CLUSTAL 2.1 multiple sequence alignment ENST00000305596.3 AGTTAGTTCCCTAACCCGAGTGAAGCCACTTCCGGGCTTCCCGGGCGCCTTCCGCAGTCC ENST00000459978.1 ------------------------------------------------------------ ENST00000305596.3 TCTTCCGGGTGATGGCGGCCGGGTGCCCCGGATGTAGCCCTGGCGCAAGCATCTCTTCTT ENST00000459978.1 ------------------------------------------------------------ ENST00000305596.3 TTTTCCACCTCGCCTTCCGCGGATTCCCAGCTTGAGAAACACCTCTTTGCCCCGTCATGC ENST00000459978.1 ------------------------------------------------------------ ENST00000305596.3 CAAAGAGGAAAGTGACCTTCCAAGGCGTGGGAGATGAGGAGGATGAGGATGAAATCATTG ENST00000459978.1 ------------------------------------------------------------ ENST00000305596.3 TCCCCAAGAAGAAGCTGGTGGACCCTGTGGCTGGGTCAGGGGGTCCTGGGAGCCGCTTTA ENST00000459978.1 ------------------------------------------------------------ ENST00000305596.3 AAGGCAAACACTCTTTGGATAGCGATGAGGAGGAGGATGATGATGATGGGGGGTCCAGCA ENST00000459978.1 ------------------------------------------------------------ ENST00000305596.3 AATATGACATCTTGGCCTCAGAGGATGTAGAAGGTCAGGAGGCAGCCACACTCCCCAGCG ENST00000459978.1 ------------------------------------------------------------ ENST00000305596.3 AGGGGGGTGTTCGGATCACACCCTTTAACCTGCAGGAGGAGATGGAGGAAGGCCACTTTG ENST00000459978.1 ------------------------------------------------------------ ENST00000305596.3 ATGCCGATGGCAACTACTTCCTGAACCGGGATGCTCAGATCCGAGACAGCTGGCTGGACA ENST00000459978.1 -------------CTA-----------GAAATG---AGACCCCA---------------- *** * *** *** ** * ENST00000305596.3 ACATTGACTGGGTGAAGATCCGGGAGCGGCCACCTGGCCAGCGCCAGGCCTCAGACTCGG ENST00000459978.1 -----------------------------------------CGCCAGGCCTCAGACTTGG **************** ** ENST00000305596.3 AGGAGGAGGACAGCTTGGGCCAGACCTCAATGAGTGCCCAAGCCCTCTTGGAGGGACTTT ENST00000459978.1 AAGAGGAGGACAGCTTGGGCCAGACCCCAGTGAGTGCCCAAGCCTTCTTGGAGGGACTTT * ************************ ** ************** *************** ENST00000305596.3 TGGAGCTCCTATTGCCTAGAGAGACAGTGGCTGGGGCACTGAGGCGTCTGGGGGCCCGAG ENST00000459978.1 TGGAGCTCCTATTGCCTAGAGAGACAGTGGCTAGGGCACTGAGGCATCTGGGGGCCCGAG ******************************** ************ ************** ENST00000305596.3 GAGGAGGCAAAGGGAGAA---AGGGGCCTGGGCAACCCAGTTCCCCTCAGCGCCTGGACC ENST00000459978.1 GAGGAGGCAAAGGGAGCAGCAAGGGGCCTGGGTGACCCAGTTCCCCGCAGTGCCCGGACC **************** * *********** ************ *** *** ***** ENST00000305596.3 