CLUSTAL 2.1 multiple sequence alignment ENST00000304546.1 GGCGGCGGGCGCTGGGAGACACCGGACGCCCGCTCGGCTGCGCTGCGGCTCAGGCCCCCG ENST00000427961.1 ------------------------------------------------------------ ENST00000304546.1 CTCGGGCCCGACCCGCTCGGTCACCGCCGGCTCGGGCGCGCACCTGCCGGCTGCGGCCCC ENST00000427961.1 ------------------------------------------------------------ ENST00000304546.1 AGGGCCATGCGGAGGCCCACGAGGAGGCCGGCGGCCACGCGCATCCCGTAGCCCAGGTGG ENST00000427961.1 ------------------------------------------------------------ ENST00000304546.1 CCCAGGTCTGCACCGCGGCGGCCTCGGCGCCATGGAGCCCCCGTATTCGCTGACGGCGCA ENST00000427961.1 ------------------------------CTTGGAGTCCCGGTATTCGCTGAGGGCGCA * ***** *** *********** ****** ENST00000304546.1 CTACGATGAGTTCCAAGAGGTCAAGTACGTGAGCCGCTGCGGCGCGGGGGGCGCGCGCGG ENST00000427961.1 CTACCACGAGTTCCAGGAGGTCAAGTACTTGAGGCACTG--------GGGGCCTGTGCGG **** * ******** ************ **** * *** ***** * **** ENST00000304546.1 GGCCTCCCTGCCCC-CGGGCTTCCCGTTGGGCGCTGCGCGCAGCGCCACCGGGGCCCGGT ENST00000427961.1 GGCCTCTCTGCCCCTCAGGCTTCTC-TCGGGAA------GCAGCGCCACCGGGGCTGGG- ****** ******* * ****** * * *** **************** ** ENST00000304546.1 CCGGGCTGCCGCGCTGGAACCGGCGCGAGGTGTGCCTGCTGTCGGGGCTGGTGTTCGCCG ENST00000427961.1 CCGGGCTGCAGCTCTGGAACCCGCGCGAGGTGAGCCTGCTGTCGGGGCTGGTATTCGCCG ********* ** ******** ********** ******************* ******* ENST00000304546.1 CCGGCCTCTGCGCCATTCTGGCGGCTATGCTGGCCCTCAAGTACCTGGGCCCGGTCGCGG ENST00000427961.1 CCGGCCTCTGCGCCATCCTGGGGGCTTTGCTGGCGCTCAGGTACCTGGACC-GGTCGCGG **************** **** **** ******* **** ******** ** ******** ENST00000304546.1 CCGGCGGCGGCGCCTGTCCCGAGGGCTGCCCTGAGCGCAAGGCCTTCGCGCGCGCCGCTC ENST00000427961.1 CGGGCGGCGGCGCCTGCCCCGAG------------TGCAAGGCCTTCGCGCGCGCCGCTC * ************** ****** ************************ ENST00000304546.1 GCTTCCTGGCCGCCAACCTGGACGCCAGCATCGACCCATGCCAGGACTTCTACTCGTTCG ENST00000427961.1 GCTTCCTGGCGGCCAACCTGGATGCCAGCATCGACCCGTGCCAGGAGTTTTACTGGTTCT ********** *********** ************** ******** ** **** **** ENST00000304546.1 CCTGCGGCGGTTGGCTGCGGCGCCACGCCATCCCCGACGACAAGCTCACCTATGGCA--- ENST00000427961.1 ----CAGAGGAAGA----GGAG--GTGCTAGTGCTGGCGACGGACTAAG-TGTAGCAGGT * * ** * ** * ** * * * **** ** * * * *** ENST00000304546.1 ---CCATCGCGGCCA-TCGGCGAGCAAAACGAGGAGCG--CCTACGGCGCCTGCTGGCGC ENST00000427961.1 GACCCAGCTCATCCACTCCGCACCCCATAGGGACGGCGATCCTGCACAACTACCTAGTGT *** * * *** ** ** * * * * *** *** * * ** * * ENST00000304546.1 GGCCCGGGGGTGGGCCTGGCGGCGCGGCCCAGCGCAAGGTGCGCGCCTTCTTCCGCTCGT ENST00000427961.1 GGCGCGTGG-------TGGTGGTTCTG----------AGTGAGCACCTGTCCCTGC-CAT *** ** ** *** ** * * *** ** *** * ** * * ENST00000304546.1 