CLUSTAL 2.1 multiple sequence alignment ENST00000337109.4 AAACCCAAAGCGGCCGCCGTAGGCGAAGGTGAAGATGGCTGCCTCTGCCTTTGCTGGTGC ENST00000421557.1 ----------------------------------ATAGCTGCCTCTGCCTTTGCCGGTGC ** ***************** ***** ENST00000337109.4 AGTGAGAGCAGCTTCAGGAATCCTACGGCCCCTGAATATTTTGGCATCTTCAACCTACCG ENST00000421557.1 AGTGAGAGCAGCTTCAGGAATCTTATGGCCTCTGAATATTTTGGCATCTTCAGCCTACCA ********************** ** **** ********************* ****** ENST00000337109.4 CAACTGTGTCAAGAATGCCTCTCTTATTTCTGCATTGTCCACTGGACGTTTTAGTCATAT ENST00000421557.1 AAACTGTGTCAAAAATGCCTCTCTTATTTCTGCATTGTCCACTGGACGTTTTAGTCATAT *********** *********************************************** ENST00000337109.4 TCAGACACCAGTTGTTTCCTCCACTCCCAGACTTACCACATCTGAGAGAAACCTGACATG ENST00000421557.1 TCAGACACCAGTTGTTTCCTCCACTCCCAGACTTACCACATCTGAGAGAAACCTGACATG ************************************************************ ENST00000337109.4 TGGGCATACCTCAGTGATCCTTAATAGAATGGCCCCCGTGCTTCCAAGTGTCCTGAAGCT ENST00000421557.1 TGGGCATACTTCAGCGATCCTTAATAGAGTGGCCCTCTTGCTTCCAAGTGTCTTGAAGCT ********* **** ************* ****** * ************** ******* ENST00000337109.4 GCCAGTCAGATCTCTAACATACTTCAGTGCAAGAAAAGGCAAGAGAAAGACCGTGAAAGC ENST00000421557.1 GCCAGCCAGATCTCTAACATACGTCAGTACAGGAAAAGGCAAGAGAAGGATTGTGAAAGC ***** **************** ***** ** *************** ** ******** ENST00000337109.4 TGTCATCGATAGGTTTCTTCGACTTCATTGTGGCCTTTGGGTGAGGAGAAAGGCTGGCTA ENST00000421557.1 TGTCATCTATAGGTTTCTTCGACTTCATTGTGGCCTTTGGATG---AGAAGGGCTGGTTA ******* ******************************** ** **** ****** ** ENST00000337109.4 TAAGAAAAAATTATGGAAAAAGACACCTGCAAGGAAGAAGCGATTGAGGGAATTTGTATT ENST00000421557.1 TAAGAAAAAATTATGGAAAAAGGCACCTGCAAGAAAAAAGCGATTGAGGGAATTTGTATT ********************** ********** ** *********************** ENST00000337109.4 CTGCAATAAAACCCAGAGTAAACTCTTA-GATAAAATGACGACGTCCTTCTGGAAGAGGC ENST00000421557.1 CGGCAATAAAACCCAGAGTAAACTCTTAAGATAAAATGACGACGTCCTTCTGGAAGAGGT * ************************** ****************************** ENST00000337109.4 GAAACTGGTACGTTGATGATCCTTATCAGAAGTATCATGATCGAACAAACCTGAAAGTAT ENST00000421557.1 GAAACTGGTATGTCCATGATCCTTATCAGAAGTGTCATGATCGAACAAACCTGAAAGTAT ********** ** ****************** ************************** ENST00000337109.4 AGATCAGAAGTTTCACTTGTTTCTCAGTTATTGGATATGTATCTTTGTGTACATATCTTT ENST00000421557.1 AGATCAGAAGTTTCACTTGTTTCTCAGTTATTGAATATGTATCTTTGTGTACATATC--T ********************************* *********************** * ENST00000337109.4 