** * * **** *** ENST00000283109.3 TAGTCTCCCCATTAAATAAACTTTTCCTACAAACTA ENST00000447743.1 -AGTA----CATGAAACGA----CTGATGCAGGA-- *** *** *** * * * **