GCCTCGA--CA-TGCGCGAGAT----CGAGCGACTGGGC----CCGCGACCCATGCTAGA ENST00000427961.1 TCCATGAGGCACTGCAGGAGTTGGCACGGGAGACAGAGGGAAGCCACAAGC--TGCAGGA ** ** ** *** *** * ** * *** * * ** * * * *** ** ENST00000304546.1 GGTCATCGAGGACTGCGGGGGCTGGGACCTGGGCGGCGC---GGAGGAGCGTCCGGGGGT ENST00000427961.1 GCTGGCCGAGGTCTGCCTGGGCCAGG--CCAACCACCACTTTGGTATGGCACTTGGTGCC * * ***** **** **** ** * * * * ** ** ** * ENST00000304546.1 CGCGGCGCG-ATGGG-ACCTCAACCGGCTGCTGTACAAGGCGCAG-GGCGTGTACAGCGC ENST00000427961.1 CTCTTTGTACATGAACACTTC--TCGACTGC----CAAGGTGTGGCAGCTGGTGGAA-GA * * * *** ** ** ** **** ***** * * ** ** * * ENST00000304546.1 CGCCGCGCTCTTCTCGCTCACGGTCAGC--CTGGACGACAGGAACTCCTCG--CGCTACG ENST00000427961.1 CATCAAGTATGTCCTG-----GGCCAGCGCCTGGAGGAGCTGGACTGCACAGACGCTGAG * * * ** * ** **** ***** ** * *** * * **** * ENST00000304546.1 TCATCCGCATT--GACCAGGATGGGCT------CA--CCCTGCCAGAGAGGAC--CCTGT ENST00000427961.1 --ATTAGAGTTTAAATCAGGGAGGACTGTGTCCCGGCCCCTTCCCTTGTTGCCAGCTTGA ** * ** * **** ** ** * **** ** * * * * ** ENST00000304546.1 ACCTCGCTCAGGATGAGGACAGTGAGAAGATCCTGGCAGCATACAGGGTGTT-CATGGAG ENST00000427961.1 CCCTGCCCCAGGTTGGTGACC-TGAAGCCACACTGGC----TGAAGGGAGTGGCAGGCTG *** * **** ** *** *** * ***** * **** ** ** * * ENST00000304546.1 CGAGT-GCTCAGCCT-----CCTGGGTGCAGACGCTGTGGAACAGAAGGCCCAAGAG--- ENST00000427961.1 TGGCTTGCCTGGCCTGGGGTCCTGAGAAAGGCAGCTCAGG----GTGGGCCCCGGTGTCT * * ** **** **** * * *** ** * ***** * * ENST00000304546.1 ATCCTGCAAG--TGGAGCAGCAGCTGGCCAACATCA-CTGTGTCAGAGCA-TG-ACGACC ENST00000427961.1 GCCAGGCAAGAATGGGGTGTTGGG-GGCAGATGCCATCTGGGTGAGGGCAGTGTGCATCC * ***** *** * * *** * ** *** ** ** *** ** * ** ENST00000304546.1 TACGGCGAGATGTCAGCTCCATGTACAA-CAAGGTGACGC---TGGGGCAG------CTG ENST00000427961.1 TGCAGCCAGAAGCCACCCCCACTCCCACTCACTGTGTCTTGTGTGGAACAAGACACCCTG * * ** *** * ** * *** ** ** *** * *** ** *** ENST00000304546.1 -CAGAAGATCACCC-CCCACTTGCGGTGGAAGTGGCTGCTAGACCAGATCTTCCAGGAGG ENST00000427961.1 TCACTTGTTCATTCACCCATTTTTTCTGTAT-TTCCTGGGAG-CCA---CCTACAGCCAG ** * *** * **** ** ** * * *** ** *** * * *** * ENST00000304546.1 AC----TTCTCAGAGGAAGAGGAGGTGGTGCTGCTGGCGACAGACTACATGCAGCAGGTG ENST00000427961.1 ACCCTGTTCTGGTGCTGAAGGGAGGTGAAGCTCGAAGC-ACACAGCCCAGGCCACAG-TG ** **** * ******* *** ** *** * ** ** *** ** ENST00000304546.1 TCGCAGCTCATCCGCTCCACACCCCACCGGGTCCTGCA--CAACT---ACCTGGTGTGGC ENST00000427961.1 TGG--GTTTGGCC--TCCTAATGCCAT-GAGTCCTGGAGACAGCGGGAAGTAGGTAGGTA * * * * ** *** * *** * ****** * ** * * *** * ENST00000304546.1 GCGTGGT--GGTGGTCCTGAGTGAACACCT--GTCCCC-----GCCAT--TCC------G ENST00000427961.1 GGGTGGTCTGGCAGCCCTG---GCACCCCTTGGTTTCTCACCGGCCATGGCCCAGACAGG * ***** ** * **** * ** *** ** * ***** ** * ENST00000304546.1 