CLUSTAL 2.1 multiple sequence alignment ENST00000370651.2 CGTGTATTGGCTCCTTCGGCTGCGGGCCGGCTCGGCTACGCGCTCTGCTCCGAGCCGCTC ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 ACTGCATGGTAGAGTCTGGTGCCCCCGCCGCCGCCTGCATCGCCGCCACCGCCGCTCCGC ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 CACGACCACCGCCGCCTCCTGCCCTGCAGCCACCGCCACCGCCTGTGTCGCCGCCGCCTC ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 GGGACCGGCTGTATGATTAGGCCACAATCTTCAATGAGTAAACATATTCCTCAATTCTGT ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 GGTGTTCTTGGTCACACATTTATGGAGTTTCTGAAGGGCAGTGGAGATTACTGCCAGGCA ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 CAGCACGACCTCTATGCAGACAAGTGAACTGTAGAAACTGATTACTGCTCCACCAAGAAG ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 CCCCCATAAGAGTGGTTATCCTGGACACAGAAGTGTTGAATTGAAATCCACAGAGCATTT ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 TACAAGAGTTCTGACCTGGATGGGGTAAACCTCAGTGCACTTCTTTTCTGTTGGCCTCAG ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 TATTACTGGATTGAAGAATTGCTGCTTCTTGTTAGGAGGTTCATTTCACTTATCATTACT ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 TACAACTTCATACTCAAAGCACTGAGAATTTCAAGTGGAGTATATTGAAGTAGACTTCAG ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 TTTCTTTGCATCATTTCTGTATTCAATTTTTTTAATTATTTCATAACCCTATTGAGTGTT ENST00000420305.1 ------------------------------------------------------------ ENST00000370651.2 TTTTAACTAAATTAACATGGCTCGAATGAACCGCCCAGCTCCTGTGGAAGTCACATACAA ENST00000420305.1 ----------------ATGGCTAGAATGAACCTCCCTGCTTCTGTGGACATTGCATACAA ****** ********* *** *** ******* * ******* ENST00000370651.2 GAACATGAGATTTCTTATTACACACAATCCAACCAATGCGACCTTAAACAAATTTATAGA ENST00000420305.1 AAATGTGAGATTTCTTATTACACACAACCCAACCAATACCTACTTTAATAGATTCTTACA ** ********************** ********* * *** ** * *** ** * ENST00000370651.2 GGAACTTAAGAAGTATGGAGTTACCACAATAGTAAGAGTATGTGAAGCAACTTATGACAC ENST00000420305.1 GGAACTTAAGCAGGATGGAGTTACCACCATAGTAAGAGTATGAAAAGCAACTTACAACAT ********** ** ************* ************** ********** *** ENST00000370651.2 TACTCTTGTGGAGAAAGAAGGTATCCATGTTCTTGATTGGCCTTTTGATGATGGTGCACC ENST00000420305.1 TGCTCTTTTAGAGAAGGGAAGCATCCAGGTTCCGGACTGGCCTTTTGATGATGGTACAGC * ***** * ***** * * * ***** **** ** ****************** ** * ENST00000370651.2 ACCATCCAACCAGATTGTTGATGACTGGTTAAGTCTTGTGAAAATTAAGTTTCGTGAAGA ENST00000420305.1 ACCATCCAGCCAGATAATTGATAACTGGTTAAAACTTATGAAAAATAAATTTCATGAAGA ******** ****** ***** ********* *** ****** *** **** ****** ENST00000370651.2 ACCTGGTTGTTGTATTGCTGTTCATTGCGTTGCAGGCCTTGGGAGAGCTCCAGT-ACTTG ENST00000420305.1 TCCTGGTTGTTGTATTGCAATTCACTGTGTTGTAGGTTTTGGGTGAGCTCCAGTTGCTAG ***************** **** ** **** *** ***** ********** ** * ENST00000370651.2 TTGCCCTAGCATTAATTGAAGGTGGAATGAAATACGAAGATGCAGTACAATTCATAAGAC ENST00000420305.1 TTGCCCTAGCTTTAATTGAAGGTGGAATGAAATATGAAAATGTAGTACAGTTCATCAGAT ********** *********************** *** *** ****** ***** *** ENST00000370651.2 AAAAGCGGCGTGGAGCTTTTAACAGCAAGCAACTTCTGTATTTGGAGAAGTATCGTCCTA ENST00000420305.1 