CLUSTAL 2.1 multiple sequence alignment ENST00000305786.2 GTAGCCGCCAGCTCGGCCGCACGTCAGGGCGCGGGAGCGCGGAGCGAGTTTGGTTGCACT ENST00000455540.1 ------------------------------------------------------------ ENST00000305786.2 TACACCGGTACTTAAGCGCGGACCGGCGTGTCCTTGGACTTAGAGAGTGGGGACGTCCGG ENST00000455540.1 ------------------------------------------------------------ ENST00000305786.2 CTTCGGAGCGGGAGTGTTCGTTGTGCCAGCGACTAAAAAGAGAATTAAATATGGGTGATG ENST00000455540.1 --------------------------------------------------ATGGGTGATG ********** ENST00000305786.2 TTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACCGTTGAAAAGG ENST00000455540.1 TTGAGAAAGGCA-GAAGACTTTTGTT-CAGAGTGTGCTCAGTGCCACA------------ ************ ***** **** ** ***** * ********** ENST00000305786.2 GAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAGACAGGTCAGG ENST00000455540.1 ----------------TGGACCCAATCTTCATGGCCTCTTTGG----AAAACAGATGAGT *** ** ***** ***** ******** ** **** * ** ENST00000305786.2 CCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGGGGAGAGGATA ENST00000455540.1 TCACTGGATTCTCTCTCACAGACATTAGTAAGAACAAAGGCATCATCTGGGGGGAGGAGA * ****** **** ***** * * ************************ ***** * ENST00000305786.2 CACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAAATGATCTTTG ENST00000455540.1 CACTGATGAACTATTCGGAGATTCTCAAGAAATATA--CCTTAAACAAAAATGATCTTCA ******** * **** ***** ** ****** ** * *** *************** ENST00000305786.2 TCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAAAAAGCTACTA ENST00000455540.1 CAGGCATTAAGAAGGAGACAGAAAGGACAGACCTGATAGCTTATCTCAAAAAGCC--CTA ************ ** ******* ***** * ***************** * *** ENST00000305786.2 ATGAGTAATAATTGGCCACTGCCTTATTTATTACAAAACAGAAATGTCTCATGACTTTTT ENST00000455540.1 ATAAGTAATAATTGGCTACTGCCTTATT----ACAAAGCAGAAATGTCTCATAACTTTTT ** ************* *********** ***** ************** ******* ENST00000305786.2 TATGTGTACCATCCTTTAATAGATCTCATACACCAGAATTCAGATCATGAATGACTGACA ENST00000455540.1 T-------CTTTCTTTTAAGAGAT----------AGGGTCT------------------- * * ** ***** **** ** * ENST00000305786.2 GAATATTTTGTTGGGCAGTCCTGATTTAAAACTAAGACTGGCTTGTGGTTAAATGAATAT ENST00000455540.1 ---TGTTCTGTTG-----TCT-------------AGGCTGG----------AGTG----- * ** ***** ** ** **** * ** ENST00000305786.2 GTTCAGTTTTTGAATTTTAATAGTAACTCCAATTCAGTAAATGGTATCACTGTTTACCCC ENST00000455540.1 -----------------CAGTGGCA----CAACC------ATGGC-TCACTGC--AGCC- * * * * *** **** ****** * ** ENST00000305786.2 TTTTAAAGATATGATTAGACTTCGTTAGTAATGTTCAACTTTTCACAAAGATGGTGAGTG ENST00000455540.1 --TCAAA----TTCCTGGGCTCA---AGCAA--------TCTTCACA------------- * *** * * * ** ** ** * ****** ENST00000305786.2 CCATCTTAAAACTTACTGGAGATTGGTTTTATATTTAGATTTATATAACTGGT-TATGTG