CLUSTAL 2.1 multiple sequence alignment ENST00000335585.5 ACATGCAAAAAGTGGGGCCTGGAGATGGGGCTGTCTTTTTTCTCCAAACACTTGCCCATC ENST00000504389.1 -CAT-----------------------------TCTTTTCCTTCTA---------CCAT- *** ****** ** * **** ENST00000335585.5 CAGGAAGGCCAGCCCTGGGCATTGAAGACTCCAGCTGACATCATCTCTACCGTTGAGTTC ENST00000504389.1 -GGATAGGGTAA--------GTTCAAAA----AGCTGACATTATTTCTCTAGTTTCGTTC * *** * ** ** * ********* ** *** *** **** ENST00000335585.5 AACCACACGGGAGAGCTGCTGGCCACAGGTGACAAGGGCGGCCGGGTCGTCATCTTCCAG ENST00000504389.1 AA--ACACTGGGGA---------------CGAGGGAGGCA-CTGGGTCATCACCTTTCAT ** **** ** ** ** *** * ***** *** *** ** ENST00000335585.5 CGGGAACCAGAGAGTAAAAATGCGCCCCACAGCCAGGGCGAATAC-GACGTGTACAGCAC ENST00000504389.1 TAGGAACCAGGGAATAAAAATG-----CAAAGTCTGA-CAAATGTAGGTTTTTACTGTAC ******** ** ******** ** ** * * * *** * * *** * ** ENST00000335585.5 TTTC--CAGAGCCACGAGCCGGAGTTTGACTATCTCAAGAGCCTGGAGAT--AGAGGAGA ENST00000504389.1 TTTTTACAGAGTCATGAGCTAGAGTTTTACTACCTGGAGAGTTTGTATATGCAGGGAAAA *** ***** ** **** ****** **** ** **** ** * ** ** * * * ENST00000335585.5 AGATCAACAAGATCAAGTGGCTCCCACAGCAGAACGCCGCCCACTCACTCCTGTCCACCA ENST00000504389.1 AAATCAA-AAGATTAAATAGCTCCTTCAGCAGAATATGGCTAATTTTCTCATCCTCACCA * ***** ***** ** * ***** ******** ** * * *** * ***** ENST00000335585.5 ----------ACGATAAAA-CTATCAAATTATGGAAGATTACCGAACGAGAT---AAAAG ENST00000504389.1 TCATAAGCAAACAAGAAAAATTATCAAAGTATTGAGGATTACTGAAGGGAATTTAAACAG ** * **** ******* *** ** ****** *** * ** ** ** ENST00000335585.5 GCCCGAAGGATACAACCTGAAGGATGAAGAGGGGAAACTTAAGGACCTGTCCACGGTGAC ENST00000504389.1 TCCCAACCAATATAACCTAAAAGATGAAGAAAAGAAACTTAAG-ACCTTTCCACAGTAAC *** * *** ***** ** ******** ********** **** ***** ** ** ENST00000335585.5 GTCACTGCAGGTGCCAGTGCTGAAGCCCATGGATCTGATGGTGGAGGTGAGCCCTCGGAG ENST00000504389.1 ATTACTAGTAGTCACTGTGCTAAA---TAGAGATCTGATTATAGAAGTAAG--------- * *** ** * ***** ** * ******** * ** ** ** ENST00000335585.5 GATCTTTGCCAATGGCCACACCTACCACATCAACTCCATCTCCGTCAACAGTGACTGCGA ENST00000504389.1 AGTCTTTGCCAA-AGTCTC--------CATCA-------TTCTGTTATCAGTGATTGTGA ********** * * * ***** ** ** * ****** ** ** ENST00000335585.5 GACCTACATGTCGGCGGATGACCTGCGCATCAACCTCTGGCACCTGGCCATCACCGACAG ENST00000504389.1 GACATGCATCTCACTAAGAGACCTTAGTGTCATCTTCTAGCACTTGACCTTCAGTATTAG *** * *** ** ***** * *** * *** **** ** ** *** ** ENST00000335585.5 GAGCTTCAACATCGTGGACATCAAGCCGGCCAACATGGAGGACCTTACGGAGGTGATCAC ENST00000504389.1 AAGCTTTA----------------------------------CTTTA-----GTAACAAT ***** * * *** ** * * ENST00000335585.5 AGCATCTGAGTTCCATCCGCACCACTGCAACCTCTTCGTCTACAGCAGCAGCAAGGGCTC ENST00000504389.1 TGCTACCTAATTCTAACCAC-TTGTTGTCACATACTTGGTGACATCAACAAAGAGAA--- ** * * *** * ** * ** ** * * * *** ** ** ** ENST00000335585.5 