CLUSTAL 2.1 multiple sequence alignment ENST00000300291.5 CCTGCCGCCAGAGGCTCCGGGTTCACTTCCGGCGTGCCTACGCCTCCTCTTGCGCTGTCC ENST00000447151.1 ------------------------------------------------------------ ENST00000300291.5 TGTTAATGGCGGGCAGTAGCCGCTGAGGGGATTGCAGATAACCGCTTCCCGCACGGGGAA ENST00000447151.1 ------------------------------------------------------------ ENST00000300291.5 AGTCTACCCTGCCTGCCACTTTCTGCTCGCCGTCAGCGCCGGAGCTCGCCAGCATGTCTG ENST00000447151.1 -----------------------------------------------------ATGTCTG ******* ENST00000300291.5 TGGTACC----GCCCAATCGCTCGCAGACCGGCTGGCCCCGGGGGG-----TCACTCAGT ENST00000447151.1 TGGTACCTACCACCTAATCACTCGCAGACTAGCTGACCGCAGAGGGAGAGCCCGATCAGT ******* ** **** ********* **** ** * * *** * ***** ENST00000300291.5 TCGGCAACAAGTACATCCAGCAGACGAAGCCCCTCACCCTGGAGCGCACCATCAACCTGT ENST00000447151.1 TCAGCAACAAGTACAACCAGCAGACCAAGCCCCTCATCCTGGAGCACACCATCAAATTGT ** ************ ********* ********** ******** ********* *** ENST00000300291.5 ACCCTCTTACCAATTATACTTTTGGTACAAAAGAGCCCCTCTACGAGAAGGACAGCTCTG ENST00000447151.1 ATCCTATTATCAATTATACTTTTGGTACAAAAGAGCCCCTCTATGAGAAAGACAGCTCTG * *** *** ********************************* ***** ********** ENST00000300291.5 TTGCAGCCAGATTTCAGCGCATGAGGGAAGAATTTGATAAAATTGGAATGAGGAGGACTG ENST00000447151.1 TCTCATCCAGATTTCAGCAAATGAGGGAAGAATTGGATAAAATTGGAATGAGGAGTAACA * ** ************ ************** ******************** * ENST00000300291.5 TAGAAGGGG-TTCTGATTGTACATGAGCACCGG-----CTACCCCATGTGTTACTGCTGC ENST00000447151.1 TAGCAGGGGATTCTGATTGTTTACAAGCACTGGTGTGGCTACTCTATGTATTACTGCTAC *** ***** ********** * ***** ** **** * **** ******** * ENST00000300291.5 AGCTGGGAACAACTTTCTTCAAACTACCTGGTGGTGAACTTAACCCAGGAGAAGATGAAG ENST00000447151.1 TGCTGGGAGCAACTTTCTTCAAGTT-CCTGATGGTGAACTTAGCCCAGGAAAAGGTGAAG ******* ************* * **** *********** ******* *** ***** ENST00000300291.5 TTGAAGGACTAAAACGCTTAATGACAGAGATACTGGGTCGTCAGGATGGAGTTTTG---- ENST00000447151.1 TTGAAGGACTAAAATGCTTAATGACTGGGATACTGAGTCATCAAGATGGAGTTCTGAAAG ************** ********** * ******* *** *** ********* ** ENST00000300291.5 ---CAAGACTGGGTCATTGACGATTGCATTGGTAACTGGTGGAGACCAAATTTTGAACCT ENST00000447151.1 ATGCAAGACTGGGTCAT-----ACTGCATTGGTAACTGGTGGAGACCAAAT--------- ************** * *************************** ENST00000300291.5 CCTCAGTATCCATATATTCCTGCACATATTACAAAGCCTAAGGAACATAAGAAGTTGTTT ENST00000447151.1 -------ATCCATATATTCCTGCATATATTACAAAGCCTAAGGAACATAAGAAGTTGTTT ***************** *********************************** ENST00000300291.5 CTGGTTCAGCTTCAAGAAAAAGCCTTGTTTGCAGTCCCTAAAAATTACAAGCTGGTAGCT ENST00000447151.1 CTGGCTCAACTTCAAGAAAAAGCCTTGTTTGCAATCTCTAAAAATTACAAGCTCATAGCT **** *** ************************ ** **************** ***** ENST00000300291.5 GCACCATTGTTTGAATTGTATGACAATGCACCAGGATATGGACCCATCATTTCTAGTCTC ENST00000447151.1 ACACCATTGTTTGAATTGTATAACAATGCACTAGGGTATGGACCTATTGTTTGCAGTCTC ******************** ********* *** ******** ** *** ****** ENST00000300291.5 CCTCAGCTGTTGAGCAGGTTCAATTTTATTTACAACTGAATTCCTGCGCAGTGGAGAAGT ENST00000447151.1 CCTCAGCTGTTGAGCAGTTTCAAATTTATATACAATGGAATTCCTGTGCAGTGGAGAAGT ***************** ***** ***** ***** ********* ************* ENST00000300291.5 AAAAGAAGCCGCTTGTCTCTGTGAGCACAGCTATATACAGTGTAGAA---TAAATGTGGT ENST00000447151.1 AAAAGAAGCCATT----TCTGTGAACATAGCTAT--ACAGTGTAGAAGAATAAATGTGAT ********** * ******* ** ****** *********** ******** * ENST00000300291.5 AGAAAAGTTTTTTTGGTTTT-ATCTCTTTTGCGATCCCTAAATTGCCACCTTTCTATTGT ENST00000447151.1 AGAAAAGATTTTTGGGCTGGGATCACACCTGTAGTCCCAG------CACTTT-------- ******* ***** ** * *** * ** **** *** ** ENST00000300291.5 TTGAATAGTAAAATTAATATGAAGAACTAGATAGTGGTGTAAACAAATGTGATAATGTTT ENST00000447151.1 -------GGGAGGCTG-------GGGCAGGATAACTGCTTGAGCCCAGG----------- * * * * * **** * * * * * * ENST00000300291.5 ATTTACTTTCGGTTCTGCTCATACTTTTTTGTACAACATTAAAGAAAATGGACTTTTTTT ENST00000447151.1 ----------AGTTCT----AGACCAGCCTGGGCAACA-------AAGTG---------- ***** * ** ** ***** ** ** ENST00000300291.5 ATTTTAATTTCTCATTAAACTTCTAAAATTCTTATAGGTGAGGATCATTTTTCCCCCCAC ENST00000447151.1 -------------------------AGACTCT--------------GTCTCTACACACAC * * *** * * * * * *** ENST00000300291.5 CTTAGGATGGTGAATGTTGCAACACAATGACAGGTTTAAGTCAGTCAAGTTTATTGGACC ENST00000447151.1 C--------------------ACACACACACACATT------AGCCAAGTGTGGTGGTAT * ***** *** ** ** ***** * *** ENST00000300291.5 CTTGCTTTGATACCATTCTTGGGCACATACTCCAAGATTGTATTAGATTTTTGTGATGAA ENST00000447151.1 GCACCTGTGGTCCCA-------GC---TATTC-AGGA--------GGCT-----GAGGCA ** ** * *** ** ** ** * ** * * ** * * ENST00000300291.5 GAGCTTCCATTACTTCTGAAAACTATATTTATCTGAGTGAGTCCAAGGTGCAACTCCTAA ENST00000447151.1 G----------------GAGAATT----------GATTGAACCCAGG----------TAG * ** ** * ** *** *** * ** ENST00000300291.5 ATGAATTGTGTTGCAGAGAACTCCCAGTATAATTCACTGACCAGTACATTTTATAACCAT ENST00000447151.1 TTGAG----GTTACAGTGAGCC------ATG-TTCGT--GCCACTGCACTCTA------- *** *** *** ** * ** *** *** * ** * ** ENST00000300291.5 