CLUSTAL 2.1 multiple sequence alignment ENST00000296490.3 -TTCTGCCTGTCGCCCCAAAATGGCGGACACAATGAGCCGGCGACGCGCCGGTTGTCCGT ENST00000489238.1 ATTGTGTACCTTTCCCCA-------GCTCCCAACCAG--------GAGCTAGTTCT---- ** ** * ***** * * *** ** * ** *** * ENST00000296490.3 GAGGTGGCTGTGAGGACGAACGGTCGGCGAGGCTCCACAGTCCAGGCAGAAGACCCTCGA ENST00000489238.1 -AGGC--CTGTGTT-----ATATTTAGC---CTTTTATTAT--------ATGACCTTTGA *** ***** * * ** * * * * **** * ** ENST00000296490.3 CCAAGCAGGAAGAAGAGGAGGAGGCGGCCCAACTGTTGGCCGACTTCCCGCTAGCCGCCG ENST00000489238.1 TTT-----------------------------CTGTTGTTTGTATTT----TAGC--CCA ****** * ** **** ** ENST00000296490.3 GCGCGGCGCCCGCCCCGCCTGGGTTGGCCCCTCGGCAGCCCGCCCGCTCGCCGCCGGGCC ENST00000489238.1 GTGTA-TGCAC-CTTCATTTAAAT----------ACA----------------------- * * ** * * * * * ** ENST00000296490.3 CCGCCCCGGCCCTGCGCCGCCGCTGCCTTCCCCAGCCGCCGCCATGAAGCTGACCGACAG ENST00000489238.1 ----------TCTGTG-------TGCAT---------ACAGATATG----TGT---ATA- *** * *** * * * *** ** * * ENST00000296490.3 CGTGTTGCGGAGCTTCCGCGTCGCTAAGGTGTTCCGCGAAAACTCGGACAAGATTAACTG ENST00000489238.1 TGTAT----GTGCATATGCAT-------ATATCTCTC----------------TCATCTG ** * * ** * ** * * * * * * * *** ENST00000296490.3 CTTCGATTTCAGCCCCAACGGCGAGACGGTCATCTCGAGTAGCGACGACGACTCCATCGT ENST00000489238.1 T---AATTTC-----------TGAGA-GTTCAGCTGAAGCA--GACG-----------GA ***** **** * *** ** ** * **** * ENST00000296490.3 GCTCTATGACTGCCAGGAGGGCAAACCAAAGAGAACCCTGTACAGTAAGAAATATGGTGT ENST00000489238.1 GTCCTACAGC--CCAGGAGA------CACATTGCATCCT-TGC--TAA------CCGTGT * *** * ******* ** * * * *** * * *** **** ENST00000296490.3 GGACCTCATCAGATACACTCATGCAGCAAACACAGTTGTTTACAGCTCTAACAAAATAGA ENST00000489238.1 -----TCACCACAAGTGTTAGTG----------AGTCTT------CCCTATTAACGT--- *** ** * * ** *** * * *** ** * ENST00000296490.3 CGATACTATTCGTTACTTGTCCTTGCATGACAACAAATACATCAGATACTTTCCTGGACA ENST00000489238.1 --------TTCATT--------TCGGAAGAC--TGAATGAAGCAAA-GCTT--------A *** ** * * * *** *** * ** * *** * ENST00000296490.3 TAGCAAAAGGGTGGTGGCCTTGTCCATGTCACCTGTGGATGACACTTTCATTTCTGGGTC ENST00000489238.1 TAG--------TGTTTGCTGTTTCCATGGCAGCC--AAGTGA-------------AGGTC *** ** * ** * ****** ** * *** **** ENST00000296490.3 TCTTGATAAGACCATTCGACTCTGGGATCTCCGGTCTCCTAACTGCCAGGGCCTCATGCA ENST00000489238.1 T---------------------TGGGAT-----GACTCC---CTGT--GTTCCTCAAGC- * ****** * **** *** * ***** ** ENST00000296490.3 TCTGCAGGGGAAGCCAGTTTGTTCTTTTGATCCAGAAGGGTTAATTTTCGCTGCAGGTGT ENST00000489238.1 -------------------TGTACTTT---------GGGG----CTCTCTCTGCAG-TAT *** **** *** * ** ****** * * ENST00000296490.3 CAACTCTGAAATGGTCAAGCTTTATGACCTTCGTTCTTTTGATAAGGGGCCATTTGCTAC ENST00000489238.1 TAACCC-------------CTTTCTG-----------CTTGGTGG------------TAC *** * **** ** *** * *** ENST00000296490.3 