CCTGCGGCTCTGCGACATGCGGGCAGCTGCCCTGTGTGACAAGCATTCCAAGCTCTTTGA ENST00000504389.1 ------------------------------------TGACAGGTAT-------------- ***** * ** ENST00000335585.5 AGAGCCTGAGGACCCCAGTAACCGCTCATTCTTCTCGGAAATCATCTCCTCCGTGTCCGA ENST00000504389.1 --AGTCTAAGG-------------------CTTCCC---AGCTACCTTCTT--------- ** ** *** **** * * * ** ** ENST00000335585.5 CGTGAAGTTCAGCCACAGCGGCCGCTACATGCTCACCCGGGACTACCTTACAGTCAAGGT ENST00000504389.1 -----------------------------TGCACACCT---------------------- *** **** ENST00000335585.5 CTGGGACCTGAACATGGAGGCAAGACCCATAGAGACCTACCAGGTCCATGACTACCTTCG ENST00000504389.1 ----------------AAGGTAAAACACTGAAAGA------------ATGGATAC-TCTG *** ** ** * * *** *** *** * * ENST00000335585.5 GAGCAAGCTCTGTTCCCTGTACGAGAACGACTGCATTTTCGACAAGTTTGAATGTGCCTG ENST00000504389.1 AGGTCAGATGAGTTATC------------ATTGCATATTTGATA--TCCAGG-----CCA * ** * *** * * ***** ** ** * * * ENST00000335585.5 GAACGGGAGCGACAGCGTCATCATGACCGGGGCCTACAACAACTTCTTCCGCATGTTCGA ENST00000504389.1 TAAAGAGA-----------AATATGAC---AGTTTACAATGTCCCTGTCT-----TTTAA ** * ** * ***** * ***** * ** ** * ENST00000335585.5 TCGGAACACCAAGCGGGACGTGACCCTGGAGGCCTCGAGGGAAAGCAGCAAGCCCCGGGC ENST00000504389.1 -------------------GTAACCACA-----CTTGAGTGAAAGT-------------- ** *** ** *** ***** ENST00000335585.5 TGTGCTCAAGCCACGGCGCGTGTGCGTGGGGGGCAAGCGCCGGCGTGATGACATCAGTGT ENST00000504389.1 ------------------CATATGC------------------CATAATAA----AGCAT * * *** * * ** * ** * ENST00000335585.5 GGACAGCTTGGACTTCACCAAGAAGATCCTGCACACGGCCTGGCACCCGGCTGAGAACAT ENST00000504389.1 TAA-------AACATCATCTATAAA----TGTTTATTTCT--------------GAATTT * ** *** * * ** ** * * *** * ENST00000335585.5 CATTGCCATCGCCGCCACCAACAACCTGTACATCTTCCAGGACAAGGTAAACTCTGACAT ENST00000504389.1 AA-----------------AAAAATCTATAAAC--TCCATGAGGAAAAAAACTTT----- * ** ** ** ** * **** ** * ***** * ENST00000335585.5 GCACTAGGTATGTGCAGTTCCCGGCCCCTGCCACCCAGCCTCATGCAAGTCATCCCCGAC ENST00000504389.1 -CTCT-GTTTTGCTCACTACTCA-CCTTTACCATCTAG---GATGC------TGCTTGGC * ** * * ** ** * * * ** * *** * ** **** * * * * ENST00000335585.5 ATGACCTTCACGACCGCAATGCAAGGAGGGGAAGAAAGTCACAGCACTGATGAGGACAGC ENST00000504389.1 AT--TTTCTAAGGTTTTAA------------AAAATATTTATTGGTTTAATGAATATA-- ** * * * ** ** * * * * * * **** * * ENST00000335585.5 TGCAGAGGTGGCAGTGTGTGGACACAGGAAGTTTGGGCCCCCTCCCTGCCCCAGCTTTCC ENST00000504389.1 TGGTGATATG--AATGTGTTATTAAAAGAAA--GGAGCAC------------AG------ ** ** ** * ***** * * *** * ** * ** ENST00000335585.5 TAGGCCAGAATTGTGTTTGGCAGTAATTGTCTGTTTAAAAAAATAAAAAGGAAAGGAAGC ENST00000504389.1 AAGA--AGAA----GTT----AATAAT--TCCATTTCA-----------------GAAGC ** **** *** * **** ** *** * ***** ENST00000335585.5 