GCAAAAATGGATAAGTACAAAACTTGATGTAAATTGTACCAATGAATACGTAAACATACA ENST00000421557.1 GCAAAAATGGATAAGTAAAAATCTCGATGTAAATTGTATCAATGAATATGTAAACATACA ***************** *** ** ************* ********* *********** ENST00000337109.4 GTGACAACATTAAACTTAGAAAAGTTTTAAAACTTAATGGATCAGACTTTGCCAGATTTG ENST00000421557.1 GTGACAACACTGAACTTATAAAAGTTTTAAAACTTAAAAAAAAAG-CT----CAAATTTG ********* * ****** ****************** * ** ** ** ***** ENST00000337109.4 GTTAGGGAAACAGAAATTTAGAATGGTGCATTATTTTTAACAAATGGTATTGGCTTAACT ENST00000421557.1 -TAAAAGACATGTAAA---AAGAAGGTGGA-----------AAATGTATTTAG---AATC * * ** * *** * * **** * ***** ** * ** ENST00000337109.4 AGTTGTTTCAGTTATGCTCTTTTAGTTGCAAGGAATCTCAAGTGG-GACAAACATAAAAA ENST00000421557.1 AGGG-----AATGATGCT------------AAAAGTTT--GGTAGAGACAAAAGAGAAAA ** * * ***** * * * * ** * ****** **** ENST00000337109.4 GACTCAAAAGCTACAAGTTAGCTCAAGCAATGTGACATTATTTCAAGGATATGTGCCAGG ENST00000421557.1 GA-----AAGTCCCAA--------AAGTGGTTTAA----GTTTGCAGCAGATG---CTGA ** *** *** *** * * * *** ** * *** * * ENST00000337109.4 GAATTCAGGAACCACCTCACCAACCCCATCTCCCACTCAGAAATCACCTCCCAGCCTCAG ENST00000421557.1 TGAT--------------ATCAAAACAATCTTC-ACTTAAAAA----------------A ** * *** * **** * *** * *** ENST00000337109.4 GAAGAGTAGAAATTGGGTGGTGCTCCTCAGCAGGGGAAGGTGGATGTTTAGGCTTGGGCT ENST00000421557.1 AAAAAAAAGA------------CTCC----------AAAGTA------------------ ** * *** **** ** ** ENST00000337109.4 CTGCATGCATGTGACTTGCTTCTTTTTGCATTGTTAACTCCATTCTCTCTATTCACCAAC ENST00000421557.1 -------CAAGCAAC------------AAATGGAAAA--------------------AA- ** * ** ** * ** ** ENST00000337109.4 TTCTCTACACAGCTTTTGCATACTTACAGTTTCTGTTCCTTTGTAATAACTTTAACTTGC ENST00000421557.1 -----TAGATAAATTAGACATCATCAAAATT-------------AACAATTTT----TGG ** * * ** *** * * * ** ** ** *** ** ENST00000337109.4 ACCTTTGAGGTTCTTTTCTACATGATGACCTTCAGCTCCTGCTGCTAGTCTCCAATTGCC ENST00000421557.1 GCATCGAAGG---------ACA-----------------------------CTAA----C * * *** *** * ** * ENST00000337109.4 AAGGGAATTTAACTGGGCCAGACTACCTTTTTATACTAGGTCTGGTTGGGTCATTGTCTA ENST00000421557.1 AAGAATGTGAAA-------AGACA----------ACTAG-------------------TG *** * ** **** ***** * ENST00000337109.4 GAGTAGGGATTGGCTGTCCTTAAGTCAGGAGCCCGCTTTGTATTAGCAGGTTTGCATGCA ENST00000421557.1 GAATGGGAGTTAA---------------------------TATTTGCAAAT---CATATA ** * ** ** **** *** * *** * ENST00000337109.4 GCAAAAAAACAGTTATGTGAGCAGTTTCACTTGGAGGTTCACATGGGGTGGCAGCACACT ENST00000421557.1 TCTGATAAAGGATT-------CATATTCA---GAATATTTA-ACACAGTAACA----ACT * * *** ** ** **** * * ** * * ** ** *** ENST00000337109.4 TAACATCTAACACACCAGGTTCATTGTGTTCATAACACTTGTCATTTACTGTAACAACAT ENST00000421557.1 CAACAATAAGCAAACTA--------------ACAACA----TAATTCA--ATAATGA--- **** * ** ** * * **** * *** * *** * ENST00000337109.4 TTTTTCATAGGAGAGTAAATAGCCCTTCAGCATGCTCATTCATGAAACAGAAGAGGCTGT ENST00000421557.1 ----TCAAAGGA-ATTTAATA-------AACAT--TTATTC--------GAAGAAGATAT *** **** * * **** * *** * **** ***** * * * ENST00000337109.4 ACAAGTGAAGACAAGGGCTTTTTATGCAAGTTTTGAAAGATAGGTATTTATTTTTTCTAG ENST00000421557.1 ACAGAT---GGCCAG-------TAAACACAT---GAAA---AGATGCTCA---------- *** * * * ** ** ** * **** ** * * * ENST00000337109.4 AGACAGGAGTTTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCATAGCTCATTG ENST00000421557.1 --ACATAA--------CCATT---CAA---GAAGTGCA-------AATCAAA----ACCA *** * * ** ** * ****** ***** * * ENST00000337109.4 AAGCCTCGCACTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCTTACTGAGTAAGGATATG ENST00000421557.1 AAATTAGATACCACT----TCA-------CACC--CATCAG----------AATGACAAT ** ** ** *** * ** * **** ** ** * ENST00000337109.4 TATTTCTTAAAAGTTAGTTTATCCACTTCAGATTT-CATGTTTTCATTTGTAAGGATAAA ENST00000421557.1 TGTTT--TAAAAAATGG------------AAATTAACAAGT----ATTGGTGAAGATGTG * *** ***** * * * *** ** ** *** ** * *** ENST00000337109.4 CTTTTCCCACAAATTTTCAACAATCATTGTAGAAACTAAGGGGGAGAAAGTAATCTCAGT ENST00000421557.1 G-------AGAAATTGGAAACACTTGT-GTA----TTGCTGGTGGGAATGTAA----AAT * ***** **** * * *** * ** * *** **** * * ENST00000337109.4 TGTTTTAGAAACGAAAAAGTTAAGC-ATTGTTTACTTGAAGTGGGCAGGGAAGCAGCACT ENST00000421557.1 ------GGGAATGTAGAAGACAATTTGGTGGTTCCTCAAAATG---------------TT * ** * * *** ** ** ** ** ** ** * ENST00000337109.4 GAGTAAAGTTCAATTGAGTGGTTACAGTCTAGGGCAGTGGTTCCCAACTCTCCGATCAGA ENST00000421557.1 AAACATAG---AATTA-----TTACCATATGATCTAGCAGTTCT--ACT----------- * * ** **** **** * * ** **** *** ENST00000337109.4 ATCATCTGGGAAGCATTTTCAAACAGCAAAGTACTTTGAAAACCATTATTAAATAGAATT ENST00000421557.1 ----TCTAGGTA-TATTACC------CAAAATAACT-GAAAGCAGGGACTCAG-ATAATT *** ** * *** * **** ** * **** * * * * * **** ENST00000337109.4 ATGCATGAATTACTGTTTCAGATCCTTTAATGTGGTAGTTGGTAATAA-TAAGATGAAAT ENST00000421557.1 GTACACCAATGTCCATAGCAG---CATTA---------TTCACAATAGCTAAGATAGAA- * ** *** * * *** * *** ** **** ****** ** ENST00000337109.4 TCCTCTGTTGTTAGTAAAATTATGAAATTGAAGTTCTGCAGCATGTCAGGCCAGGATTAT ENST00000421557.1 -------------GCAAA----TCAAAT----ATTCATCAACAGATGA----------AT * *** * **** *** ** ** * * ** ENST00000337109.4 TAGGGAGATTCCTCGAAACTAGTGTGTGTTTATTAAAAGGAGAAAGGATAACAATAGAAT