CLUSTAL 2.1 multiple sequence alignment ENST00000318066.1 CGCGCGCGCAGTCGCGCGCGGGTCGTGCCGTACCACCGTCGCGGGCAGGCTCGGCCACGA ENST00000545592.1 ------------------------------------------------------------ ENST00000318066.1 GCGCCAGAGCCCCGCGCCTCCCCTCGCGGCCTGTCCCAAGTCCCTGCCCCGCAACAGAGC ENST00000545592.1 ------------------------------------------------------------ ENST00000318066.1 GTCACTTCCGCCATCCCCGGCAGCGGTTGGGGCGGGGCGCACGGGGGAGGGGGCCAGGTC ENST00000545592.1 ------------------------------------------------------------ ENST00000318066.1 GGAGGGAAGCCCGCCCGTGCCCGAGCCCGCGCCCGAGCAGGGACTACATTTCCCGAGGGG ENST00000545592.1 ------------------------------------------------------------ ENST00000318066.1 CCTCGGCGGCGGCTGCGGCGACGGGCGCGGCAACGTCCCCCGGAAGTGGAGCCCGGGACT ENST00000545592.1 ------------------------------------------------------------ ENST00000318066.1 TCCACTCGTGCGTGAGGCGAGAGGAGCCGGAGACGAGACCAGAGGCCGAACTCGGGTTCT ENST00000545592.1 ------------------------------------------------------------ ENST00000318066.1 GACAAGATGGCCGGGCTGCCCCGCAGGATCATCAAGGAAACCCAGCGTTTGCTGGCAGAA ENST00000545592.1 ------ATGGCTGGGCTGCCCCGTAGAATCATCAAGGACAACCAGCATTTGCTGGCAGAA ***** *********** ** *********** * ***** ************* ENST00000318066.1 CCAGTTCCTGGCATCAAAGCCGAACCAGATGAGAGCAACGCCCGTTATTTTCATGTGGTC ENST00000545592.1 GGAGTTCCTGGCATCCAAGCAGAATCACGTGAGAGCAACACCTGTTATTTTCATGTGGTC ************* **** *** ** ********** ** ***************** ENST00000318066.1 ATTGCTGGCCCTCAGGATTCCCCCTTTGAGGGAGGGACTTTTAAACTTGAACTATTCCTT ENST00000545592.1 ATTGCTGGCCCTCAGGATTCCCCCTTTGAGGGAAGGACTTTTAAACTTGAACTATTCCTT ********************************* ************************** ENST00000318066.1 CCAGAAGAATACCCAATGGCAGCCCCTAAAGTACGTTTCATGACCAAAATTTATCATCCT ENST00000545592.1 CCAGAAGAATACGCAATGGCAGCTCCTAAAGTACGTTTCATGACCAAAATTTATCATCCT ************ ********** ************************************ ENST00000318066.1 AATGTAGACAAGTTGGGAAGAATATGTTTAGATATTTTGAAAGATAAGTGGTCCCCAGCA ENST00000545592.1 AATGTAGACAAGTTGGGAAGAATATGTTTAGATATTTTGAAAGATGAGTGGTCCCCAGCA ********************************************* ************** ENST00000318066.1 CTGCAGATCCGCACAGTTCTGCTATCGATCCAGGCCTTGTTAAGTGCTCCCAATCCAGAT ENST00000545592.1 CTGCAGATCTG-ACAGTTCTGCTATCGATCCAGGCCTTGTTAAGTGCTCCCAATCCAGAT ********* * ************************************************ ENST00000318066.1 GATCCATTAGCAAATGATGTAGCGGAGCAGTGGAAGACCAACGAAGCCCAAGCCATAGAA ENST00000545592.1 