CLUSTAL 2.1 multiple sequence alignment ENST00000331923.4 CTCTCTCTCTTTCTCCAAGTATTGAGAGCGCGTGGGAGCATAGGCGCATG-CGCGCTCGT ENST00000449315.1 ------------------TTATGGAGAATGAGAAGAACTTTAGATG-ATGATGTATTCAT *** **** * * * * *** * *** * ** * ENST00000331923.4 GGGGTGCGCGGTAGCAACAGAGGACTCGACCCGGCTGGAGCTCCGGAGAGCGCGCGTGCG ENST00000449315.1 G----------------------------CCCTTCTA----TTCAAAAAA------TGTC * *** ** * * * * ** ENST00000331923.4 CCGTCACGAGCTCGGCGCTGCCGGGGCCGCGGTGTGGAAGCGAGTATTCGACCGCCGTGC ENST00000449315.1 TTAGTAAAAATTCTA---------GGTCTTTTTTT-----------TTCAATAACTGTTT * * ** ** * * * *** * * ** ENST00000331923.4 GGGCCGCGGGGATGTTCCGAAAGGC-CCGGCGGG-TGA-ACGTGCGCAAGCGGAACGACT ENST00000449315.1 G----------ATCTTCTATAAAACTCCAGTGGAATGGCATTTTCTCAAATAAAACTCTT * ** *** ** * ** * ** ** * * * *** *** * ENST00000331923.4 CCGAAGAGGAAGAGCGGGAACGCGATGAGGAGCAGGAGCCGCCGCCGTTGTTGCCGCCGC ENST00000449315.1 CT----AGAATTACCAATAA----ATGATTTACTAGATACATTCCTATGACTTTT----- * ** * * * ** **** * ** * * * * ENST00000331923.4 CGGGCACGGGCGAAGAGGCGGGCCCCGGTGGCGGCGACAGGGCCCCTGGCGGGGAGTCGC ENST00000449315.1 ----TAGAATTCAGGATATGGAAAT-GACAGCATCAACAAAGCCC-------AAAAT--- * * ** ** * ** * *** **** * * ENST00000331923.4 TGCTGGGCCCGGGGCCGTCGCCGCCTTCC---GCGCTGACCCCGGGCCTCGGGGCTGAGG ENST00000449315.1 ----------GTAACCA--ATTGCTTTCCCAAACAGTGGCTT--AGCTTTGGAGAGAAG- * ** ** **** * ** * ** * ** * ** ENST00000331923.4 CCGGGGGCGGCTTCCCCGGCGGCGCGGAGCCCGGCAACGGGCTGAAGCCGCGCAAGAGGC ENST00000449315.1 ---AAAACTAATTCTCAGTTAG---AAAACTTGTCAATACCTTGTATACTTGTACAA--- * *** * * * * * * *** ** * * * * * ENST00000331923.4 CTCGCGAGAACAAAG--AGGTGCCCCGGGCCAGCCTGCTCAGCTTCCAGGACGAGGAGGA ENST00000449315.1 TTTACAAAAACAGTGTTAGGTGCTCTGGTCT-----------------------GGAAAA * * * **** * ****** * ** * *** * ENST00000331923.4 AGAAAATGAAGAAGTTTTCAAAGTGAAGAAATCAAGTTATAGCAAAAAGATAGTAAAATT ENST00000449315.1 GAGAAATGCAGGGG------------AAAAAT---------GCAA-------GTAAAACT ***** ** * * **** **** ****** * ENST00000331923.4 GCTCAAGAAGGAATATAAAGAAGATCTTGAAAAATCGAAGATTAAGACAGAACTCAACTC ENST00000449315.1 ------------------------CCTTGCAA--TTG---------------TTCAAGCC **** ** * * **** * ENST00000331923.4 ATCAGCTGAAAGTGAACAACCTTTGGACAAAACAGGACATGTTAAGGATACAAATCAAGA ENST00000449315.1 -----CTGGGTATTGCTATCTCTTG-------CAAG---TGTGAAAGA----ATTTAAGA *** * * * *** ** * *** ** ** * * **** ENST00000331923.4 AGATGGAGTTATCATCAGTGAACATGGTGAAGATGAAATGGATATGGAAAGTGAAAAAGA ENST00000449315.1 ---------TTTTATTAAGGA-------------GAAATAGATCT-----------ATGA * * ** * ** ***** *** * * ** ENST00000331923.4 GGAAGAAAAGCCAAAGACTGGTGGAGCTTTTTCAAATGCTTTATCTTCATTGAATGTTCT