ENST00000455540.1 ----CCTCAAGCCTCCTGAG-----------TAGCTGGGACTACA-----GGCGTATGCC * * ** * * *** ** * * ** * ** **** ENST00000305786.2 AATATATTTAAATACTGGGGAAATTGCTTCACTGTCTTAGAACCAAGCAAGATTCACCTG ENST00000455540.1 AACACACTTGG---CTG-----AT--CTTTAAT-TTTTA------------ATT------ ** * * ** *** ** *** * * * *** *** ENST00000305786.2 TGTTTTGTGTTCATGTTCATTTGCCTCTTAAAGGCAAGGGTTGAAGATAAATAAGGTAGC ENST00000455540.1 --TTTTGT---------------------AGAGACGAGAGTTT---------------GC ****** * ** * ** *** ** ENST00000305786.2 AATGTCTATAGTTTTGGCCTTAACTATGCCAATCTAATTATAATTCCCTGTATTTAAAAT ENST00000455540.1 AGTGT-------------------TGTGC-AGGCTGGTCTCGAACTCCAG-GCCTCAAGC * *** * *** * ** * * ** * * ** ENST00000305786.2 GGTTTCTTTTACTTATTGAAAGGCATTTTAGTGTGGTTTATGTGTAATATTAAAGATTAT ENST00000455540.1 AGTC-CTCTCACTT------TGGCCTCCCAAAGTGCT---------------GAGATTAT ** ** * **** *** * * *** * ******* ENST00000305786.2 TCAACACCTCTCACATCTTACAGATCTATAAGGTCACATGCTTTTAAAATAGTAGCAAGT ENST00000455540.1 ---------------------AGGT--ATGAG-CCACT-------------GTGACCAGC ** * ** ** *** ** * ** ENST00000305786.2 TAAACTTCACTCTTGAATTCTTTACAATCTAAGTCAAACTAAGTTATAATTTAGGATTGT ENST00000455540.1 ---------CTCATGACTT-TTTA-AATGTGTGTCA----------TAATTTA--ATTGA *** *** ** **** *** * **** ******* **** ENST00000305786.2 CTTTAAACAGCCATTCAGAAACAAAACTGTAGAACTGTGTATTTGATTGGGAATGGTGCT ENST00000455540.1 TCTCATACA-----CCAGAA-------TTCAGATC----------ATT---AATGAC--- * * *** ***** * *** * *** **** ENST00000305786.2 TTTGCCAACTTAAAAGGATTAAAGTAACGGAGATATACACAAATTTTAAAATTATGTGTG ENST00000455540.1 ------------------------TGACAGA-ATAT-------TTTTG------------ * ** ** **** **** ENST00000305786.2 ATCACAAGACTAAAGATAATTAAAAAGAAAACCACAGATCATGACTTTTTGACTGTGCTT ENST00000455540.1 -------------------TTAGACAG-----------TCCTGA---TTTAACTAAGTCT *** * ** ** *** *** *** * * ENST00000305786.2 GATTTCATGACTGATGCACAAATTTTAATGATTAAAAAGTGCAGGAGCCCTAAATGTCAG ENST00000455540.1 GGCTT-ATGGTTAA---ATGAAT----ACAATTA----------GTTTCTTGAATTTTGA * ** *** * * * *** * **** * * * *** * ENST00000305786.2 TGCAGCAGCCCTAAATGTCAGTGCAGCAGTGTTAACCAGTCATGGTGCTAGATTGTTTAC ENST00000455540.1 T--AGTAATTCCAAT--TCAGTA----AATGTTCTC---------------ACTGTTTCC * ** * * ** ***** * **** * * ***** * ENST00000305786.2 TTGGTTTTCTAGGACTGCCTCAACTAGAATAACACTTCACTAATTGACTCTTAGTTTCTT ENST00000455540.1 T----CTTCTA--------------AAGATAAGTTTGGACT---TGATTAGTAA------ * ***** * **** * *** *** * ** ENST00000305786.2 TGCTCAGATTGAGAACTGCAGCATTTATGCCAGACATGGACAGAGGAATGCCTGTGGTCA ENST00000455540.1 TGTTCAACTT-------------TTCA---CAAAGATGGA-----GAATGCC----ATCA ** *** ** ** * ** * ***** ******* *** ENST00000305786.2 