CLUSTAL 2.1 multiple sequence alignment ENST00000306024.3 GCGCAGCAACCTCCACCAGGCCTCCGCGTCTGGACTCCCGCCCTGCCTCTGGGCCTCCTC ENST00000453255.1 --ATGGCGGACGACGC-AGACC---------AGAAACGCACT------------------ ** * * * ** ** ** * * * ENST00000306024.3 CGCCCACCGGCGGCGTCTCCCGCGAAGCCCGCTGGGCCTCGCTCTCACCCTCCTCCTCCT ENST00000453255.1 -----ACCGACACTGT----AGAGGAGCCC-CTGGATCTTA------------------- **** * ** * * ***** **** ** ENST00000306024.3 CCTCACGCCGGGCCTTGCTCTTGGCCTTGGATTTCTGGCTGCGCAGTTCGCGTCCCCGCG ENST00000453255.1 --TCAGGCTAGGCCTAG---ATGAGCT--AATTACT----------TT------------ *** ** ***** * ** ** *** ** ** ENST00000306024.3 GCTCCCCGCCGGCCGCGCGTTTCCGAGCCATGTTGCTTGTCTGGGC--AAATTCCACTTC ENST00000453255.1 ------------------ATTTT--ATTTAT-TTATTTTTTTGAGACGGAGTCTCGCTCT *** * ** ** ** * ** * * * * ** ENST00000306024.3 GCGAGTGACGCACCCGGCCGCGATGCGCTAGAACGCCGGCCCCGCCCCGAGGCGGTGCGC ENST00000453255.1 GT--------CGCCCGG---------GCTGGAGTGCAG----TGTC-----GCAAT---C * * ***** *** ** ** * * * ** * * ENST00000306024.3 TTGGCCACGCCCCTTCGTTGGAGGCCTAGTCACGCCCCTAAAGGAAGCTCCACCCCATAC ENST00000453255.1 TCGGC---------TCACTGCA-----------------------AGCTCCGCCTC---- * *** ** ** * ****** ** * ENST00000306024.3 CCGTGGCCACTAAAAAACTGCGGGAAGCAGGAAAGAGCACAACAGGTTTCTCTCTATTTC ENST00000453255.1 CCGGGTTCAC----------------GC--------------CA---TTCTCCTC----- *** * *** ** ** ***** ENST00000306024.3 CGGTGTATTGTATCCTCACGTTTCCGGAGATTGACGTTGCTCTTGTGTTCTCGCGAGAGG ENST00000453255.1 -------------CCTCA-GCCTCCTGAG-------TAGCT------------------- ***** * *** *** * *** ENST00000306024.3 CGGGAAAGGGCGCAGGGTTTGAAACATGGCGGACGACGTAGACCAGCAACAAACTACCAA ENST00000453255.1 -GGGA------------------------------------------------CTAC--- **** **** ENST00000306024.3 CACTGTAGAGGAGCCCCTGGATCTTATCAGGCTCAGCCTAGATGAGCGAATTTATGTGAA ENST00000453255.1 --------AGGCGCCCGC------CACCACGCCCGGCT----------AATTT------- *** **** * ** ** * ** ***** ENST00000306024.3 AATGAGAAATGACCGAGAGCTTCGAGGCAGATTACATGCTTATGATCAACATTTAAATAT ENST00000453255.1 --------------------TTTG----------------TAT--------TTTTAGTA- ** * *** *** * ** ENST00000306024.3 GATCTTGGGAGATGTGGAAGAAACTGTGACTACTATAGAAATTGATGAAGAAACATATGA ENST00000453255.1 ------------------------------------------------------------ ENST00000306024.3 AGAGATATATAAATCAACGAAACGGAATATTCCAATGCTCTTTGTCCGGGGAGATGGCGT ENST00000453255.1 ------------------GAGACGGGGTTTCACCATG---TTTG-CCAGGATGGTCTCGA ** **** * * * *** **** ** ** * * ** ENST00000306024.3 