ENST00000449315.1 GACCGAAGAGCCTATTATTTG-----CTTT----GAT--TTTATTTTCAGTATATGCATT * *** **** * * * * **** ** ***** **** * *** * ENST00000331923.4 TCGTCCAGGAGAAATTCCAGATGCAGCTTTTATACATGCTGCAAGGAAAAAGCGCCAAAT ENST00000449315.1 GTGTACA----------TATATAAAG--TTTAT-TAAGCTGTAA-------------AAT ** ** * ** ** ***** * **** ** *** ENST00000331923.4 GGCCCGAGAATTGGGAGATTTCACTCCTCATGATAATGAGCCTGGTAAAGGCCGCCTTGT ENST00000449315.1 A--CTGATTCTTGT----TTTGAC--------ATGAAGAGTCTTATTG---------TAT * ** *** *** ** ** * *** ** * * * ENST00000331923.4 TAGAGAAGATGAGAATGATGCCAGTGATGATGAAGATGACGATGAGAAACGCCGGATAGT ENST00000449315.1 TAAAAAATGTGAGAGTT-------------TAAAG----------GGAACTCCTAATCAT ** * ** ***** * * *** * *** ** ** * ENST00000331923.4 TTTTTCTGTGAAAGAAAAGTCACAAAGACAAAAAATTGCTGAGGAAATAGGAATTGAGGG ENST00000449315.1 TTATTC--------------------------------CTGAGAATGAATGAAT------ ** *** ***** * * **** ENST00000331923.4 GAGTGATGATGATGCTTTAGTAACTGGAGAACAGGATGAAGAGCTCAGCCGATGGGAACA ENST00000449315.1 --GTAATCAGCA-ACTTTTGTCCCTAGTTA-CAGC-TGAAGAA--TGTTTGATAGT---- ** ** * * **** ** ** * * *** ****** *** * ENST00000331923.4 GGAGCAGATAAGGAAAGGAATTAATATCCCTCAGGTTCAAGCCAGTCAACCCGCAGAAGT ENST00000449315.1 -GGGCAGAGAAG-----------ATAT------GATTTAAG------------------- * ***** *** **** * ** *** ENST00000331923.4 GAATATGTACTACCAGAACACTTACCAGACAATGCCTTACGGCTCATCCTATGGCATTCC ENST00000449315.1 ------ATATTGGGAAAAGACACACTGGGCAGT---------------TGAGGGTAGTCA ** * * ** ** ** * ** * * ** * ** ENST00000331923.4 TTATAGTTATACGGCCTATGGATCATCAGATGCCAAATCTCAAAAAACAGATAATACAGT ENST00000449315.1 GGAAAAGCA---GGCTTGTG------CAGAGG--GAG----AAAGGGAATGTAATATGAA * * * *** * ** **** * * *** * ***** ENST00000331923.4 CCCTTTCAAAACTCCCAGTAATGAGATGACTCCCGTTACTATTGATTTGGTAAAGAAACA ENST00000449315.1 TACTTT------TCCAAATGA--GGATGTCTCC--TTTCTA---------------GACA **** *** * * * **** **** ** *** *** ENST00000331923.4 GCTTAAAGACAGGTTGGACTCCATGAAAGAATTGCACAAAACAAATCGACAGCAGCATGA ENST00000449315.1 TCTTT---GCAG--------CCAC---ACAATTTAACACAGCAAATTTGCA--TGTTTAG *** *** *** * **** *** * ***** ** * * ENST00000331923.4 GAAACATCTGCAAAGCCGAGTGGACTCTACCAGGGCTATTGAAAGAT-TAGAAGGGTCTT ENST00000449315.1 AAAGTATTTATTGAGTTGAAT------TACAA-------TGAAAAATATAGAAGAGATCC ** ** * ** ** * *** * ***** ** ****** * ENST00000331923.4 CTGGGGGTATTGGTGAACGGTATAAATTTTTGCAAGAAATGCGAGGGTATGTCCAAGACT ENST00000449315.1 CAAGAGATACTT--------TGCCTATTTT-------AATCCTAGGATTGATCCCAAATT * * * ** * * ***** *** * *** * *** * * * ENST00000331923.4 TGCTTGAGTGTTTCAGTGAAAAGGTGCCACTGATTAATGAACTTGAATCAGCAATACATC ENST00000449315.1 -----------------GTAAAGGC-CCA--GACAGGTGGACTC---------------- * ***** *** ** ** *** ENST00000331923.4 AGCTGTACAAACAGCGAGCTTCCCGCCTTGTCCAAAGACGACAAGATGATATTAAAGATG ENST00000449315.1 --CTGTGCTGGCTG--------------TTTCCATGGGCT-------------------- **** * * * * **** * * ENST00000331923.4 AATCTTCGGAGTTTTCAAGCCATTCAAACAAAGCTCTGATGGCACCAAATCTTGACTCCT ENST00000449315.1 --CCTCTGCAGGCTCCAGGAC-TTCAGA-AATGCCCTGGAAG----AAACCCTGACCC-- ** * ** * ** * * **** * ** ** *** * *** * **** * ENST00000331923.4 TTGGACGCGATCGGGCACTGTATCAAGAGCATGCAAAACGTCGCATTGCAGAGCGGGAGG ENST00000449315.1 --------GA---AGAACTCCATCA----------------CTCATC------------- ** * *** **** * *** ENST00000331923.4 CCAGGAGGACTCGTCGTAGACAAGCCAGAGAACAAACCGGTAAGATGGCAGATCACCTTG ENST00000449315.1 --------ACTCATTG--GACAA--CAGAGG----------------------CTTCTTG **** * * ***** ***** * **** ENST00000331923.4 AAGGCCTTTCCAGTGATGATGAAGAAACTTCTACAGATATTACTAATTTCAATCTGGAAA ENST00000449315.1 ATGTTTGCTGAAGTGATGGTGGGGTGA-----------------AAGCTCAACCT----- * * * ******* ** * * ** **** ** ENST00000331923.4 AAGATCGAATTTCAAAAGAATCCGGCAAAGTTTTTGAAGATGTCCTTGAAAGTTTCTATT ENST00000449315.1 --------ACTT-----------------------------ACCCTC------TTCTGCT * ** *** **** * ENST00000331923.4 CAATTGACTGTATTAAATCACAGTTTGAAGCATGGCGTTCAAAATACTACACATCCTACA ENST00000449315.1 TA------TGTGATAGAGCATGTGTTGAATCAGGCCATT---AAT--TTGGGGTCTTT-- * *** ** * ** ***** ** * * ** *** * ** * ENST00000331923.4 AAGATGCTTACATTGGCCTTTGTTTGCCAAAATTATTCAACCCCCTCATACGACTTCAGC ENST00000449315.1 ---GTTCTT---TCGGGTTATGTTTGATAAGAACATTT---------------------C * *** * ** * ****** ** * *** * ENST00000331923.4 TCCTCACTTGGACTCCTCTTGAGGCAA--AATGTCGTGACTTTGAGAATATGCTGTGGTT ENST00000449315.1 TCCTCATCTGGATTAACAGAGACACAAGCAATGCAGAAACCACTGGAAAAT-TTGTAG-- ****** **** * ** *** **** * ** *** ** *** * ENST00000331923.4 TGAATCTTTGCTGTTTTATGGTTGTGAAGAACGAGAGCA-AGAAAAAGATGATGTAGATG ENST00000449315.1 TGAAAGGTGGCT-TCTGATTCTTAGAAAGGACAGGGTTTTATAAATATTTAAGGTAGGTA **** * *** * * ** ** *** ** * * *** * * * **** * ENST00000331923.4 TTGCCCTACTACCTACCATTGTGGAAAAGGTGATTCTTCCTAAACTAACAGTGATAGCTG ENST00000449315.1 TAGACCT-CTCTCTCTC-----------------TCTTTCT---CTCTCTGT-----CT- * * *** ** ** * **** ** ** * ** ** ENST00000331923.4 AAAATATGTGGGACCCTTTTTCTACAACACAGACTTCAAGAATGGTGGGAATTACACTAA ENST00000449315.1 -------------CTCTCTCTCTCCCTCTC---TCTC--------------TCTCTCT-- * ** * *** * * * ** * * ** ENST00000331923.4 AATTAATCAATGGATATCCTTCAGTAGTGAATGCAGAAAATAAAAATACACAGGTATACC ENST00000449315.1 --CTCATC------TATCCATCATTTGTCCATAGAAAGGAAAGAGTTTTATAAGTAT--- * *** ***** *** * ** ** * * * * * * * * **** ENST00000331923.4 