GTTCACCGCCACAAATCATAAAATGGACATGACTGTGGAGTCTTACAGTTCAGGGTTCTT ENST00000504389.1 -TCCA--GGCACTAGTC---TATTCCCCATGA-TATAGAATAAAACAGC----AGTCCTG * ** * *** * ** * * ***** * * ** * **** ** ** ENST00000335585.5 TCATTCACGTCCCTTCCTGTCTCGGTCTGCGGTCTTTACCACATCAATAGGACTTTTTAT ENST00000504389.1 CCTTCCAGGT-----ACTATCT--GTCTG----------------AAGAAGACCCTGAA- * * ** ** ** *** ***** ** * *** * * ENST00000335585.5 GCGTCCGGGTTAATTTTTCACTCCAGTGCGTCCTGTTGCAGGGACCGGAGCTGATGGGAG ENST00000504389.1 --ACACTGAATAAGTACTTA---------GTTTTGT------------------------ * * *** * * * ** *** ENST00000335585.5 CTGCTTCTCCCCCATGCCTCACTGGTCCCAGATCAGGGCTCCAGGGACAGATGATGAGTC ENST00000504389.1 ---CTTCTTCTGAATGTG-CAATG---------TAGAACTCAAGTGTC------TATGTT ***** * *** ** ** ** *** ** * * * ** ENST00000335585.5 TCAAACGAGCCAGCCAGGGGTTCTTTTGGTTATAAATGGGGCAATTCGCCCTGTCTCAGA ENST00000504389.1 TC--------CAATCAATG----TTTTAATTTTAAA--AAGCAAA--GACA---CTCAGA ** ** ** * **** ** **** **** * * ****** ENST00000335585.5 GCT-GATGACCTCACCGTTGTTTTTTGGATGGTGAATTCATGCTGAGAATTTGCAGATGC ENST00000504389.1 ACCCAAAGAC---GCTATTGTTCCCAAAGTAGT----TTGTAT--AAAATGTG------- * * *** * ***** * ** * * * *** ** ENST00000335585.5 AAGCTCCTCTCCTAGGTCTTCTGAATGTCTTGAAACATCCCAGGTCCCAGGTCTGGTGCG ENST00000504389.1 AAGT----------GATTTTACAGATGTTCTGGAATATA------CACATAACTA----- *** * * ** **** ** ** ** * ** ** ENST00000335585.5 GTTTCCCGAGAGGAGCGGAGTGGGGTTTGTCTTCTGTGTGCCTGTGTCCTCATCTGATTC ENST00000504389.1 ------CAATAAATGCATTGTGG-------CTACTG------------------------ * * * ** **** ** *** ENST00000335585.5 ACCTGCCATTTGCTGAGCCTCTGCTGTGTACCAGGCGTGGTGCTCAGCCCTAGA-GGCAG ENST00000504389.1 ----GCCAGTCACCAGGTCTCTG-TGTGT-----------TGATCGGCCACAGACGAGAG **** * * * ***** ***** ** ** *** *** * ** ENST00000335585.5 TTGACTTACCCTCTGCAGCCCTCCCTGCCGCCTCACCCTTCAGCATTCACTGGGCACCTT ENST00000504389.1 ----------CTCTGTAGCCGGTGATAAAGC--------TCAGAGTGGA--GGGCA--TT ***** **** * ** **** * * ***** ** ENST00000335585.5 CCCGGA--GCGGACACTGACTCCCATGCACGATTTTTTGGAATCTTCCTCCTGACTGTGA ENST00000504389.1 GCAGGAAGGCAGAAAGTGAC----AT-CAC-----TCTGG---CTTAATCC-----ATGA * *** ** ** * **** ** *** * *** *** *** *** ENST00000335585.5 GGTGGGTGTTCATTCATTTCCTCCATAAACACCAACTTCTCGAAGCGTGCCAGGCTCTGG ENST00000504389.1 TG--------CCTTGATTCC-------AACA--GGCTTGT-------TGCCAA--CATAG * * ** *** * **** *** * ***** * * ENST00000335585.5 GCTGGATGCTGGGGATAAGCGGGAACCCTTAGGATCCCCTCTGTCCACGAGAAGAAGCTG ENST00000504389.1 AC------------ATAATTGAAGAACTCTAGA----CATTT---------AAAAAGC-- * **** * * * *** * * * ** **** ENST00000335585.5 AGGCTCTGAGCGGATGCACAGGTCACCCATGGCAGGTGCCGTGCAGTGGTGTCAGGAACC ENST00000504389.1 ------------------CATGTTACC--------------------------------- ** ** *** ENST00000335585.5 