CLUSTAL 2.1 multiple sequence alignment ENST00000323303.4 AAAGAGGCTCGTGGCGCCCGCCTTCCGGTGCCTCAGTCCCTGCCAGTAGCCACCCGACGC ENST00000451333.1 ------------------------------------------------------------ ENST00000323303.4 CGTCCGGCTGTTCCTCGTTCGCCCTCTCCCTCCGCCTAGCCCGCTTCTACCCGGACGGCT ENST00000451333.1 ------------------------------------------------------------ ENST00000323303.4 CCCGGCGCAGGCTGCAGCTGTTCCGTCAGCTGCCGCTCCTCCTCCCAGACGCAGAGCGCC ENST00000451333.1 ------------------------------------------------------------ ENST00000323303.4 GCTCTGCCCCGCCCCCCGCGCAGGCTGCCGTCCCTACATCCGGGTACCGACTCCAGCCGC ENST00000451333.1 ------------------------------------------------------------ ENST00000323303.4 CTAGACGCTGGCACTATGGTCATGGCGGAGGGGACGGCAGTGCTGAGGCGGAACAGGCCG ENST00000451333.1 ---------------ATGGTCATGGCAGAGGGGATGGCAGTGCTGAGGCAGAACAGGCAG *********** ******* ************** ******** * ENST00000323303.4 GGCACCAAGGCGCAGGATTTCTATAATTGGCCTGATGAATCCTTTGATGAAATGGACAGT ENST00000451333.1 GGCACCAAGGCACAGGATATCTATAATTGGCCTGATGAATCCTTTGATAAAATGGACAGT *********** ****** ***************************** *********** ENST00000323303.4 ACACTAGCTGTTCAACAGTATATTCAACAGAACATAAGAGCAGATTGCTCCAATATTGAC ENST00000451333.1 ACACTAGCTGCTCAACAGTCTATTCAACAGAACATAAGAGCAGATTGCTCCAATATTGAC ********** ******** **************************************** ENST00000323303.4 AAAATTCTTGAACCACCTGAAGGCCAAGATGAAGGTGTGTGGAAGTATGAACATTTAAGG ENST00000451333.1 AAAATTCTTGAAGCACCTAAAGGCCAAGATGAAGGTGTATGGAAGTATGA-CATTTAAGA ************ ***** ******************* *********** ******** ENST00000323303.4 CAGTTCTGCCTTGAGCTAAATGGACTTGCTGTCAAACTTCAGAGTGAATGCCATCCAGAT ENST00000451333.1 CAATTGTGCCTTGAGCTAATTGGACTTGCTGTCAAACTTCAGCGTGAATGCCATCCAGAT ** ** ************* ********************** ***************** ENST00000323303.4 ACTTGCACTCAAATGACAGCAACTGAACAATGGATTTTTCTTTGTGCAGCTCATAAAACT ENST00000451333.1 ACTTGTACTCAAATGACAGCAGCTGAACAATGGATTTTTCTTTGCATAGCTCATAAAACT ***** *************** ********************** ************* ENST00000323303.4 CCAAAAGAGTGTCCTGCTATAGACTATACTAGACACACACTTGATGGTGCTGCATGTCTT ENST00000451333.1 CCAAAAGAGTGTCGTGCTATAGACTATACTAGACACACACTTGTTGGTGCTGCATGTCTT ************* ***************************** **************** ENST00000323303.4 CTGAATAGCAATAAATATTTTCCCAGCAGGGTTAGCATAAAGGAATCATCTGTAGCGAAA ENST00000451333.1 CTGAATGGCAATAAATATTTTCCCAGCAGGGTTAGCATAAAGGAATCATCTGTAGTGACA ****** ************************************************ ** * ENST00000323303.4 CTAGGATCAGTATGCCGTAGGATTTACAGAATATTTTCACATGCTTATTTTCATCATCGG ENST00000451333.1 CCAAAATCAGTATGCCGTAGAATTTACAGAATATTTTCACATGTTTATTTTCATCATTGG * * *************** ********************** ************* ** ENST00000323303.4 