CLUSTAL 2.1 multiple sequence alignment ENST00000343769.4 GAACAGGGCGGCTTCTGGTTTGGCGGGTCCTTTGTCTCTCGGTGCAGCCGGAGCTCCAGG ENST00000419323.1 GAAGAAG-TAGCATCTCACTCA---------CTGTTCCTGGGA--AGATGGAAAAGT-GA *** * * ** *** * *** ** ** ** *** * ENST00000343769.4 TCTCCTCTTCACTACTCTGTGTCCTGTGCTCCTACAGGCCCAGCCTCTGTGGCCCTGTGA ENST00000419323.1 TGATCCCTTAA---------ATCCTGCAATTGAA-------AACATTTGTGACCCTGAGG * * *** * ***** * * * * * **** ***** * ENST00000343769.4 CCTGCAGGTATTGGGAGATCCACAGCTAAGACACCAGGACCCCTGGAAGCCTAGAAATGG ENST00000419323.1 ---GCAGGTAT---GAGAGGCAC---TAAGAAA-----ATCCTTTGTTGGTGAGACAGAG ******** **** *** ***** * * ** * * * *** * * ENST00000343769.4 GACCATTGCAATTTAGAGATGTGGCCATAGAATTCTCTCTGGAGGAGTGGCATTGCCTGG ENST00000419323.1 AACATTTTCACCCCAGGAA-------AAAGAGATCA---TAGAGAAGT-------CATGA ** ** ** ** * * *** ** * *** *** * ** ENST00000343769.4 ACACTGCAC--AGCGGAATCTATATAGGAATGTGATGTTAGAGAACT----ACAGTAACC ENST00000419323.1 AAACTGTACTGAACAAAATACTTATGGGAAAGAGGGGTTGTAAAAGTGATGAATGTAGAC * **** ** * * *** *** **** * * *** * ** * * *** * ENST00000343769.4 TGGTCTTCCTTGGTATTGTTGTCTCTAAGCCAG-ACCTGATCGCCCATCTGGAGCAAGGA ENST00000419323.1 AGTTCTTCACTAAGAA-ATCAAATCTTATTCAACAGCAAAGGATCCA-------CACTGA * ***** * * * *** * ** * * * *** ** ** ENST00000343769.4 AAAAAACCTTTGACTATGAAGAGACATGAGATGGTAGCCAACCCCTCAGTTATA----TG ENST00000419323.1 AGAGA------GACCCTGTAAATACA-AAGTTTGTGGC-AAGCCTTCAGTGGGAACACTA * * * *** ** * * *** ** * ** ** ** ** ***** * * ENST00000343769.4 TTCTCATTTTGCCCAAGATCTTTGGCCAGAGCAGAACA--TAAAAG-ATTCTTTCCAAAA ENST00000419323.1 GCCTCTATCTCCAGAAGATCCACA--CTGGGGAGAACCCTTATAAGTGTGATGAGCATAG *** * * * ****** * * * ***** ** *** * * ** * ENST00000343769.4 AGTGAT----ACTGAGAAGATATGAAAAACGTGGACATGGAAATTTACAGTTAATAAAAA ENST00000419323.1 AAGGGCCTTCACTGTGAAAGCCTGCATTATA-GAAGCTGTATTTTCACAGACACTATGAA * * **** *** ** * * * * ** * ** **** * ** ** ENST00000343769.4 GGTGTGAA-AGTGTAG-ATGAGTGTAAGGTGCA-CACAGGAGGTTATAATGGACTTAACC ENST00000419323.1 --TGTGATCAGTGTGGCAAGACTTTCATTTGGAGCTCAG---ATCTTAGTAAAC---ATC ***** ***** * * ** * * * ** * * *** * ** * ** * * ENST00000343769.4 AGTGTAGTACAACTACCCAGAGCAAAGTATTTCAATGTGATAAATATGGGA-AAGTCTTT ENST00000419323.1 AGAG-GCTTCA--TACT-GGAGGGAAATCCACAAGCGTAATG--TATGCAATAAGACCTT ** * * ** *** *** ** * * ** ** **** * *** * ** ENST00000343769.4 CATAAATTTTCA--AATTCAAATAGACATAATATAAGACATACTGAAAAAAAACCTTTCA ENST00000419323.1 CA-GAATTCTGACCATCTCAAA----CATCAGAGAATACATACTGGAGAGAAACCCTACA ** **** * * * ***** *** * * ** ******** * * ***** * ** ENST00000343769.4 AATGCATAGAATGTGGCAAAGCTTTTAACCAGTTCTCAACCCTTATAACACATAAGAAAA ENST00000419323.1 AATATCTTATGCATGGGAAAGCTTTTAATCAGAGCCCACTCTTTCTTAAGCATCATAGAG *** * *** *********** *** * ** * ** * * *** * * * ENST00000343769.4 TTCATACTGGAGAGAAACCCTA-CATTTGTGAAGAATGTGGCAAAGCCTTTAAGTACTCC