CGTCCGGGTCTTCACACAAGGTTCTCTCCAGTCCATCTCGTGGGCGGCTCATGTTAGAGC ENST00000504389.1 --------TCTT---ACAA--TTTTTCCCA------------------------CAGAGT **** **** ** * *** **** ENST00000335585.5 GACATTCAAATGGAAGGTTTGGAAAGGAATGCCTCTGTCTTGTGAAGTAGGACATGGCAG ENST00000504389.1 GG-------ATGTAAAGGATCAAAAACAATG--------------AGCA--ATGTGG-AG * *** ** * * *** **** ** * * *** ** ENST00000335585.5 ACTTGGCGACGACAAGGGTCCAGGAGAACTGAGACGCAGGATGGAAGACAGAGAAGACCC ENST00000504389.1 AT------------------CAACATAATTG--------GATAAAACCTA------ACC- * ** * ** ** *** ** * *** ENST00000335585.5 CCCGGAGCTCCTCGCTCTGCTTGGTGGCTTCAGGAGTGTGGCCCTCCCCAGGACTCCACT ENST00000504389.1 -----AGGTCATCAT--------GTAGCCTATAGAA-------------AGGG--CCACT ** ** ** ** ** * ** *** ***** ENST00000335585.5 TCATCCTGGGCTTGCACCCTCCTTGAGCCAATGCACTGAACTGCCTTTGAAAGGAAATTG ENST00000504389.1 CTAT---------------------AATCAA-GCA-------------------AAAATG ** * *** *** *** ** ENST00000335585.5 CATGTTCTGACCATTTTAGGATACCTTTACTTTAAGGACCACACAGTCCCAGAGGACACA ENST00000504389.1 C-----CAAACCAGTTT------TCCT-----------------AGT----GATGACCCA * * **** *** * * *** ** *** ** ENST00000335585.5 TCCCTCGGGAACTCTGCCCCTCTGACAATGAGGGCCACAGAGAAGGTGGTGTTTCCATGG ENST00000504389.1 TCTTTTG--AAC---------CTGGAACTGTAG---ACATAGAT--TGGGGAT--CATG- ** * * *** *** * ** * *** *** *** * * **** ENST00000335585.5 TAGATGCTCCTGTTCTGGTGATACCAAACCTGCCCACCCCTCTGAGTCGTCTTTGCTCAT ENST00000504389.1 -AG--------GCTTTGG-AATACTGGCTCT-TACGCTCTTTTGATTC---TCTGTCCAA ** * * *** **** ** * * * * *** ** * ** ** ENST00000335585.5 GGACTTGCAGCAGAGCCACGTAGTTTGGCATTTTGATTCAGAAAGTGGGGAGCAGAGACC ENST00000504389.1 GGG-------------------ATCTTATATCTT-------------------------T ** * * ** ** ENST00000335585.5 CAGCCAAATCCAAACTTTTTTTTTGGTTTTGTTTTGTTTTGTTTTTTACAAGATATAACA ENST00000504389.1 CAGCTAAATTTAAA------------------------------------AGATGAAACA **** **** *** **** **** ENST00000335585.5 TAACCCAGGAAACAGACCCAGCTGAGGTTATTCTCA-GTGGATTACAGTATACTTTTGTG ENST00000504389.1 TAATCTT----ATAGCTCTAGCATGAATAAATCACACGTTAAATGTTCTATAATATTGTG *** * * ** * *** * * ** ** ** * * **** * ***** ENST00000335585.5 TGTGTAAAAGCACAAAGTGCATGTGTACTCACTTCTGGCCATATAACATTTACACAGGGA ENST00000504389.1 TTTACAATA----AAGACTAATAAATATCAATTATTGAGCATGCAAT-TCTAT------- * * ** * ** ** ** * * ** *** ** * ** ENST00000335585.5 AATGGATCATTGATTTTTTTTTAATCAACGTGAATGAAGAATGTTTGTTTATATATCACT ENST00000504389.1 ------TTTTTGATGTC-------TCCAGGTAAGTGACAACAGTAAGTTCAAAT-----C * ***** * ** * ** * *** * ** *** * ** ENST00000335585.5 ATAAAATCCAGTTGAC-CTGGACAGTATTATATGTACATATCTATTCTAATTAAATTTAA ENST00000504389.1 AGAGAA--CAGTTGTCACTGAA-------------ATACAGCT------------TCTAA * * ** ****** * *** * * * * ** * *** ENST00000335585.5 