AAAAGTGACATGGAACTTTTAACAGCAAACAACTTTTGTATTTGGAGAAATATTGTCTTA ***** * * **** ************* ****** ************* *** *** ** ENST00000370651.2 AAATGCGGCTGCGTTTCAAAGATTCCAACGGTCATAGAAACAACTGTTGCATTCAATAAA ENST00000420305.1 AAATATGCTTGCACCTCAGAAATCCCA---------GAAATAACTGTTTCCTTCAGTAAA **** * *** *** * ** *** **** ******* * **** **** ENST00000370651.2 A--TTGGGG---TGCCTAATGCTAC-----TGGAAGTGGAACTTGAGATAGGGCCTAATT ENST00000420305.1 GGGTCAGGGGACTTCCTAATGCTATGGCCTTGAGAGTGAAACTTGAAATGGAACTTTATT * *** * ********** ** **** ******* ** * * * *** ENST00000370651.2 TGTTATACATATTAGCCAACATGTTGGCTTAGT-------AAGTCTAATGAAGCTTCCAT ENST00000420305.1 CATTTTATACATTAGCTAATATGGAGGCTTGGTGAATACTAAGTCTAATGAAGCTTATAT ** ** * ****** ** *** ***** ** **************** ** ENST00000370651.2 AGGAGTATTGAAAGGCAGTTTTACCAGGCCTCAAGCTAGACAGATTTGGCAACCTCTGTA ENST00000420305.1 AAGAACCTTGAAAAGCAGTTTTAGAAGCTCCCAAGCCTGTCAGATTTGG-AACCTCTGTA * ** ****** ********* ** * ***** * ********* ********** ENST00000370651.2 TTTGGGTTACAGTCAACCTATTTGGATACTTGGCAAAAGATTCTTGCTGT-CAGCATATA ENST00000420305.1 TTTGATGT----------TATTTTGACACTTAATAAAAATTTCTAGCTTTTCAATATTTA **** * ***** ** **** **** **** *** * ** ** ** ENST00000370651.2 AAATGTGCTTGTCATTTGTATCAATTGACCTTTCCCCAAATCATGCAGTATTGAGTTATG ENST00000420305.1 AAAGGTGTTTTTCATTTGTATCAATTGT-------------------------------- *** *** ** **************** ENST00000370651.2 ACTTGTTAAATCTATTCCCATGCCAGAATCTTATCAATACATAAGAAATTTAGGAAGATT ENST00000420305.1 ---------------------------ATCTTATCAAGATATAAAACATTTAGAGAAGTG ********** * **** * ****** * * ENST00000370651.2 AGGTGCCAAAATACCCAGCACAATACTTGTATA-TTTTTAGTACCATACAGAAGTAAAAT ENST00000420305.1 AGGTGCCAAAATGCCCAGAAGAATACTCATATACTTTTTAGTCTCATA------------ ************ ***** * ****** **** ******** **** ENST00000370651.2 CCCAGGAACTATGAACACTAGACCTTATGTGGTTTATTCCTTCAATCATTTCAAACATTG ENST00000420305.1 -------------GACAC-----CTTAGGTGATATATTCCTTCAGTCATTT-AAACTTTG **** **** *** * ********** ****** **** *** ENST00000370651.2 AAAGTAGGGCCTACATGGTTATTTGCCTGCTCACTTTATGTTTACATCTCCCACATTCAT ENST00000420305.1 AAGGGAGGACCCATATGGCCATT----TGCTCACTTTGTGTTTATATTTTGCACATTCAA ** * *** ** * **** *** ********** ****** ** * ******** ENST00000370651.2 ACCAATATACGTCAGG-TTTGCTTAACCATTGATTTTTTTTTTTTTTTACCAAGTCTTAC ENST00000420305.1 ATTGATATATAGAAGGGTTTGTACAACCATTGACTTTGCTGCATTTCTACAATGTCTTA- * ***** *** **** ********* *** * *** *** * ****** ENST00000370651.2 AGTGATTATTTTACGTGTTTCCATGTATCTCACTTTGTGCTGTATTAAAAAAACCTCCAT ENST00000420305.1 GGTGATTAATTT----GTTCCTATAAATTTCATTTT-TGTTCTGTTATAAAAATTTCCGT ******* *** *** * ** ** *** *** ** * * *** ***** *** * ENST00000370651.2 TTTGAAAA-----------------------------TCTACGTTGTACAGAAGCACATG ENST00000420305.1 CCTGAAAAATCACACTTACCTCTGGTTGACAATTCAATCTACATTGCACAGATGCACCTA ****** ***** *** ***** **** * ENST00000370651.2 TCTTTAATGTCTTCAGACAAAAAAGCCTTACA-TTAATTTAATGTTTGCACTCTGAGGTG ENST00000420305.1 TCTTTAAAGTCTCCAGACAAAAACGAGTTATAGTTAATTTGAAGTTTGCACTTCGGGGTG ******* **** ********** * *** * ******* * ********* * **** ENST00000370651.2 CAACTTAACAGGGAGGGCCTGAGAAAAGAATGGGAGGGGGCTATTAATTATTTTTAGCAA ENST00000420305.1 CAACTTA-CAGAGAGGGGCTGAGAAAATAATGGGAGGGTACTACTAAATATTTCTAGTAA ******* *** ***** ********* ********** *** *** ***** *** ** ENST00000370651.2 AATGTTGCCTTTGTCTTGT---GCAAACATGT-AGAATATGCTCTTTAATTTAGTAAAAT ENST00000420305.1 AATATTTTCTTTGTCACATATAGCAACTATTTTAGTAAATGTT-TTAACTTTAGTAAG-- *** ** ******* * **** ** * ** * *** * ** * ******** ENST00000370651.2 ATTTTTTTAAAAGGTAGAGATGCTTTGTTATTGTAATCATAAACTTCCTGAAATTCTTGT ENST00000420305.1 -TATTTTTAAAAGGT-GAAATACTTCATTATTGCAGCTACAAA-----------TCTTAT * ************ ** ** *** ****** * * *** **** * ENST00000370651.2 AATTTTTTTCCCATACTTATCAGAAGTGTGTTTACCAACTTATTTTTGTTTGAAAGTGTG ENST00000420305.1 AAT--------------------AAATAT-TCTAGGAATCC---------------TGTA *** ** * * * ** ** *** ENST00000370651.2 ATTTTTTTTTTCCTTCCCAACCTCTCTTGCAAAAAAAGAAATGGGTTTCTGCTAATGAAT ENST00000420305.1 ATGTTTTATTCT-------ACACCTATT--------AGAAGTTG---TTTACCAA-GTAT ** **** ** ** ** ** **** * * * * * ** * ** ENST00000370651.2 TGAGCAGACATCTAATATTTTATATGCCTTTTGAGCTGTGTAACTTAATATTTGGATACT ENST00000420305.1 TA----------------CTTGTAT-----TGGAGCTG----AATTAA--CTTGTATTC- * ** *** * ****** * **** *** ** * ENST00000370651.2 TGACAATTTGTTTTATTATGTAATTGATAAAATGGTGATGTGTATTAATGTTAGTTCAAC ENST00000420305.1 -----ATTTATTTAAT---GGAATAGGGAGAAGAGTAATAA--ATTAATATCA------- **** *** ** * *** * * ** ** ** ****** * * ENST00000370651.2 CATATATTTATACTGTCTGGGGATGTGTGGTTATAGTTCTGTGGGAGAAATAATTTTGTC ENST00000420305.1 CACA----------------------GTGTTTGT--TTC--------AAATAAAT--ATC ** * *** ** * *** ****** * ** ENST00000370651.2 AGTGTTCACCAGCTTGTAAAAACTTAGTGCGAGAGCTGAAACATCTAAATAAATAATGAC ENST00000420305.1 AATATTCA--------TAATAATTC----------------TCTTTAAA------GTGAT * * **** *** ** * * **** *** ENST00000370651.2 ATGCATTTATCATCATTGAGATTGGTTTGCTTAAAATTAACTTATTTTGTAGAAGACAAA ENST00000420305.1 AT-CA-----CATCATG---------TTGCT----ACCAA--TATTA-GTAGGACAGCCA ** ** ****** ***** * ** **** **** * * * ENST00000370651.2 ATGAATTGCACTTCACTTAATGTGTGTCCTCATCTTTTTACAAATAAATGAAGGATTATA ENST00000420305.1 ATGAAAT--ATTCCAC--AATG--------AATATTTTTGTAAAAAAAGGAAGTCTTAT- ***** * * * *** **** ** ***** *** *** **** **** ENST00000370651.2 AATGATGTCAGCATTTTAGTAAACTTTTAGACAAAATTTGTTAGGGTCATTCATGAAAAC ENST00000420305.1 --------------TTTA--------CTAGATGAAAT--------ATTATTTGTG----- **** **** **** * *** ** ENST00000370651.2 TTTAATACTAAAAGCACTTTCCATTATATACTTTTTAAAGGTCTAGATAATTTTGAACCA ENST00000420305.1 ---------------------TATTGAATAGTTTCTAAA-----------CCCTAAGCCA *** *** *** **** * * *** ENST00000370651.2 ATTTATTATTGTGTACTGAGGAGAAATAATGTATAGTAGAGGACAGCCTTGGTTTGTAAA ENST00000420305.1 A-------------------AAGAAA------------------AGCCTCAG------AA * ***** ***** * ** ENST00000370651.2 GCTCAGTTCCACTAGTTCATGGTTTTGTGCAACTTCTGAGCCTCAGTTTTCTCCTTTGCA ENST00000420305.1 CCTCAA--------------GG---------------GAG-------------------- **** ** *** ENST00000370651.2 