CAGATATTTGATGAATATGAAAATGAAACATTTTTGTGTCATCGGTTTACTAAGTTTGTG ENST00000451333.1 CAGATATTTGATGAATATGAAAATGAAACATTTTTGTGCCATTGGTTTATTAAATTTGTG ************************************** *** ****** *** ****** ENST00000323303.4 ATGAAATACAATTTGATGTCCAAGGATAACCTGATTGTACCAATTTTAGAAGAGGAAGTA ENST00000451333.1 ATGAAATATAATTTGATGTCCAAGGATAACCTGATTGTACCAATTTTAGAAGAGGGAGTA ******** ********************************************** **** ENST00000323303.4 CAGAATTCAGTTTCTGGGGAAAGTGAAGCATGAAGGGAATCATA-GGAAAAATGTACTGA ENST00000451333.1 CAGAATTCAATTTCTGGGGAAAGTGAAGCATGAAGGGAATCAAATGGGAAAATGTACTGA ********* ******************************** * ** ************ ENST00000323303.4 TCATATAATTAACATTA----TGTACTGTATATATCATTTTAGACACATCAATCATGTAT ENST00000451333.1 TCACATAATTAACATTAATTACGTACTGTATATATCATTTTAGACACATCAATCGTGTAT *** ************* ******************************** ***** ENST00000323303.4 CCATATTATAGCTTCTTTGTTTAGTATAGGTTTTTGTATGCTGGGTTTGCCTTTTAAAAT ENST00000451333.1 CCATATTATAGCTTCTTTGTTTAGTATAGGTTTTTGTATCCTGTGTTTGCCTTTTAAAAT *************************************** *** **************** ENST00000323303.4 GGGAAATACTTTTTAAGTTATTCATAAGCTGTATATTCACCAGTGTGGCACTCATGGTTT ENST00000451333.1 GGGAAATACTTTTT---TTTTTTTT----TTTTTTTTT-----TGCGACA---------- ************** ** ** * * * * ** ** * ** ENST00000323303.4 TTAAATAAGATTAGTATTATCTGTTTATAATGCCTGTTAATAAAAGAATTTACAGTTTGG ENST00000451333.1 ------GAGTTTCGCTCTAT----------TGCC------------------CAGGCTGG ** ** * *** **** *** *** ENST00000323303.4 TAAAATTGCTGCTAAACAATCATTGGATCACAATCCTCATCAGACAAACCCATCTGTAAA ENST00000451333.1 ----AGTGCAATGGTGCGATC-TTGGCTCACTGC------------AACC--TCCGC--- * *** * *** **** **** **** ** * ENST00000323303.4 AAAAATGAGGGAGAGCTTGAGGTTTCACACAAGCCATTTACTAAAGAGGTAGAAATGTTT ENST00000451333.1 ---------------CTCCCGGGTTCA-------------------AGGGA--------T ** ** **** *** * * ENST00000323303.4 TCTATTGGTTTTACCTTGAGTTTAGATATCCTAAAAAATTCTGTAGTACGTAGTTTTGTC ENST00000451333.1 TCTCCTG-------CCTCAGCTT------CCCAA--------GTAGCTGGGATTACAGGC *** ** * * ** ** ** ** **** * * * * * ENST00000323303.4 TTACCTGTTAACTTTCCCCAATTGAGATAAAAGTGTTTTAAAATTCTGTTTATAGTTTTT ENST00000451333.1 --ACCTGCCA-CCATGCCCAGCT------------------AATT---TTTGTA-TTTTT ***** * * * **** * **** *** ** ***** ENST00000323303.4 GATATGCATATATAATTATGTGTATATCTAAATACAAATGCAAATGAAGCATTAGTAATA ENST00000451333.1 AGTAGAGACG---------GGGTTTCACCA--------TGCTGGCCAAGC--TGGT---- ** * * ** * * * *** **** * ** ENST00000323303.4 CTTAAATAATTTTACTGTGCTACATAAAGTATAACATACTTGGAAAGGATTTACCGTTCT ENST00000451333.1 CTCGAAC-----TCCCG----ACCTCAGGTG--ATCCGCCTGC------CTTGGCCTCC- ** ** * * * ** * * ** * * ** ** * * * ENST00000323303.4 