GATCCATTAGCAAATGATGTAGTGGAGCCATGGAAGACCGACGAAGCCCAAGCCATAGAA ********************** ***** ********* ******************** ENST00000318066.1 ACAGCTAGAGCATGGACTAGGCTATATGCCATGAATAATATTTAAATTGATACGATCATC ENST00000545592.1 ACAGCTAGAGCAGCGACTAGGCTATATGCCATGAATAATATTTAAATTGATCCAATCGCC ************ ************************************* * *** * ENST00000318066.1 AAGTGTGCATCACTTCTCCTGTTCTGCCAAGACTTCCTCCTCTTTGTTTGCATTTAATGG ENST00000545592.1 AAGTGTGCATCGCTTCTCCTGTTCTGCCAAGACTTCCTTATTTTTGTTTGCATTTAATGG *********** ************************** * ****************** ENST00000318066.1 ACACAGTCTTAGAAACATTACAGAATAAAAAA-GCCCAGACATCTTCAGTCCTTTGGTGA ENST00000545592.1 ACACAGTCTTAGAAACATTATAGAACAAAAAAAGCCCAGAAATCTTCAG-CCTTAGGTGA ******************** **** ****** ******* ******** **** ***** ENST00000318066.1 TTAAATGCACATTAGCAAATC----------TATGTCTT---GTCCT--GATT---CACT ENST00000545592.1 TTAAATGCAAAAGAAAAAAAAAAGTAATGGATAAGCCCCAGGGTCCTTGAATTTATCACA ********* * * *** ** * * ***** *** *** ENST00000318066.1 GTCATAAAGCATGAGCAG-AGGCTAGAA--GTA--TCAT--CTGGATT------GTTGTG ENST00000545592.1 GAAAGAAAGTAGTGGTGGCAGGCCGGCGTGGTGGCTCACGCCTGTAATCCCAGCACTTTG * * **** * * * **** * ** *** *** * * * ** ENST00000318066.1 AAACGTTTAAAAGCAG-TGGCCCCTCCCTGCTTTTATTCATTTCCC-CCATCCTGGTTTA ENST00000545592.1 GGAGGCC--AAGGCGGGTGGATC--ACCTGAGATCAGGAGTTCGAGACCAGCCTGGCCAA * * ** ** * *** * **** * * ** *** ***** * ENST00000318066.1 AGTA-TAAAGCACTGTG---AATGAAGGTAGTTGTCAGGTTAGCTGCAGGGGTGTGGGTG ENST00000545592.1 CATGGCAAAACCCTGTCTCTACTAAAAATACAA---AAATTAGCTG----GGTGTGGTGG * *** * **** * * ** ** * ******* ******* * ENST00000318066.1 TTTTTATTTTATTTTATTTTATTTTATTTTTGAGGG----GGGAGGTAGTTTAATT---- ENST00000545592.1 CTCATGCCTG---TAATCCCAGC--ACTTTAGGAGGCCAAGGCGGGTGGATCACCTGAGA * * * * ** * * *** * ** ** *** * * * * ENST00000318066.1 TTATGGGCTCCTTTCCCCCTTTTTTGG--TGATCTAATTGCATTGGT--TAAAAGCA--- ENST00000545592.1 TCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAAAACCCCGTCTCTACTAAAAATACAA * * * * ** ** * * ** ** * * * ***** * ENST00000318066.1 --GCTAACCAGGTCTT-TAGAATATGCTC-TAGCCAAGTCTAACTTTATTTAGACGCTGT ENST00000545592.1 AAATTAGCTGGGTGTGGTGGTGCGCACCTGTAGCC----CCAGCTAC-TTGGGAGGCTGA ** * *** * * * * ***** * * ** ** ** **** ENST00000318066.1 AGATGGACAA--GCTTGATTGTTGGAACCAAAATGGGAACATTAAACAAACATCACAGCC ENST00000545592.1 GGCAGGAGAATCGCTTGAACCCGGGAGGCAGA---GGTGCAGTGAGCCGAGATCGCACCA * *** ** ****** *** ** * ** ** * * * * *** ** * ENST00000318066.1 