CLUSTAL 2.1 multiple sequence alignment ENST00000356015.2 CCCGCGCGCGGGCAGCTCACTTCCGCCCGGCAGGTGACAGCCGCGGGGCTCCGAGCCGCC ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 GGCAGCCCGGACGCACCGGGAGAGCGAGAGGTGGAGGCCGCGGACATTTTGGTGCCAAGC ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 CGAACCGAGCCGGGGCGCCGGGAGCTATTGGGACCTGCGGAAGCCTGGCTACAGATAAGG ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 GACCAAAATGACTGACTCAAAATATTTCACCACGACCAAGAAAGGGGAGATCTTCGAGCT ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 GAAGGCAGAGCTCAACAGTGACAAGAAGGAGAAGAAGAAGGAGGCAGTGAAGAAAGTGAT ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 TGCATCGATGACCGTGGGCAAAGATGTCAGTGCCCTCTTCCCCGATGTGGTCAACTGCAT ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 GCAGACGGACAACCTGGAGCTGAAGAAGCTAGTATACCTCTACTTGATGAATTACGCCAA ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 GAGTCAGCCTGACATGGCCATTATGGCCGTCAACACCTTTGTGAAGGACTGTGAGGACCC ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 CAACCCCCTCATCCGAGCCCTGGCAGTGCGGACCATGGGCTGCATCCGCGTTGACAAGAT ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 CACAGAGTACCTGTGCGAGCCACTCCGGAAGTGCCTGAAGGACGAGGATCCATATGTGCG ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 CAAGACAGCAGCTGTGTGCGTGGCCAAGCTCCACGACATCAACGCCCAGCTGGTGGAGGA ENST00000448124.1 ------------------------------------------------------------ ENST00000356015.2 CCAGGGCTTCCTGGACACCCTTAAAGACCTCATCTCCGACTCTAACCCCATGGTGGTGGC ENST00000448124.1 ----------------------------------------------------GTGGTGGC ******** ENST00000356015.2 CAATGCAGTGGCAGCGCTCTCAGAAATTGCCGAGTCTCACCCCAGCAGCAACCTGCTCGA ENST00000448124.1 CAACGCAGTGGCAGCGCTCTCAGAAATCGCCGAGTCTCACCCGAGCAACAACCTGCTCCA *** *********************** ************** **** ********** * ENST00000356015.2 TCTGAACCCACAGTCCATCAACAAGCTGCTGACAGCCCTCAATGAGTGCACCGAGTGGGG ENST00000448124.1 TCTGAACCCACAGTTCATCAACAAGCTGCTGACAGCCCTGATTGAGTGCACCGAGTGGGG ************** ************************ * ****************** ENST00000356015.2 CCAGATCTTCATCCTGGACTGCCTCGCCAACTATATGCCCAAGGACGACCGCGAGGCCCA ENST00000448124.1 CCAGATCTTCATCCTGGACTGCCTCACCAACTATACGCCCAAGGACGACCGCGAGGCCCA ************************* ********* ************************ ENST00000356015.2 GAGCATCTGTGAGCGGGTCACCCCCAGGCTCTCCCATGCCAACTCCGCTGTGGTGCTCTC ENST00000448124.1 GAG-----GTGAGCGGGCTGCCCT-------TTGCTTGCCAGCCCAGCCTGAGGACCCTT *** ********* *** * * ***** * * ** * * ** ENST00000356015.2 TGCTGTGAAGGTGCTGATGAAGTTCATGGAGATGTTGTCTAAGGACTTGGACTACTACGG ENST00000448124.1 GTCCTCAGGGGCTCCAACCAGGCAC-TGGGCCTCGGGCCTTAG---TGGGCCCTTTCTAG * ** * * * * * *** * * ** ** * ** * * * ENST00000356015.2 CACACTGCTCAAGAAGCTGGCCCCACCCCTGGTCACACTGCTGTCAGCCGAGCCAGAGCT ENST00000448124.1 TACCTTGCCCCATAA------CCCACCCTCAGACACAC--CTA------AAGGGAGGCCT ** *** * * ** ******* * ***** ** ** ** ** ENST00000356015.2 GCAGTATGTGGCCCTGCGCAACATCAATCTCATCGTGCAGAAAAGGCCTGAGATCCTGAA ENST00000448124.1 GC-----------CTGCTTCCCACC--TCTC------CAGA----GCC--AGGT----AG ** **** ** * **** **** *** ** * * ENST00000356015.2 GCATGAGATGAAGGTGTTCTTCGTGAAGTACAACGACCCTATCTACGTGAAGCTGGAGAA ENST00000448124.1 GCAGGAGA-------GTT-----------------GCCTT------GGGCAGCTA----- *** **** *** ** * * * **** ENST00000356015.2 GCTGGACATCATGATCCGCCTGGCCTCTCAGGCCAACATCGCCCAGGTGTTGGCAGAGCT ENST00000448124.1 --TGGGCATA------CGCATGGCCT----GGCC----------------TGG--GAGCT *** *** *** ****** **** *** ***** ENST00000356015.2 GAAAGAGTACGCAACAGAAGTGGATGTGGACTTTGTACGGAAGGCTGTGCGTGCTATTGG ENST00000448124.1 AACAGAA-GCCCAGGGCACCTCTGT-TGAGTTCAGTACGTGG----GTG-GTGCCAG-AG * *** * ** * * * ** * ***** *** **** * * ENST00000356015.2 CCGCTGCGCCATCAAGGTGGAGCAATCTGCGGAGCGCTGTGTGAGCACGCTGCTCGACCT ENST00000448124.1 CCACTGC-TCATTGA--------ATTCT------CACTGGGTGT--------CTGGGGCT ** **** *** * * *** * *** *** ** * ** ENST00000356015.2 CATCCAGACCAAGGTCAACTATGTGGTCCAGGAGGCCATCGTGGTCATCAAGGACATCTT ENST00000448124.1 CTGCCGGG-------------TGCTTTCCA------CACTTTAGTCTTTAATG-CAACTT * ** * ** **** ** * *** * ** * ** *** ENST00000356015.2 CCGCAAGTACCCCAACAAGTATGAGAGTGTGATTGCCACACTGTGTGAGAATCTGGACTC ENST00000448124.1 TCATCATCATCCC----------------------CCAC-------------------TT * * * *** **** * ENST00000356015.2 CCTGGATGAGCCTGAGGCCCGGGCTGCCATGATCTGGATTGTGGGCGAGTACGCGGAACG ENST00000448124.1 TCCAGATGAG---GGAGCTCCAGCT---------TAGA--------GAG---GTGGAGGG * ****** * ** * *** * ** *** * *** * ENST00000356015.2 GATCGACAACGCAGATGAGCTGCTGGAGAGCTTCCTCGAGGGCTTCCATGACGAGAGCAC ENST00000448124.1 AAATG----TGCAGGT---CCCCC----AGCT------AGGGCTCACCTGACT------T * * **** * * * **** ****** * **** ENST00000356015.2 ACAGGTCCAGCTGCAGCTGCTGACAGCCATTGTGAAACTCTTTCTAAAGAAGCCAACAGA ENST00000448124.1 AT-GGTCT---------------TAACCAACAAGATACCCTCC------AAGTCAG-AGG * **** * *** ** ** ** *** ** ** ENST00000356015.2 GACCCAGGAGCTGGTGCAGCAGGTCCTCAGTTTGGCCACTCAGGACTCAGATAACCCAGA ENST00000448124.1 AAGTGGGGAGTTGGCAT------------------CTATACAGGATGTA----------- * **** *** * * ***** * ENST00000356015.2 CCTGCGGGACCGTGGCTACATCTACTGGCGCCTGCTGTCCACGGACCCGGTGGCAGCCAA ENST00000448124.1 -CTACATGCCAGT----------ACTG-TGCTTGTTCTTT-------------------- ** * * * ** **** ** ** * * ENST00000356015.2 