TAGTTTTGTGATGTGTAACAGTGTATAATTACATACTGAATTATTTCATGCATAGTCTGT ENST00000455540.1 CAA----------------AGCCTAT---TGGAAATTGA----TTTTATG---------- * ** *** * * * *** *** *** ENST00000305786.2 GCCATACACATTTAGAGTAGTCCTTGGAGATTTTATGGAGATGGTGAGCACAAGGTAAGT ENST00000455540.1 ----------TTTTGA---------------TTTAT----AT---------------AGT *** ** ***** ** *** ENST00000305786.2 CATAAAGAATAATGAGAAAATAAATCTATGCTGGTGCAGCTGAGAACTGTATCTTTGTGG ENST00000455540.1 TATATA------------AATGAATATATG---------------AATATATTT------ *** * *** *** **** * * *** * ENST00000305786.2 GACAGTGAGAAGACTGAGAAGATGTGAATCCATGGTCTCAAAGGTGATAGGGACGATTAG ENST00000455540.1 --------AAATACTGGGGAAATCCC--TTCACTATCTCAGAACCA--AGCAAGAATTAC ** **** * * ** * ** ***** * ** * **** ENST00000305786.2 ATAGGTGTTTTAAGGCCTGAAAGCAATTTATAACATATGAGTCTTATTTTTATTTATAGA ENST00000455540.1 CT--GTGTTTTAA-----------------------------CTTGTGATCATT------ * ********* *** * * *** ENST00000305786.2 AATGTGGAAAGCTTGCTGTAATTCATATTTGAAGTCCTAGTCTGAGTTCTGGTGGGGAAT ENST00000455540.1 ---------AGCCTG-------------TTAAGGGCAAGGGCTGAA----GATAAGG--- *** ** ** * * * * **** * * ** ENST00000305786.2 TTAAAAATGCATCCTGGAAATCCTTTAAAGATTTCAGACTTTGAAAGGCCTTGTAGCAGA ENST00000455540.1 -TAGCAATG---TCTG------CTTTATA--TTTTTGGTCTTAA------TTATGTCA-- ** **** *** ***** * *** * ** * ** * ** ENST00000305786.2 GGACTTGGTGACTGTATAAAGTTAGTGGTATTCAGGGACAGTGTAGCAAGTAGCTTACAA ENST00000455540.1 --ATCTAAT-------TAGAATTCCTGGTATCCAA------------------------- * * * ** * ** ****** ** ENST00000305786.2 GGGGACAATTCTGGACTAATGAGAAAGACCTGAAGTGAAGGCTAGAGAGTTGATTTTTTT ENST00000455540.1 ------AATGCT----------------------------------------ATTTTTAT *** ** ****** * ENST00000305786.2 TTTTTTTGGCATCCTGGAAATGATACAGGAAACATATTAAGATAGATACAGAAATGTGTT ENST00000455540.1 TTTCTTT-----CTT-----------------------------------------TGTT *** *** * * **** ENST00000305786.2 CAACCTTCCATCTTGGCTAGTTGTGGCGTTTAGTTTGTTTTTTGAGACATGGTCACGCTG ENST00000455540.1 C----TTC--TTTT------TTAT-------------TTTTTTGAGACAGGGTCTCGCTT * *** * ** ** * ************ **** **** ENST00000305786.2 TGTCGCCAAGGCTGGAGTGCAGTGGTGCGATCT-CGGCTGGCTGCAACCTCTATTTCCCA ENST00000455540.1 TGTCGCCCAGACTGGAGTGCAGTGGTATGATAAACAGCTCACTGCAGGCTCAACCTCCCA ******* ** *************** *** * *** ***** *** * ***** ENST00000305786.2 GGCTCAAGCGATTCTCTCACTTCAGCTTCCCAAGTAGCTGGGACTACAGGTGTTCGCCAC ENST00000455540.1 GGCTCAAGCCATCCTCCCACCTCAGCC-CCCGAGTTGCTGAGACTAGAGGCAGGCACCAT ********* ** *** *** ***** *** *** **** ***** *** * *** ENST00000305786.2 CATGCCCAGCTAATTTTTT----------TGTAGAGATGGAGTTTTGCCATGTGGTCCCA ENST00000455540.1 CATGCCAGGTTGGTTTTTAAAAAATTTTATGTAGAGACTGGGCCTCACTTTGTTG-CCCA ****** * * ***** ******** * * * * *** * **** ENST00000305786.2 