TGAGGCACTGCACGAGC-TGGCACAGGAGATGGAGGGCAGCGACAAGCCACAGG--AGCT ENST00000427961.1 TGGGGC-TGGCAGGAGCCTGGGCCCAGAGTTCCAGTGCTGTGGGAAAGGGTGGGGCAGGT ** *** *** **** *** * *** * ** ** * * ** ** ** * ENST00000304546.1 GGC--CCGGGTCTGCTTGGGCCAGGCCA--ATCGCCACTTTGGCATGGCGCTTGGC--GC ENST00000427961.1 GGTGACAACATTAAGTGGAGCCTTGTCTTTGTCATGATTGCAGCCTGG-GCTGGGCCAGC ** * * * * *** * * ** * * ** *** *** *** ** ENST00000304546.1 CCTCTTTGTACATGAGCACTTCTCAGC-TGC-CAGCAAAGCCAAGGTGCAGCAGCTAGTG ENST00000427961.1 CTTGCCCACGTGTACACGCCTGTGGGTGTGCACACCTCTTCCTGGAGGAGGAAGCCGG-G * * * * * * * * *** ** * ** * * * *** * * ENST00000304546.1 GAAGACATCAAGTACATCCTGGGCCAGC---GCCTGGA--GGAGCT----GGACTGGATG ENST00000427961.1 GGAGGGACCA-GTGC--CCTGGGCCAGCCAGGCCTGGGCTGCATCTTCTAGAGCAGCTTG * ** * ** ** * *********** ****** * * ** * * * ** ENST00000304546.1 GACGCC-GAGACCAGGGCTGCT-----GCTCGGGCC----AAGCTCCAG--------TAC ENST00000427961.1 TACACTTGAGTTTGACCCCGTTCCCTTGCACAGGTAGATGAAGCTCCAGGGAGAGTCTAT ** * *** * * * ** * ** ********* ** ENST00000304546.1 ATGATGGTGATGGTCGGC-TACCCGGACTTCCTGCTGAAACCCGATGCTGTGGACAAGG- ENST00000427961.1 TCTCCAGCAGCCCTGGGCACACCCAGAGGTGTAGCCTCAACCAGAGGGTTTGG-TAACCT * * *** **** ** * ** **** ** * * *** ** ENST00000304546.1 -AGTATGAGTTTGAGG-----TCCATGAGAAGACCTACT-TCAA---------GAACATC ENST00000427961.1 CAGGCTGAGTTCAAAAGTAAATGTGTGAAAAGGCGTCCAATCAATGTGGGATAAAGCACA ** ****** * * *** *** * * * **** * ** ENST00000304546.1 TTGAACAGCATCCGCTTCAGCATC-CAG-CTCTCAGTT----AAGA-----AGATTCG-- ENST00000427961.1 TTGGGGTGGGGTGGAGAAGGTATCACAGACTCCAGGTTGGCAAAGACCTAAAAATCCACC *** * * * *** *** *** *** **** * ** * ENST00000304546.1 ----GCAGGAGGTGGACAAGTCCACG--TGGCTGCTCCCCCCACAGGCGCTCAATGCCTA ENST00000427961.1 CATAGTAGGGTGGAGGGAGGTGGATGAATAGGCGCCCCACACACCAG-ACTCAAG----A * *** * * * ** * * * * ** ** * *** * ***** * ENST00000304546.1 CTATCTACCCAACAAGAACCAGATGGTGTTCCCCGCGGGCATCCTGCAGC-CCACCCTGT ENST00000427961.1 GCATC-ATTCAGGACG--TCAAGTTGTGCACATCCCAGG-ATACAGCAATTCCATCCCGG *** * ** * * ** * *** * * * ** ** * *** *** ** * ENST00000304546.1 ACGA---CCCTG-----ACTTCCCACA-GTCTCTCAACTACGGGGGCATCGGCACCATCA ENST00000427961.1 GAAAGTGTCCTGCAGAAACTTGGCACACGTGTCCCAGG-ATGTAAGCACCAACGTGTGCA * **** **** **** ** ** ** * * *** * * ** ENST00000304546.1 TTG-GACATGAGCTGACCCACGGCTACGACGACTGGGGGGGCCAGTATGACCGCT----- ENST00000427961.1 AAGTGGCATTGTTTAA---ATAGCCA-GAC-ACTGAAAAACCCAA-ATGCTCATCAACAG * * *** * * * ** * *** **** *** *** * ENST00000304546.1 CAGGGAACCTGCT--GCACTGGTGGACGGAGGCCTCCTACAGCCGCTTCCTGCGAAAGGC ENST00000427961.1 CAGAAAAAGTGTCAGGAGTTTCATAACTGGAATATTATACAGCAA-----TGGAAATGAC *** ** ** * * ** * * ****** ** ** * * ENST00000304546.1 