CLUSTAL 2.1 multiple sequence alignment ENST00000305786.2 GTAGCCGCCAGCTCGGCCGCACGTCAGGGCGCGGGAGCGCGGAGCGAGTTTGGTTGCACT ENST00000519781.1 ------------------------------------------------------------ ENST00000305786.2 TACACCGGTACTTAAGCGCGGACCGGCGTGTCCTTGGACTTAGAGAGTGGGGACGTCCGG ENST00000519781.1 ------------------------------------------------------------ ENST00000305786.2 CTTCGGAGCGGGAGTGTTCGTTGTGCCAGCGACTAAAAAGAGAATTAAATATGGGTGATG ENST00000519781.1 --------------------------------------------------ATGGGTGATG ********** ENST00000305786.2 TTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACCGTTGAAAAGG ENST00000519781.1 TTGAAAAAGGCAAGAGAATTTTTGTTCAGAAGTGTGCCCAGTTCCACACTGTTGAAAAGG **** ********** ****** ** ******* ****** ****** ********** ENST00000305786.2 GAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAGACAGGTCAGG ENST00000519781.1 GAGGCAAACAGGTGGCTGGGTCAAATCTCCATGGTCTCTTTGTGGGGAAGACAGATCAGG ******* ** * ***** ********************* * ********* ***** ENST00000305786.2 CCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAGGCATCATCTGGGGAGAGGATA ENST00000519781.1 CCATTGGATTCTCTTATACAGAGGCCCATAAGAACAAAAGCATCTCCTGGGGAGAGGATA ** ***** ****** **** *** *********** ***** ************** ENST00000305786.2 CACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAAATGATCTTTG ENST00000519781.1 CACTCATGGAGTATTTGGAGAATCCCAAGAAGCACATCCCCGGAACAAAAATGATCTTCG **** *************************** ******* ***************** * ENST00000305786.2 TCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAAAAA-GCTACT ENST00000519781.1 CAGGCATGAAGAACAAGGCAGAAAGGGCAGCCTTGATAGCTCATCTCAAAAAAAGCTACC ***** ***** **** *********** *** ****** *********** ***** ENST00000305786.2 AATGAGTAATAATTGGCCACTGCCTTATTTATTACAAAACAGAAATGTCTCATGACTTTT ENST00000519781.1 AATGAATAATAACAGGTCACTGTGTTATTTGTTACAAAACAGAAATGTTTCATGACTTCT ***** ****** ** ***** ****** ***************** ********* * ENST00000305786.2 TTATGTGTACCATCCTTTAATAGATCTCATACACCAGAATTCAGATCATGAATGACTGAC ENST00000519781.1 TAATCTGTACC-----TTAACAGATCTCATACACAAGAATTCAGATAATGAATGACTGAC * ** ****** **** ************* *********** ************* ENST00000305786.2 AGAATATTTT-GTTGGGCAGTCCTGATTTAAAACTAAGACTGGCTTGTGGTTAAATGAAT ENST00000519781.1 AGAGTATTTTTGTTGGGCAGTCTTGATTTA--ACCATGACTGGCTTGTGGTTAAATG--- *** ****** *********** ******* ** * ******************** ENST00000305786.2 ATGTTCAGTTTTTGAATTTTAATAGTAACTCCAATTCAGTAAATGGTATCACTGTTTACC ENST00000519781.1 --GTTAAAT----GAATAT--------------GTTCGGT------TAT-----TTTA-- *** * * **** * *** ** *** **** ENST00000305786.2 CCTTTTAAAGATATGATTAGACTTCGTTAGTAATGTTCAACTTTTCACAAAGATGGTGAG ENST00000519781.1 --TTTTA---------TTATATTTT----------------TTTT----GAGATGG--AG ***** *** * ** **** ****** ** ENST00000305786.2 TGCCA-TCTTAAAACTTA--CTGGAGATTGGTTTTATATTTAGATTTATATAACTGGTTA ENST00000519781.1 TTTCACTCTTGTCGCCCAGGCTGGAG----------------------TGCAA-TGG--- * ** **** * * ****** * ** *** ENST00000305786.2 TGTGAATATATTTAAATACTGGGGAAATTGCTTCACTGTCTTAGAACCAAGCAAGATTCA ENST00000519781.1 TGCGA-----TCTCAGC---------------TCACTG-------------CAA----CA ** ** * * * ****** *** ** ENST00000305786.2 CCTGTGTTTTGTGTTCATGT---TCATTTGCCTCTTAAAGGCAAGGGTTGAAGATAAATA ENST00000519781.1 TCTGTCTCCCCTGTTCAAGTGATTCTCCTGCCTC---------AGCATTCCAAGTAGCTG **** * ****** ** ** ****** ** ** * ** * ENST00000305786.2 AGGTAGCAATGTCTATAGTTTTGGCCTTAACTATGCCAATCTAATTATAATTCCCTGTAT ENST00000519781.1 GGATTACA--------GGTGCCCGCC---ACCACGTGCAGCTGATTTTTGTATT-TGTAG * * ** ** *** ** * * * ** *** * * **** ENST00000305786.2 TTAAAATGGTTTCTTTTACTTATTGAAAGGCATTTTAGTGTGGTTTATGTGTAATATTAA ENST00000519781.1 TAGAGATGGGGGTTTCACCATGTTGCCAGGC---------TGGTCT-------------- * * **** ** * * *** **** **** * ENST00000305786.2 AGATTATTCAACACCTCTCACATCTTACAGATCTATAAGGTCACATGCTTTTAAAATAGT ENST00000519781.1 --------CGA-ACTCCTGACCTC-------------AGGTGAT---------------C * * ** ** ** ** **** * ENST00000305786.2 AGCAAGTTAAACTTCACTCTTGAATTCTTTACAATCTAAGTCAAACTAAGTTATAATTTA ENST00000519781.1 AGC----------CCGC-CTCGGACTCC-------------CAAAGTG---------CTG *** * * ** * * ** **** * * ENST00000305786.2 GGATTGTCTTTAAACAGCCATTCAGAAACAAAACTGTAGAACTGTGTATTTGATTGGGAA ENST00000519781.1 GGATTAT------------------------AAGCGTAAGCCATCACGCCCGGT--GAAA ***** * ** *** * * * * ** ENST00000305786.2 TGGTGCTTTTGCCAACTTAAAAGGATTAAAGTAACGGAGATATACACAAATTTTAAAATT ENST00000519781.1 T-----TTTTTC---------------------------------------TTGGAAATT * **** * ** ***** ENST00000305786.2 ATGTGTGATCACAAGACTAAAGATAATTAAAAAGAAAACCACAGATCATGACTTTTTGAC ENST00000519781.1 AT---TGCTCCCA----------TTATTGAGAA------------TCA------------ ** ** ** ** * *** * ** *** ENST00000305786.2 TGTGCTTGATTTCATGACTGATGCACAAATTTTAATGATTAAAAAGTGCAGGAGCCCTAA ENST00000519781.1 ----CTAGGCGTAATGGC---------AACTCTGGTAAT--------------------A ** * * *** * ** * * * ** * ENST00000305786.2 ATGTCAGTGCAGCAGCCCTAAATGTCAGTGCAGCAGTGTTAACCAGTCATGGTGCTAGAT ENST00000519781.1 ATGTT-----------TCTAAA---------AGC----TTAAT--------GTGTT--AC **** ***** *** **** *** * * ENST00000305786.2 TGTTTACTTGGTTTTCTAGGACTGCCTCAACTAGAATAACACTTCACTAATTGACTCTTA ENST00000519781.1 TGTTTA--AGGTTT-----GTTCGCC---------------CTCCATTAATC-------A ****** ***** * *** ** ** **** * ENST00000305786.2 GTTTCTTTGCTCAGATTGAGAACTGCAGCATTTATGCCAGACATGGACAGAGGAATGCCT ENST00000519781.1 TCTTCTCCG------TGGATGGCTTCCG----TGCATCATACATGAAGAAAGGCAG---- **** * * ** ** * * * ** ***** * * *** * ENST00000305786.2 