CTTTAAGATGCAGTATGATCGAACTTGTGAGTGGACAGGACTTAAATTCAGCAATGATGG ENST00000489238.1 TCT-----------------GTACCTGTGTGTG-ATAG---------------------- * * ** **** *** * ** ENST00000296490.3 CAAGCTCATCCTCATTTCCACCAACGGCAGCTTCATTCGTCTGATTGATGCATTCAAAGG ENST00000489238.1 -----------TCACTTTTGC-----ATGGCTTC-TGTGTCTGGCTTGTG---------- *** ** * ***** * ***** * ** ENST00000296490.3 AGTGGTGATGCACACATTTGGGGGTTATGCCAACAGCAAAGCTGTCACACTGGAGGCTTC ENST00000489238.1 -------------GCATTTAGGGAT-------------AGGGTGTTATA----AAG---- ***** *** * * * *** * * * * ENST00000296490.3 ATTTACTCCAGACTCTCAGTTTATTATGATTGGTTCAGAGGATGGCAAGATCCATGTCTG ENST00000489238.1 ---TATATCAAACTC----TTTAT-ATGCTAAATTCTAAGGA-----AAATTTAT----- ** ** **** ***** *** * *** **** * ** ** ENST00000296490.3 GAATGGAGAGAGCGGTATAAAAGTAGCTGTGTTGGATGGTAAACACACAGGCCCGATTAC ENST00000489238.1 ---------------CATA----TGACT-TCTTACATAG--GACACA------------- *** * ** * ** ** * ***** ENST00000296490.3 CTGTTTGCAATTCAACCCCAAGTTCATGACTTTTGCCAGTGCGTGTTCCAACATGGCCTT ENST00000489238.1 -------------------------ATGA-----------------------ATGATATT **** *** ** ENST00000296490.3 TTGGTTGCCCACCATTGATGACTGACCCTGTTGCTGCTTGGCTATTTCTGTATAGTGAGG ENST00000489238.1 ATGG-------CCACTG--------CTTTGTT---------TCATTTGAAATTAATAAAC *** *** ** * **** **** ** * * ENST00000296490.3 GCGGCCAGCAGGAAGAAACTCAGAGGGAACTGAGATAATAGTGGGATTGGATCATTTGAC ENST00000489238.1 ATAAC-------ACGAGATTAAAGGGATACT----TTATATC--CATGAGTTCATTTATT * * ** * * * ** *** * *** ** * ****** ENST00000296490.3 TGGGCTGGAGAACATCCTTTTACATG-GCCTTCCCATGGATGTGCTGTACATCTGCTCAA ENST00000489238.1 T---TTACACAACAT-----TACATTTGTCTTTTCATAA------TGTTTATTT------ * * * ***** ***** * *** *** *** ** * ENST00000296490.3 AAGAAAATAATTACTTTGATGAGCGTCTTCAAAAGGACTCTTGGTGCAACAGACTCAATT ENST00000489238.1 ------ATAAACACGTATATGCACATACC-------ATTTTT-------------CAATT **** ** * *** * * * * ** ***** ENST00000296490.3 GGAACTCAGCTTTTCTAACTGTCACTGCACCAAGCTCTGCTGGAGGAGTG--ACCAGACT ENST00000489238.1 GGAATGGAAATATTTTCGTTGTCAATAC-CTGA----TAGTGAGGAAGTATTACAAGA-T **** * * ** * ***** * * * * * ** * *** ** *** * ENST00000296490.3 CACGATTTGGTATAGTGGGGCTCTCAAGCATCTTCAATTTGAATGT-ACATGCTG-CTGA ENST00000489238.1 AAT--TTCAGGACACTA---CTCCTTATTATTTTAACTTTAAAAATTATAACCTGGCCGT * ** * * * * *** * ** ** * *** ** * * * *** * * ENST00000296490.3 GGAGCCGGTGAAGTCATCAGTTCCGCACATCCCTTCTACCCTCCAACTGCATGGGAAGCC ENST00000489238.1 GCA--CGGTGG----CTCAGGCCTGTA-ATCCC-----------AGCACTTTGGGAGGCC * * ***** **** * * * ***** * * ***** *** ENST00000296490.3 AAAGTCCTGGTTTTGAAATGCTTGGGCAGCTCAGCCGCTTGCCCTCACCCTGCATGTCTT ENST00000489238.1 GAGG--CTGGT---GGATCACA-----AGGTCAGGAGTTCGAGACCA--------GTCTT * * ***** * * * ** **** * * * ** ***** ENST00000296490.3 GTTACTGGGTCTCCCTGTGTACTTGTGGCATTATCCACAACCATCATGTTTCTTAGGTGC