CAATCAAAGGATTGGATTACTTTTTTCCCCCTTGTAAAGAGGTTCGAGAATGTGGTCAAT ENST00000504389.1 CAGTGAAGG---TCAAGTACT---------------AGAAGGT--GATCTTCAGGTCATC ** * ** * * * **** * **** ** * ***** ENST00000335585.5 TGTATAGATAGCGTGTTAAAGCCAAAACCCAGCTCTGAGGGCCTTACCCATTACTTGGAT ENST00000504389.1 TGCTGAAAT-GTATGTC---TCCAGAG----GCTTTTAAGACCTG----------CAGAG ** * ** * *** *** * *** * * * *** ** ENST00000335585.5 ATTTGCTACGATCCATCTC--CCTTTGTGAGTCAAATGTTAAGAGAAGAAACTTGTATTT ENST00000504389.1 TTTTCCAGCTTTTCATCTCAGTCACTATAA-TTAATCATTAA----------TTTTGTTT *** * * * ****** * * * * * ** **** ** * *** ENST00000335585.5 GCAGCTAGAGGTTACTGTCACATCATAGATTTAACATTTACCATCTTCAAA--GTACAAA ENST00000504389.1 G-AACTAAT-----CTGAAAAGTTATG---TCAACATTT-------TTAAATTGCACAAA * * *** *** * * ** * ******* * *** * ***** ENST00000335585.5 TCTTACATGTCCTTCAAAAGGAGGTCTTAATACAGTTCCTAGTTCCTTACTTCTGTTTTA ENST00000504389.1 GTTTACAAG---GTAGGAAGTTGGCCAGAAATGAGGAAATA-----TTA-------TTTA ***** * * *** ** * ** ** ** *** **** ENST00000335585.5 AACTTTGGGTACCAAACCAAAAAGAAGAAAAAAGAAAGGAAAAGATCTTCTTTGAAGAAA ENST00000504389.1 AAAGATGA----------AAAAATCAGAAATAATTAGTGAAAGAAT--------GAGCAA ** ** ***** ***** ** * **** ** ** ** ENST00000335585.5 AGTATGTCTCTGGATCCCTGGAAAATAATGATGTCCAAAGCAAATTGTGAAGATCAAATG ENST00000504389.1 AATGTAT----GAATC--------ATGAAGA-GTT----GCAAAT---GACCTTTACATA * * * * * *** ** * ** ** ****** ** * * ** ENST00000335585.5 TGTGTTAAGAAAAGGTGTCGAGGGGAGGGACAAAACCAGAAACGGTGGAAGGACCAGTGT ENST00000504389.1 TGC------CAAAATCATCAATGAGA-----AAAACCAAATCCTGTGA---------TGA ** *** ** * * ** ******* * * *** ** ENST00000335585.5 AATAGTCACAGACTTGCATCCTGGCTCTGCTTACATTTCCTGGTACTCTCGAATGTACGG ENST00000504389.1 AATA---------TTG------------------ATTTTTCAAT----CAAAGTGT---- **** *** **** * * *** ENST00000335585.5 GCGTTCACATAGTCATTGTGAAGTTG-TTGGGGTTTTTTTGGTTTTGTTTTTAATTTAGC ENST00000504389.1 -CATTT-TATATATACTCTGAAGCTGACCAATATGCTTTTGGCCAAATTATT--TTTAGC * ** *** * * ***** ** * ****** ** ** ****** ENST00000335585.5 TCTTCTCTGAGGACGAAGCTGTTGGTGGTGGTGGTGGTGGGGGTGGTGGTGTGGGATACA ENST00000504389.1 -------------CAAATCACCTAGCGTTAACAA----ATGGGCAATTACA------ACA * ** * * * * * *** * *** ENST00000335585.5 TGGTGGTCAAGTTGTCAGCCCTGATCAGTTTGGACTCTGTAACTCATAGGTGCATTCTTT ENST00000504389.1 TGTTGGGAAATATGCCGA----GAGC----TGGA------------TAAGTGTA------ ** *** ** ** * ** * **** ** *** * ENST00000335585.5 TTTTCTTTGGTGTCTCACAAATTACCCAATTGTTGAATAAAACTATAAATATGTTAATAC ENST00000504389.1 -------------------AGACACC----------GTGGAAGCACA-------TAACTC * *** * ** * * *** * ENST00000335585.5 CAGCTTTTTCCAATAAAATAACAAATGTTACATCAAAAACGA ENST00000504389.1 CA---TCTGCCTGCAAGGTA--------TGAGTCAA------ ** * * ** ** ** * ****