CLUSTAL 2.1 multiple sequence alignment ENST00000329271.3 TGTCCGGAAGTCCTGAGAGGGAAACGCCCGCAAAGGCTGGTTTTTAAGCGGGAGCATCTC ENST00000448626.1 ------------------------------------------------------------ ENST00000329271.3 TTCACTCGCAGCAAGTGCGCGTGCGCTGCCTCTCAGCCCAAATTGGAAACATGGCCGTAC ENST00000448626.1 ------------------------------------------------ACATGGCCGTGT ********** ENST00000329271.3 GGTCGCTGTGGGCGGGCCGGCTGCGGGTGCAGCGCCTACTGGCCTGGAGTGCCGCGTGGG ENST00000448626.1 GGTCGCTGTGGGTGGGCAGGCACCAGGTGCAGCACCTACTGGCCTCGAGTGCCTTGTAGG ************ **** *** * ******** *********** ******* ** ** ENST00000329271.3 AGAGCAAGGGATGGCCGCTTCCATTCAGCACTGCCACCCAGAGAACTGCTGGTGAGGACT ENST00000448626.1 AGAGCAAGGGATGGCCGCTTCCATTCTGCACGGCCACCCTGATAACTGCTGGTGTGGACT ************************** **** ******* ** *********** ***** ENST00000329271.3 GCCGTTCTGAGGACCCTCCTGATGAGCTTGGGCCCCCTCTTGCTGAACGAGCCTTAAGGG ENST00000448626.1 GCTGTTCTGAGGACGCTCCTGATGAGCTTGGGCCCTCTCTTGCCCAACAAGCCTTAAGGG ** *********** ******************** ******* *** *********** ENST00000329271.3 TAAAAGCTGTTAAACTGGAGAAAGAAGTCCAAGATTTAACAGTGAGATACCAGAGAGCTA ENST00000448626.1 TAAA-GCTGTTAAACTGGAGAAGGAAGTCCAGGATTTAACCATGAGATAGCACAGAGCTG **** ***************** ******** ******** ******* ** ****** ENST00000329271.3 TAGCTGATTGTGAAAACATAAGGAGGCGAACCCAGAGATGTGTGGAAGACGCCAAGATAT ENST00000448626.1 TAGCTGATTGTGAAAACATAAGGAGGCAAACCGAGAGATGTGTGGAAGATGCCAAGATA- *************************** **** **************** ********* ENST00000329271.3 TTGGAATCCAGAGTTTCTGTAAGGACTTGGTGGAGGTGGCTGACATTTTGGAGAAGACTA ENST00000448626.1 ----------------------------------GGTGGCTGACATTTTGGAGACGACTA ******************** ***** ENST00000329271.3 CAGAGTGCATTTCTGAAGAATCGGAGCCTGAGGACCAAAAGCTCACTCTGGAGAAGGTCT ENST00000448626.1 CACAGTAAATTTCTGAAGAATCAGAGCCTGGGAACCAGAAGCTCACTCTGGAGAAGGTCT ** *** ************** ******* * **** ********************** ENST00000329271.3 TCCGAGGGTTGTTGCTTTTAGAAGCAAAGCTGAAAAGTGTGTTTGCCAAGCATGGCCTGG ENST00000448626.1 TCCGAGGGTTGTCACTTTTAGAAGCAAAGCTGAAAAATGTGTTTGCCAAGCATGGCCTGG ************ ********************** *********************** ENST00000329271.3 AGAAACTGACACCCATTGGTGACAAATATGACCCCCATGAGCATGAACTCATCTGTCATG ENST00000448626.1 AGAAGCTATCACCCATTGGTGACAAATATGACCCCCAAGAGCATGAACTCATCTGTCATG **** ** **************************** ********************** ENST00000329271.3 TGCCAGCTGGTGTTGGGGTGCAGCCTGGCACCGTGGCATTAGTAAGACAAGATGGCTACA ENST00000448626.1 TGACAGCTGCTGTTGGGGTGCAGCCTAGCACCGTGACATTAGTAAGACCAGATGGCTACA ** ****** **************** ******** ************ *********** ENST00000329271.3 AACTTCATGGCCGCACCATTAGGCTTGCCCGAGTGGAAGTGGCAGTGGAGTCTCAGAGAA ENST00000448626.1 AACTTCATGGCTGCACCATTAGACTTGCCCGGGTGGAAGTTGCTGTGGAGTCTCAGAGAA *********** ********** ******** ******** ** **************** ENST00000329271.3 GACTGTGAAGAGGCCATCAGGAACTGGATGTTCTCCCAGAGCGCAGTCACCTATGTTTCT ENST00000448626.1 GACTGTGAAGAGGCCATCAGGAACTGGATGTTCTCCCAGAGTCCAGTCACCTATGCTTCT ***************************************** ************ **** ENST00000329271.3 TTTATTTATTAAACTAGGTTTGTATTGTACATGAGGTACTTCATGTGATATGTTTTGGAT ENST00000448626.1 TTTATTTATTAAACTAGGTTTGTATTGTACATGAGGTACTTCATGTGATATGTTTTGGAT ************************************************************ ENST00000329271.3 TTAGTCATATTGGCTTTATTTCTAAGATATTCTATTGATTTAATGTGACCTGTTTGGTCT ENST00000448626.1 TTAGTCATATTGGCTTTATTTCTAAGATATTCTATTGATTTAATGTGACCTGTTTGGTCT ************************************************************ ENST00000329271.3 CATCAGAAGTCTTACCATTGGGCATTTGAACAGTGTGACAGGTGTTCCAATGGCCTTTAT ENST00000448626.1 CATCAGAAGTCTTACCATTCGGCATTTGAACAGTGTGACAAGTGTCCCAATGGCCTTTAT ******************* ******************** **** ************** ENST00000329271.3 CAAAACATGTTTAGGAAAATTGGTACTGTGATAAATTTGAATCCAAAATCCTTTTAACTA ENST00000448626.1 CAAAACCTGCTTAGGAAAATTAGTACTCTGATGAATTTGAATCCAAAATCCTTTTAACTA ****** ** *********** ***** **** *************************** ENST00000329271.3 TGGGTTTTCAACTACATGTTTCTTCCTAGCGGTCTCTATAACAGGAATTGTGTAGTATCT ENST00000448626.1 TATGTTTTCAGCTACATGTTCCTTCCTAGTGGTCCCTATAACAGAGAGTGTATAATATCT * ******* ********* ******** **** ********* * *** ** ***** ENST00000329271.3 TGTATTTTGTGGAAAAAGGAGATGGTAGGGATTGGTTCAACATTTGGGTACTTAGAGGAT ENST00000448626.1 TGTATTTTGTGGAAAAAGGAGATGGCACGGATTGGTTCAACATTTGGATACTTAGAGGAT ************************* * ******************* ************ ENST00000329271.3 AAAGCTTCGTGGTCGTATAAATTTAGATCATTTGGATTGATTTTTATACACATAGATT-- ENST00000448626.1 AAAGCTTCATGGTTGT--AGATACAGA-CACAAAGAACC-CTTCAAAAAAAATCAATGAA ******** **** ** * ** *** ** ** ** * * * ** ** ENST00000329271.3 TTCAGGACTTTACCTTTTGTTTTGTTTTTTTCCTTTTAGCCATCTTTTGTTCTTGTAATC ENST00000448626.1 TCCAGGA----------------GCTGGTTTTTTTTAAAGGAT------------TAA-- * ***** * * *** *** * ** *** ENST00000329271.3 CCAACTAGATAGGCTTTATGCTCACATCATTGTCCCATACCCACCCCTTTCTCATCCCCA ENST00000448626.1 CAAAATAGATAGACT-----------------------ACTTGCC--------------- * ** ******* ** ** ** ENST00000329271.3 TTTGCAGGGGCTAAAGGTCTAGATGAGACTTGGAAGGCAAGGAGCATCGAAATTTGAGAT ENST00000448626.1 -------AGACTAA-----TAAAGAAAA----AAAGACA-GAAGAATC-AAAT---AGAC * **** ** * * * *** ** * ** *** **** *** ENST00000329271.3 ACCCAGGACCCTTTCAAGCAAGAATGGCCAAAAAGCCTTGTGCTGTCTTTGCTCTTCAAA ENST00000448626.1 AT--------------AACAAAAAATGATAAAAGGA---ATATCACCACTGATCC-CACA * * *** ** * **** * * * ** ** ** * ENST00000329271.3 TTATTTTCAGCCTCCTTGTCATATAATCATTTCAGGCAAACTGAGGCAACACTAACAGCT ENST00000448626.1 GAAATACAAACGACC--ATTAGAGAAT-ACTATAAACACCTCTATGCAA-ATAAACTAGA * * * * ** * * * *** * * * ** * **** * *** ENST00000329271.3 AATGACCCAGATGGCTCTATTTGGGTAATTTACCTACAACTTATTCCACCAGCCTTTACT ENST00000448626.1 AA--ATCCAGAAG-----AAATGGATAAATT-CCTG-GACACATAC-ACC--------CT ** * ***** * * *** *** ** *** ** ** * *** ** ENST00000329271.3 CCTCTGCCCTTTTGTCAATTTTACCTTATAATCCTTTATTAAATGATGGGAGGTGGTGAT ENST00000448626.1 CC-------------CAA----------------------GAATAA------------AC ** *** *** * * ENST00000329271.3 CAGGACAAAAGTGTTAGGTTCCCATGATTTCTCATTTCATTTATTAATAGTTAATGCTGA ENST00000448626.1 CAGGAAGAA---GTCAAATCCCTAA-------------ATAGACCAATAACAAGTTCTGA ***** ** ** * * ** * ** * **** * * **** ENST00000329271.3 ATTTTTTTTTAAGTTTCCTCTGGCTCTATTTATGTTACTTTTTGCGATAAGAACACTTAA ENST00000448626.1 A--------------------------ATTGAGGC----------------AGTACTTAA * *** * * * ****** ENST00000329271.3 CATAAGTATTCTCTCCTCTTGGCAATTTTTTTTTTTTTTCCTGTGTTGCCCAGGCTGACC ENST00000448626.1 TA---------------------------------------------GCCTA-------- * *** * ENST00000329271.3 TCCAACTCCTGGGCCCAAGCAATCCTGCCTCAGCCTGCCAAGTAGCTAGGACTACAGGCG ENST00000448626.1 -CCAAC---------CAAAAAAA---AGCCCAG------GAACAGACAGATTCACAGCCG ***** *** ** * *** * ** ** **** ** ENST00000329271.3 TTCACCACTGCGCCCGCAAAGTTTTTTTGTTGTTTTTTTTTTTAAGTTGGTACTCACAAA ENST00000448626.1 AATTCTACCAGAGGTACAAAGAG--------------------GAACTGGTAC------- * ** ***** * ****** ENST00000329271.3 TCACTACCTCTGTTATATTGACAAGCTCTATTTCCTATTCTTTGTATCTGTTAAGTCACA ENST00000448626.1 -CATTCCTTCTG----------AAAC--TATTCC------------------AAACAATA ** * * **** ** * **** * ** * * ENST00000329271.3 TCTGTGTAAACATTGAGCTCACCTTTTATATATTAACCTCTAGAATTAATGGGCCTATGT ENST00000448626.1 -----GAAAAAGAGGGACTC-----------------CTCCCTAACTAAT---TTTGTGA * *** * *** *** ** **** * ** ENST00000329271.3 GGTTTTTTTTCAGTCTTATAGCTGGTGTTCTGTAAAAGATTTGTCCAATAAACGACTTAA ENST00000448626.1 GG-------CCAGCATCATC-CTGATACC------AAAACCTGGCAGA-----GACATAA ** *** * ** *** * ** * ** * * *** *** ENST00000329271.3 TGAATGATACATCAGTCAGATTTTAGGAAGGCAGTCAATTATGGATATTTTAATGTTGGA ENST00000448626.1 CAAAAAAGA--------AAATTTCAGG----------------------CCAATAT---- ** * * * **** *** *** * ENST00000329271.3 AGAGGCCTTAATGATCAAATCTCACCCTTTCTGCTTCTGAAGTATGAAAATCTAGTCTTT ENST00000448626.1 -----CCCTGATGA------------------ACTTC---GATGTGAAAATC----CTC- ** * **** **** * ******** ** ENST00000329271.3 TTAGGACTGGACACAAGGAAAATAATCTCTAAACTATTGACTAAATTCCAGTGAGAGTAT ENST00000448626.1 ---------------AATAAAATACTCGCAAAA--------TGAAT-CCAGT-AGCACAT * ****** ** * *** * *** ***** ** ** ENST00000329271.3 GAATGAAGAACAACTAGATATTAATGTCAATCATTTAAGATTAATGGGCATGCAATTAAG ENST00000448626.1 CA-----GAA-AGCT---------TATCCACCAC--GAGA-------------AAGTTGG * *** * ** * ** * ** *** ** * * ENST00000329271.3 