TGAGTGCATCGTCCGTCTCTATGACAACTTCACTGTCTACAACCAGCGGGT-GAACGGGA ENST00000427961.1 CAGGC---TTTTCTAACA-TACAACAGATTAAATCTC-ACAAACATAAAGTTGAACAAAA * * ** * ** *** ** * * ** **** ** ** **** * ENST00000304546.1 AACACA-------------CGCTTGGGG-AGAACAT------CGCAGATATG-------- ENST00000427961.1 TATACAAATCACAAAGGAACACATAGGATAGAATATATCTTACACATACATGAAGTTCAA * *** * * * ** **** ** * ** * *** ENST00000304546.1 ----GGCGGCCTCAAGCT------GGCCTACCACGCCTATCAGAAG-TGGGTGCGGGAGC ENST00000427961.1 ATGGGGCAAACCTAAACTATATGGGGGATAAAACGATGAAAAGAGGCTGGGTGCAGTAGC *** * ** ** ** ** *** * *** * ******* * *** ENST00000304546.1 ACGGCCCAGAGCACCCACTTCCCCGGCTCAAGTACACACATGACC--AGCTC-----TTC ENST00000427961.1 TCACACCTGTAATCCCAGTAACTAGGCTGAGGTGGGCAGATCACCTGAGGTCAGGAGTTC * ** * **** * * **** * ** ** ** *** ** ** *** ENST00000304546.1 TTCATTGCCTTTGCCCAGAACTGGTGCATCAAGCGGCGGTCGC-AGTCCATCTACCTGCA ENST00000427961.1 AAGACCAGCCTGGCCAACA--TGGTG----AAACCCCCGTCTCTACTAAAAATACAAAAA * * * *** * * ***** ** * * *** * * * * *** * ENST00000304546.1 GGTGCTGACTGACA-AGCATGCCCCTG-------AGCACTACAGGGTGCTG-GGCAGTGT ENST00000427961.1 TTAGCTGGGTGTGATGGCATGTGCCTGTAATCCCAGCTATTCTGGAGGCTGAGGCAGGAT **** ** * ***** **** *** * * ** **** ***** * ENST00000304546.1 GTCCCAGTTTGA----GGAGTTTGGCCGGGCTTTCCACTGTCCCAAGGACTCACCCATGA ENST00000427961.1 AATC--ACTTGAACCCGGGAGGTGG--AGGCTG--CAGTAAGCCGAGA--TCATGC---- * **** ** *** **** ** * ** ** *** * ENST00000304546.1 ACCCTGCCCACAAGTGTTCCGTGTGGT-GAGCCTGGCTGCCCGCCTGCACGCCCCCACTG ENST00000427961.1 -CACTGCACTCCAGT---CTGGGTGACAGAGCAAGACT--CTGTCT-CAAAAACAAA--- * **** * * *** * * *** **** * ** * * ** ** * * ENST00000304546.1 CCCCCGCACGAATCACCTCCTGCTGGCTACCGGGGCAGGCATGCACCCGGTGCCAGCCCC ENST00000427961.1 -------ACAAAAAAACTA-TGAAAATAAAATGAGTATCCAAATATTCAGTGGTGGTCGG ** ** * ** ** * * * * ** * * *** * * ENST00000304546.1 GCTCTG-GGCAC-CACCTGCC-TTCCAGCCCCTCCAGGACCCGGTCCCC-----CTGCT- ENST00000427961.1 GTGTGGTGGCTCACACCTGTAATCCCAGCCCTTTAAGAGGCCAAGGCAGGAGGACTGCTT * * *** * ****** * ******* * ** ** * ***** ENST00000304546.1 --GCCCCTCA-CTTCAGGAGGGGCCTGG--AGCAGGGTGAGGCTGGA-CTTTGGGGGGCT ENST00000427961.1 GAGCCCAGGAGTTTTAAGACCAGCCTGGGCAACATAGTGAGACCCCATCTTTAAAAAGAA **** * ** * ** ****** * ** ***** * * **** * ENST00000304546.1 GTGAGGGAAATATACTGGGGTCCCCAG--ATTCTGCTCTAAGGGGGCCAGACCCTCTGCC ENST00000427961.1 AAAGAAAAAAAATTCAGTGGTAAGAAAGAATAGTGTTTTCGATGGGAAAGG---TATG-- *** ** * * *** * ** ** * * *** ** * ** ENST00000304546.1 AGGCTGGATTGTACGGGCCCCACCTTCGCTGTGTTCTTGCTGCAAAGTCTGGTCAATAAA ENST00000427961.1 -GGGTGG--TGTGGGGGA---ACCCTGGCCACAATCA-ATTTCTTGATCTGGGTGGCGG- ** *** *** *** *** * ** ** * * ***** ENST00000304546.1 TCACTGCACTGTT ENST00000427961.1 TTACT---TTGGT * *** ** *