CLUSTAL 2.1 multiple sequence alignment ENST00000299259.5 AGCTGAGAGTGACGCCTCTGAGCCGCGGAGGATTGTGGGAGGAGGTTGTCTCCAATTTCT ENST00000422282.1 ------------------------------------------------------------ ENST00000299259.5 CCTCCCCCTCCCGGCCAAGATGTCTGACATGGAGGATGATTTCATGTGCGATGATGAGGA ENST00000422282.1 ------------------------------------------------------------ ENST00000299259.5 GGACTACGACCTGGAATACTCTGAAGATAGTAACTCCGAGCCAAATGTGGATTTGGAAAA ENST00000422282.1 ------------------------------------------------------------ ENST00000299259.5 TCAGTACTATAATTCCAAAGCATTAAAAGAAGATGACCCAAAAGCGGCATTAAGCAGTTT ENST00000422282.1 ------------------------------------------------------------ ENST00000299259.5 CCAAAAGGTTTTGGAACTTGAAGGTGAAAAAGGAGAATGGGGATTTAAAGCACTGAAACA ENST00000422282.1 ------------------------------------------------------------ ENST00000299259.5 AATGATTAAGATTAACTTCAAGTTGACAAACTTTCCAGAAATGATGAATAGATATAAGCA ENST00000422282.1 ------------------------------------------------------------ ENST00000299259.5 GCTATTGACCTATATTCGGAGTGCAGTCACAAGAAATTATTCTGAAAAATCCATTAATTC ENST00000422282.1 ------------------------------------------------------------ ENST00000299259.5 TATTCTTGATTATATCTCTACTTCTAAACAGAATTCTGATTTTTTATGTCAGATGGATTT ENST00000422282.1 --------------------------------------------------AGATGAATTT ***** **** ENST00000299259.5 ACTGCAGGAATTCTATGAAACAACACTGGAAGCTTTGAAAGATGCTAAGAATGATAGACT ENST00000422282.1 A-----GGAATTCTATAAAACAACAACAGAAGCTCTAAAAAATGCTAAGAATGATAAACT * ********** ******** ****** * *** *************** *** ENST00000299259.5 GTGGTTTAAGACAAACACAAAGCTTGGAAAATTATATTTAGAACG-AGAGGAATATGGAA ENST00000422282.1 GTGGTTTAAGACAACTACGAAGGTTAGGAAATTAAATTGAGAATGGAGAGGAATATGGAA ************** ** *** ** * ****** *** **** * ************** ENST00000299259.5 AGCTTCAAAAAATTTTACGCCAGTTACATCAGTCGTGCCAGACTGATGATGGAGAAGATG ENST00000422282.1 ACGTTCAAAATATTTTACACCAGTTACATCAATCATATCACACTGATTACGGAGATGACA * ******* ******* ************ ** * ** ****** * ***** ** ENST00000299259.5 ATCTGAAAAAAGGTACACAGTTATTAGAAATATATGCTTTGGAAATTCAAATGTACACAG ENST00000422282.1 ACCTGAAAAAGGATAC--AGTTATTAGAGAT------TTTAGAAATTCAACTGTACACAG * ******** * *** ********** ** *** ********* ********* ENST00000299259.5 CACA-GAAAAATAACAAAAAACTTAAAGCACTCTATG-AAC--AGTCACTTCACATCAAG ENST00000422282.1 GACGTAAAAAATAACAAAAAACTGAAAGTACTCTCTATAACTGGGCCAGTTCTTGTCAA- ** ***************** **** ***** * *** * ** *** **** ENST00000299259.5 TCTGCCATCCCTCATCCACTGATTATGGGAGTTATCAGAGAATGTGGTGGTAAAATGCAC ENST00000422282.1 TTTGCCATCCCATATCCATTAATCATGGAA-TTATCAGAGAATGAAGGGGCAAAATGCCC * ********* ***** * ** **** * ************* * ** ******* * ENST00000299259.5 TTGAGGGAAGGTGAATTTGAAAAGGCACACACTGATTTTTTTGAAGCCTTCAAGAATTAT ENST00000422282.1 TTAAAAGAAGGTCATTTTGAAAATTCACACTCAA---TTTTTGATGCCTTCAAGAATGAT ** * ****** * ******** ***** * ******* ************ ** ENST00000299259.5 GATGAATCTGGAAGTCCAAGACGAACCACTTGCTTAAAATATTTGGTCTTA-GCAAATAT ENST00000422282.1 AATAAATTGAGGAGTTCCATGTGAATCATTTGCTTAAAATATTTGGCCTTAAGGAAATAT ** *** * *** * * *** ** ***************** **** * ****** ENST00000299259.5 GCTTATGAAATCGGGAATAAATCCATTTGACTCACAGGAGGCCAAGCCGTACAAAAATGA ENST00000422282.1 GCTGAAGAACTTGG-AATAAATTCATTTGACTTGCTGGAGGCCACATCATGCAAAAGTGA *** * *** * ** ******* ********* * ******** * * ***** *** ENST00000299259.5 TCCAGAAATTTTAGCAATGACGAATTTAGTAAGTGCCTATCAGAATAATGACATCACTGA ENST00000422282.1 TGCAGAAATTCTAATAATGATGAGTTTAGTAAGTTCCTATCAGAATGA------CATTAA * ******** ** ***** ** ********** *********** * ** * * ENST00000299259.5 ATTTGAAAAGATTCTAAAAACAAATCACAGCAACATCATGGATGATCCTTTCATAAGAGA ENST00000422282.1 ATTTGAAAAGGTTCTGAAAATAAAACACAGCAACATTATGGATGATCCCCTAA-GAGAAA ********** **** **** *** *********** *********** * * *** * ENST00000299259.5 ACACATTGAAGAGCTTTTGCGAAACA-TCAGAACACAAGTGCTTATAAAATTAATTAAGC ENST00000422282.1 AAA-AGCAAAGAGCTTTT-CAAAATAGTCAAAGC--AAGTGCTTACAAAATT----AAGC * * * ********** * *** * *** * * ********* ****** **** ENST00000299259.5 CTTACACAAGAATAC------ATATTCCTTTTATTTCTAAGGAGTTAAACATAGATGTAG ENST00000422282.1 TTTATACAACAACACCCGGCCATATTCCTTTTATTTCTAAGGAGTTAAACATAAATGTAA *** **** ** ** ******************************** ***** ENST00000299259.5 CTGATGTGGAGAGCTTGCTGGTGCAGTGCATATTGGATAACACTATTCATGGCCGAATTG ENST00000422282.1 CTGATGTAGAGAGCCTGCCAATGCAACACATGT-----AACACTATTCGTGGCCAAACTG ******* ****** *** **** *** * ********** ***** ** ** ENST00000299259.5 ATCAAGTCAACCAACTCCTTGAACTGGATCATCAGAAGAGGGGTGGTGCACGATATACTG ENST00000422282.1 ATCAAGTCAACCAA----------------------------------------ATAC-- ************** **** ENST00000299259.5 CACTAGATAAATGGACCAACCAACTAAATTCTCTCAACCAGGCTGTAGTCAGTAAACTGG ENST00000422282.1 ---------------------------ATCCTCTTAAGGAGGCTGTAGTTAGTATAATGG ** **** ** ********** **** * *** ENST00000299259.5 CTTAACAGAGAACAAGCTTTTACAGACGTCCTTAAGGCAACAGTGCAGAGATGTAATCCT ENST00000422282.1 CTTAACAGA---CAAGTTTTTATAAATGTACTTACGGCAACAGTGCACAGATGGTGACTT ********* **** ***** * * ** **** ************ ***** * * ENST00000299259.5 TAAAAGAAC-TGG---GAATGGCAAAACTACTGTCGGTTGATGTGTCCTGAAAATTATTG ENST00000422282.1 TAAAAGAACACGGAATGAATGGCAAAAGTATTGTCAGTTGTTACGTTCTGAAAATTACTG ********* ** *********** ** **** **** * ** ********** ** ENST00000299259.5 GAGTTATGGCAGAAGTG---------------------CTTTTTTGATCAACTGGTTT-G ENST00000422282.1 CTGTTATAAGAGAGGTGGGTTGTTTTGTTTTGTTTTGTTTTGTTTGATCAACTGGTTTTG ***** *** *** ** **************** * ENST00000299259.5 TGTTTTG-CTGCTGCATTTATCCCAAGAAAAACAGCTTTAATCTCCAGAAGAAAACCAAA ENST00000422282.1 TGTTTTGGCTAATTCATTTATCCCAAGAAAAACACCCTTAATTTCCAGAAGAAAACAAAA ******* ** * ******************** * ***** ************* *** ENST00000299259.5 ATACCATGGGATTTATGCTGTATTGACATCTTGCCCTAAACGTACAACATCATAGTAATT ENST00000422282.1 ATGCAATAGGATT-ATGCACTATTGCCATCTTGC---AAACTTCT-------------TC ** * ** ***** **** ***** ******** **** * * ENST00000299259.5 TGTCATGGGCAACATGACCAGAGAGAAGATTTTTGTCATGATTTTAAATACACTGACACG ENST00000422282.1 TATAAAGGGT--------CAG-GTAAAAATTTTTG----GCTTTGCAAGCCATTCA-GTG * * * *** *** * ** ******* * *** ** ** * * * ENST00000299259.5 CTACTGTTGGTTAAATTTAAACATGTTTTACCTGCAGAAATTCTCTCACAAATAACCTGC ENST00000422282.1 CTGCAGTTATTCAACTCT---------TCCCTTGTAGAG---CAGCCATAGACAATATGT ** * *** * ** * * * * ** *** * ** * * ** ** ENST00000299259.5 AAT--AACTTGAAATGC-ATACCCTTTTGAACACTTCCTTTTCTCATGTATAAATTAAAA ENST00000422282.1 AAATAAACAAGCACTGCTGTGTCCTAACAAA-ACT--------TTATTTATAAAAGCAAG ** *** * * *** * *** ** *** * ** ****** ** ENST00000299259.5 TGTTTGCTGCATTTTGCAAAATGTCAATTCTCTAAAAATGTGTCCGTATATTTCTGTACC ENST00000422282.1 CGCATGCCAGGC---GCAGTAGCTCA--------------TGCCTGTA-ATCCTAGCACT * *** *** * *** ** * *** ** * ** ENST00000299259.5 TGCAGTGTAGTAAAGGTTTAGACGA---AACCCCATAATTATAGTGGCATACTGTCACTT ENST00000422282.1 T----TG----GGAGGCCGAGGCGAGTAAACCACTTGAGCCCAGGAG---ATTGAGACC- * ** *** ** *** **** * * * ** * * ** ** ENST00000299259.5 AGGTTTCAAGCAGCAAAATAAACAGTGCAGCTC---AGAAAT-TGTAGTTTGGTTCTTGA ENST00000422282.1 AG--CCTGGGCAACATGGCAAA-ATCTCATCTCTACAAAAATACAAAAATTAG--CCGGG ** *** ** *** * ** *** * **** * ** * * * ENST00000299259.5 TGTGTTTTTATTACATTTGGAGTTGTTTTGTTTTTTAGTACCTTCGAAATTTCAAATTAT ENST00000422282.1 CGTGCTGGCAT-ACACCTG-------------TCTTAGC-TATTCGGGAGGCTGAAGCA- *** * ** *** ** * **** **** * ** * ENST00000299259.5 TTTATCTTCAGTTAATGATTTTAAAAAGCCTGGGGGCAAATAAGTTGGTTATTTGCTTTC ENST00000422282.1 ---------AG---AGGATCCCTTGAGCCCAGGAGGTAG--AGGTTG-CAGTGAGC---C ** * *** * ** ** ** * * **** * ** * ENST00000299259.5 AAGTTTTTAAAAGTAGTCTTTA--TTGATAGAGTAAG-GAGAACTACTTTCTAACAAAAC ENST00000422282.1 AAGACTGTGCCACTGTGCTCCAGCCTGG-GCAGTAAGAGAGAGAGCCTGTCTTATACAAC *** * * * * ** * ** ****** **** ** *** * * *** ENST00000299259.5 ACGTGCATAGTTATGACAGTGATGCTTTAAAGGAATAAAATTCTTTTTTTTTAAAGAGTG ENST00000422282.1 A-----ATAACAACAACAACAA------AAATGAATAAAC-------------AAAAGTG * *** * *** * *** ******* ** **** ENST00000299259.5 ATATTCCTTTTCAAAAGAATACTAACTCTCAGAA-------TGTTCACTTTAA--ACGAA ENST00000422282.1 AGAGGC------AAACTGAACCTGGCCCTGAGGTGGTAGTTTGTTAACCCTTGTTATAAG * * * *** * ** * ** ** **** ** * * * ENST00000299259.5 TATGCCAGAACATAGACAGCTAAATGAATGTTAC--TCTGCATAGTGATCATGCTGGAAG ENST00000422282.1 TATACTACAACACAG-----TAATT---TGTTATGGTCAGCA---TGACCA-GAGAGAAG *** * * **** ** *** * ***** ** *** *** ** * **** ENST00000299259.5 GTTATT-TCCTAATGCCAGCAATCTACCATTGCCCAAAACCTGCTGAGTTTACTCTTTTA ENST00000422282.1 