TCTCCATTTAAGATTAATGGGCATGCAATGAAGTCTCCAGCAGACAATCAGATGTTGTTG ENST00000448626.1 CTTC--------ATCCCTGGG-ATGCAAGGGTGGTTCAA---------CATATGC----- ** ** **** ****** * * ** * ** *** ENST00000329271.3 GATGTCTAGATTATATAGGTTTAGGTTGAAGTTATAAAATAAAATAAAATTCATTTTCCA ENST00000448626.1 -------AAATCA-ATAAATGTA------ATCCATCACATAAA-CAGAACCAATG----A * ** * *** * ** * ** * ***** * ** ** * ENST00000329271.3 CTGGAACTCTATGACATTCAGTGGAGTGGTGGAAAGTTAACCTCTTATACATTATAGATA ENST00000448626.1 CAAAAACCACATGA----------------------TTA---TCTCA------ATAGAT- * *** **** *** *** * ****** ENST00000329271.3 ATTCTAAGACAGCACACAAACTTATCAATAAAGCCATCTCCTTGTGGGCCTTACCATCTT ENST00000448626.1 -----------GCAGAAAAGGCCTTCAATAAA---ATTT-------GAC---ACC-CCTT *** * ** ******** ** * * * *** *** ENST00000329271.3 CATCAGATTTAGACCCTTAAAAAACAAGTAAATATGCACTTTTAAAATGCAA-TCAAAAG ENST00000448626.1 TAT--GCTAAAAACTCTCAATAAACTAG-------GTATTGATGGAACATATCTCAAAAT ** * * * ** ** ** **** ** * * * * ** * ****** ENST00000329271.3 ACTGGTGGTTAAGCTTGTAAAACCAGAACATCTTTTGGCATTCCACTAAGTATATATTGT ENST00000448626.1 AATAAGAGCTA----TTTATGACAAG---------------CTCAC--AGCCAATATCAT * * * ** * ** ** ** *** ** **** * ENST00000329271.3 AAATTTAATGAACAATCAAGGTTCACAATAGGAAGTTGTCTTTTTTTGCCTTCCATTCTG ENST00000448626.1 A--CTGAATGGGCAAA----------AACTGGAAG-------------CATTCCCTT--- * * **** *** ** ***** * **** ** ENST00000329271.3 TGAGATTTGACAGATGGTGACAATAAGAAAATGAGCTGATTGTAATTACTCTCTGTGTGT ENST00000448626.1 TGAAAACTGGCA--------CAATGCAAGGATG-----------------CCCTGT---- *** * ** ** **** * *** * **** ENST00000329271.3 TTTTTTATTGCTAGCTATCATTACCAGTTAGAATTAACATTAATTACAATTAACAATAAT ENST00000448626.1 ---CTTACCACTC-CTAT---------------TCAACAT-AGT----ATTGG----AAG *** ** **** * ***** * * *** ** ENST00000329271.3 TTTAGGTATGGAATGTTATGATTACCTAAAGAGATGTCTCTACCTAATGAGCTCAAGTGA ENST00000448626.1 TTCTGGCCCGGGCAATCAGGC-------AAGAGA------------AAGAAATAAAG-GG ** ** ** * * * ****** * ** * *** * ENST00000329271.3 TCCTCCCACCTCAGCCTACCAAGTAGCCAGGACCACAGGCAAGTGCACCACCATGACTGG ENST00000448626.1 TATTC---------------AAAT----AGGAAGAGAGG-AAGT-------CA-AACTG- * ** ** * **** * *** **** ** **** ENST00000329271.3 CTAGTTTTGTTTTTTGGTTTTTGGTTTTTGGTTTTTGGTTTTTTTTTTTTGGTTGGT-TG ENST00000448626.1 ---------------------------------------TCTCTGTTTGCAGATGACATG * * * *** * ** ** ENST00000329271.3 GTTGTTTTTTACAGGCGGGGTCTCACTATATTGTCCAGGCTAGAAGAATTTTCTAATGGT ENST00000448626.1 ATTGTATATT-TAG--AAAACCCCATCATCT----CAGCCCAA---AATCTCCTTAAG-- **** * ** ** * ** ** * *** * * *** * ** * * ENST00000329271.3 CTATTACACCTCCCGTTTTGGCAAGTAAATTCAGAATAATTTTAGGTTCTTTTGTTATTC ENST00000448626.1 -----------------CTGATAAGCAACTTCAGCAAAGTCTCAGGAT------------ ** *** ** ***** * * * * *** * ENST00000329271.3 