CT-CACTAATAACATTGCTGTCAAGTGTAGATTCCCCCCTTCAAAAAAA----------G ENST00000545592.1 CTGCACTCG-AGCCTGGGTGACAGGGCGAGAGTCTGCCTCAAAAAAAAACGACAAAGAAG ** **** * * * * ** ** * *** ** ** ******* * ENST00000318066.1 CTTGTGACCAT-------TTTGTATGGC--TTGTCTGGAAACTTCTGTAAATCTTATGTT ENST00000545592.1 GTAGTGGCAATAAGAATATTTCCACAATAGCTACATGGAGACTCCTGAAA--------TT * *** * ** *** * * **** *** *** ** ** ENST00000318066.1 TTAGTAAAATATTTT---TTGTTATTCTACTTTGCCTTT----GTACAGTTTATTTTACT ENST00000545592.1 TAACTCAAATATTCAAAGCTGCCACTTTATTTTATATCACAAGGTGAAGTGAGACATACC * * * ******* ** * * ** *** * ** *** *** ENST00000318066.1 G--TGTTTAT-TTCATTT-TCCCAATTTGA--------CAATCGTAT-----TTTAAAAT ENST00000545592.1 AGCTCCTTATATTCATTCCTCCCAGCTATAGGAAGAATCAGTCTTACATCCCTCTGTCCT * **** ****** ***** * * ** ** ** * * * ENST00000318066.1 TGAAACT--------GATGGAACATTCTT-----TCTTGGT---CTTCACCATCTGACAA ENST00000545592.1 TTATACCTCTGCAAAGAAGCAATACTTTTACATATCTTGATGTGCTCTTCTATTTG-CAA * * ** ** * ** * * ** ***** * ** * ** ** *** ENST00000318066.1 AT---TGAATGGCAAGAGGTGGATTTTGCCAGTT------TCTTTTCACTGAT------- ENST00000545592.1 GTCTATGAATAGCACCT--TATTCCTAGCCACTTAAAGCATCAATATGCTGGGAAGGGGG * ***** *** * * **** ** ** * *** ENST00000318066.1 ------GCAGATTTGTGTTAAGATAGTACTGAATGG-AGTATTTATAAACTGGCCCTGAG ENST00000545592.1 AAAAGGGAGGAAGTGTGGCAAAGAAGATTAGGATAGCAGCGTT---GCAGTAGAAATAAG * ** **** ** ** * ** * ** ** * * * * ** ENST00000318066.1 CATG-CATAAAGCATCAGTATCTGACCTT----------------TTTTTA--------- ENST00000545592.1 CAAGATAAAAAGAATCATTATTCAGCCTCCCATAGCCAAAATAGATTTTCATGTCGGCAA ** * * **** **** *** *** **** * ENST00000318066.1 -------ACCTTCT--------AGGAATT----TGAAATAAATGTGTTTGT---GTTG-- ENST00000545592.1 CAAGCCAATCAGCTTGAAAGGCAGGACTTGTCATGAGAGAAACAAGTTTTCTAAATTAAT * * ** **** ** *** * *** **** ** ENST00000318066.1 ---------TCTG-ATTAGATGA--TCA---TTGGT-GTCTTG-CCACAATGTTTAAAAA ENST00000545592.1 TTATCTCCCTCTGTAATACATCAAGCCAGGCTTGGTAGACTTGGTCACAGAATTTATATG **** * ** ** * ** ***** * **** **** **** * ENST00000318066.1 TTA------CTGTACAGGA--AAGTCACAGCAAAGATAGCAGTTGTGACTG-ACATGTAG ENST00000545592.1 TTGAAGGCTCCACATAGAATTAAGTGAAAGCAGGAAAACC--TTGCCCCTGCAAATTTGG ** * * ** * **** * **** * * * *** *** * ** * * ENST00000318066.1 GACTTTCAC-AGTTGTGCCACATTTTTGCCTAAAAT-TTGGGT--TATGACATTTTTCTT ENST00000545592.1 GAGAATCATGAAGGGAAACAGAGGTAGACCAAGGAGGTTAGATGCCAGGGTTCTTTTTTC ** *** * * ** * * ** * * ** * * * * **** * ENST00000318066.1 GGTTCTT--ATCTGAAAATTTCATCTGTAACCT---------TTCATGTGTGT-TAAGAA