CCAGGCCTTGGT--TTGCAAGCAACAG-ACCTTAAACATACAGGAAACTATTAAAATTGG ENST00000447151.1 ----GCCTGGGTGACAGAGAGAGATGGTGTCTCAAA-ATA----AGGTTTTTTGTTTTAT **** *** * ** * * ** *** *** * * ** ** ENST00000300291.5 CTCGATCAGTAGTCATAGGAATTGGTATAAGAAGAGACTCATTTAGAGCTCAGAGTTTTC ENST00000447151.1 TTCTTTCCTGATCCCTA--AATTG----------ACACCTATTT----CCC------TCC ** ** * * ** ***** * ** **** * * * * ENST00000300291.5 TTCACATAATGGGGGTATTAATTATTTGTGCTGTTGCGAAATTATGTGTCTTATTCTTAA ENST00000447151.1 CTCCC----------------TTCCTCCCTCTCTCTC-------TTTCTTTCTTTCCT-- ** * ** * ** * * * * * * *** * ENST00000300291.5 AGCCATGGTAAAAATAGGGATCTGTGAAGGAAATTTCTAAAATTGGATGTATTAGGTTTT ENST00000447151.1 --------------------TCTTT--------TTTTT----TTAGACG----GGGTCTT *** * *** * ** ** * *** ** ENST00000300291.5 GAACTCTGAGATTGCACAAATATTCAATTAACTTGAAGTTGTGTACATAGAGAAGAAAAT ENST00000447151.1 G--CTCTG---------------TCACCTAGGCTGGAGT--------------------- * ***** *** ** ** *** ENST00000300291.5 TTGGTTTTAGCAAATGACAGAGCCTTCAAAAATATTTTTGGAATAATGTGAATCAACCGA ENST00000447151.1 ---------GCAG-------------------------TGGCACGATCTCAGCTCACTGC *** *** * ** * * ** * ENST00000300291.5 AAACTGGGGGCAAGGCAGAGGACAGGTTTTCTCAGGTTAAGAGAAAAACGAAATTTTAAA ENST00000447151.1 AACCCCCG-------------------CCTCCCGGGTTCA------AGCG--ATTCTCGT ** * * ** * **** * * ** *** * ENST00000300291.5 AACTTTAAAAAATACTGATAAATTCGGATCAAATTTGGGGGAATAAAAAATATTAGAGCA ENST00000447151.1 GTCTC---AGCCTCCCGAGTAGCTGGGACTACA-----------------------GGCA ** * * * ** * * *** * * *** ENST00000300291.5 AAGGAGTTTGCTGGTTGTGTCATTATTTAATGATCAAAGTATAGCATGTATGCCTTATTA ENST00000447151.1 ---------------TCTGCCACCAC------ACCCG-GCCTGCCACCTATTCTCTATTG * ** ** * * * * * ** *** * **** ENST00000300291.5 CAGACTTGTTGACTA-TAGGCTTAATGTAAAAAGGAATCTTGCCAGATGTAGCTACTTAA ENST00000447151.1 T-------TTAAATAGTAAAATTAATATAAAGAA--------CTAGAT--AGTGGGGTAA ** * ** ** ***** **** * * **** ** *** ENST00000300291.5 GGAAAAAAGGGTTTTTAATAGAAATGAACTTTTGATTAGTATGGTGCCAGTCACAGGGCT ENST00000447151.1 AGAAATATGA-----TAATGCTTATGTACTTTTGGTT---------CTACTTA------T **** * * **** *** ******* ** * * * * * ENST00000300291.5 ATTTTCCTGAATATTGGGTGATGTCAAAGGTATATGATACTTGAGGAAATCAGGCCAAGT ENST00000447151.1 ACTTTTTT----------------------TGTACAACATTCAAGAAAAT---------- * *** * * ** * * * ** **** ENST00000300291.5 GTAGCTGAGCAATTAATAAACACTCAAGTTTTTTTAGTTGGGGTCATGTCAAACCCTCAC ENST00000447151.1 