GGCTCTCCGGGTTGGCCGACCAGATGGTGGCCCGGGGCAACCTTGGTGTGTACCAGGAAA ENST00000459978.1 GGCTCTCCGAATTGGCCGACCAGATGGTGGCCCAGGGAAACCTTGGCATGTACCAGGAAA ********* ********************** *** ******** ************ ENST00000305596.3 CAAGGGAACGGTTGGCTATGCGTCTGAAGGGTTTGGGGTGTCAGACCCTAGG-ACCCCAC ENST00000459978.1 CGAGGGAACAGTTGGCCATGCGGCTGAAGGGTTTGGGGTGCCAGGCCCTAGGGACCCCAC * ******* ****** ***** ***************** *** ******* ******* ENST00000305596.3 AATCCCACACCCCCACCCTCCCTGGACATGTTCGCTGAGGAGTTGGCGGAGGAGGAACTG ENST00000459978.1 AATCCCACACCCCCACACTCCCTAGACATGTTCGCTGAGGAAGTGGCAGAGGGGGAACTG **************** ****** ***************** **** **** ******* ENST00000305596.3 GAGACCCCAACCCCTACCCAGAGAGGAGAAGCAGAGTCGCGGGGAGATGGTCTGGTGGAT ENST00000459978.1 GAGACCCCAACCCCTACCCAGAGAGGAGAAGCAGAGTTGCCAGGAGATGGTCTGGTGGAT ************************************* ** ****************** ENST00000305596.3 GTGATGTGGGAATATAAGTGGGAGAACACGGGGGATGCCGAGCTGTATGGGCCCTTCACC ENST00000459978.1 GTGATGTGGGAATATAAGTGGGAGAACCCGGGGGATGCCGAGCTGCATGGGCCCTTCACC *************************** ***************** ************** ENST00000305596.3 AGCGCCCAGATGCAGACCTGGGTGAGTGAAGGCTACTTCCCGGACGGTGTTTATTGCCGG ENST00000459978.1 AGCGACCAGATGCAGACCTGGGTGAGCGAAGGCTACTTTCCTGATGGTGTTTACTGCCGG **** ********************* *********** ** ** ******** ****** ENST00000305596.3 AAGCTGGACCCCCCTGGTGGTCAGTTCTACAACTCCAAACGCATTGACTTTGACCTCTAC ENST00000459978.1 AAGCTGGACCCCCTTCGTGGTCAGTTCTACAACTCCAAACGCATTGACTTTGACCTCTAC ************* * ******************************************** ENST00000305596.3 ACCTGAGCCTGCTGGGGGCCCAGTTTGGTGGGCCCTTCTTTCCTGGACTTTGTGGAGGAG ENST00000459978.1 ACCTGAGACTGCTGGGGACCTAGTTTGGTGGGCCCTTCTTTCCTGAACTTTGTGGAGGAG ******* ********* ** ************************ ************** ENST00000305596.3 GCACCAAGTGTCTCAGGCAGCGAGGAAATTGGAGGCCATTTTTCAGTCAATTTCCCTTTC ENST00000459978.1 GT-CCAAGTGTCTCAGGCAGTGAGGAAGTTGGAGGCCATTTTTCAGTCAATTTCCCTTTC * ***************** ****** ******************************** ENST00000305596.3 CCAATAAAAGCCTTTAGTTGTGTACTGGGGCCTTGGCTGTGCTGATGGCCAGAAGCCAGG ENST00000459978.1 CCAATAAAAGCCTTTAGTTG-----TGGGGCCTTGGCTGTGCTGATGGCCAGAAGCGAGG ******************** ******************************* *** ENST00000305596.3 GGCCTTCTCCACAGTCCCTTTGGACTTGTCTTGGTCCCTGAGTA----CTCCCATGAAGA ENST00000459978.1 GAACCTCTCCACAGCCCCTTTGGACTCGCCTTGGTCCCTGAGTGTTTGCTCTTATGAAAA * * ********* *********** * ************** *** ***** * ENST00000305596.3 TCCTTCTTGGAGGTGCCTGTCAGGTATCCTGTGGCCTCCCTGCCTGGACTCTGCTTGCCG ENST00000459978.1 TCCTCCTTGGAGGTGCCTGTCAGGGGTCCCGTGGCCTCCCTGCCTGGACTCTGCTTGCCA **** ******************* *** ***************************** ENST00000305596.3 TGTAAACACCCCCAACTGCGCTGCTCTGTGCTCCTCTCCCAGGTTTCTTGTTCGATTCCT ENST00000459978.1 AGTAAACACCCCCAACTGTGCTACGAAGAA----------AAA------AAAAGAAACCT ***************** *** * * * ** *** ENST00000305596.3 CTTAGGTCTTTGGCTTTCAGGACCTCAGATTCTTTATCCTTGTAGCCACCAGAGGACAGA ENST00000459978.1 C-----------ACTTACAAAAC-TAAG------------TGAAAACA----AAAATACA * *** ** ** * ** ** * ** * * * * ENST00000305596.3 GCCCCAGAAGTGGATGTTTT---AGGCCCAGAAGGACCAGGGCATCGAG---AAGACATT ENST00000459978.1 TTTTTAAAAAAGTGTTCTTTGGGAGGGCGAGGCGGGC--GGATCACGAGGTCAGGAGATG * ** * * *** *** * ** ** * ** **** * ** ** ENST00000305596.3 GGGACCCTGTTGGGGGTGAGCATGG--AACCCTCTTACTCTCGCTTCACCCTCTCAAGCT ENST00000459978.1 GAGACCATCCTGG---CCAACATGGTGAAACCCCGT-CTCT-GCTTTA-------AAA-- * **** * *** * ***** ** ** * * **** **** * ** ENST00000305596.3 CCTTAGATGCTGGGCAGAAGTGGGATGAGTGGCCCAAGACCGAGATCCCTAAGGTTCTGA ENST00000459978.1 ----AAA-----AAAAAAAAAAAAAAAATTAGCCGGGGGC------------GGTGGCGG * * * ** * * * *** * * *** * ENST00000305596.3 GAGCCAGTGTCTTCCCTAATCTGGCTTTCCTCTATCCTTGCCGTCGTTCCCACAGCCCTT ENST00000459978.1 GCGCC--TGTAGTCCC--AGCTG------CTCGG-----GAGGTTGAGGCAGGAG----- * *** *** **** * *** *** * ** * * ** ENST00000305596.3 CAGTGAAGTGCAAACTCAGTGGCCAAGT-----GTGGGCCAAG-TGTG--CATTGTACT- ENST00000459978.1 -AATGGTGTG-AACCTGGGAGGCAGAGCTTGCAGTGAGCTGAGATAGGACCACTGCACTC * ** *** ** ** * *** ** *** ** ** * * ** ** *** ENST00000305596.3 -GGCACAGAGAGGGGCAGTGACTCACTGGAGATCACAGGAATCAAAGGGCTGGCCCAGAC ENST00000459978.1 CAGC-CTGGGCGGAAGAGTGAGACTCC----ATCTCAAAAAAAAAAAAAAAAAAAAAAAA ** * * * ** ***** * * *** ** ** *** * * ENST00000305596.3 CCAGTG--GGCTCCTTTCCCAGACCTTTCTTGGCA--CAAAGCCTTTGCTGCCTGGCCTT ENST00000459978.1 AAAGTGTTGACATTTTTCCTAAGAATT----GGAAACCAGAATATTTTTTAACTTA---- **** * * ***** * ** ** * ** * *** * ** ENST00000305596.3 GGAGGCCCTGCGGCCTACATTCTCTGGACCCCACTATGTGCCTGGCACAGGGCTAGTGCC ENST00000459978.1 ---------ATGATTCATAGT-TCTAG-------TACAAGCAATAAATAGGTCCAGC--- * * * * *** * ** ** * *** * ** ENST00000305596.3 TTGAGGAAACTGAGGTAGCTGGGTTGGTCCCCTTCC----AGGAATTCAGAG-----TCT