GGAGGTGGTGTTGGCTGAGAAGCCACTCATCTCTGAAGAGACGGACCTC-ATCGAGCCCA ENST00000448124.1 -----TTTTTTTTTTTT--------TTTTTTTTTGAGGCA--GGATTTCTGTC--CCCCA * * ** * * * * *** * *** ** ** **** ENST00000356015.2 CACTGTTAGACGAGCTTATCTGCTACATCGGCACGCTGGCTTCCGTCTACCATAAGCCTC ENST00000448124.1 GGCTG------GAGCT-----GCAGCCCCAACCTCCTGGGCTCAATC------AATTCTC *** ***** ** * * * **** ** ** ** *** ENST00000356015.2 CCAGTGCCTTTGTGGAGGGGGGCCGGGGCGTCGTGCACAAGAGCCTGCCACCTCGCACGG ENST00000448124.1 CTAG--------------GTAGCTGGGAC------TACAGATGCATGCCA----ACATAC * ** * ** *** * *** ** ***** ** ENST00000356015.2 CCTCGAGTGAGAGCGCAGAGAGCCCTGAGACAGCCCCTACTGGAGCACCTCCTGGGGAGC ENST00000448124.1 CCACTAAT--------------TTTT---ATATTTTTTGTCGAGACAGGTTTT------C ** * * * * * * * * ** * * * ENST00000356015.2 AGCCAGATGTCATCCCCGCCCAGGGCGACCTGCTGGGTGACCTCCTCAACCTGGACCTCG ENST00000448124.1 ACT---GTGTCGTCC------AGACTGGTCT-------CACCCAACCAAACT---CCTGG * **** *** ** * ** *** *** ** *** * ENST00000356015.2 GCCCCCCAGTGAGCGGCCCACCCCTGGCCACCTCCTCGGTGCAGATGGGAGCTGTGGACC ENST00000448124.1 GCTC------AAGCAGTCCACCC------ACCTC---------------AGC------CT ** * *** * ****** ***** *** * ENST00000356015.2 TTCTTGGCGGTGGCCTTGACAGCCTGATTGGGGGCACCAACTTCGTGGCACCTCCAACAG ENST00000448124.1 TGCCTGGCCTTGTTCTTTACAT-----------GCGTTATGTCAGTTAAGCCCCCAGCAA * * **** ** *** *** ** * * ** ** *** ** ENST00000356015.2 CAGCAGTACCAGCCAATCTTGGAGCACCCATCGGCAGTGGCCTGAGTGACCTCTTTGACC ENST00000448124.1 C-------CCTG-------TGAAGTAGGCATCATCA----------------TCTTGATT * ** * ** ** * **** ** **** ENST00000356015.2 TGACCAGTGGCGTGGGCACCCTGTCAGGATCATATGTGGCCCCCAAAGCAGTCTGGCTCC ENST00000448124.1 ---CTATAGATGAGGAAAC----TGAGGCTCAGA-GTGATTTCAA-------CTTGCT-- * * * * ** ** * *** *** * *** * * ** *** ENST00000356015.2 CAGCCATGAAGGCTAAGGGGCTGGAGATCTCAGGCACCTTCACCCGCCAGGTGGGCTCCA ENST00000448124.1 -------GGGGGTTAGCAGGCAGCAGA------------------ACCAGG--------A * ** ** *** * *** ***** * ENST00000356015.2 TCTCCATGGACCTGCAGCTGACCAACAAGGCCTTGCAGGTCATGACCGACTTTGCCATCC ENST00000448124.1 TTT----AGATCT----TTCTCCTACAA--------AAAACATG------TTTGTT-TTT * * ** ** * ** **** * **** **** * ENST00000356015.2 AGTTCAACCGCAACAGCTTTGGCCTGGCCCCCGCCACCCCCCTCCAGGTCCACGCGCCAC ENST00000448124.1 TGTTCGTTTGAGACAG----GGTCTTGCTCT-GTCACCC------AGGTTGGTGTGC--- **** * **** ** ** ** * * ***** **** * ** ENST00000356015.2 TCAGCCCCAACCAGACAGTGGAGATCTCCCTGCCTCTCAGCACGGTGGGCTCGGTCATGA ENST00000448124.1 ----------------AGTGG------CACCG--TCACAGC-------------TCAC-- ***** * * * ** **** *** ENST00000356015.2 AGATGGAGCCTCTGAACAACCTCCAGGTGGCCGTGAAGAACAACATCGATGTCTTCTACT