ENST00000545592.1 TTTTCCTTGACTTGAAA--CCAACCCTTAAGATAAATGGGAGCTTATG-GAGTATAAGAA *** * * ***** * * *** * * *** * ** ****** ENST00000318066.1 ACACTGATCTGATCATTTGGGAT---------TTGCTG-AGGCAT----TTGTGAGTCT- ENST00000545592.1 AATCTAA---GGTCACCAAAGATAGTAGCATGTTTCTGTGGGCATGACACAGAGAGGCTG * ** * * *** *** ** *** ***** * *** ** ENST00000318066.1 ----TCCTTA---TAAACCTG---------ATGAGCAGATCTCAACTAT------CTAGC ENST00000545592.1 CAGATCCTTAAAACAACTCTGGCTCATTGTATAAGGGGA-CATGACTATACGAATCTAGT ****** ** *** ** ** ** * ***** **** ENST00000318066.1 TTGT--GTGTC-------------ATCAGAAAGGTTTATCCCTTT--------------G ENST00000545592.1 TTTCCAGTGCCTGGAAATAAGGAAATCAAAGATGCCTGTATGTTTTGCCAGGGAAGATAG ** *** * **** * * * * * *** * ENST00000318066.1 AGA-GTAT-CAAGTCCTCAGT-TAATGATTCTTGCTT----TCA--------TCCCTCCA ENST00000545592.1 AGAAGCATGCAGAACAATAGTGTAACAGCACAAGGCTAGAGTCAAAGCAAAGTTGCTACA *** * ** ** * *** *** * * * *** * ** ** ENST00000318066.1 GTATTTGCTG--------------TGGGAGCTCG---TTTTATTCTTTAATTTGGAATTC ENST00000545592.1 GCATGCAATGACTTCCAGGAAGAACAGGAGCTAGAGATTCCAGCCATGAGTATGCTGTTA * ** ** ****** * ** * * * * * ** ** ENST00000318066.1 AGTAATTTTTC-TTCTTTATTG--ACGAATTCCTCCCCTCACAAAACTGTTCTTTCCCAC ENST00000545592.1 AATATTTAAAAACTCACTATCAGAACAAAAAAAAACCCTGATAGG-TAGTATTTGCCCAT * ** ** ** *** ** ** **** * * ** ** **** ENST00000318066.1 CTCTCTC-CATATCTAATTCCTGATTCTTGTTATTTTTAAGTCATAA----ATGTAGCCA ENST00000545592.1 TTTTATGGTGTAAATCATCCC--ACTATAGTCAATTTCAAGCTCCAACATGACATCACTA * * * ** * ** ** * * * ** * *** *** ** * * * * ENST00000318066.1 GTCATAAATACA-TAAATGTTAACCTTCGGGTTGCAACCTTGTCTCTTGCAGTT-TAAGG ENST00000545592.1 CTTATGAGTTTAGTAAGAGATG----TGTAGTAGCACACTATTTTATGGTATTTCTACCA * ** * * * *** * * * ** *** ** * * * * * ** ** ENST00000318066.1 TAATGGATATTGTAGCCCATTTGAATTTTCTTCACTCTTATTCTCGTAATTCTGGAGTTT ENST00000545592.1 TAA-AGATATGATAG---ATGTGAACGATCT-CATAGATATTAGTAAAACACAGTAAAAT *** ***** *** ** **** *** ** **** ** * * * * ENST00000318066.1 CTTCAGATTGTGGTGTATTTT----ATTGTGCTC--------CTATGTAAGATGAAGAAT ENST00000545592.1 ACTCAGGAAATGATGAGTTTTTAGTATTGTATTTGATATAATTTATTTAAG-TGAAAA-- **** ** ** **** ***** * *** **** **** * ENST00000318066.1 TAACTATTAAAATTACATTTTCAACATACAAAAGCTTTTGATGACTGGTAACTGGTATCC ENST00000545592.1 TGTCTATTAAG--TACA-----AATTTATATAAGTTATATAT-ATATATATATATTTTTT * ******* **** ** ** * *** * * ** * ** * * * ENST00000318066.1 TTCCAAATAAATGCATTGCTTGGT ENST00000545592.1 TTTT-------TTTTTTTTTTGAA ** * ** ***