TAAAGGCACTTTTATTGAGAATGAGAAGAACTTTAGATGATGATGTATTTATGCCCTTAT ENST00000449315.1 TTAAGGTA--------------GGTAGAGACCTC-----------TCTCTCTCTCTTTCT * **** * * * ** * * * * * * ** * ENST00000331923.4 ATCCCAAAAATGTCTTAGAAAATAAAAATTCTGGGCCTTACTTGTTTTTTCAACGACAGT ENST00000449315.1 CTCTC-----TGTCTC-------------TCT----CTCTCTCCCTCTCTC--------- ** * ***** *** ** ** * * ** ENST00000331923.4 TTTGGTCTTCAGTTAAGCTGTTAGGCAATTTTCTTCAGTGGTATGGCATTTTCTCAAATA ENST00000449315.1 -----TCTCT-------CTCTCA------TCTATCCAT--------CATTTGTCCATAGA *** ** * * * * * ** ***** ** * * ENST00000331923.4 AAACTCTGCAAGAGTTATCAATAGATGGTTTATTAAATCGATATATTCTCATGGCTTTTC ENST00000449315.1 AAG----GAAAGAGTTTT--ATAAATA-TTTA--AGATAGGTATG-------GGCCTCTC ** * ******* * *** ** **** * ** * *** *** * ** ENST00000331923.4 AGAATTCAGAATATGGAGATGACAGCATCAAAAAAGCCCAAAATGTAATCAATTGTTTCC ENST00000449315.1 -----TC------------------TCTCT------CTC----TCTCACTCACTCTCTCT ** ** * * * * * * * * ** ENST00000331923.4 CCAAACAATGGTTCATGAATCTGAAAGGAGAAAGGACTATTTCTCAGTTAGAAAACTTTT ENST00000449315.1 CT---CTCTCTCTCATTC-TCT--------------CTGTCTCT----------ATCTCT * * * **** *** ** * *** * * * ENST00000331923.4 GCCGATACCTTGTACACTTAGCGGATACAATTTATAGAAATAGTATCGGGTGTTCTGATG ENST00000449315.1 CCC--TCTCTCTCTCATCTATC---CATCATCTGTCCACACAG-ATACAATG----GATG ** * ** ** ** * * ** * * * * ** ** ** **** ENST00000331923.4 TGGAAAAAAGAAATGCA---AGGGAAAACATAAAACAGATAGTAAAACTCCTTGCAAGTG ENST00000449315.1 TGGCAGGAGGGAGT-CACTCAGTGAAAA-----AAAAGAAACTAAGGTTTCTTG-----G *** * * * * * ** ** ***** ** *** * *** * **** * ENST00000331923.4 TTCGAGCTTTGGATCATGCTATGTCTGTTGCAAGTGACCACAATGTGAAAGAATTTAAGT ENST00000449315.1 CCTGA---TTAAATGAGAGAATGC--------ACTTACCA-----TTAA-----TTGGGT ** ** ** * *** * * **** * ** ** ** ENST00000331923.4 CTTTGATCGAAGGAAAATAGATCTATGAGACTGAAAAACCTATTTGCTTGATTACCATTC ENST00000449315.1 TTT--------GGAAGA-----CTATGGGAGTG----GCACATTTG--GGAGGAAAAATC ** **** * ***** ** ** * ***** ** * * ** ENST00000331923.4 CCAATGTGTAAATTTTGTATATATGTAAAGTTTCTTAAACTGTAAAATAGCAATTCTTGT ENST00000449315.1 ---------AAGTTCTGTTT---TG-AGTGTT-------CTGT----TTG-AGTTCCTAT ** ** *** * ** * *** **** * * * *** * * ENST00000331923.4 TTTAATACAAAAAACATTATATTCAATACTGTGTCCTTAAATGATATTTCTTCAGAATGA ENST00000449315.1 C----------AGACAT-----------CTGGG-----AGAGAGTACTTATGCAGAACTC * **** *** * * * ** ** * ***** ENST00000331923.4 AAGGAATTCAGATTATTTCTAGGAGTCTATGAATGTTTTCTTTACTGCCTGTCATACTTT ENST00000449315.1 AGGGGA----------------GAGGCCACATATGTTTG----ACCACTT---------- * ** * *** * * ****** ** * * ENST00000331923.4 GTTTACTGAAGTATTTTGTATGGTCATTTAAATTAACCCTCTCAGTTAATTGTCCCCTGT