ENST00000459978.1 ---AAAAGTTTAAGGGCTTTGAAATTCTCTCCTTCTCTTTGGAAAGGAAGGGGTATTTTT * * * *** ** * ** ***** * ** ** * * * ENST00000305596.3 GGTGGCAGGGGCATGGGAAATAGACAG-ATGTAATTCTATAGCCTGGGCCTGGCACCCTC ENST00000459978.1 GGTTTCTTG--CTTTGAAA---GACAGTAAGCCACTACAAAGACTCTG--TGG-----TT *** * * * * * ** ***** * * * * * ** ** * *** * ENST00000305596.3 CACCTCCACGCCCCACCAGCATTGCCTTACGCCTCCCTTGCCCCA-----CGTTAGATGG ENST00000459978.1 AACCTTCAC------TCA--ATGATCTGATCTTTCCACAGCTGCAGAGGGTGCTAAGTGA **** *** ** ** ** * *** ** ** * ** ** ENST00000305596.3 TTTCTTCCGGTTTTGCACTCTGGCTGCCCCTTGGAG---TCTCCTGGGGAGCTGTAATAT ENST00000459978.1 CA----CAAGAA--GCAATATAAACATTTCAGAGGGAAATTTCTGAAAAAGTGGTGACAG * * *** * * * * * * ** ** ** * * ENST00000305596.3 CTCTTTGGAGATTCAGATTGAGCTGGTCTAGGTTGTGGCCCAGGCATTGGGCATTTTGGA ENST00000459978.1 GAATAAATGAATT---GTTTAGTTGCTTCTTGGTGTAAAAAAAAGAAAAGGTGATTTTGT * *** ** ** ** * * *** * * ** *** * ENST00000305596.3 AGCC----CCCAGGTG------TTTTCAGCTTGCAGCCAGGCCGAGAGA------GAGCC ENST00000459978.1 AGTCAATGCCAAAATGATCCCTTTTTCA--TTG--GGAAGGAAGAGGGATGGTATGAGAA ** * ** * ** ****** *** * *** *** ** *** ENST00000305596.3 CCTGAGTCAGATCCCCATGGTTTAGGCACACCTAGCGGGAGGGGTGGCTCCTGGACCCCA ENST00000459978.1 CTGTAATATAGTTCCCATTGCT---ACTGACCTAATGCGTGA--TGGCTTATAAACCACA * * * * ***** * * * ***** * * * ***** * *** ** ENST00000305596.3 CCGTGGTTGGAGAGCTGAGCATGTGTGTGGCTTTAGTGG-GGTCTGTTAGTTATGGGGGT ENST00000459978.1 TT------------TTAAACACA---ATAGATAAAGCAACAGTCTGCTGAATCCCAGTTT * * ** * * * ** ***** * * * * ENST00000305596.3 CTGGGCACTGGAGCTGCAGGACACTTGGGATCCCAGGTCAGAAAGGGCCAGATGAGCAAC ENST00000459978.1 ATATGTA----AGC----AGATATATTAGA----AAGTCAGAAGACTCCATGTAA--AAC * * * *** ** * * ** * ******* *** * * *** ENST00000305596.3 TAGGAAAGACTTGGGGGCCAGGGCGGAGTGGGGTCACCTGACACTCTTGTGAGGCCCCTT ENST00000459978.1 CAACAA-----TGGAAATCTGATAGAAGGCAGTCCACCTC---CCTTTATGAAGC----- * ** *** * * * ** * ***** * ** *** ** ENST00000305596.3 CTAGTGCCTGCTCACACCGGAATTTCATTCACTCCAAGAAGCCATCAGGGGTAAGATACC ENST00000459978.1 -TAATGCT--CTTAAAC----ATCTC--CCAATCCTA----CCAT--------ACATACT ** *** ** * ** ** ** ** *** * **** * **** ENST00000305596.3 TTCCTTTAAACGTCACTAAGAAAGAAGAGGCCTGCCGGTGACACAGTAAGATGCCATTGA ENST00000459978.1 CACCTCCAAG-ATCGCAATATTTGCTAAATCCTTCCA--AGTTCCTTTTGTTTCCCT--G *** ** ** * * * * *** ** * * * * ** * ENST00000305596.3 