CLUSTAL 2.1 multiple sequence alignment ENST00000349901.7 CGCTTCTGCCCTGGCCCTCTGCGGGCCGCTCCGCCGGTGCT-----GTCCCTGGGCGCCT ENST00000454247.1 CAGTATGGAATAGGAAATAC-CAAATAAATCAGCCAGTGAATAAGGATCCTAGGAAAACT * * * ** * * ** *** *** *** ** ** ENST00000349901.7 C-CGTGCTCTCAGCCAACCACCTCTGA---GAGCGCCCACTCGAGCGCCCCGGGAGCCAG ENST00000454247.1 AGCAGGAGCTCCTCCACCCAAGGCTGAACTGGAAGCCAA---GAGT---CTGAAAGACAG * * *** *** *** **** * *** * *** * * ** *** ENST00000349901.7 -----AGGGCGGGGGTCCTCGCCGGGACCCTCCTGTGGGCCCAGGG----GGACAA---- ENST00000454247.1 TTGCAAATGCTAGGGTAATAATATAGACTTTAAAGAGAACACGGAGATGTGGGTAATAAT * ** **** * *** * * * * * * * ** ** ENST00000349901.7 -AAGTGGCTCT-----CAATCCAGCA--CATGCACATTG---AAGCAAGTT-------AA ENST00000454247.1 GAAGTAACTCTGTTGCCAGGTCAACAGACATGGAGCTTCTCTGTTCAGATTCCCTTTCAA **** **** ** ** ** **** * ** ** ** ** ENST00000349901.7 ----AGGATTTAAT-ATGAAGCACAG-AAGC--AGATAGTGCCAAATAGCAAGCAGTAGT ENST00000454247.1 CCTCAGGCTCAAATCATCCATCACTGTGAACTTAGACTGAGTGAAAGAGGAGACGACAAC *** * *** ** * *** * * * *** * * *** ** * * * ENST00000349901.7 TGTTACACATTTGGTGAGCA-GGGCAGCATTTCCTT----CTCCCA-------------- ENST00000454247.1 C--CGGAGAATTTGTGGCTGTGGGAAGCCTCCTCTTACAACGCTTAAAAATGATGAAGAC * * ** *** *** *** * *** * * * ENST00000349901.7 -CTGCTGCTGAGATGGCAGAAATTAGTCGAATTCAGTACGAAATGGAATATACTGAAGGC ENST00000454247.1 CCTGCTGTTGGTAGAGTGAAGAGAGGGCCTTCTTTGCGTGAAA---AACCTATCCATCAC ****** ** * * * * * * * * **** ** ** * * ENST00000349901.7 ATTAGTCAG-----CGAATGAGGGTCCC-AGAAAAGTTAAAAGTAGCA------------ ENST00000454247.1 AATGGTTGGTTGGTCAGATGTGATTCTCTATTACCGTTTAATGTTGCAGCTAATCTTCTC * * ** * * *** * ** * * * *** ** ** *** ENST00000349901.7 -----------CCGCCAAA---------CGC-TGACCT----------GGAACAAGG--- ENST00000454247.1 TCTTCTGCTCCTCATCACATTAGTGTCACGCATGGTCTTCCAAATTTGGAAACAACGTTG * ** * *** ** ** * ***** * ENST00000349901.7 ---------ATTCCAAGA-----AGGAGTTCCAAATGCTAGTGTGATAA-TGCAAGTTCC ENST00000454247.1 GACAACTTAACCTCAGGAGATGAAAGATTTTCAAAC-TTAGTG-GACATCTGCAACTTTC * ** ** * ** ** **** ***** ** * ***** ** * ENST00000349901.7 GGA----GAGGAT---TGTTG---TAGCAGGAAATAATGAAGATGTTTCATT-----TTC ENST00000454247.1 AGAAGAAGAGAACAAATAATGGACTAAAAGGGAAAAGGACATGTACTTCATTATTGCCTC ** *** * * ** ** *** ** * * * ****** ** ENST00000349901.7 AAGAC------CAGCAGATCTTGACCTTATTCA----GTCAACTCCCTTTAAACC-CCTG ENST00000454247.1 TTGGCATTTAATAGCTGGCTCTGGTTTCATTCACAGAACCAATGATCTCCACACCATCAG * * *** * ** * ***** *** ** * *** * * ENST00000349901.7 GCAC--------------TGAAAACAC------------CACCTC-------GTGTACTT ENST00000454247.1 GCATAAAAGCAGACAACATAAAGATACAGCAGATTTCCTTGCCTCTGCCTCTGCATATTT *** * ** * ** **** * ** ** ENST00000349901.7 ACGC---TGAGTGA--AAGACCACTAGATTT-TCTGGATTTAGAAAG--ACCTCC----T ENST00000454247.1 TTGTCATTGTCTACCTAAAACTTCTCATTTTGTATAGTTTTGGTAAATAACCTTTACTGT * ** * ** ** ** *** * * * *** * ** **** * ENST00000349901.7 ACA-ACCCCTCAAAATG----AAGAAATCCGAGCA-GTTG-----GCAGACTAAAAAGAG ENST00000454247.1 