TGTCCTGGTTGCCCCTCCACTGAGAGTTGGCTGAAACAAAGAATTTGTCCTGTATGGAAA ENST00000453255.1 TCTCCTGA-----CCTC------GTGTT--CTG---------------CCCGTCT----- * ***** **** * *** *** ** ** * ENST00000306024.3 ACGGGAGACTTTGTACAGTGGCCTCTCTAAAAGTACAAAACATTCATAAGAGAAACCTGC ENST00000453255.1 ------------------TGGCCTCCC--AAAGTGC------------------------ ******* * ***** * ENST00000306024.3 ATACATTTTGATATTAAGAAATAATTCCGGGGATTCTTCCACTCCTGAAATGAGTTGATT ENST00000453255.1 --------TGGGATTA-----CAGGTGTGAG----CCACTACGCCTG-------TCG--- ** **** * * * * * * ** **** * * ENST00000306024.3 TGCAGATAACTCACAACTTCTTAAGCTAAATGGTATTTTCATTTTTCTCAAGCTCT-CCA ENST00000453255.1 ------TAACTCACAACTTCTTAAGCTAAATGGTATTTTCAGTTTTCTCAAGCTCTTCCA *********************************** ************** *** ENST00000306024.3 ATAAATATGACCACCAAGATGCAGAACTCTTT--CAGGACTTCTTTTGCTCCATTATTCT ENST00000453255.1 ATAAACATGACCA---AGATGCAGAACTCTTTTTCAGGACTTGTTTTGCTCCATTATTCT ***** ******* **************** ******** ***************** ENST00000306024.3 CACAGATACTTA-CTGATTTTTCTTTTCTTTAAATTGGTGTTTCCTTGTAGATTTTTTTA ENST00000453255.1 CACAGATATTTTTCTGATTTTT-TTTTCTTTAAATTA------------AAATT------ ******** ** ********* ************* * *** ENST00000306024.3 AGTGCGGTCTTCTGTCTTGTGAATTATTTAAAGTAAGCATGTCTTACCTTCACTTAGCAC ENST00000453255.1 -----GGTGTTTCCTCGGGGGAAAAA---AAAAGAAGAAAATTCTTCCTTCGTTTTG-AA *** ** ** * *** * *** *** * * * ***** ** * * ENST00000306024.3 ACATTTGCAGTGCACCTACTGTGTTTGAGGCACCAGGTTTGAGTGCTGGGAACCAGAGTT ENST00000453255.1 AAAT-----------------------AAACATTAG---TAA---TTCAAAA--AAAGT- * ** * ** ** * * * ** * *** ENST00000306024.3 TTATCAAAATGCTTTCTGGGCCAGACATGGTGGCTCATGCCTGTAATCCCAGCACTTTGG ENST00000453255.1 -----AAAAT------------AAACAA-------CATGTCTATA----------TTTGG ***** * *** **** ** ** ***** ENST00000306024.3 GAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGCGTTTGAGACCAGCCTGGCCAACATGG ENST00000453255.1 AA--------TGAGTTAACCA---------AAGTAT----GACT-----------CAT-- * ** ** * ** * * * *** *** ENST00000306024.3 TGAAACCCTTTCTCTACTGAAAATATAAAAATTAGCCAGGCGTGGTGGCGCATACTTGTA ENST00000453255.1 -------CTATTTCTACT------ATGGAA----------------------TACT---- ** * ****** ** ** **** ENST00000306024.3 ATCCCAGCTACTCAGGAGGCTGAGGCAGTAGACGCTTGAACCCAGGAGGCAGAGGTTGCA ENST00000453255.1 ATGCCTTC-ATTAAAAATGATGATTCA--------TTGAA-----------GAATCTGCT ** ** * * * * * * *** ** ***** ** *** ENST00000306024.3 GTGAGCCAAGATCACACCATTGCACTTCAACCTGGTCAACAGAGCGAGACTCCGTGTCAA ENST00000453255.1 