GGCTGGTCTCAAACTCCTGAGCTCAAGCAATCCGTCCACTTGCCTTGGCTCCCCAAAGTG ENST00000455540.1 GGCTGGTATGAAACTCCTAGGCTCAAGCAATCC---TA-TTACCTTGGCCTCCCAAAGGG ******* * ******** ************* * ** ******* ******* * ENST00000305786.2 CTGGGATTACAGGCGTGAGCCACCAGGCCCTGCCTGGTTTTCAAATTCAGAAATCTTATT ENST00000455540.1 CTGAAATTACAGGAGTGAGCCACTGTGCCCTACCTA--------------AAATTCTACT *** ******** ********* ***** *** **** ** * ENST00000305786.2 ATTTAACC-CAGAAGTAATCAGCCCAGTAGTAACTTAGGTTTAATTTTTTTTCAGGTTTA ENST00000455540.1 TTTCAATTGCTGAA--AGGCATTTTAGT-GTAATTTATGTGTAAC-----ACCAAATAAA ** ** * *** * ** *** **** *** ** *** ** * * ENST00000305786.2 AAATTTTTCTCATTTATTTTTTCTGAGACGGAGTTTCGCCCTTTTCGCCCAGGCTGAGTA ENST00000455540.1 GAATATTTATCACTTAT----------AAGAAATT--------------CAGGCCGGGCA *** *** *** **** * * * ** ***** * * * ENST00000305786.2 CAGTGGTGCAATCTCAC-TGCAACCTCCGCCTTCCAGTTGCAAGTGATTCTCCTGCCTCA ENST00000455540.1 TGGTGGC----TCGCACCTGTAATCCCAGGCCT----TTGGGAG----------GCC--A **** ** *** ** ** * * * * * *** ** *** * ENST00000305786.2 GCCTCCTGAGTAGCTGGGATTACAGGCACCC--GCCACCACGCCTGGCTAATTTTTGTAT ENST00000455540.1 ATCACAAGGTCAG--GAGATCGAGACCACCCTGGCCAACA----TGGTGAAACAC--CAT * * * ** * *** ***** **** ** *** ** ** ENST00000305786.2 TTTTAGTGGAGATGGTGTTTCACCATGTTGGCCAGAC-TGGTCTTGGACTCCTGACCTCG ENST00000455540.1 CTTTACTA-AAATACAAAAAAAAAAAATTAGCCGAGTGTGGTGGTGCAC-----ACCTC- **** * * ** * * ** *** **** ** ** ***** ENST00000305786.2 TGATCC-ACCCACCTTGGCCTCCCAAAGTTCTAGGATTACAGGTGTGAGCCACCACGTCC ENST00000455540.1 TGATCCCAGCTACTCAGGAGGCT-GAGGCAGGGGAATT----GCTTGAACCAAGGAGGCA ****** * * ** ** * * * * *** * *** *** * * ENST00000305786.2 GGCCAATTTTTCTCATTT----CTATGCCTCCTATATTAAGGTCTGTGTTGGCACAGA-T ENST00000455540.1 GA--GGTTATAGTGAGCCGAGATCATGCCAC-TGCACTCCAGCCTG----GCAACAGAGC * ** * * * ***** * * * * * *** * ***** ENST00000305786.2 GAGTAACTGCCATGTTCTAGGTCAGTTATACCCAAGCACTTCTGGTGGTTTAAAATGTGA ENST00000455540.1 AAGACACTGTC----------TCAAAAAAAAAAAAGAAGTTCAGGTGG----AATTTTGA ** **** * *** * * *** * *** ***** ** * *** ENST00000305786.2 TTCTGTAACTTTTTTATTT-TTATTTTTTTGAGATAATTTCACTCTTGTTGCCCAGGCTG ENST00000455540.1 TT--GAAAATGTGTTATACATTGTTATTTTTAGAAGA-------------GCCTA---CA ** * ** * * **** ** ** **** *** * *** * ENST00000305786.2 GAGTGCAATGGCGTGATCGCTGCTCACCGCAACCTCCGCCTTCCAGGTTCAAGCGATTCT ENST00000455540.1 GATTTCTA-----------CTGTTGA--GCTATTTT------------------ATTTCT ** * * * *** * * ** * * **** ENST00000305786.2 CCTGACTCAGCCTCTCAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCCAGCTTATT ENST00000455540.1 CCTTTCTTTTCTTTTTAAATTATTATG-TTA-AAACAGA--------------------- *** ** * * * ** * * * *** ** ** ENST00000305786.2 