ENST00000421557.1 AAACAAAATTTC-----------ATGTATATATACAATGGAG------TATTATT----T * * *** * *** * *** ** **** ** * * * ENST00000337109.4 GTTCTAAAACCAGAAGTCCAAGTGCGTGTCTACTTATGGGACCAATAAATAAAGAACAGA ENST00000421557.1 AGCCTTAAAT--AAAATTTTGATACATG-CTAC------AAC--ATGAATGAATTTTGGA ** *** ** * * * ** **** ** ** *** ** ** ENST00000337109.4 CATTTGATTTGAGGTGAGGTAAAAGCCTGAAACATGGAATGGCATTCTGTTTTGATGGAT ENST00000421557.1 AATACTATGTTAAGTAAAATA--AGCCAGACACATCAGACAA---------TTATTGGAT ** ** * * ** * ** **** ** **** * ** ***** ENST00000337109.4 TTTCATTTCTTCGCACTTCTGAGACGGCAAAGCCAACCACTTAGAAGCCTTCCACATCTT ENST00000421557.1 TTTC---------------TAAGA----AGAATT--CCACTTACAAGA----AGTATCTA **** * *** * * ******* *** **** ENST00000337109.4 TGTCACCTGCCTGGCTCCTGCTCTCTGATGTACCTCTGGGTAGTGAGATGGAAATGGTGC ENST00000421557.1 GAATA---GGCAAATTCATA------GAGACAC------ATAGTAGGATAGTGAT--TAC * * * ** * ** ** **** *** * ** * * ENST00000337109.4 CTGCAGAAGTTGGG-GAGAAGGATACTTTTGCACAGCCTCCATGATGTCTTTATTGCAAA ENST00000421557.1 CTG--GGAGTGGGGTGGGGAGGA------------------ATGAGG-CATTATTGTG-- *** * *** *** * * **** **** * * ****** ENST00000337109.4 TATGGATGACAAGGGTCTCTGTTACAGGGGCCTCAGAGCACCTTCGTTTCTCCTCTAGAC ENST00000421557.1 ------TAATAAG---------TACAGAG-----------CTTCTGTTT----------- * * *** ***** * * * **** ENST00000337109.4 CAGGGACAGGTGTAGAGATAAGGACTGGCAACCAGAGCCTCAGCATCCAAAGATGGACTG ENST00000421557.1 --GGGAT-GATGAAAAAGT--------------------------TCTGGAAATGGAT-- **** * ** * * * ** * ***** ENST00000337109.4 AAGTGGGATGGCTGACAGGCACATAACTTACGGGAAAGGGAATTTCATACATACGATTTT ENST00000421557.1 -AGTGG------TGATAG---------TTGCG------------CCACAC---------- ***** *** ** ** ** ** ** ENST00000337109.4 TGTTTTGTGGGTAGGAGGGCTTATCATCAACACTGATTTTATAATCTGACAATAAATGTC ENST00000421557.1 -----TGTGAAT----GTATTTAGTGCCAATG--AATTGCATACT-------TAAA---- **** * * *** *** *** *** * **** ENST00000337109.4 TTTCATTAAAGAGTTTACCTAAATGATGTTCGATTATATGTATAATTTATAAAATATTTA ENST00000421557.1 ----ATGGAAAATTTTATC----------------ATATGTATAGTTTAC---------- ** ** * **** * ********* **** ENST00000337109.4 TGTATAGTTTGTTTATTCAGGTATATGTATAATTTATTGAACACCTACTATGTCCCAGCA ENST00000421557.1 --CACAATTTTTTTGAAAAAGT----------TTTATT---------CTACAAATCAGTA * * *** *** * ** ****** *** *** * ENST00000337109.4 TATCTACAAAACTGGGTACATACATACTGTCTAACTGCTAATCCACATTTCCAGTCTTAC ENST00000421557.1 AACTTA-AAAGTTGGAT-------CACAGCTTAGC-----AT----------AGATTATT * ** *** *** * ** * ** * ** ** * ENST00000337109.4 