TTGTGCCAGG-------CATTG---------------------ATGA-------TATAAA ** **** * ***** ** * * ** ENST00000306024.3 AAAAAAAAAAAAAAAAGTTTTCTGCCCTCAAGTCT-TCTGGGGAGGCAGATGTTTAAACC ENST00000453255.1 AGAAACCAAGATGAGGACTCTCCCCTCTTGAGGTTATATGAGTAAACAGATGCTTAACAC * *** ** * * * ** * ** ** * * ** * * ****** **** * ENST00000306024.3 AACAATTGCAGGCAGTAAGATTAGTGCTGATAGAATCATGCACATGCAGGATGCCATAGG ENST00000453255.1 A-TAAT----GGGAATAA---TTGTA-TGACAAAAGTATCTATA---GTGACAC--TGAA * *** ** * *** * ** *** * ** ** * * ** * * ENST00000306024.3 AGCATGGGGAAGAGCACCCAAATATGGGAGAAAGGGGCAGAGGGACATTGTAAACATCAA ENST00000453255.1 ACCACAGAGAAGAACAC--AGACTCTGGAACCAGGTGCGCGGGGGTTCTGGGAAGATAA- * ** * ***** *** * * *** *** ** *** ** ** ** * ENST00000306024.3 CCCTGCAGTAGAAGACAGAGCAAAGCATGATTTCTCTTTTCTCTGGCCTGATTTAATTCT ENST00000453255.1 -------GTAGGA-ACTCACCAGGGCACA--------------------GAGATGG---- **** * ** * ** *** ** * ENST00000306024.3 AAGGTCAGACGTTCAGCTTGATCATAACCTGTTTATAATTATGACTCAGACCATTTTTCC ENST00000453255.1 -GGGTCA---------CCTAGGCAGAA--------------------AGAACAT-----C ***** * * ** ** *** *** * ENST00000306024.3 ACTCTTGGATCATTGGCCATTAATGATGAGGGGTCTCAAACAACATGTCTCAGTGACACA ENST00000453255.1 AC-----GTGCAAAGGTCA---------AGATGCATGAAATGGTACGATTTA--AACAGA ** * ** ** ** ** * * *** * * * * *** * ENST00000306024.3 GTA-AAGCAGAAATTGGCTGAAAGCAAAGCTGTTTTTATTTCTAGC--TTCAGTCAGCAC ENST00000453255.1 GGACAGGAAGAAATTGAATAGGATAGGAGC-----------CTAGCATTTCAGGCAGGA- * * * * ******** * * *** ***** ***** *** * ENST00000306024.3 ATAATGCTTAAAACCTAAAGAGGAAAGTAAAAGCGTGTTACAATCTCTCAAACTTTATCA ENST00000453255.1 ---GTGGCCAAAA-------ATGAGGCTGAGAG-AT-TTGTAGATCATGAAATGT----A ** **** * ** * * ** * ** * * *** * * ENST00000306024.3 AGACAGGGCTTAGAACCTGACATCCTCCGCTATGGTCATTCCATTTTGAAATGTAGAAAA ENST00000453255.1 AGGTAA----CAGAGTCAAA-----------ATAG-----CTTTTTGGTAATGT------ ** * *** * * ** * * *** * ***** ENST00000306024.3 TCCAACTTGTGGATGGTTTGTCTGTAAATGAGCTGAATGTGTGTGCGTGTTCATTATCAA ENST00000453255.1 -----CTCACTGATGGC------------------AATGTG---GAGGGT---------A ** ***** ****** * * ** * ENST00000306024.3 GCACGATATGCTCACAAATGCACAGTACTTTAAGCCTTGTGCAAGAAAGATGCTTTCAGT ENST00000453255.1 GCATGATGGG-----------ATAGTA--TTAA---------AGAAAGGACACC------ *** *** * * **** **** * ** ** * ENST00000306024.3 AAACATATTTAAAAGGTTTTATTTTCCTTACTAATGGTACATGCCCCTGCAAGTTCATGG ENST00000453255.1 ------ACCCAGAAAGCTGT-----------------TACA-GTTCC--CAAG------- * * ** * * * **** * ** **** ENST00000306024.3 