ENST00000419323.1 TACACACTG-AGAGAAACCTTATCACTT-TAAGGAATGTGGAGAAAGCTTTAGTCACAAT * ** **** ********* ** ** ** * * ******** ** ***** ** ENST00000343769.4 TCTGCCCTTAATACACATAAGAGAATTCATACTGGAGAGAAACCATACAAGTGTGATAAA ENST00000419323.1 GGAGGCCTGACATCGTATGAGAGACTGCACACAAGAGAGAAGTCTTATAAAAGTAAAGTA * *** * * ** ***** * ** ** ******* * ** ** ** * * ENST00000343769.4 TGTGACAAAGCCTTTATTGCATCCTCAACCCTTAGTAAACATGAGATCATTCATACTGGA ENST00000419323.1 TTTGGGGAAGTCTGCATTGAGAGCTCACACTTCATTAACTATCCCAACATTCATACAGGG * ** *** ** **** **** * * * *** ** * ********* ** ENST00000343769.4 AAGAAACCCTACAAGTGTGAAGAATGTGGCAAAGCTTTTAACCAA--------------T ENST00000419323.1 GAAAGACTTCCTCATTGCCCTGAATATGGAAAATGCTTTACTCAAAATGAAGGTCTTATT * * ** * ** **** *** *** **** *** * ENST00000343769.4 CCTCGACA----CTTACTAAACAT----AAGAAAATTCATACTGGAGAGAAACCCTACAA ENST00000419323.1 TCCCATCAGAACCTTTTTAGACATTAAAAAGAAAACCCATATCAGAGAAAAAAGATATAT * * ** *** ** **** ******* **** **** *** ** * ENST00000343769.4 A--TGTGAAGAATGTG-GCAAAGCTTTTAACCAATCCTCAACACTTACTAAACATAAGAA ENST00000419323.1 ACCTCTGATGAATGTGTGTAAAACTTTG---TGTTTCTC--TAGTAATTGACCTTTAGAG * * *** ******* * *** **** * *** * * * * * * * *** ENST00000343769.4 AATTCATACTGGAGAGAAGCCCTACGTTTGTGAAGAATGTGGCAAAGCCTTTAAGTA--- ENST00000419323.1 AGTAGATATAGAAGGGAAATATTTTGAATATAACAATTTTG---AAATGTTTGAATGGCA * * *** * ** *** * * * * * * * ** ** *** * * ENST00000343769.4 ---------CTCCCGTATCCTTACTACACAT---AAGAGAATTCATA---------CTGG ENST00000419323.1 GCTTCTTGCCTCACTTAACTTTAGTAAATTTGTCAAGAGCATGCCCAGGAAATGGGTTGG *** * ** * *** ** * * ***** ** * * *** ENST00000343769.4 AGAGAAACCATACAAGT-GTAATAAATGTGGCAA-AGCCTTTATTGCATCCTCAA----- ENST00000419323.1 CTAGAACTTGTTTTAGCAGAAATAAATGTGTTTTCAGTCATTAT--CCTCCTTAAGGAAA **** * ** * ********** ** * **** * **** ** ENST00000343769.4 ----------CCCTTAGTAGACA----TGAGTTC---ATTCATA--TGGGAAAGAAACAT ENST00000419323.1 GGGTCAGTCTCACCCAGTGACCAGTTCTAAGTTCCCGACTCTTAGATGGGAAATGAAGAG * * *** ** * ***** * ** ** ******* ** * ENST00000343769.4 TAC---------------AAATGT--GAAGA-----ATGT----------GGCAAAGCCT ENST00000419323.1 TATTTTGTGTGAGCCTGTAGATGTTTGAAAACTTTGATATTCAGAGGGTAGGCGAAATGG ** * **** *** * ** * *** ** ENST00000343769.4 TCATTTGGTCCTCAGTCCTAACTAGACATAAGAGAG-TTCATACTGGA-GAGAAGCCCTA ENST00000419323.1 TCACTCACTCCTGAGACTTCCTTTGTGAAAACAGAGCTTTGTAATATTTGTGATTCCCTG *** * **** ** * * * * * ** **** ** ** * * ** **** ENST00000343769.4 C----------------AAATGTGAAGAATGT--GGCAAAGCCTTTAAG-TACTCCTCTA ENST00000419323.1 CTCTCTCTTTCAGGAAAAGATGCTCACTATATCCAATAAAGCTTATAAAATACTG----G * * *** * ** * ***** * *** **** ENST00000343769.4 CCCTTAGTTCACA-----TAAGAGA--AGTCAT--ACTGGAGAGAA------AC-CCTAC ENST00000419323.1 GTATCAGTTGAAAGGTATTAAGACATCAATTGTCGGCTGGGTGCAGTGGTTCACACCTGT * **** * * ***** * * * * **** * ** *** ENST00000343769.4 AA-------ATGTGAAGAA--TGTGGCAAAG------CCTTTGTTGCA---TCCTCAACC ENST00000419323.1 AATCACAGCATTTTGAGAGGCTGAGGCAGGAGGATCACTTGAGTCGAAGAGTTCGAGACC ** ** * *** ** **** * * ** * * * * *** ENST00000343769.4 --CTTAGTAAACAT---GAGATCATT---CATACTGGAAAGAAACCCTACAAGTGTGAAG ENST00000419323.1 AGCCTGGGCAACATAGTGAGACCCTTGTCTCTACAAAAAATAAATTAGCTAGGCGTG--- * * * ***** **** * ** *** *** *** * * *** ENST00000343769.4 AATGTGGCA-AAGCTTTTAACCAGTCCTCATCCCTTACTAAAC----ATAAGAAAAT--- ENST00000419323.1 ---GTGGTGCAGGCCTGTAA----TCCTGGCTACTTGGGAGGCTGAGGTGGGAGAATCAC **** * ** * *** **** *** * * * ** *** ENST00000343769.4 TCATACTGGAGAGAAACC--CTACAAATGTGAAGAATGT----GGCAAAGC-TTTTAACC ENST00000419323.1 TTGAGCCCAGGAGGAATAGGTTGCA---GTGAGCTGTGTTCATGCCACTGCACTCCAGCC * * *** ** * ** **** *** * ** ** * * ** ENST00000343769.4 --------------AGTCCTCTTCCCTTA---CTAAACATAAGA---AAATTCATACTGG ENST00000419323.1 TGGGCAACAGAGTGAGACCCCTCCTCAAAAAACTAAAACTAAAACTAAAATAAAAATTAA ** ** ** * * * ***** *** * **** * * * ENST00000343769.4 AGAGAAA-----------CCCTACAAATGTGAAGAATGTGG--CAAAGCTTTTAACC--A ENST00000419323.1 AAAAGAAATAAATTGTTTTCTTGTCTCTGTTCAAAACCTGGACCACTATGTGTAGTCCTA * * ** * * *** * ** *** ** * ** * * ENST00000343769.4 GTCCTCAACCCTTAT-TAAACATAAGAAAATTCATACTA---GAGAGAAA---------- ENST00000419323.1 TTCCCAGACTGTCACACAGATCTAGTGATGTTGGTACAAATTGAGAGAAAGGGAACCAGA *** ** * * * * ** * ** *** * ******** ENST00000343769.4 ------CCCTACAAATGTGAA-GAATGT----GGCAAAGCTTTT--CACCTA---TCCAC ENST00000419323.1 TGGTTCTTCCTCATCTTTGTATGCATGTAGCTGGCATAGTGATTGGCATTTGCATTCCAT * ** * ** * * **** **** ** ** ** * **** ENST00000343769.4 ACAC-CTTACTACACATAAGATACTTCATACTGGAGAGAAAC----------CTTATAGA ENST00000419323.1 AAATGTTTATTGAA-ATGAGTTAAATTAAAATAAATAGAATTAAATCCTGGACTTATATA * * *** * * ** ** ** * * * * * **** ****** * ENST00000343769.4 -TGTA------GAGAAT------------GTGGCA-AAGCTTTTAAC-----CATTCTGC ENST00000419323.1 GTGTACTTGCTGAAATTCAGTTTTAAGAAGTGGCATAAAGTGAAAACAAAAGTATTTTA- **** ** * * ****** ** * *** *** * ENST00000343769.4 AACCCTT-------TCTTCACA-------TAAGA---AAATCCAT-----TCTGGAGA-- ENST00000419323.1 AACTTATGTAGAAATATTGACGAGATGGCTAAAATGGAAATCTCTGATCTTTTGAAGATG *** * * ** ** *** * ***** * * ** *** ENST00000343769.4 -----GAAACCATACGAGTGTGATAAATGTGGCAAAGCCTTTATTTCACCCTCAAGCCTT ENST00000419323.1 TATATGTAATT-CATGAGT-TGATA--TGTAGGAGGGCATTGCTTCCTCCCACA-GCTTC * ** * **** ***** *** * * ** ** ** * *** ** ** * ENST00000343769.4 AGTAGACATGAGATAATTCATACTGGGGAGA----AACCCTAG--AAGTGTGAAGAATGT ENST00000419323.1 AG-AATCATACAGTAAT--AGACTGGGGGGATCATAGGCCTGACCAAGTGGGACTATTGT ** * *** **** * ******* ** * *** ***** ** * *** ENST00000343769.4 --GGCAAAGCCTTCAAGTG---------------------GTCCTC---ACACCTTACTA ENST00000419323.1 TAAGTTATGCTCTTAAATAAAGAAAAAAAAAGTAACATCAGTTCTTTAAGTACTTTGTTC * * ** * ** * ** ** ** ** * ENST00000343769.4 TA-CACTGAGA-------GTTCTG-----AACT----TACTCTGT-AACCATCCCAAA-- ENST00000419323.1 TAACAATGTAATTATTGTGTTCTGTCTAAAACTATGATACAGTGTTAAACTTCTCAAGGT ** ** ** * ****** **** *** *** ** * ** *** ENST00000343769.4 CTCCTC------CCAGGCACAGTCTGGCAGAGGTCCTGCCATTTCGGAGACCTGGAGGAA ENST00000419323.1 TTCCTTTGTCTACGAGCTACAGTCCAGTGTTGTTCCCCGTCTTTTTGTGAC--------- **** * ** ****** * * *** *** * *** ENST00000343769.4 GTGGCCCATTTACA---GCCATGTAGGCAGGCCTGCAGAC-CTTGGCCTTTACTACGGTA ENST00000419323.1 ATGGCCTGTCTTCACTTACTGTGGAAACAAACTAACATATGCTTCTTTTTTATT----TA ***** * * ** * ** * ** * ** * *** **** * ** ENST00000343769.4 CCTGAAGTGGTTCAATGACTCAGTTTCA----GTTACCTGAGCCACAGCTTAA-GGT-CA ENST00000419323.1 TTT--ATTTATTTTGCGACGGAGTTTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCG * * * ** *** ****** ** *** ** ** * *** * ENST00000343769.4 GTTCTGCCTATATAGAAAC-CCACACAGTTAACCTGAGGAAATGCTC----TCTGGTACT ENST00000419323.1 ATCTCGGCTCACTGCAAGCTCCGCCCCTCCAGGTTTAAGCAATTCTCCGCCTCTGG-AGT * * ** * ** * ** * * * * * * *** *** ***** * * ENST00000343769.4 CACTGAAAGCCACACTCATCCACATCCTGATACAAGGCCCACCATATGCAGACCTGACTG ENST00000419323.1 AGCTGGGA-TTACAGGCG--CGTGCCACCATGCCAGGCTAATTTTTTGTATTTTTAGTAG *** * *** * * * ** * **** * * ** * * * ENST00000343769.4 CCAAAACATGCCCTAGTGTCT--GCCGTACAGAG--TGAAGTCCTGAAGG-ATATTTAGT ENST00000419323.1 --AGACGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCAC * * * * *** *** * * **** ****** * * ENST00000343769.4 CTGTCCAAAACTA-AAATG--AAGATTTCAACTCCC--CAACCCCCTCTAACAAGC--CA ENST00000419323.1 CTGCCTCAGCCTCTAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCTGCTTCT *** * * ** ** ** **** ** * *** * ** * ** * ENST00000343769.4 GCTAAAGGTGGACTATAGTGCAGACCCAGCAACCTTGTGACCAGGCTAAAACCCCTCATC ENST00000419323.1 TTTAAAAGGAAACTCTGAGATAAAAAATACGAAGTTCTCTTCAA---AAAAGCAATCAGC **** * *** * * * * * ** * ** **** * *** * ENST00000343769.4 ACTACAAATTCAGAGGGCATCTCATCACCCTAAGGGCCCAACGAAAGATCTTTACCTTCT ENST00000419323.1 TTTTCA---TTAAAGGGAAACT-AT-------GGAGTACAACACTTGAGTTTTTTTTTTT * ** * * **** * ** ** * * **** ** *** ** * ENST00000343769.4 AACATCAGTTTATGAAAACTTGAAAAGGTGTTTGCTCCATCAAATTCAGACACCAGTACA ENST00000419323.1 ----TTTTTTT-------TTTGAGATGGAGTCT-CACTGTT--GCCCAGGCTGGAGTGCA * *** **** * ** ** * * * * *** * *** ** ENST00000343769.4 A-AACTATATTAT-GCCCATTGT-------CTGGTTCTATTTTAAT-------GTAGC-- ENST00000419323.1 ATGGCGAGATTTCAGCTCATTGCAACCTTCCCCTCCCTGCCTCAGTCTCCCAAGCAGCTG * * * *** ** ***** * ** * * * * *** ENST00000343769.4 --ACTGGAA------GTGTGTGGCAGAAGAATTAGTCAAAGA----------AATAAAAA ENST00000419323.1 GGACTGGGACTACAGGCGCCCACCACTACACCCAGTTAATTTTTTTATTTTTAGTAGAGA ***** * * * ** * * *** ** * ** * * ENST00000343769.4 TAG----CCATTGAAATTG-- ENST00000419323.1 TGGGGTTTCACCGTGTTAGCC * * ** * * *