ACATACTCTTTATAATGTGACAGGAATTGTAAGTACGTTACATGTGTAAATTAATTATCA *** ** * * * **** * *** * ** * *** * * * *** * ENST00000349901.7 --AGCGGTCTATGAGTGAAA----------ATGCTG--TTCGCCAAA------ATGGA-- ENST00000454247.1 CCACAAGCTTATGGGGTAGGTACCCCTATTATGCTCATTTTACCAAAGAGGTAATGGAGG * * **** * * ***** ** ***** ***** ENST00000349901.7 -----------------CAGCT---------------------GGTCAGAAATGATTCTC ENST00000454247.1 CTGAAGGGGTTTGTCTGCAGCATGAGCTTATTATAAGTGGCAAGGCCGGAACTGAAACTC **** ** * *** *** *** ENST00000349901.7 TACCTGTGT------------TGCGTGGT-----------GGGT-----CTGCTGC---- ENST00000454247.1 AGACTATACGTCCCCTCCAGATACATGCTCTCAATCCCTAGGATGTTCCCTGATGAACAG ** * * * ** * ** * *** ** ENST00000349901.7 ----CGCCAC----TTCTA--ATCCTCATCATGACAAC---GTCAGGTA---TGGCATTT ENST00000454247.1 AGAGCGTCACAGTCTTCTATAATTCTCAGTGT-ACAATTTGGTGAGACAGGATGGCTTCT ** *** ***** ** **** * **** ** ** * **** * * ENST00000349901.7 CA-------AATAT-----------AG-ATACAACCATTGAAGG---------AACGTCA ENST00000454247.1 TATTACCTCAATTTCTTCTTATCCTAGCATGAACTCCTTTGAGGCTGTAGCCTGATGCCA * *** * ** ** * * ** *** * * ** ENST00000349901.7 GA-----------TGACC----TGAC-TGTTGTA-----------GATGCAGCTTCACTA ENST00000454247.1 GAGTCAAGAGAAACAACCCTTTTCACATTTTGTAAGTAGCACAATGATACACTTTTGTAA ** *** * ** * ***** *** ** ** * ENST00000349901.7 A----------GACGACAGATAAT------------------CAAACTA--------AAT ENST00000454247.1 ATTCTTTACATGTTAGCAAACAATGTTTTTGCTTTTTTTTCACATGTTATTCCTTGAAAT * * ** * *** ** ** *** ENST00000349901.7 AGACGTCTACAACTTCTGGAAGAG-----GAGAACAAA--------------GAACGTGC ENST00000454247.1 ATACTTGGAAAATTTGTGTGAGGGTGAAAGAGAACACAATGTAATTTCTTTGGAATTTTT * ** * * ** ** ** ** * ******* * *** * ENST00000349901.7 TAAAAGAGAAATG--GTCATGT-------------ATTCAATTACT-------------- ENST00000454247.1 TATGTAGGCAATAAAGTCATCTGTAAGTAGTGACAATTTTATTTCTTCCTTTCTGATCTA ** * *** ***** * *** *** ** ENST00000349901.7 -GTAGCTTT--------CTGGCTGCTTAATAGC--TGGCTCTG-GTTTCGCCGCTA---- ENST00000454247.1 AATACCTTTTATTTCCTCTTTTTGCTTCATTGCAATGGCTAAAAGTTCCAGCACTATGTT ** **** ** ***** ** ** ***** *** * * *** ENST00000349901.7 -----------GAGGTAACATCAGCCCTC-----------------------AAAAATAC ENST00000454247.1 GAATATGAGTAGTGGGAGCAAAAATCCTTGCCTTGCTCCTGATCCCGGGGGAAAAAATTT * ** * ** * *** ****** ENST00000349901.7 TGTCT--------------CAAC---AGCTGGAAATATA--AAAGAT------------- ENST00000454247.1 AGTCTTTCACCTTTGCGTACAATGTTAGTTGTAGATCTTTTGCAGATGCTCTTTTATCAA **** *** ** ** * ** * **** ENST00000349901.7 -TTGCAAAC------TTCTTTGTTTCT------------GTCTCTG--CAT---TGTATG ENST00000454247.1 GTTGAGGACATTCCATTCTATATTCCTAGCTTGATGAGAGTTTTTAATCATGAATGGGTG *** ** **** * ** ** ** * * *** ** ** ENST00000349901.7 CC--ATTTTATAG---TCCACACCCTGA-------AAATG----TATTTCTTCCAGAAAG ENST00000454247.1 TTGGATTTGATAAAATTCTTTATCTTTGTCGGTTGATATGATAATATTTTTTTTGGACTA **** *** ** * * * * *** ***** ** ** ENST00000349901.7 TCTGGA----GGAAGGA---------------------------------CCTATATTTG ENST00000454247.1 TTTATATGCTGGATGGATTACATTGGTTGGTTTTTAAATGTTGAAACAGCCTTGCATTCA * * * *** *** * * *** ENST00000349901.7 TAGAA--------------GTAAAGGTATAT-----------TCTGTCACTCAGCTGTAT ENST00000454247.1 TGGAACATAACCAAACTTAATCAGGGTATATAATTCTTTTTATATATTGCTTAATTCTAT * *** * * ******* * * * ** * * *** ENST00000349901.7 TCAC----GTCT---GAGCAGTTCTGCAGTAACACCTGC--------TTAA--------- ENST00000454247.1 TTGCTACAATTTTTGAAGTATTTTTGTGCTTATATTTATGGGGGTTGTTGATCTGTAGGT * * * * ** * ** ** * * * * ** * ENST00000349901.7 -------------AATTCTCCCTTTGCAT-------------------------GTTTTG ENST00000454247.1 TTTATTTTTTTTTGGTACTGTCTTTGTACTGGCTTTGGTACCAGGGTACTACTAGCTTTA * ** ***** * * *** ENST00000349901.7 TAAATAGG---------CTCCAGTTTTGTTTTTTAAAA--GGAATTTATTTTTTGCCTCA ENST00000454247.1 TAAAATGAAAGTGTTCCCTCCTTTTCTATTTTCTAGAATTGGTATTAATTCTT--CTTTA **** * **** ** * **** ** ** ** *** *** ** * * * ENST00000349901.7 ----TCAGTCCACCCAACTGATTC-TGAA------TGGGAGAGA---GTCTG---TAGAG ENST00000454247.1 AAGGTTGTTCAACATAATTTACTTATGAAACTCATTTGGACAAATTAGTGTGATTTAGCC * ** ** ** * * * **** * *** * * ** ** *** ENST00000349901.7 AA--TTGATTCAGAA------------AAGTGTCTGTGAAAGAAAAACAATT----ATTT ENST00000454247.1 CAGTTTTATTTTTAATGATTTTTGCTTAAGTTTCTGTCACTGAGAACCCGTCTTCCATTT * ** *** ** **** ***** * ** ** * * **** ENST00000349901.7 TGTCCTGTTTCTCAAACAG-TGTT-------------------------------AAGCA ENST00000454247.1 TTTCCTATTCTTAAAATGGGTGTTTCATTGAAGTTTTACATCCTCTCCAAAACTTAAGGT * **** ** * *** * **** *** ENST00000349901.7 GTTTT-GTTAATAGA-----CATTTTTGCATCGACACTTCAACATT-----AACACTTT- ENST00000454247.1 GTTTTAGTTAGTGGGGCTGTCAGTCTAGCACTTTCCTCTCAGAACTCTTGGGGAACTTGT ***** **** * * ** * * *** * *** * * **** ENST00000349901.7 -----CAAAGTCATGGTCTGGTGCCAGATTTA-------AGA---AACTCGAACCACCT- ENST00000454247.1 ATACACAATGGCATGCCCTGTGATAGGATCCACAGGGGCAGACAAAGCTGGTAGTCTCTC *** * **** *** *** * *** * ** * * ** ENST00000349901.7 ---AATATT--------TCATA-----ACCTT-CTTCAT------TAGGTACTTGTA--- ENST00000454247.1 TGGAATGTTATAGGAGCTCATGTATTCACTTAGCTCCATATCCTGTGGCTGCTTGAATTC *** ** **** ** * ** *** * * * **** * ENST00000349901.7 -------CAGATTAATTT---CTAA--------CATTGCAG----------CAGTTTCAT ENST00000454247.1 CCTCTCCCAAGCTAGCTCACACTGAGAAACAGGCACTGCAGAAAAGGCAATCAATCTGAA ** ** * ** * ** ***** ** * * * ENST00000349901.7 ATGTGTGCAATATG-------------------------------TGCAT---------- ENST00000454247.1 ACTTG-GAAATAGGAGGCAGAGAGGGGGCAGGAAAGAAGGAGTGGTGCAGGGAACCAAAC * ** * **** * **** ENST00000349901.7 ------TCTTTCATTTTAGTTTTGCACTTG-------GTTTTC----TATAAAGTAC-GT ENST00000454247.1 TGGGAATGTTAAATCTTCCTCCTGCCCTTACCAAGCTGTATTCAGAATGTAAAACATAGT * ** ** ** * *** *** ** *** * **** * ** ENST00000349901.7 TTTTACTCAGTTCATGCGTGA-ACAATTTAAAAAA----CGACAGAA---TAAGGTACA- ENST00000454247.1 GTTTGGTTTGG-CATTGGTATTACAGTTGGAAAAAACTTCAAGAGAAACTCAATTTATAC *** * * *** ** *** ** ***** * * **** ** ** * ENST00000349901.7 ----AATGT--------------------AGTGT--------------ATTT ENST00000454247.1 TGGCAATCTTTCTCTATTGCTTTTTTAAAAGTCTCCCTTTAAAAAAACATTT *** * *** * ****