GCAACAACGGACTGGTACATACAGG-ATGA-TCACAATGGTAAGGCACATAAATTATTTT ENST00000451333.1 ----CAAAGTGCTGGGAT-TACAGGCATGAGCCACTGTGCCTGGCC---TAAAATG---- *** * **** * ****** **** *** ** * * **** * ENST00000323303.4 CCCACTGGAAACCTGCCCTGTCCACCCCTTCTCATTTCCCTTAACCTTATCTTCAAACTA ENST00000451333.1 ------GGAAAT---------------------ACTT--TTTAAG-TTATTCATAAGCTG ***** * ** **** **** ** ** ENST00000323303.4 CTTTAGCTGAGAAGCTTTTCACCAGACTGAGTTAGTGGTGGCTTATACCTATTTATATTT ENST00000451333.1 -TATA------------TTCATCAG--TGTGGCACTCATGATTTTTAAATA---AGATTA * ** **** *** ** * * * ** ** ** ** * *** ENST00000323303.4 GTATTAATTGCTTACAGATTATACCTCATATTAGCAATTACATTACACTACAAGAAAATG ENST00000451333.1 GTATTATCTGTTTATA----ATGCC---TGTTAATGA--------------AAGAA---- ****** ** *** * ** ** * *** * ***** ENST00000323303.4 TATTTGCATAGGCTCTTGCTTATCTTTGTTTTGCAAAATTGTTCTACTTAGAAAACAGTC ENST00000451333.1 --TTTACA-------------------GTTTGGTAAAATTG--CTGCT----AAACAATC *** ** **** * ******* ** ** ***** ** ENST00000323303.4 CTTAAAATAGTTTGACTCTTCCTGTTAGTAATATATTAATCTTTCATTTAACCAGCTAGG ENST00000451333.1 ATTAGA------TCACAATCCTCATCA--AGCAAACCCATCT------------------ *** * * ** * * * * * * * **** ENST00000323303.4 CAGCATTAAATAGAATTGAAGAAATACCATAGTATTTATTTTACACCCCCTCTCCCACGA ENST00000451333.1 ----ATTAAAAAAAAAAAAAAGAGTG----AGAGCTT---------------------GA ****** * ** ** * * ** ** ** ENST00000323303.4 AGTTTATGTTTGGATTACATGCACGTGTGAGATTATTTGCAATAATTCATAGGTTCCAAG ENST00000451333.1 GGTTT----------CACAC---------AAGCCATTTAC--TAA---AGAAGT---AGA **** *** * **** * *** * * ** * ENST00000323303.4 GGTGTTGATGAATAGTCATACATTTTTTTGGACTTTGTTATAATTCATTGTGGTAAGAAT ENST00000451333.1 AATGTT----------------TTCCTTTGG-TTTTACCCTGAGTT-------------- **** ** ***** *** * * * ENST00000323303.4 GATTGAAATGCAGATTTAACAATCTTATAATCTATTGAATGCCATTTTTGATAAAGCACT ENST00000451333.1 --TAGATATCC----TAAAAAATTCTATAGTACA--------CAGTTTTG---------- * ** ** * * ** *** **** * * ** ***** ENST00000323303.4 GGAGGTCTTATTGCCAAACTGATTGTAATGAGGCAGTAAGGGTGAAAACATTGTACATGT ENST00000451333.1 -----TCTTACCTCTTAACTTTCCCCAA-------------ATGA--------------- ***** * **** ** *** ENST00000323303.4 TGTGAAGAAAGTATTTAAATCCAACTTTTGAACAGATTTAACAAACATGAGGAACTTTTT ENST00000451333.1 ---GATAAAAGTGTTTTAA----AATTCTG-------TTTACAG-----------TTTTT ** ***** *** ** * ** ** ** *** ***** ENST00000323303.4 TATTTAGAAGGATAATTTTGAAGATGAAAATGTATTCATCTTAATTGTTTTTTCAAATTT ENST00000451333.1 GATATGCATATATAATTATG----------TGTATATCTATAAGCAGGTTCTCCAGGTGG ** * * ****** ** ***** * * * * ** * ** * ENST00000323303.4 AAGGGAATAATTTATACCATCTTTTCAGACAAGAATGTACAGCAAAAATAAGGGGAACAG ENST00000451333.1 CCTGGAAAA-------CTGGCTCCCCACACA--------------------------CAG **** * * ** ** *** *** ENST00000323303.4 TAGTATACTGAGAGTGTGTGTATGTATAGTGTATGCCTTTCCAAGCTTGCCAGTCTTTTT ENST00000451333.1 GGGCAAACTGACACTG-------------------CCTTTTC---TCTGCAGGCATTTCT * * ***** * ** ***** * *** * *** * ENST00000323303.4 GGCTTTGAACACTGCCCATCAGCTACAGT-CATTACTGTTCCCCAACCCACAACTATCTT ENST00000451333.1 GG---TAGA----GTTCACAAG-TAAAGTGTACTACTGG----------------ATC-- ** * * * ** ** ** *** * ***** *** ENST00000323303.4 TTAAGAAGTCTTAGTTCACAGTGAAAGGAATGATGACTTTGAAATTATGGATTTATATTA ENST00000451333.1 ------GGTCTCA-CTGACAG---GGGCACAGAGGGCTCC-------------------- **** * * **** * * ** * ** ENST00000323303.4 ATGGCACTATAAACCAATGGTAATGGTAATTTTTAAACTTGCTAAATATTGAGAAACTAA ENST00000451333.1 -TGGCGCT--GGACAGATGG----GACACCATTCAACGCCGCCCAG--------AACAAA **** ** ** **** * * ** ** ** * *** ** ENST00000323303.4 ACTACTAAGTTAATAAATTATATATAGCAGTGTAGCTGTTCTCTCTAGATGGTGTCTCAC ENST00000451333.1 GC--GTGAGTC--TAGCCACCATCTGGC------GCTGTCC----CAGGCACTGTCTT-T * * *** ** ** * ** ***** * ** ***** ENST00000323303.4 AATGGATTTCTGTTGCTTGACTATTTTCTTAGTGAATATTTATACTAAGGTAGTGACTGA ENST00000451333.1 GGTGGA---------CCTAGCTACACACTGTGTGTCCCTTCCCAGTAAG----------- **** * * *** ** *** ** * **** ENST00000323303.4 GATTTGGTGATCTGGCTGAGTATTTTGAAACACATTTTGAATAATATGGCTTAGTGTTAA ENST00000451333.1 ----TGGTAGT---GTTGTGTGT------ATATGTGT-GTGTGACGTG-TGTGGTGTGTA **** * * ** ** * * * * * * * * ** * **** * ENST00000323303.4 CGGGGACTTAAATATGATTTTTTTTTCTTACTCATTTCACCTTCCCTGTACTGTATGTTT ENST00000451333.1 TGTGG-TGTATGTGTGGTGTGT-------------------------GTGCCATGTATGT * ** ** * ** * * * ** * * * * * ENST00000323303.4 GGAATTGATCATAAAACATCTCCAAAAGAAAATAATCAGTTTGTAGTCTTGCTTTTGTAT ENST00000451333.1 GGCATG---TGTAATGCAT------------GTGGT--GTGCGAGGTGTATGTGTGGTAT ** ** *** *** * * ** * ** * * * **** ENST00000323303.4 TCATGTTGATAATCTTACTAATTGTGAAGTTGATTCACTACTATACTAGGTAAGACCTAA ENST00000451333.1 GTGTGT-GATG-----------TGTG---------------TGCGTTTGG--ACACACAG *** *** **** * * ** * ** * ENST00000323303.4 GTGAAACAGTTCCTGTTTTTCCTTAATACTGTTTTCAGAATTTTGAAAATGTACTTATAT ENST00000451333.1 GTG---TGGTC----------------ATCGCTCTCA----CCTGGA------CTCCT-- *** ** * * * *** ** * ** * ENST00000323303.4 ATACATAAATACTACTAAAAAATTAATGAGCCTGGCAAACCATTGATTTATAAAAGTAAG ENST00000451333.1 -----------CCAC-AGAGGGTCA----------------------TTAGGAAAGGACA * ** * * * * *** **** * ENST00000323303.4 TGTTCTAAGAGGGGAACAAGACAGTTCTGTGTGATAAGGAAGTTAGGCTCCACTTTTTGT ENST00000451333.1 GGTCCTGAGGCTGGCA-------------TGCAGCCAGTGAGT--GGGTC---TTTCTGT ** ** ** ** * ** ** *** ** ** *** *** ENST00000323303.4 TTGAATTACCCTATGTATATCCGAAGGTAAACTTAGGCTTTTCTTTCCAAAAGATCGTAT ENST00000451333.1 