ATTTTTGTTATGATTTTA--AATATACTA------ACATGTTATTAATTTTATACAT--- ** ** * * ** * *** *** * * * * * * **** * * ENST00000299259.5 GAATTGCATTCAAAGTTAATTTGTCACA-CACACTA-AACTTTATGATTATACATTGTTT ENST00000422282.1 GCTTTGCCCTCAGAA--ACTTTGTCACAACCTGCTACAACTTGA--AATGTATATCTCTT * **** *** * * ********* * *** ***** * * * ** ** ** ENST00000299259.5 TAAAAAATATAGTATTAGGAAGCTTGATTATTTTTAGTTACCATTACTTGGCACCAAATG ENST00000422282.1 TGAACACTTTTGTACT--------------TTTTT---------CACATAATAACAAATG * ** * * * *** * ***** ** * * ****** ENST00000299259.5 AAAGTTTCCAAAACTTCCACCTAACTTTGAGGTAATGCAGAAAGTATATAACTGGCTTTG ENST00000422282.1 ------TTAAAAATGTTTGCTGCATTTTGCAAAAGTCT-----GTATATTCCTGTCTATG * **** * * * **** * * ****** *** ** ** ENST00000299259.5 AAG-GCAATCCCAAAAGAGTTTTAAAGGTTTTTTG-AGCAGTGGCAGTATACTTAGGAGA ENST00000422282.1 CAGTGTAGT-----ACACGTTTCAATAAAACCCTGTAATTGTAGTGGTATA--------- ** * * * * **** ** ** * ** * ***** ENST00000299259.5 ATGAACTGTGGCCTTCCAAGGTAACTACCTTAAAGGAACTCAGCTCATTTGAATGTATTG ENST00000422282.1 -TAGTCCCTGACATTTCAAG-CAGCAA-----AATAAAC------------AGTATATAC * * ** * ** **** * * * ** *** * * *** ENST00000299259.5 AGTTTTGGATGTATTTGTTTCATTTTTTAAAAAGTTCACATTATTTTATAGTGTCGAAAG ENST00000422282.1 AGCTCA--------------CAAATTATAAACA---CAAACTGACACACA----TGA--- ** * ** ** **** * ** * * * * ** ENST00000299259.5 GAAGAACTAGGATTAACATAATTTCTTTGGTTTTTCTATTGCTTGTTATTATTATGTAAA ENST00000422282.1 GACTGGCTAAAATAAAAATA--------------CCAAATG-TTGGTGAGAATATGAAAT ** *** ** ** *** * * ** *** * * **** ** ENST00000299259.5 AACTGGGTGGCAGTTCAGAAGGAAGATTGTGGTTACAGAAGAGTGACAACCAAGAATTTT ENST00000422282.1 TACTGG-----AACTCTCAA---------TGGTTGCTAATGGGTG-------------TG ***** * ** ** ***** * * * *** * ENST00000299259.5 TTGATCATTAAATCAGATTTTATAAACAGTGGAAGGAGCATGGACTTAAAACAAGGCATG ENST00000422282.1 TAAATGATATAACCA--CTTTG--------GTAAAGAACATGG----------------- * ** ** ** ** *** * ** ** ***** ENST00000299259.5 CTTATTCGGTTTTGTCAAAATTTTACGAAAATATGTGATATATATTTATACTAAAAATAT ENST00000422282.1 ------CAGTTTC-CCAGAAAGTTA-----------AATATATACCTA-ACTAC-----C * **** ** ** *** ******* ** **** ENST00000299259.5 ATAATCCTTAGATTTAGAAAAGCAATCAGTTAATGTCTTTAGCAGACTAAAGCAGTATTA ENST00000422282.1 ATGACCC-------------AGCAATTC-----CATTCCTAATACCCTCATGT-GTAATA ** * ** ****** * ** * ** * * *** ** ENST00000299259.5 AACACAGGTACAAGTTGGAAATTGTAGAAAACGGAAAGAAAACAAAAGACAAAATGTCTA ENST00000422282.1 -------GCCCAACT----------AGAAACC-----------------TCAAATGTCCA * *** * ***** * ******* * ENST00000299259.5 TGGTAGGGAATAAAAGTTTAAGATATTATAAAATTATGTGTATTTTCTCTTTTACATAAA ENST00000422282.1 TC-TACAGA--AAAAGT----GATA------AATTATG-GTATATCC------------A * ** ** ****** **** ******* **** * * * ENST00000299259.5 TCATTTGTGAAAAGTGTGCTAAACTTTTTTTACAAGAGTGATATTAATTAGGATTTATTT ENST00000422282.1 