GTGGTCATAGTTTTGTGATGTGTAACAGTGTATAATTACATACTGAATTATTTCATGCAT ENST00000519781.1 -----CAAAGTC-----ATGCCTAATATTGAAAAACTA---AGTAAGTAATTTC---CAT ** *** *** *** * ** * ** ** * * * * ***** *** ENST00000305786.2 AGTCTGTGCCATACACATTTAGAGTAGTCCTTGGAGATTTTATGGAGATGGTGAGCACAA ENST00000519781.1 ACTCTGTG---TTCTTATCT---GTAATCT---AGGATCTC--------------CACA- * ****** * * ** * *** ** *** * **** ENST00000305786.2 GGTAAGTCATAAAGAATAATGAGAAAATAAATCTATGCTGGTGCAGCTGAGAACTGTATC ENST00000519781.1 --------------------------------CTA-ACCAGTG-GGCTGTGGGCT----- *** * *** **** * ** ENST00000305786.2 TTTGTGGGACAGTGAGAAGACTGAGAAGATGTGAATCCATGGTCTCAAAGGTGATAGGGA ENST00000519781.1 --------------------TTGAGA---------TCTATGGGCACGTAGTT-------- ***** ** **** * * ** * ENST00000305786.2 CGATTAGATAGGTGTTTTAAGGCCTGAAAGCAATTTATAACATATGAGTCTTATTTTTAT ENST00000519781.1 ---TTAAAT--GTGTTTTATTATTTGAAA------------------------------- *** ** ******** ***** ENST00000305786.2 TTATAGAAATGTGGAAAGCTTGCTGTAATTCATATTTGAAGTCCTAGTCTGAGTTCTGGT ENST00000519781.1 -TACAGAAGTG----AAG------GTAACACAT-------------GTCTGAGT------ ** **** ** *** **** *** ******** ENST00000305786.2 GGGGAATTTA-AAAATGCATCCTGGAAATCCTTTAAAGATTTCAGACTTTGAAAGGCCTT ENST00000519781.1 -----GTTTATAAAATGGAT-------------------TTTC----------------- **** ****** ** **** ENST00000305786.2 GTAGCAGAGGACTTGGTGACTGTATAAAGTTAGTGGTATTCAGGGACAGTGTAGCAAGTA ENST00000519781.1 ----------------------TATAAG-------------------------------- ***** ENST00000305786.2 GCTTACAAGGGGACAATTCTGGACTAATGAGAAAGACCTGAAGTGAAGGCTAGAGAGTTG ENST00000519781.1 -------------CAATTC------------------CTG-----------------TTG ****** *** *** ENST00000305786.2 ATTTTTTTTTTTTTTGGCATCCTGGAAATGATACAGGAAACATATTAAGATAGATACAGA ENST00000519781.1 GTTCTCTTGTTCT----------------------------------------------- ** * ** ** * ENST00000305786.2 AATGTGTTCAACCTTCCATCTTGGCTAGTTGTGGCGTTTAGTTTGTTTTTTGAGACATGG ENST00000519781.1 AATATTTGCAATTCTCTTTCCAGG--------------------GTCTTGTGGCACACAC *** * * *** ** ** ** ** ** ** *** ENST00000305786.2 TCACGCTGTGTCGCCAAGGCTGGAGTGCAGTGGTGCGATCTCGGCTGGCTGCAACCTCTA ENST00000519781.1 TCTCCCTACAT----GAGGCCGGTGTAC----------------CCAACTAAAACCT--- ** * ** * **** ** ** * * ** ***** ENST00000305786.2 TTTCCCAGGCTCAAGCGATTCTCTCACTTCAGCTTCCCAAGTAGCTGGGACTACAGGTGT ENST00000519781.1 -TTCCTA----------ACTTATACACTTTGGCC---------------ACTGTAAGT-- **** * * * ***** ** *** * ** ENST00000305786.2 TCGCCACCATGCCCAGCTAATTTTTTTGTAGAGATGGAGTTTTGCCATGTGGTCCCAGGC ENST00000519781.1 -------------------ATTTTTTCG-AATGATACACATTCA--AAG--------GGC ******* * * *** * ** * * *** ENST00000305786.2 