AGAAGAGAAAAACAAGTGTGGGTG--AGC--TGATGGAGGCTTCATCTTAGGTGAGGAGG ENST00000453255.1 AAAAGGGGATGA-GGGCCTGAGTGGCAGCAATGACAGTGG---------AGATGAGGA-- * *** * * * * ** *** *** *** * ** ** ****** ENST00000306024.3 CAGGAGAGACACCCTCCCTTCACTTGTGCCATCCCCACGCTTTGTCCTTAAGCTGTAGTG ENST00000453255.1 CTGGAG------------------TGGAGCA------------------AAG-------G * **** ** ** *** * ENST00000306024.3 GTCCCAGGAGATAACCTGTTTACAGCAGCCCATTCAGTATTGAAAAATGAACTCCCTCCT ENST00000453255.1 GTC--AGGAGACA------TCACAGAGGTCTA---------AAGGGCAGGACTTG----- *** ****** * * **** * * * * * *** ENST00000306024.3 GCAGAATGTTAGAAGAAACAACCTCAAAGACCTCAGGCCGCCTGTGGTCATTAGTATGTG ENST00000453255.1 GTGAGAGGTTAAGGGGAG-----------------GGCAG------------AGT----- * * **** * * *** * *** ENST00000306024.3 GCAGCAAGATTGAACCTGCCTGCCTCCTACCTGTGTGAGCCTGTGGTGTGGGTGTGGTAC ENST00000453255.1 ----CAAGAT--AACACA----------------GAGAGTCTGACATGTGGCTG-GGTA- ****** *** * *** *** ***** ** **** ENST00000306024.3 CAAGGCCCTGGCTCTGGGCAGTCTGTTGGCTCCTGGTGTTCACTAAGGCGTGGGGTGACA ENST00000453255.1 ----GGCCAGGCTCCGG-------------TCCT---------TAGGA---GGAAGAACA * ** ***** ** **** ** * ** *** ENST00000306024.3 GGCCATCTGGCCTCGCTCTGCCAGTCTGCAGTTCTCCCCAGCACTGCATTCATTTTTAGT ENST00000453255.1 GATTGG--GGGCTGGATCTG-------------------ATTACTGC----GCTTTGAGG * ** ** * **** * ***** *** ** ENST00000306024.3 GGTTTCTGATAGTCACACTGAATTCCTGGACACTTTCTTCTCTTCATTCTTAGTTATCTT ENST00000453255.1 GGCCTGAGATA------------TTCTGTAGGC------------------AGATATGTT ** * **** * *** * * ** *** ** ENST00000306024.3 TCTCCTTTTTCTCCTGGAACTGATAGTTTACACTAAAACTTTTGGCTGTGAGGA-CTTGA ENST00000453255.1 C--------------AGAG--GGAGGCTTGGGTCAAAAAG--TAGCTTTTAGGGTCTTGA ** * * ** **** * *** * *** ***** ENST00000306024.3 TTATACACATTTCTAAAACCCATGAACCTTAATATCTGACACTGTTACTCTCATATGCAC ENST00000453255.1 A-----GCATTTAAATGATAGTTGAAGCCAAGGGTTTGA-------ACACTAAT------ ***** * * **** * * * *** ** ** ** ENST00000306024.3 ACACAACTAAAACATACCAACCTACTTCATTTCCTAGCTGCTAAGATACAAGGGGAGGGA ENST00000453255.1 ---CAGGGAAAATGGACAGA----------------------AAAATACAGGGGAAA--A ** **** ** * ** ***** *** * * ENST00000306024.3 CAATAAAAGGTTAACTGCAGAATAGCCACC-TATGTGTCAGG---AAATGGAGGGAGGGG ENST00000453255.1 CAGTCCAGGGATAG---------AGCTTCTGTATGTTTAGGGGCTAAATGGAGAAAGAAG ** * * ** ** *** * ***** * ** ******** ** * ENST00000306024.3 AGGCAATGTGTGAGTCCTTTTGGAGCTGGGACTCAATCCACAACAGAGACAGCTCAAGCA ENST00000453255.1 AGCTGGTA---GA----TTGAGAAGGTGAGA-TCAA-CTA-GGTAGGAAGA----AAACA ** * ** ** * ** ** ** **** * * ** * * ** ** ENST00000306024.3 