ENST00000448124.1 ---TGCAGCCTCAGA----CTCCCAGAT-----TCAAG--------TGAT-TCCCCTGCC ** ****** ** * **** * * *** *** ** ** * ENST00000356015.2 TCAGCACCTTGTACCCACTGCACATCCTCTTTGTGGAGGACGGGAAGATGGACCGGCAGA ENST00000448124.1 TCAGCCTCCTG-AGGAGCTG--------------GGATTACAGGC--ATGCACCACCA-- ***** * ** * *** *** ** ** *** *** ** ENST00000356015.2 TGTTCCTGGCCACATGGAAGGATATTCCCAATGAGAATGAGGCCCAGTTCCAGATCAGAG ENST00000448124.1 --TACCAGGCTA-----------ATTTTTTGTA--------------TTTT--ATTAGAG * ** *** * *** * ** ** **** ENST00000356015.2 ACTGCCCCCTCAATGCAGAGGCTGCGAGCAGCAAGCTGCAGAGCAGCAACATCTTCACTG ENST00000448124.1 AC---------------GAGGTTTC-ACTATCACTGTGTTGGCCAGGATGGTCTTGA--- ** **** * * * * ** ** * *** * **** * ENST00000356015.2 TCGCCAAGAGGAACGTGGAGGGCCAGGACATGCTCTACCAGTCCCTGAAGCTGACCAACG ENST00000448124.1 TCTCCT--------------GACCT---CGTGATCCGCC-GCCTC---AGCCTCCCAA-A ** ** * ** * ** ** ** * * * *** **** ENST00000356015.2 GCATCTGGG--TGCTGGCG-GAGCTGCGG-ATCCAGCCGGGCAACCCCAGCTGCACGGAC ENST00000448124.1 GCG-CTGGGATTACAGGCATGAGCCACTGTGCCCGGCCG---ATCCTCAGCC-------- ** ***** * * *** **** * * ** **** * ** **** ENST00000356015.2 TTAGAGCTGTCCCTGAAGTGTCGAGCACCAGAGGTGTCCCAGCACGTGTACCAGGCCTAC ENST00000448124.1 ----------TCTTAAAGTGCTGGG-ATTACAGGTGTG--AGCTACTGCACTTGATCTCC * * ***** * * * * ****** *** ** ** * ** * ENST00000356015.2 GAGA--CCATCCTCAAGAACTGAGACCCCGGCCAGCGCCCACCCCAGCCTTCTGCCCGCC ENST00000448124.1 AAGCTTCCATCTT-----GTTAATTCCTATCCTAATAGTCGTCCCGCACTGTTGCCTGTC ** ***** * * * ** * * * *** ** **** * * ENST00000356015.2 CCATC-GAGG--AGGCCCCTCGGGGGCAGCACATCTTCCTCCTCGCAGGAGGGACCAGGC ENST00000448124.1 CCACCTGAGGCCAGGCACCT--GAAGCTG-------TCCTCAGC-CAACAG----CATAG *** * **** **** *** * ** * ***** * ** ** ** ENST00000356015.2 GGGGCTCCAGGCCACTCAGTGGGCTCCCTGGTCCTGATGGCAGAACCCACCCGATCCCTG ENST00000448124.1 TATGTCTTACGTGCCTC-------CCTCTGGTTCATTTGGAAG------TTAGATACC-- * * * *** * ***** * *** ** *** ** ENST00000356015.2 GGGTAGGGCACCACCCCCTCCTGGGGTGAGAGCGCAGTGCACTCCCGTGCTCTGGGACAC ENST00000448124.1 -----GGGAATTATCCCCTGCCAGGGT-AGGGAGGGAT-CACTC--ATGCTT------GC *** * * ***** * **** ** * * * ***** **** * ENST00000356015.2 CCCTGCTCCTGTGGCTGTGATGTGGGGTTAAGTGAGGTGGGGACCAAAGGAAACAGAGCC ENST00000448124.1 CTCCTTTCCT-TAGGGGAGATCT----TTGAG-----------CTGAAGG---CAGAGCT * * **** * * * *** * ** ** * **** ****** ENST00000356015.2 AGAGCAGCCACAGAAGCTGTGCCTGAAGGGTGAGTGTGGAGCTTGCCCCTCCGGCTCACA ENST00000448124.1 C-AATAGTGACAAGAA--------GGAGAAGGAG-GAGGAG------------------- * ** *** * * ** *** * **** ENST00000356015.2 