TGGTCTCAAACTCCTGAGCTCAAGCAATCCGTCCACTTGCCTTGGCTCCCCAAAGTGCTG ENST00000519781.1 TGATTTCA---TCCTGG--------AAT---------------GACT------------- ** * *** ***** *** * ** ENST00000305786.2 GGATTACAGGCGTGAGCCACCAGGCCCTGCCTGGTTTTCAAATTCAGAAATCTTATTATT ENST00000519781.1 ---TTAAAGG-----------------------------------AGAGACTTTACT-TT *** *** *** * *** * ** ENST00000305786.2 TAACCCAGAAGTAATCAGCCCAGTAGTAACTTAGGTTTAATTTTTTTTCAGGTTTAAAAT ENST00000519781.1 TAA----AACGTGTTC--CTTAGT----------GTTCAA---------AG----AAAAT *** * ** ** * *** *** ** ** ***** ENST00000305786.2 TTTTCTCATTTATTTTTTCTGAGACGGAGTTTCGCCCTTTTCGCCCAGGCTGAGTACAGT ENST00000519781.1 CTTTCT----------------------GTTT-------TCCATCTTAACTGGGT-CATT ***** **** * * * *** ** ** * ENST00000305786.2 GGTGCAATCTCACTGCAACCTCCGCCTTCCAGTTGCAAGTGATTCTCCTGCCTCAGCCTC ENST00000519781.1 TGT------TCACAGCAAAT---GCCTTTTA----------------------CAACTTT ** **** **** ***** * ** * * ENST00000305786.2 CTGAGTAGCTGGGATTACAGGCACCCGCCACCACGCCTGGCTAATTTTTGTATTTTTAGT ENST00000519781.1 GTGGGT-GATGGAACTTCAT---TCCAACTTTAAAGCTGAA-AACTTTT----TTCAGGT ** ** * *** * * ** ** * * *** ** **** ** ** ENST00000305786.2 GGAGATGGTGTTTCACCATGTTGGCCAGACTGGTCTTGGACTCCTGACCTCGTGATCCAC ENST00000519781.1 GCAGTTC-TGTTTGAACACATACATTAAACTTCTCTCAAATACCAGAG-----GGTCTAT * ** * ***** * ** * * *** *** * ** ** * ** * ENST00000305786.2 CCACCTTGGCCTCCCAAAGTTCTAGGATTACAGGTGTGAGCCACCACGTCCGGCCAATTT ENST00000519781.1 ---TGTTTATTTTCTGAATTTGCAAA--TAAAAATGT----------------------- ** * * ** ** * ** * *** ENST00000305786.2 TTCTCATTTCTATGCCTCCTATATTAAGGTCTGTGTTGGCACAGATGAGTAACTGCCATG ENST00000519781.1 ------------TGACTTC-------AGGGCTATATTT-----------TAATTTTCAGG ** ** * *** ** * ** *** * ** * ENST00000305786.2 TTCTAGGTCAGTTATACCCAAGCACTTCTGGTGGTTTAAAATGTGATTCTGTAACTTTTT ENST00000519781.1 TACT-------TCAAATTCTACCACTCTTCCTTCTTTAAAACATAATT------------ * ** * * * * * **** * * ******* * *** ENST00000305786.2 TATTTTTATTTTTTTGAGATAATTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTG ENST00000519781.1 TATTTATATATTTTTA-------TTGATTC--------------GGGGAGCAATAG---- ***** *** ***** ** * ** ** * ***** * ENST00000305786.2 ATCGCTGCTCACCGCAACCTCCGCCTTCCAGGTTCAAGCGATTCTCCTGACTCAGCCTCT ENST00000519781.1 ---------------------------------------AATT----------------- *** ENST00000305786.2 CAAGTAGCTGGGATTACAAGCATGCGCCACCATGCCCAGCTTATTTTGTGTTTTTAGTAG ENST00000519781.1 ----TAGAAAGAAAGAAAAG--------------------------TGTATTT-----AG *** * * * *** *** *** ** ENST00000305786.2 AGACAGG-GTTTCTCCATGCTGGACAGGCTGGTCTTGAACTCCCGACGTCAGGTGATCTA ENST00000519781.1 AAATAGAAGCTTCTT-----TGGA--GGC------------------------------A * * ** * **** **** *** * ENST00000305786.2 CCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCTGGCCAATT ENST00000519781.1 CATGTAT--ACATTCCAAA---------CTAAAGGT------------------------ * ** * * * ***** ** *** ENST00000305786.2 ATGTAATTTTTTAAAAAGGACATTTCTATCAGGGATATATACCTTCAGAAATAAGGAAAT ENST00000519781.1 ---TAATTTATTGTAATGAAAATTATTGTCA----------TCTTCTTAAATTA-----C ****** ** ** * * *** * *** **** **** * ENST00000305786.2 AGGGGAAAAAAAGAGCACTAT-AAACCACATGTTTTCATTTCTAGTGCTTCGCTGTAAGT ENST00000519781.1 AGCAGAAAAAAACCCCAATGTTAAATTTCTTATAATCATATTAAGTTTCTC-----AGAT ** ******** ** * * *** * * * **** * *** ** * * ENST00000305786.2 GGCTAGGTTGGTAGAATCAAAAACAAGGGCCAGATGTATTTAAGGGGTATTCAGATGCCA ENST00000519781.1 GGCT-------TATAATT------------------TGTCCCATAGATATTA-------- **** ** *** * * * * **** ENST00000305786.2 CCTACATGCTTATTTTGTCTAGAACAGTGCTGTCTAATAGAACTTTCTGTGACGATGGAT ENST00000519781.1 --TTCATGTTTGCTC------AAACAG--ATACACAGTGAAGGTT---------ATACAT * **** ** * ***** * * * * ** ** ** ENST00000305786.2 ATTTTGTAGACTTTTGCTGTCCAGTGTGGTAGCCACTAACCACATGTGGCTGTTAAGCCC ENST00000519781.1 GTCTTATATAATTTTG-----------GA--------AATTAAGTATTGCTATAAAACCT * ** ** * ***** * ** * * * *** * ** ** ENST00000305786.2 TTGAAATATAGCTAGTGTGACTAGAAAGTATTTTATTTTAAATTTACATAGGCACAAGTG ENST00000519781.1 TC----TAT-GCTA--------AGAAAAT---TCATACTAGAACTA-----ATGTATGTG * *** **** ***** * * ** ** * ** * *** ENST00000305786.2 GCTAGTGGCTACTGTATTGACATTCTGGGTCTAGGACTAGAACCAGTGGTCTGTAACAAA ENST00000519781.1 GAT------TATTGTATTGTTATTTTA--------ACAATAA--ATTTGCTTTTACAAAA * * ** ******* *** * ** * ** * * * * ** *** ENST00000305786.2 AGTACTTTCTCTTTACTCTATTAAATCTAGAATTAGCCGGGCATGGTCGCTCATGCCTGT ENST00000519781.1 AGGG---------------GCTATATCCAGAATCA------CATGG-------------- ** ** *** ***** * ***** ENST00000305786.2 AATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGCGTTTGAGACC ENST00000519781.1 AATTG-------TTGGCAATTCAATGTA-----------TGA--TCCTGTATTTGATGCC *** **** * *** * * *** ** * ***** ** ENST00000305786.2 AGCCTGGTCAACATGGCGAAACCCTGTCTCTACAAAAAACATAAAAATT-AGCCAGGTGT ENST00000519781.1 A--CTTTTCA------------------TCTGCGAGGGCGAGAGAAATTTAATCATAGAT * ** *** *** * * * * ***** * ** * ENST00000305786.2 GGTGGTGGGC---ACCTGTAATCTCAGC--TACTTGGGAGGCTGAGGCACAAGAATCACT ENST00000519781.1 GGTGGGGAGGTCAACCGGTAAGTTTTGCATTTATTGTGTGTCTA---------------- ***** * * *** **** * ** * *** * * ** ENST00000305786.2 TGAACTTGGGAGGTGGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCAAGCCTGGG ENST00000519781.1 TGTGTTTGTGTGTTCA----TGTATTGAGACA------TTTCATC---CCCAAATTT--G ** *** * * * ** * **** ** * ** * *** * * ENST00000305786.2 TGACGAGTGAAACTGTCTCCAAAAAAAAAAAAAAA---- ENST00000519781.1 TTAGATGTGGAA--------AAAATGCGTATAATTTCCT * * *** ** **** * **