AGTAGTTTTGCAGACTTAAAAGTGTAAATTTAGAATTAGAAGATGAAGCTATAGTAGTAA ENST00000448626.1 ---------ACAAAATCAAT-GTGCAAA-----AATCACAAGA-ATTCCTATA-CACCAA ** * * ** *** *** *** * **** ***** * ** ENST00000329271.3 GAATCTCAAGCTGAAGGGCTTTGGGGAGCCAAAGCAGCATATTAGAGCATAGGCTTGAAC ENST00000448626.1 CAAT---AGACAGA-----------GAGCCAAAT-----TATGAG----------TGAAC *** * * ** ******** *** ** ***** ENST00000329271.3 TTAAATCTCAGCTCAGTCACCTGCAGGACTTTAGGCACCAGTGATTTCACCCTTCTGAGC ENST00000448626.1 T----------CCCATTCAC------AACT----GCTACAAAGA------------GAA- * * ** **** *** ** ** ** ** ENST00000329271.3 CTGTTTCTTTATTCGTAAAATGATTATAATAATTCTTTCACAGCGTTGTGAGGATTAAGT ENST00000448626.1 ---------------TAAAATACCTA--GTAATCC------AAC-TTACAAGGG------ ****** ** **** * * * ** *** ENST00000329271.3 GAAATGTGTTAAATGCCTACTACAGTAGGTGCTCAGATATTTATTTTTATTTTTTTATTA ENST00000448626.1 ---ATGTG--AAGAACCT-CTTCA--AGG-----AGA-------------------ACTA ***** ** *** ** ** *** *** * ** ENST00000329271.3 TGCACATTGTTTTTCCTGCCTTTTTATGGCTGTCTAAAGTCTAGGGAAAAGGGAAGACTG ENST00000448626.1 CAAACC----------------------ACTGCTCAAGG---AAATGAGAGAGAACAC-- ** *** ** * * * ** *** ** ENST00000329271.3 GTTAATGATGAGTAGAAAAAACTTGTAAGCTAATCATTCACTGACTTATTTTCCTTCCAT ENST00000448626.1 ---AA--ACAAATGGAAAAA--------------------------------CATTCCAT ** * * * ****** * ****** ENST00000329271.3 TTTCTGGTTTTTAAAATTAGCCACACCACAGGAAACCCACATTTTTAGATGGAAAGAGCA ENST00000448626.1 CCTCATG-------AAT----------ATGAAGAACCAATAT----------------CA ** * *** * **** * ** ** ENST00000329271.3 AGAAAATTGTGTCAGTGCTCTTAGTTATTTTCATCTTAATGGTATAGTGAAAAGACATTG ENST00000448626.1 TGAAAATGGCCATACTGCCCAAAGTAATTT-------------ATAG---------ATT- ****** * * *** * *** **** **** *** ENST00000329271.3 ACTTGAGATGATACTAAGGAAGCTTTGGCTCACTCTCACTTGAAGAGGGGATCTTGGTGT ENST00000448626.1 --------CAATGCTA-------------TCCCCATCA---------------------- ** *** ** * *** ENST00000329271.3 TGTAGTACTTGGACTGTACAAATGTTTTACTGACTTTTCTTACTGCTGTAAAGGAATCAG ENST00000448626.1 ---AGT----------TAC--------CACTGACTTTCTTCAC---------AGAATTAG *** *** ********* * ** **** ** ENST00000329271.3 GCAGTTGGGTATTGATATGTTATTTGGTGCTCTCATTCATGGCAAAGGATTTGATAAATA ENST00000448626.1 ---------------------------------------------------------AAA * * ENST00000329271.3 AAAGTTCTTTAAACACTAAAGCAAAATCAAATGAGCAAAACTAAGGATGAAATGTAATAT ENST00000448626.1 AAACTACTTTAAATT-----------TCATATG----GAACCAAAAAAGAGGCCCTATA- *** * ******* *** *** *** ** * ** *** ENST00000329271.3 TCATCAGAACAAGGATCACTGAGAAAAAATATTCAGAAACAACTTTAATAAAACCTGAAT ENST00000448626.1 --ACCAAGACAA---TC-CTAAGCAAAAAGA----------------ACAAAACTGGA-- * ** **** ** ** ** ***** * * ***** ** ENST00000329271.3 TGAAATAACTGCA ENST00000448626.1 -GGAATCA-TGC- * *** * ***