GGACTTCAATAAT-AATAGAAA-------------------GATCATGTCATATAC---- * * * * *** **** * * * ******** * * ENST00000300291.5 ATGGTGGTTAAGTAGTGACTAACTGTGCATGTCCTTCATGGTAGGTGAGCACCAGTCTCC ENST00000447151.1 ---------AAATAGAGA-TAGTTTT--ATTTTTTT-----------------AGCTCCC ** *** ** ** * * ** * ** ** ** ENST00000300291.5 ATGATCAAAAATGCCCCAGTTTCCTTTGAAAAAGCCACTAGTTCTGTGAATTGTC-CTTT ENST00000447151.1 ATTTT---GAATGCTTTTTTTTTTTTTTTGAGAG---GTGGCTC-----ACTGCCACCTC ** * ***** *** *** * ** * * ** * ** * * * ENST00000300291.5 TCCCTCCTGCCCCTAACAGTCCTACCCCTCTAGCCTACATTAGCATATTTCTCATGTAAT ENST00000447151.1 TGCTTCCTGGGCTCAAGGG----ATCCT-----CCCACCTCAG----TTTCCCAAGTAGC * * ***** * ** * * ** ** ** * ** **** ** *** ENST00000300291.5 GTATTTTGCTGGTAAGCTCAT-CCATTAGCTGCGTCCTTCAGCTATTCCTTTAGATTGGA ENST00000447151.1 ----TGGGACAACAGGCACATGCCACCA--TGC-----CTGGCTAATTTTTTGCATTTTT * * * ** *** *** * *** **** * *** *** ENST00000300291.5 GGAAGTGGATATGAAGATGGATTGATTCAGCTCACCTTCCATGATTGCTTTTGAGGGAAA ENST00000447151.1 GG---TGGAGACG-----GGGTTTCTCCATGTTGCC---CA-GGCTGGTCTT-------A ** **** * * ** ** * ** * ** ** * ** * ** * ENST00000300291.5 AGCTACAGTGGCCACATTTCAGATGTTCACTTTTGCAATTTGTGGAGGGTGGAGAGAGGT ENST00000447151.1 AACTCC--TGGGCTCA----AGCTATCCACC----CGCCTTG------------------ * ** * *** * ** ** * * *** * *** ENST00000300291.5 AGACTTTTGTTGTGTGTTTTATAAAGTACTCTCAGTAAGGAGTGTTTGAGTTGAAGAGTC ENST00000447151.1 ---------------GCCTCCTGAAGTACT-------GGGATTAC---AGGC-AAGAGCC * * * ******* *** * ** ***** * ENST00000300291.5 ATCTGATTCGAGGCCACTCATGTTCTTTGTAACTTAAACTTTGACCAAGAAATTCTTCAC ENST00000447151.1 A-CTG---------CGCCC-----------------------GGCCAA------CTTCAT * *** * * * * **** ***** ENST00000300291.5 TTCTCACTTCTTCACTTCTTCCCAATATACAGTAAGTACGTGAGCCAGTCATCCATACAC ENST00000447151.1 CT---ATTT------TTCTTGCC---------TAATTGC--------------------- * * ** ***** ** *** * * ENST00000300291.5 TAAGGCCTAGTTGAGAAAAACCTTTGATTCAGGATGGCTGGGTTACTAACCTTGAAATGT ENST00000447151.1 -----CCTTTCT----AAAACCTC-----CAGGA---CCATGTTG----------AATAC *** * ******* ***** * *** *** ENST00000300291.5 AAGAGATCTGGTTTTGAATGTAAAAGTTGCAACACACAAACGGAAGTCTTAAAAACTTTT ENST00000447151.1 AA-----CTGGC---------AAGAGCGG--GCACAC------AAGTTTTG-----TTGT ** **** ** ** * ***** **** ** ** * ENST00000300291.5 TGCTCTGGTCAGTTACAGGTGGATCCCCAATAATCTGTTTTTGGTTTTCTGATGGAAATA ENST00000447151.1 TGTTGTTGTTG-----------------------CTGTT----GTTTCTTGA-------G ** * * ** ***** **** *** ENST00000300291.5 ATAGAATTAGGGGAAATCAAATCTGGTTGGTAGGTGTCTACAGTATTAGAAGAGGGTATA ENST00000447151.1 ATGGAGTC--------TCAC-TCTG------------TCAC----CCAGGCTGGAGTGCA ** ** * *** **** ** ** * ** * ENST00000300291.5 AGGGCACTGTTTAACACTAAGTTCTAATACTTCCAGAAACTGTGCATTCCAGATCTACAT ENST00000447151.1 GTGGTGCAATCTCA-ACT---------CACTGC---AACCTCCGCCTCCTGGGTTCAAGT ** * * * * *** *** * ** ** ** * * * * * * ENST00000300291.5 -ACTAAATGCTCTTATCATTTTGAAATGGGCTCTTGATTAATAGACCCATATTTTTTAGT ENST00000447151.1 GATTATCTGC-CTCAGCCTCCC-AAGTAG---CTGGAATTATAGGCACCT---------- * ** *** ** * * * ** * * ** ** * **** * * * ENST00000300291.5 GGCTTCTATGTTGTATATTTGTCTAAAATGAAAGCTCTTTTGCGTTCTAAAACTACAATA ENST00000447151.1 -GCCCCCATGCC-------TGGCTAA----------TTTTTGTATTTTTAA--TA-AAGA ** * *** ** **** ***** ** * ** ** ** * ENST00000300291.5 TATGTCATCTTATTTTCCCTGAGTATCCAAGTATAGTGCAGATTCTATGTAAAACTACTA ENST00000447151.1 TGGG-------GTTTCACCATATTGGCCAGG-------CTGGTTTTG-----AACTCC-- * * *** ** * * *** * * * ** * **** * ENST00000300291.5 AATGACACTGGAATATGTTTAGTAGATTAGGGGGAAAAACTATAAAGGTTTATACAATTG ENST00000447151.1 --TGACCTTGTGATCCATCTGCC---TCGGCCTCCCAAAGTGCTGGGATT---ACAGGCG **** ** ** * * * * *** * * ** *** * ENST00000300291.5 TTTGTAGTTACATTTAGGATGGACTTATCCCTTTGGAGAAGAGTGAAGTTTGTTTTTTCG ENST00000447151.1 TGAGCCACCATGCCCGGCCCAGACA---CTTTTT----AAGAG----GCCTGCACTCCAG * * * * *** * *** ***** * ** * * ENST00000300291.5 CC-ATGTGATGAAG-ACCACTGTGATTTTTTAAAAAAGTAGATAATACTTAAAATGGCGT ENST00000447151.1 CCTGGGTGACAGAGCGAGACTCCG---TCTCAAAAAAAAAAAAAA-----AAAA------ ** **** ** *** * * * ****** * * ** **** ENST00000300291.5 AATAATTCTGCACTTGAATTTGTACTGTTAACAGCACATTTGGAAGATTTTAAAACTTTT ENST00000447151.1 AAAAA--------------------------------------AAGGCTTTA-----TTT ** ** *** **** *** ENST00000300291.5 TATTGTCTTATAAATAGCATTCACTTATTATTTTGGATATTTAAGGGTTCCATTAAGTTA ENST00000447151.1 TACC----------TAG-----ACCTGTTAG-----------AAAGGATCTAATAA---- ** *** ** * *** ** ** ** * *** ENST00000300291.5 ACACTGTATTTGGACAAAGTGTGACCAAATTAGCCAGTCTGTTTTCTTCCATGTTTAATT ENST00000447151.1 ACAATGG---CAGAGAAAA-------AAATAAA-------GCTTCCTACC-TGTCT---- *** ** ** *** **** * * ** ** ** *** * ENST00000300291.5 AGAAGTGAGAGGTAGAAGTACTTCAAATTCAACAGGCCAGCAAGCAATCGGCTTAAAATT ENST00000447151.1 -----TGGG-GACAGAAAGA-----GATTCAAC-------------------------TA ** * * **** * ******* * ENST00000300291.5 CCCTTTCTTAAATGTTGTGCTCTTATGTTCTCGGCTTTTTAATGACTTTATTTTTACAGT