GCCCCGGCAGCCCCTGGCTCCTTGGTCTCTCCGGTTGGTGTTAAAGGGCCCTCCACTGCC ENST00000448124.1 ------GCAG-------------------------TGAAG--AAAGTG------ATTGC- **** ** * **** * * *** ENST00000356015.2 ACCTCTCATGGGATGGACCCTGCCAACCTGGCCTGGGTGTGCAGGGAGGGGTTCCCCTTG ENST00000448124.1 ---------------------ATCAA--TGACC---GTGGGCAAAGATG-------TCAG *** ** ** *** *** ** * * ENST00000356015.2 GTAC-CAGGAGAGCTGCTCACTTAGGGCCTGGGGCTCAAGGAGCTGTAGGTGCCGGCAGA ENST00000448124.1 GTGTGCAGGAG-----------TAGG-CCTGGTG-----GCAGCTG--GAAGCTGGCTGA ** ****** **** ***** * * ***** * ** *** ** ENST00000356015.2 GGGGCAGAGCTAGGCTGGGAGGAGCCCAGGGCCTGCACCACCCACTTGCAACCACCAGGC ENST00000448124.1 CGGG-----------------------AGGGTTTATA---------------------GC *** **** * * ** ENST00000356015.2 TGGTGCCCTGCAGCTGTGCCAGTTGGGCCACAGCCTCCCGAGTGCTGACCCACATGGTCA ENST00000448124.1 TGGGGTCC------------------ACTTCAGTCTCTC----------CTTTAGGGT-- *** * ** * *** *** * * * *** ENST00000356015.2 AGACCAGGCAGAAGCTCCCAGAGCCCCTGTCTCGGGCTCCCCACCGACTGGCAGCTGCAC ENST00000448124.1 -GTCTAGGGA-------------CCCATGTCTC----CCCTCAT------ACAGCT---C * * *** * *** ****** ** ** ***** * ENST00000356015.2 TATCCCCAACTCCCCACTTCTGCCCCAAGGGTGGTCACTGCCTGTGATACATTCCTCAGT ENST00000448124.1 CCTTCATAAA-----ACTTTATTCCCA---GTAGAAAAT-TTTGT------TTACTCAGG * * ** **** **** ** * * * *** ** ***** ENST00000356015.2 G-TCGCCTCTGAGCCCAGGCCTCCTGCCACAAAGACTGGGCCGAGAGATGGGGCTGGGTA ENST00000448124.1 AATCAC----AAGCCCAGA-----TGCCG-ACAGGTCAGGT--GGTGATGGAG-TGAGTT ** * ******* **** * ** ** * ***** * ** ** ENST00000356015.2 AGCGGGTGCGCCTCCTGTTTGGGTTTCTTCGGGGTTTCTCTGTAGTGTCTGCTGCCCTCC ENST00000448124.1 AACTGGAG-----------TAGGT------GGG----------AAAGGCAGC-------- * * ** * * *** *** * * * ** ENST00000356015.2 TCCTGGCCTCCCAGGTTTCAGTTGTGTCTGACAGAGCATTAGGTTTTCCTGTTACTGCTG ENST00000448124.1 ------------AGGC-------------GATGGAG---TGGGT---------------G *** ** *** * *** * ENST00000356015.2 TGTAATAATAAAGAAAGATTCGGCTTTTGGCAATCACGGACACTTTTTTCCCCTCCACCG ENST00000448124.1 TGGCATGA---------ACTC---TCTTAGAAA-------------------CTCCA--G ** ** * * ** * ** * ** ***** * ENST00000356015.2 AATGTCAGGATTGAAAGCTGCCTCCGAGTGGTTGGGGATGGTTTTCTGACCCTACGGTAA ENST00000448124.1 AGGATCAGTACTG-----------------GCTGGGGAAGA------GGACCCAGTGTGG * **** * ** * ****** * * ** * ** ENST00000356015.2 CTAGATCTAATATATATCATCAGAAAATATATATTGTATGTTTACTCTTATTTTCAGAAA ENST00000448124.1 CCAGGTCT-------------------------------------TCTAGTTTTTAAAAA * ** *** *** **** * *** ENST00000356015.2 GA---GAAAAT---GAATAAAAATGATGACATC- ENST00000448124.1 GAATGGGAAATCTGGGCCAGGCGTGGTGGC-TCA ** * **** * * ** ** * **