TTT--TTTCCCCCTGC----CCTA-------CTCAGGCCTG--GTTCCAAGGGATCCT-- ** ** *** ** ** * ** **** * ****** **** * ENST00000323303.4 AGTCAATTCATTCTTTTTCTC-CTATCACATCTGGGAAAGTAGCTAACTTTTAACTATTT ENST00000451333.1 -GCCCACTCAGAAAGTATATTATTGTGAATTCTGGGATGGGAGCTTGC----AGCT---- * * * *** * * * * * * ******* * **** * * ** ENST00000323303.4 ATGTTCCCATAAGTAACCCTTCTTTTGTGTGTATACATTTCCTTTTCTCTGACTTGAGAT ENST00000451333.1 ------TCATAGACACCCCTCCCTGTCCCTGGATCC---------TCAGTAACT-AAGA- **** * **** * * * ** ** * ** * *** *** ENST00000323303.4 GTCAAATTTGGATTTCTAGAACAGTTTCTCAGTTAAATTCTTGATGACTTAACAACTTTT ENST00000451333.1 GC--AACCTGAG---CACAGACA--CCCTCAGGGTACTCCTT------CTCCCAGCC--- * ** ** * *** ***** * * *** * ** * ENST00000323303.4 ACTATCAGAATACAATTAGAAATCCTTGGTCAGGCACAGGGGCTCACGCCTGTAATCCCA ENST00000451333.1 -CTGTCCTCATCC---TAGGGCCACTAGG---GGATGAAGGACCCAT--CTCAAGTC--A ** ** ** * *** ** ** ** * ** * ** ** * ** * ENST00000323303.4 GCACTTTGGGAAGCCAAGGCAGACAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGA ENST00000451333.1 GCTCCCT-------------AGAC---TCATCCCATGTCAG---CTCCCTAGGAGCCACA ** * * **** *** * * ***** ** * **** * ENST00000323303.4 CCAACATGGAGAAACCCTGTCTCTA-CTAAAAATACAAAAATTAGCCGGGCGTGGTGCTA ENST00000451333.1 GCACCAGGAAGGGATGCTGCCTTCATCTAACAGTATAAA---------GCCCTGTTG--- ** ** * ** * *** ** * **** * ** *** * * ** ** ENST00000323303.4 CTCGTGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGTGGAGGTTGCGGTGAGCTG ENST00000451333.1 -TCTTCGGGTTTTGGGAAAAGAATC-----AGTCTGACAACTGG------CGGCA---CA ** * ** * ** * ****** * * * * *** *** ENST00000323303.4 AGATCGTGCCATTGCACTCCAGCCTGGGTAACGAGCAAAACTCCGTCTCAAAAACTCCGT ENST00000451333.1 AGAATGGGCAG----ACTGAAGACTGTGT------CCAAATTCAG---CAGAAGT----- *** * ** *** ** *** ** * *** ** * ** ** ENST00000323303.4 CTCAAAAAAAAAAAATCCTTGAT-TACATTGTTAGTAAGGACTGTGTTACGA--TTATAA ENST00000451333.1 ---GGAATGACATGACCTGTGACACCCCCTATCAGTGGG---TGTGCAAGAAGCCCATGG ** * * * * *** * * * *** * **** * * ** ENST00000323303.4 ACACATTTATTGGTTGATGTCAAATTCACTGTAATAGTAGAACTAAGTTTTTTATGTGAG ENST00000451333.1 GCCAGGGTGTGGCCTGAGGGCAGG----CCAGAGCTGAGGGGCTGC-TCCTGCTTGCCAA * * * * *** * ** * * * * ** * * ** * ENST00000323303.4 TACTTTGCCCTACTGTCTATATGATGACATCTTTTTTGAGCAGCTAAATTTTAAATTGTA ENST00000451333.1 TACTG-ACCCTCCT-CCT---CGATGCC-----TTCGGAGCCTCTGAGCTCTG------- **** **** ** ** **** * ** **** ** * * * ENST00000323303.4 TATACTTTATTTTGTGAATCCTT--GTTGAATGTGCTAAAGGTTTCTTTGTGTAGTTCTT ENST00000451333.1 -----CTTGTTCTCTGGGACCTTCCGTTGG---------------CCTTGTGGA---CTT ** ** * ** **** **** * ***** * *** ENST00000323303.4 CCATGCTATGCGAATATTTTAGTAAAAGTAGTTGATTTTTA ENST00000451333.1 CC-TGCCTTG------TTCT--------------------- ** *** ** ** *