ENST00000447151.1 CCTTTTTGGGGAAATTAT--TATTAT-----------TTTGA-GAC---------AGAGT ** *** * ** * * **** *** * *** * *** ENST00000300291.5 ACTTGTTCAGTCACTTGAGATGAAATGCTTGGGGTAGCTTTTCCATCCTCAAACTTAATG ENST00000447151.1 -CTCCCTCTGTCACTCAGGCTGGAGTGC----------------------------AATG ** ** ****** * ** * *** **** ENST00000300291.5 TTTTTACTAGTTCATAGTGTTTGGAACAGTATATGCCAATCACTGAGACTGCATCAGAGT ENST00000447151.1 G-----------CATAATCTT-------------------------GGCT-CACCA---- **** * ** * ** ** ** ENST00000300291.5 TTGCAATTTTGTATGTTTCATTGCCAAAGAAGGCTTAGTGGTTGTTGACTGTAGTATAAG ENST00000447151.1 ---CAACCTC---TGTCTC-----------------------------CTG-------AG *** * *** ** *** ** ENST00000300291.5 TCAGCTTTCTGTAGCATAAGATTTGATTTTCCCATACTTACTTCACTTGTTATACATCAC ENST00000447151.1 TTAGTT-------------------ATTCTCCCATCTCAGCCTC---------------C * ** * *** ****** * ** * ENST00000300291.5 TGATTATTTGGGTTAAACTGGACTCATTTCAAGCAGTTTGCTTTTGTTCAAATCGTGATG ENST00000447151.1 CGAGTAGCTGGG-------------ATTACAGGCA-------------CGCGCCACCATG ** ** **** *** ** *** * * *** ENST00000300291.5 AGAAACCTAATACTGTAATTTGATTTGAGCCATAAAACACATTTTAATATTAGCTTGTAT ENST00000447151.1 -----CCCAGC----TAATTT---------------------TTTAAT------------ ** * ****** ****** ENST00000300291.5 TATAGTTATTAAGCTTGTTTTTGTGGAAAAAAACTTACTAAAACCTAGGTAACTCTAGAT ENST00000447151.1 -----------------TTTTAGTAGAGA------------------------------- **** ** ** * ENST00000300291.5 TAGGCCAGTTCAGGTGTATTTTGTATCTTAGTAATGGATCATATCGTAAAAATAGAGATA ENST00000447151.1 --------------CGTGGTTT--------------CACCATAT-----------GGGTG ** *** * ***** * * ENST00000300291.5 AGTTGGGAAGATATATTGATTATGCTGTTCTGTTGAGGGAAAGGTCATGTATTTAGAAAT ENST00000447151.1 AG---------------------GCTGGTCTCT-----------------------AACT ** **** *** * ** * ENST00000300291.5 TTAAACTTTTGGTTATTGTGTTCACATCATAGTATTCAAGCATCATTTATAGTTTGGTTT ENST00000447151.1 CCTGACCTCAGGTGA-----TCCACCT------------GCCTCA----------GGCTC ** * *** * * *** * ** *** ** * ENST00000300291.5 TGAGAACTTTTCTGGTATTACGTTTATGGCAAATGTATAAAAGAAACAAGTTTTGGTTAT ENST00000447151.1 CCAA---TGTGCTGGGATTAC--------------------------AGGCGTGAGCCAC * * * **** ***** * * * * * ENST00000300291.5 ATTTTTATATTTGTAAAGTAAGTTTGGTTAAAGTGATCACTGTTCTTTTTTTATTTTATT ENST00000447151.1 CTC------------------GCCCAGCCAGGGAAATTA------TTTTTAGCTTTTAT- * * * * * ** * ***** ****** ENST00000300291.5 GTCATTTCAATAAAAAATATTTGAAAGAGAA ENST00000447151.1 -------------------------------