TTGTGTTTTTAGTAGAGACAGGGTTTCTCCATGCTGGACAGGCTGGTCTTGAACTCCCGA ENST00000455540.1 ----------AATGGGG---GGGTCTTGCTATGTTGACCAGGCTGCTCTCGAACTCCCGG * * * * **** * * *** ** ******* *** ********* ENST00000305786.2 CGTCAGGTGATCTACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACC ENST00000455540.1 CCTCAAGCAATCCTCCCATCTCAGCCTCCCAAAGTGCTGGAATTACAGGTGTGAGCCACT * *** * *** ** *** ***************** ******** ********* ENST00000305786.2 ACGCCTGGCCAATTATGTAATTTTTTAAAAAGGACATTTCTATCAGGGATATATACCTTC ENST00000455540.1 GTGCCCAGCCTGTTAAACTATTTT------------------------ATACATA----- *** *** *** ***** *** *** ENST00000305786.2 AGAAATAAGGAAATAGGGGAAAAAAAGAGCACTATAAACCACATGTTTTCATTTCTAGTG ENST00000455540.1 -------------TAG----------------TATAG-CCATCT-TTTTCA--------- *** **** *** * ****** ENST00000305786.2 CTTCGCTGTAAGTGGCTAGGTTGGTAGAATCAAAAACAAGGGCCAGATGTATTTAAGGGG ENST00000455540.1 ------------------------------------------------------------ ENST00000305786.2 TATTCAGATGCCACCTACATGCTTATTTTGTCTAGAACAGTGCTGTCTAATAGAACTTTC ENST00000455540.1 --------------------ACTTCTTTTGTCT-------------TTAAGAGATTTTTT *** ******** *** *** *** ENST00000305786.2 TGTGACGATGGATATTTTGTAGACTTTTGCTGTCCAGTGTGGTAGCCACTAACCACATGT ENST00000455540.1 TTTTA--------ATTTT------------------------------------------ * * * ***** ENST00000305786.2 GGCTGTTAAGCCCTTGAAATATAGCTAGTGTGACTAGAAAGTATTTTATTTTAAATTTAC ENST00000455540.1 -----------------AAT-----------------------TTTTATTTTTGA----- *** ********* * ENST00000305786.2 ATAGGCACAAGTGGCTAGTGGCTACTGTATTGACATTCTGGGTCTAGGACTAGAACCAGT ENST00000455540.1 -------------------------------GACA----GGGTCT--------------- **** ****** ENST00000305786.2 GGTCTGTAACAAAAGTACTTTCTCTTTACTCTATTAAATCTAGAATTAGCCGG-GCATGG ENST00000455540.1 --------------------------CACTCTGCCA--TCCAG-----GCTGGAGTGCAG ***** * ** ** ** ** * * ENST00000305786.2 TCGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTC ENST00000455540.1 TGGC----GCC----ATCTTGGC-------------------------TCACT------- * ** *** *** ** ***** ENST00000305786.2 AGGCGTTTGAGACCAGCCTGGTCAACATGGCGAAACCCTGTCTCTACAAAAAACATAAAA ENST00000455540.1 -------------CAACCT------------------CTACCTC---------------- ** *** ** *** ENST00000305786.2 ATTAGCCAGGTGTGGTGGTGGGCACCTGTAATCTCAGCTACTTGGGAGGCTGAGGCACAA ENST00000455540.1 -----CCGGGT----------------------TCA------------------------ ** *** *** ENST00000305786.2 GAATCACTTGAACTTGGGAGGTGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCA ENST00000455540.1 -------------------------------AGTGATTC----TCCTGCCTCT------- ***** * * **** ** ENST00000305786.2 AGCCTGGGTGACGAGTGAAACTGTCTCCAAAAAAAAAAAAAAA ENST00000455540.1 --CCCATGTAAC------------------------------- ** ** **