TC--TAATGGAA----TACTACCC------------AGCAATACAAATGAA-------CC ** * ** ** * *** * ** *** *** * ENST00000299259.5 TTCAATATAATTTGGAGACCCTTTGTTATCCAAATAAAAATGATGAGTTTTTGTGCCTGT ENST00000422282.1 TCTAATACA---TGAAA--------CAACACAAATAAATCTCA-AAAACATTATGT---T * **** * ** * * ******** * * * ** ** * ENST00000299259.5 ATTCAAATATGTATGCATGTGATAACCCTTGAAAGCTAAAGCCCTTCTTAACTTTTGAGT ENST00000422282.1 GAGCAAAAGCCCATG---GTGACA------GAAACCGAAA----TGGTTACC---TGGG- **** *** **** * **** * *** * *** * ** * ENST00000299259.5 TGATGGAATTAGAATTCAAAGATTTGAATGAAATGATTTAACCTTTATCCTCCAATTCTT ENST00000422282.1 -GGTGGGAG-GGAAATCAA----CTGAA--AAGGGGCATAAGGG--AACTTTCTGAGATG * *** * *** **** **** ** * *** * * * * * ENST00000299259.5 ACAGTGCCCAGTTCTCCTGTGCTATCTTTGCTTTGTACAATAGTGCATCTTCCACTTTCT ENST00000422282.1 ACAGAAAT--GTT----TATATTTTCTTTGGTGTTTACACAAATATA------------- **** *** * * * ****** * * **** * * * ENST00000299259.5 AGAGAGAAAGCATGCACTTGTTATTTGGAAAACTGGGCTAAATATATAACAGTATCCAAA ENST00000422282.1 ----AGAAA--------TTGTCA------AAACTCATCAAAATG---AACA-CAT---AA ***** **** * ***** * **** **** ** ** ENST00000299259.5 GTTATACCATAATAATTTATTGTAATTGTGTATTACATAGCTTTGTTTACCCAGATATAG ENST00000422282.1 GGTGTAT-------GTTTATTGTA--TGTAAATTATACTAC-------ACTCACAAA-AA * * ** ********* *** **** * * ** ** * * * ENST00000299259.5 GTGCGTTCTTTTTTTTCTGTTAGTCATCTGTGACTTTTGTTCTGGAATACAGGTTTTTAA ENST00000422282.1 CTGTAATCTCACATTCCC------CACCT----CCCTCCACC-----------------A ** *** ** * ** ** * * * * ENST00000299259.5 ATATATCTTAACAGTCTGACTAACTTAAAATAATTTATTCTTCCCTTAAAACATTTTTCT ENST00000422282.1 ACATTTCTCAACAGTTC----------------TCTATTCTT---GTGAA-----TGGCA * ** *** ****** * ******* * ** * * ENST00000299259.5 GT-GTTTTTGTGCATCAAATATTGTAGAGTTGAAATCTTAGAGATTGCTTATCGAAATAT ENST00000422282.1 GCAGGTTTTAC-CACC-----TTGT----TTCTGATTCTAG---CTACC-AT-GAATCAT * * **** ** * **** ** ** *** * * ** *** ** ENST00000299259.5 AAATTTAGGGGAAGTTAAAAATCGATTGGCAAATTTGTAGCATTTATTCACTGATTAAAT ENST00000422282.1 CACT-------GATCTGGAGATCTTTCTGCAGAGTC-TGG-ATTCTGTCTCT-------T * * * * * *** * *** * * * * *** ** ** * ENST00000299259.5 CTTTTCCACTTTTGTGAAAACCATACCAGTGGTTTACATCATATTGTAATGTGTTCATCT ENST00000422282.1 CCTTTCCACTTCTA-GTGCATCAC-CCAAAGG-------CAGA---------------CC * ********* * * * ** *** ** ** * * ENST00000299259.5 CATTCTTCTTTTTATCCCTAAACCTAGCTAAAAGTTACTGCAAAGAAATCTTTGGCTGCC ENST00000422282.1 CATGCTTCATCTTA--CCAAGACTAATATAACAGC--CT------AAATGATTGTCT--- *** **** * *** ** * ** * *** ** ** **** *** ** ENST00000299259.5 ACAAGTAGATGCTCTCTACTACAAGAGCTGGATTTCCATTACTCACTCTTGCTCTTACAT ENST00000422282.1 -----TAGTCGCTTTGGGCTACTCTAACAAAAT----ATTACAAACT------------- *** *** * **** * * ** ***** *** ENST00000299259.5 TAAAGTTGTTGATTAAATACTTTTTCTCTACATCTT ENST00000422282.1 --GGGTGGCTTATAA--------------------- ** * * ** *