ENST00000449315.1 -----CTGCA--------TATGG--ATGGAAATTAA-------AGCCAACTGA-----AT *** * ***** ** ******* ** ** ** * ENST00000331923.4 AAACGATGTGTGCAGTGTAAATTGTGTAATTATGCATATATATATTTATACCACCATGGA ENST00000449315.1 GGATGAGATGAGC----------------TCACAGATAAATGTAA------------GAA * ** ** ** * * *** ** ** * * ENST00000331923.4 CTTACTTTCACACTGGAAATTTGTGGTGTTTTTCCACAGAGGAAGCCTTTTAACAGCAGA ENST00000449315.1 ---------AGACAGGAGACATTTGG-----------AGACTGAGTCTTCATGCAAT--- * ** *** * * *** *** ** *** ** ENST00000331923.4 AAATTATCCGGTAGCAAATTGTCTTAGGGAAATTACTACACTGTTGTAACAAAAGGGCTG ENST00000449315.1 --GCCATGCTTTGG---------TTAGGGAAACGAGTA------------AGAGAGGCTG ** * * * ********* * ** * * ***** ENST00000331923.4 GCAAGTGACTAAATGTTCATTACCTTTTGGTTAGCGTTGCTATCACTGTAGCTGTGCTGC ENST00000449315.1 AGAAG-GAGTGAGTA-------------GGGTGGCA-----------GGAG--------- *** ** * * * ** * ** * ** ENST00000331923.4 CTTAACAT-TGAGAGTTGAGTTGTGGACTTAGTCATTGAGTGAATGTTGAACTTTCTTCC ENST00000449315.1 ---GACATATGAGAGA------------------ATGGAGAGAATG----GCTTT----- **** ****** ** *** ***** **** ENST00000331923.4 TTGAATCAGCGTTAGAGTCAAATGTGGGTTTAATGTGA-ATGCTAAATGA-ATATGCAAC ENST00000449315.1 TTGGA----------GATCAAGTGAAGGC--AATGTATCATGG-AAATGAGAGGTGCTG- *** * **** ** ** ***** *** ****** * *** ENST00000331923.4 ATAGTTTCAAATG--GAACATAGAAATTTCACTTTTGAAAATAATAAACCCACAACCTAA ENST00000449315.1 ATGGTGTCAAATGCTGAGTTGAGTAAGATAATCCTGGAAAA--ATGACCATTAGATTTGA ** ** ******* ** ** ** * * * ***** ** * * * * * ENST00000331923.4 TTGCATGGTTTTGGGCTGACCGTCCTGTCTCATTCATGATTTTACTCCCTGCCCAGCTTG ENST00000449315.1 TGACATGG-----GGTTGACC---------------------------TTGCCGAGGGTG * ***** ** ***** **** ** ** ENST00000331923.4 CAGATACATGCATTTGAATTTTAGTAGTCTGTCATATTTAAAATCCCACATATGTGAGTT ENST00000449315.1 -----------ATTTTCCTTTTATT-GTCAGTCCAATTGAA------------GTGATTT **** ***** * *** *** *** ** **** ** ENST00000331923.4 AAATATGCAATAAAGAATACGCCTTGCTGATTAGCCACACCCAGGCAATTTAATATCCAT ENST00000449315.1 CAA---------AAGATTA--------TGAT------------GGAAA---AAAA--GAT ** **** ** **** ** ** ** * ** ENST00000331923.4 GGTCTTCTATAATGTTTATACCACATTGTAAATATTCAGAGAACTTGTTTTAAAGTTTAT ENST00000449315.1 GGG------------------------------ATTCAGGGA--TTGT-----AG---AT ** ****** ** **** ** ** ENST00000331923.4 GCTTTC--TGA-TTCTGTGATTTTCAAAAGAGGAATTTTTTTGGAAATTAAGGACTATCG ENST00000449315.1 GCTTTTGATGAGTCCTGCTAT------AAGGGGAA--------------GAAGAC-ATC- ***** *** * *** ** *** **** * *** *** ENST00000331923.4 TTTGATAATTATATATGTAATTAAGATTTAGCCAAGCATTAAATTAATTTTTAAATATA ENST00000449315.1 -TCGACAA----------------GA---AGCT-------------------------- * ** ** ** ***