ENST00000489238.1 GCCAATA------------------TGGTGAAACCC----------CGTCTCT-----AC * * * *** * ** ** *** * ENST00000296490.3 CAAACATTTACAGAAACATTTTCATATATCTTGGGGTCAGAGAAAGGGACAGATACAGAA ENST00000489238.1 TAAAAAT--ACAGAAAAATT-------AGCT----------------------------- *** ** ******* *** * ** ENST00000296490.3 GGACCTTGCTTGCAGGAAGCCATGCAGTTAGTTTCTGCAGTTAGTCGTGTGAGGCTAGGT ENST00000489238.1 -GAGCTTGTTGGC----------GCA-----TCCCTGTAATC------------CCAGCT ** **** * ** *** * *** * * * ** * ENST00000296490.3 GGTTGGGCAGGCCTCGGGCTGTAGGTGTTGGGTGGGAAAAAGACCCAAGGGCCTGAAAGG ENST00000489238.1 ATTCAGG--------AGGCTG--------AGGCAGGAGAATTGCTTGAA--CCCGGGAGG * ** ***** ** *** ** * * ** * *** ENST00000296490.3 GAGGGAAAGGGGAGGGTAGCGGGAGGGTAGCAGGTGAGTTCCTAGGGCTGGAAGGTTTAG ENST00000489238.1 CGGAGGTTGCAGTGAGC--CGAGATCACACCAC-TGCACTCC--AGCCTGG--------G * * * * * * ** ** * ** ** *** * **** * ENST00000296490.3 CAGCAGCCTGGTGCAGTGCCCTGTCATCAAGACAAACCCACGGTCCTCCTGGGTGCCTAC ENST00000489238.1 CGATAG---GGCG-AG-ACTCCGTC-TCAAAAAAAA------------------------ * ** ** * ** * * *** **** * *** ENST00000296490.3 CAAGCTTGGTTTGTACAAAAGCAAGGTGGGAGTCTATTTTTGTACATGAGATACATCACA ENST00000489238.1 ----------------AAATAAAAAATAAAAAATAATAATAGTA----------ATCATG *** ** * * ** * *** **** ENST00000296490.3 CTTACCTGTGGGCCAGTATTGTGAAGTGAGTCTGAGTTGTTTACACTGATGCCTTCCCTG ENST00000489238.1 TTCAATTA------ACTATTGAAAAATA------------TCACATTTAA---------- * * * * ***** ** * * *** * * ENST00000296490.3 CCCACCACAAATTGTGTACATAGTCTTCAGATGATACCACCCCTTTCCCCAGCTCCCAAC ENST00000489238.1 ------AAGAAT------CATA-----CAAGGGACA-------TTTAGTCATTTCC---- * *** **** ** ** * *** ** *** ENST00000296490.3 CAAGAGCTGGTTCTAGGCCTGTGTTATATGTCATATTTAGCGTTTTTATATATGACCTTT ENST00000489238.1 --AGAACT-----------TGAGTTACAAAAAGTATATATTATATTTATAAA-----GTT *** ** ** **** * *** ** * ****** * ** ENST00000296490.3 GATTTCTGTTGTTTG------TATTTTAGCACAGTGTATGCACCTTCATTTAAATACATC ENST00000489238.1 AATTTCTGAAGTGGGACTAATTATTTTAGCCAAGT-----CACC-----------ATGCC ******* ** * ********* *** **** * * ENST00000296490.3 TGTGTGCATACAGATACGCATATATGTGTGTGCGTATGCATATATCTCTCATCTGTAGTT ENST00000489238.1 TGTA-GTGGATAGAC---CAAATG-GAACACTTGGAGGGATG-GTTTCTCAACCTGAGCT *** * * *** ** ** * * * * ** * ***** * ** * ENST00000296490.3 TCCAAGAGTTCAGCTGAAGCAGATGGAGTCCTGCAGCCCAGGAGACACCCTGCATCCCTG ENST00000489238.1 TCACATGATTCTCCTGGGGCA-------CCTTTTAA---AAGTGGCAAGAGAAATCTCAA ** * *** *** *** * * * * * * ** *** * ENST00000296490.3 CTAATAGTGTTTGCCACAAGTATTAGTGAGTCTTCCTTATTAATATTTTCATTTCAGAAG ENST00000489238.1 ATAATAGTGACTTGAACAAG----ATTGAGGTTT----------ATTTT--TTTCAAGTA ******** * ***** * **** ** ***** ***** ENST00000296490.3 ACTGAAGCAAAGCTGATAGTGTTTGCTGTTTCTTTGGCAGCTAAGTGAGGGTCTTGGGAT ENST00000489238.1 