GGGCCCTGCCATGGTCCACACTGAGGTTTCCTCTGCAGTGGTGCTGTCCACTGAGGGGTT ENST00000453255.1 AAAACC-----------------AGG--------------------------GAGG---- ** *** **** ENST00000306024.3 ATGGTGTGAGGGCCCCTGGGAGCCACGCCTTGGACTTCTGAGTCTGCAGAGCACTCGGCT ENST00000453255.1 ATGGTGTCAGAG------------ACACCCAAGA------AGT----AGAA-AC----CT ******* ** * ** ** ** *** *** ** ** ENST00000306024.3 CCAGCCAGCTGGATGGCAGGTGGTCAGTGGAGCTGGTGACTGGTGGTTTCTGCAATGAGG ENST00000453255.1 CAAGGTAG---------AAGTAGTCAATAGT-----------------------ATCAAA * ** ** * ** **** * * ** * ENST00000306024.3 TGTCAGATTA-GCCTA-AGGGAAGCCTCTTCAGCAAGTATCATGCCTG-GATCCCGGTCT ENST00000453255.1 TGTCAAAAGACGCTCATAGGCCAGGCACGGTGGC-----TCACACCTGTAATCCCAGC-- ***** * * ** * *** ** * * ** *** **** ***** * ENST00000306024.3 TGGTTGTTTTATGAGAGGCCGATATGAATTGCCATTGCCTCCCACAAAGAAAAATGGACA ENST00000453255.1 -----ACTT--TGGGAGGCTGA------------------------------GGCGGGCA ** ** ***** ** ** ** ENST00000306024.3 AAATATGGGACCACATCTTTGAGATGAAATGTGCCCAAAATGAAAAGTAACTTGAGTATC ENST00000453255.1 GATCATGAGGTCAGAAGTTCGAGAC----------------------CAGCCTGA----- * *** * ** * ** **** * * *** ENST00000306024.3 CCAAGTTAAACTTAATCATTAGCTGCAAATGGACGATTTTCAAATTTCAAATAGTGATTT ENST00000453255.1 CCAA------------CAT------------GATGA------------------------ **** *** ** ** ENST00000306024.3 TTGAAGATTTGCCCAAACTAGAGTACTATCCCTCTTCACACTAAGAGGCAGAAAGTGGTT ENST00000453255.1 ---------------AACC------CCATCTCT------ACTAAAAA-TACAAA------ *** * *** ** ***** * * *** ENST00000306024.3 TCACACACCCTTTTATTTAATCAGCTAAAGTGGGTGCGGTGACACACACCTGTAAACTCA ENST00000453255.1 ------------------AATCAGCC-----GGGCATGGTGGCGTGCGCCTGTAATCTCA ******* *** **** * * ******* **** ENST00000306024.3 ACCACTAAGGAGACTGAGGCGGGAGGATTACTTGAGCCCAGGAGTTCGAGATCAGCCTGA ENST00000453255.1 GCTACTCAGGAGGCCGAGGCAGGAGAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTGA * *** ***** * ***** **** ** ***** ** **** *** * *** ENST00000306024.3 GCAACATAACAAGACCCTGTCTCAAATAATACTTAGCTATTACCCATATTGCTTTTAGCC ENST00000453255.1 GC------------------------TGAGATTGCACCACTGCAC--------TCCAGCC ** * * * * * * * * * * **** ENST00000306024.3 TGCTGCCAGGAGGGGAGAAATGTTATTGTTTGAACAGATGTCAGATGTGAGTAATGCTCA ENST00000453255.1 TG----------------------------------GGTGACAG-----AGCAAGACTCC ** * ** *** ** ** *** ENST00000306024.3 GCTGTGTTCAATGTAGAAAATTAATAAAAGTTCCAGGAGTCATCCTGGCTAGATCAA ENST00000453255.1 GTC----TCAA---AAAAA-------------------------------------- * **** * ***