TCTAAAGATGCGTCTTGATTTCAGAAAGGTCCGGAAGTGGAAAGCAGGTTTCAGGGCTGC ENST00000459978.1 TTTAAA-ACACATTTTCACT----AAAGG-CAGAAAAATTAACTAAGGCATCACAGCAG- * **** * * * ** * * ***** * * ** ** *** *** ** * ENST00000305596.3 TGAGGTACAGGGTTCTCCTGTAGGCCCCAGGGATGGTCTCAGGGGTGCTGAGTGCGTGCG ENST00000459978.1 -GA-----AGGGCCATTCTAAAAGCTCCATGGACTAT------GGCTTTGAGTAAGC-CT ** **** * ** * ** *** *** * ** ***** * * ENST00000305596.3 TGGTAAATGGATGGAGCCCAGGGGCGCCTCCTGCCAGTGTCCTCCAGGCACTCAAACCTA ENST00000459978.1 TTTCAGGTGGGGGTAGAGTAAAAACATTTCCAAAAACACTAATTTGG-----TAGCCCTG * * *** * ** * * *** * * * * * *** ENST00000305596.3 GCCCTTCTGAAGCCGACCTCACGTGACCTCACAGCCCCTCCTGAAGGC-GCCTCACTGAT ENST00000459978.1 TGCCTTTTCA---TCACCTCAGATAA----ACAGGTAAAGTAGATAGCTAGCATACCCAG **** * * ****** * * **** ** ** * ** * ENST00000305596.3 GACGGTGGGTGGAATAACAGCCCCC--------AGAGATGTCCAGGTTTGGAACCCCAGG ENST00000459978.1 GGAAGTAGCTGGC-TAGCACACCTCTTGATTTGAAAGGTATCCAATATACTGTTTTTATT * ** * *** ** ** ** * * ** * **** * * ENST00000305596.3 ACGTGGGAAAGTGT-TACCT--TGCGTGGCAAA-AGGGACCCGGCGCCTGTGCTTCAGTT ENST00000459978.1 AAAGAATAAATTGTGTGCCTACTAAATGGTAAATATGTGTTAAGCTTCC-TGAAACA-TT * *** *** * *** * *** *** * * ** * ** ** ** ENST00000305596.3 CAGGATT--TCGTGGTGGGGAGATGACCGTGGATGGTTGAGGTGGGCCCTGAGTAATCAT ENST00000459978.1 AAGCATTACTCATG-CATATCCATTACTTCTACCTGT--ATGCAAGTACTTATCAATCAT ** *** ** ** ** ** ** * * * ** * ****** ENST00000305596.3 GGGGGCCCTTATAAGGGAAGGGGAGTCA--CGAGGGTCTGCGCATGAAGCAAGGAAGCTT ENST00000459978.1 TA---CTGTCTTAAGGAAACAGTATACATTCAATACTTAGGGGGAAAATGAATGCAATTG * * ***** ** * * ** * * * * * ** ** * * * ENST00000305596.3 CTGGCTGTGAAGATGGCAAGAA-GGCCTGGGG---CCAG-GCGA--TGAGGTGGCCCCTG ENST00000459978.1 CCGTC-ATGAAAACTGAAAAAGTGATGTGAGGAGACTAATACAAACCAAAGTG-CCTCCA * * * **** * * ** * * ** ** * * * * * *** ** * ENST00000305596.3 GAGGAGCTGGAAAAGGCATTGGATTCTGCCCCAGAGCCTCCGTGGAGAAACAAAGCCGCA ENST00000459978.1 ATGGAACAATAAAATGCCCTAG----TACCACAGAGTCCTC------AACCATAATC-CA *** * **** ** * * * ** ***** * * ** ** * * ** ENST00000305596.3 CTGACAAGACTTCAGCCTGGT--GAAAACCA--TTTTGGA---CTCCTGACCTCTAGAAC ENST00000459978.1 ATGA-GGCATTTTGTTTTGTTTTGTAAATTAAACCTTGGGTAGCTACTACTTACTAAATT *** * ** ** * * *** * **** ** ** *** * ENST00000305596.3 TGT----AAGATAATAAATTGGTGTGGTTTTCAACCTCTCA ENST00000459978.1 CATCCTTAAAAGAATCTGTTGG-GTAGC------------- * ** * *** **** ** *