AC---AACAAGAATGAAAGCA--------------GGCAG-----------TCTTAA--- ** * *** *** ** ***** **** ENST00000296490.3 GACTTGCTGTGTTCCTCAAGCTGCACTTTGGGGCCATCTCTGCAGTATTAGCCCCCTTTT ENST00000489238.1 -------------TCTAAAGTAGCAACCCAAAG--ATTTCTG------------------ ** *** *** * ** **** ENST00000296490.3 TGCTTGGTGGTACTCT--GTCTGTGCCTGTGTGTGTGTGTGATAGTCACTCTTGCATGGC ENST00000489238.1 -GGTTGATGTCACTATAAGTCTGTGTCC-------------------------------T * *** ** *** * ******* * ENST00000296490.3 TTCCATGTCTGGTTTGTGGCATTTGGGGATAAGGTGCTGAAGCCAGAGCATTTGCAGTTT ENST00000489238.1 TTCCCT-----------------------TAAGGT-------------------CAATTT **** * ****** ** *** ENST00000296490.3 GTTTGAGGCCTCGTTGCCAATGATAGATCACTCCTGTTGACCTGGTATGTCTGCTTGCTT ENST00000489238.1 ---TAAG------------ATGGTAA-------CTGTAGCTTCAGT-TGTTTCTTCAATT * ** *** ** **** * ** *** * * ** ENST00000296490.3 GCTGCTTTTCCTTGCTTTCTCTTGGAAGAGGAAAGGACTCTGGTCAGGCCCAGGCTGAGT ENST00000489238.1 AGTGCTAC------------------AGAATACAGGATTTTAA-CAGG------------ **** *** * **** * * **** ENST00000296490.3 GAGATGAGCTGCAGCTGGCTCATGGCCTTCTTAGAGCAGAGAGAGGAGTATGTCATTTTA ENST00000489238.1 ----------GTACTTG--TCAT---CTCC----AATAAATTTAG---------ATTCTG * * ** **** ** * * * * ** *** * ENST00000296490.3 CTAAGTTCCTAAACAAACATTTATGCAGGCAACACTCCTTGCAGATCCAGAAACTGAGGC ENST00000489238.1 TTAAAA---AAGACAAATATTTGT------------------AGATT-AGAAA------- *** * ***** **** * **** ***** ENST00000296490.3 ACAATAGGGTTATGACTTGCTCAAGAATATGTAGCTGCTAGGGGGTAAATCAAGGCATCA ENST00000489238.1 ACAAT--------------------------------------------------CTTTA ***** * * * ENST00000296490.3 CAATTTCTGTTCAGCGGGCAGGAATAGGCTGTGAATTGCTAGCACTTTTTTTTTTTAAGC ENST00000489238.1 CTACTCCTGT------------GATGTTCTATGAAGT-CCATCACTTCACTGTTCTGA-- * * * **** ** ** **** * * * ***** * ** * * ENST00000296490.3 AATTACTTTTTGACTTGTTCCTCTGAAAGTGCAAGAGGCGTACACCTTTCCCAAATGTAG ENST00000489238.1 AGTTAC------ACTTA-----------------------------------AAATATAA * **** **** **** ** ENST00000296490.3 ACTAGAATCTGCAGGATGCCACCCACTGTATAGTTCTGCTTTCCCAGAGAGGAAGAACTT ENST00000489238.1 AACA-----------ATAACA-----TGAATAG-------------GAAAGAGATAATGT * * ** ** ** **** ** ** * ** * ENST00000296490.3 TTAGAAACCAAATGATCTTAATTGTTATTGCCCACCCCTGGCTTTTCCGGGTAGAAAATT ENST00000489238.1 ---AAAATTATATCACCT-------------CCACACT-----------------AAATA *** * ** * ** **** * **** ENST00000296490.3 CACAGTAGGAATGATTGTTAAGAGAGAGTGCTTGGAACCATGGGTTAACAGGAAAGGCTA ENST00000489238.1 TA-ATTAGAAGCTATTAT-GATAAAGACAACTTATAA------------ATGAAAATATA * * *** * *** * * * *** *** ** * **** ** ENST00000296490.3 CCTAACTTCACATATCTGCAACCAGAGCAGCCACCAAGCATTACTTAGCAGCAGGAAAAT ENST00000489238.1 CA-AATTTTGCA----------------------CAAACTTTATTTTCCAT----GAAGT * ** ** ** *** * *** ** ** ** * ENST00000296490.3 GATTGTATTTGAGTTCCTGTGTGTCCAAAACTGAGCACCATGTTCTTTGAAAACATGCCA