AAAGGACATAATGATTAGTTAAGCCCTAATTTAGATTTGAGGAAACTGAAGCTGAGAGAG ENST00000421557.1 AAAGGA-------ATTATTTT--TCCCCACCTAGA---------------------AGAG ****** **** ** ** * **** **** ENST00000337109.4 GGTTAAGTAAATTACCCAAAGTACAGCTAATAAGACCCAGAATCTCAGTCTCACTCCTTG ENST00000421557.1 G---AAGT-----------GGTAAAACTG-TAAG----------------CTGCTACGTG * **** *** * ** **** ** * ** ENST00000337109.4 GGATCCTGTGTATTTCCCTGAGTCTTCTAACATATGAAAATTCATATCTAAATCAACAAG ENST00000421557.1 G----CTGTA----------AGTCATGGGGCA---AGAAAATCTTTTCT----------- * **** **** * ** *** ** * *** ENST00000337109.4 TGACTGTAATCTGGTACTATAAATACTAAATAAACACTTCTTCATAACACTGTACCAATT ENST00000421557.1 ---CT----TTTGGTATGATTA---------------TTGTTCAT----TTG----AATT ** * ***** ** * ** ***** ** **** ENST00000337109.4 CAGCTTTTAAATTTTATTACTTTGCTTTCCTGTCCTTTGCCAACTCTTAACCTAGTTAAT ENST00000421557.1 C-GCTTCAAGAGGTATTTATATAGT------------------------ACCTAAGTA-- * **** * * * *** * * ***** ** ENST00000337109.4 CCTAGTTCTGTTGACATTGGACCAGGCTCAGTAAATAAACGAATGGATTTCCAGCCTTTT ENST00000421557.1 ------CCTATTA----TGG--CAGACC-----AATAAGC-AGTGGATACATAGTATATT ** ** *** *** * ***** * * ***** ** * ** ENST00000337109.4 TTTCCCATCTGTTCCTGCTTTTAGTCCTCTGAATCTGCTTCTTTTCTTACTGCTGCTTTA ENST00000421557.1 TTA---------------------------GAA----CATCTGTCATTAC-GTGG----A ** *** * *** * **** * * * ENST00000337109.4 TTTTACAGTGATTTTGTCAAACATAGAATACAGGACTAAAAATGCAAAGAAATTGGGTCT ENST00000421557.1 CTATAGAATAAT------AAAGATTGGCTATAAGAC--------------AATTAGA--- * ** * * ** *** ** * ** * *** **** * ENST00000337109.4 GTGTTTAATTTTGATGTTTCAAATTTTGAGCTTCCAAGTCTTTGTGGCCACCCAATGAAG ENST00000421557.1 ------------GGTATTTGGTATTTT--------------------------ATTGAAG * * *** ***** * ***** ENST00000337109.4 TTTGAGTCTGCCTGTTCAGATGTGAAAGGTAAGGGCTGCAGCAGGTTTAAGGGTGGCCCT ENST00000421557.1 C---AGTCT-------------CAAAAGGT------------------------------ ***** ****** ENST00000337109.4 TCACCACCCTGTTGTCACCTGCACAGGCACTCCCCCATTTGCAGATGAAGAAATGTTCAG ENST00000421557.1 --------CTGTTG--------------------------ATAAATAAATTGATTTCTAG ****** * ** ** ** * ** ENST00000337109.4 AGAAGAAAAATGATGGACCAAACGTCTGTTTGCACAATTGAAACTCTACCAGTGGACTAT ENST00000421557.1 GGGT-----------------ACGCCT----------------------CAGTG------ * *** ** ***** ENST00000337109.4 TCTATTTTCACAGCTACCTAGTTTCTGCCGATGATTTTTTTAAATGTGAAATAAACAGTG ENST00000421557.1 ------TTTAC------------CCTGCC------------------------------- ** ** ***** ENST00000337109.4 ATACTTTCAGGTT ENST00000421557.1 -------------