ENST00000489238.1 AACCATGT--------CTACACATTAAAAA----------TGTT------AAAAAAGC-- * * * ** * **** **** *** * ** ENST00000296490.3 CCTCAAGGCTGGGCGCGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCG ENST00000489238.1 ------AGCTGAG-------------------AA---CAATATTTT-------------- **** * ** ** * *** ENST00000296490.3 GGCGGATCACCGGAGGTCGGGAGTTTGAGACCAGCCTGACCAACATGGAGAAACCCCATC ENST00000489238.1 -------TACAGAAGGCCA---------------------CTACA-----AAA----ATT ** * *** * * *** *** ** ENST00000296490.3 TCTACTAAAAATACAAAATTAGCCGGGCGTGGTGGCATGCGCCTATAATCTCAGCTACTT ENST00000489238.1 ACTACT---GTTAAAAGGTTAGAAGGAT--------------CTA-AATTTGAACTAC-- ***** ** ** **** ** *** *** * * **** ENST00000296490.3 GGGAGGCTGAGGCAGGAGAATTG-CTTGAACCCAGGAGGCGGAGGTTGCGGTGAGTTGAG ENST00000489238.1 -------------------ATTGTCTTTAGTCCAA-------ACCTCTTAGTGGATT--- **** *** * *** * * *** ** ENST00000296490.3 ATCGTGCCATTGCACTCCGGCCTGGGCAACAACAGCAAAACTCCGTCTCAAAAAAAAAAA ENST00000489238.1 -------CATTA-ACTCC----------ACCAAAATAAATTTTTG--------------- **** ***** ** * * *** * * ENST00000296490.3 AAAAAAAATGCCACCTCACAGTCTCTATCGTTGGGCCCTGTGGTTGCAAAGCTGCCTCCT ENST00000489238.1 AAGTGAAATAAC-CCTTGT--TCTCAA---------CATGTGAT------ACTACATTT- ** **** * *** **** * * **** * ** * * ENST00000296490.3 GAATTAAGAAGGAAAGGGAAAAGATATAGCTGGAAGCGAGTGGAAGAGATGCTGAGGGCT ENST00000489238.1 ----------------------GATATAA----AAGT---TTAAACAAATTTT-----TT ****** *** * ** * ** * * ENST00000296490.3 GGGGCTGCACAGACGTGCTCAGCAGGGCTACAGGTGCTCAAGCCCTATTGGGGATGGGTG ENST00000489238.1 AGAACTG----------------AGGACAATAA-TGACCTGACCCT--------TGAGTA * *** *** * * * ** * **** ** ** ENST00000296490.3 GGGAGTGGGGCAGCGGCGTTTGCCACCTTAAGAATTGGGGCCAAAGCCACTGATGTTTAT ENST00000489238.1 -----------------------------AAAAAGTATGGCC-----------TTTTTGT ** ** * **** * *** * ENST00000296490.3 TTGACAGTGACACTGCACTGGGTACTTAAAGAAATTATTTCCCGTTGTAATTATAATTAC ENST00000489238.1 TT--------------------TATT------AGTTAT-----GCTG--ACCATAGTCC- ** ** * * **** * ** * *** * ENST00000296490.3 TGCTTATTAAGGAAAATATGGGAATTTTAGAAAGAATCAAGTTTGCCACCCAAATGCTAC ENST00000489238.1 ----------------------AATTTT-----GAAT--AGTGTGCTTTATAAA------ ****** **** *** *** *** ENST00000296490.3 CACTGTTAATCTTTTGGTGTTAAATGTTCCCCCTAGACATTTCTGTGCATAGATTTTTGG ENST00000489238.1 ------------------GTAAAAT--------------TTTCTGTG---------TCAG ** **** ******** * * ENST00000296490.3 TGTGTTTACATAGTCGTTATTCTGTATATACAATTTTATGTCCCTTTTGTACTTAACGTA ENST00000489238.1 CATACCTTAAAAGT----------TAGAAAC-------------TTTTGCAATTA----- * * * *** ** * ** ***** * *** ENST00000296490.3 TAAACATTTTTTCCATGTTACAGTCTTAAACAGAATTTTATGGCTGCA ENST00000489238.1 --------TTTCCCA----ACAG----AGAT-GAATTAATTCACAGCA *** *** **** * * ***** * * ***