AATTAATAATTACATACCTTTATAGATTTTGAAATTAATTTAAATATTAGTATTTGGTAC ENST00000420305.1 GAT--ACAATCATGTACT------GACCTT----------CACACAGTAACATCT----T ** * *** * *** ** ** * * * ** ** * ENST00000370651.2 ATGAAGGCTTAATGTTAAGTTTCCTTTAATGATCCACAATAATCCCTTTGATCACGTTAA ENST00000420305.1 ATAAAGCATTAAT----------------------ACAA------CTTAG---------- ** *** ***** **** *** * ENST00000370651.2 TCTAAATCTAGATGTCTTTGTCTAATTTTTTTTGAATAGCAGTTATAAATGTAAAGGACT ENST00000420305.1 --TGAAACTGCAAGT--------------------ACAGCA---ATAAGTATAAACAACC * ** ** * ** * **** **** * **** ** ENST00000370651.2 CAAAGTTTAAGTAAAAAGTGATACTCCACCTTGTGTTTCAAAGAATTTAGTTCCACCTCT ENST00000420305.1 TCAGG----AGCACAAA--------------TGTG-------GAACTTAG---------- * * ** * *** **** *** **** ENST00000370651.2 TCATACCAGTTTAACACTTAATATATTTCATTGGATTTTAGACAGGGCAAAAGGAAGAAC ENST00000420305.1 ------CAAT----CACTCCTTAT---------------------GGTAAAAAGAGTAA- ** * **** *** ** **** ** ** ENST00000370651.2 AGGGGCCTCTGGAGGCCCTTGGTTATTTAAATCTTGGATTATTTGTGATAGTAATCACAA ENST00000420305.1 -------TC---AGAC-----GATATTTA--------------------------CAGAA ** ** * * ****** ** ** ENST00000370651.2 ATTTTTGGCTAATTTTTAACCTGAGGTTTTGTTTTTTTTTTAAAGGAAATGCAGCCTAGT ENST00000420305.1 AA----GGACAAT-----ACC---------------------AAGAAAGAATAGTGTAGT * ** *** *** *** ** ** **** ENST00000370651.2 CTTGAGAACATAATTTTATATAATCAATTACTAAATGTTAAAC-TATTACCACACAGCCC ENST00000420305.1 -----------------ATGTAA---------AAATATCGATCCTATTGTT--------- ** *** **** * * * **** ENST00000370651.2 ATAAAACAGCATTTGCGTTTATTGAGAGAGAGGATGTGCCATCATGATTAATGAAAACTA ENST00000420305.1 ---------CATTT---TCCTTTGATAGAAA-----TACTATT--------------CTA ***** * **** *** * * * ** *** ENST00000370651.2 TCTTTTGAGTTTGAAAAGAAATTAATTTGCAGTGTTTGGATTGTATATATGGTGCTAAAA ENST00000420305.1 CCCTCTTAGC-----AGGGTATCA-----CAGTGGTTGAAGTGTAT-------------- * * * ** * * ** * ***** *** * ***** ENST00000370651.2 ATAAATTAATTTACTTTATAAACCTTATCTGTACATTATACGATGTGATGAAATTTGCTT ENST00000420305.1 ---------TTTCCT------GCTTTAT----------------------GAATTTG-TC *** ** * **** ****** * ENST00000370651.2 TTTATCCAAATATTTTGTATCTTGTAAATATGGCTAATTATAGGAATGCCTATAATACAT ENST00000420305.1 CTTGGCCATGTGTTTTG---CTT-------TAGCCAAT----GGAATA------------ ** *** * ***** *** * ** *** ***** ENST00000370651.2 CTTAGATTCCTTATATCTAATAAGAGTTCAAAGAGTTATGAGTTGAAGTCTTGAATGCAG ENST00000420305.1 -TTAG-----------TTGACATGA-----------TGTAAGC-AAAGTTTTGAA----- **** * * * ** * * ** **** ***** ENST00000370651.2 GAAACTATCTGATAGTGTTCTAAAATTTGGTTACTTGGGTTTGGATACCCTTAGTGGGAT ENST00000420305.1 --------------ATATTCTAACA-----------AAGTTTGG---------------- * ****** * ****** ENST00000370651.2 GATGTAAATAGAGGCTAGCTACCTAGGCTTGTCTATAGCAACCATAATGTTGATGTAAGT ENST00000420305.1 ---------------------------CTTGTCT------------TTCTTGACATTTCT ******* * **** * * ENST00000370651.2 AATGCGGTTACTGAATCATAAGAAAATGCCATCTCTTTTTAGTTGAAGGAAAACTCTGGA ENST00000420305.1 GAT-------CTG---CGTGAGAAAA-----------------------AATACCCT--- ** *** * * ****** ** ** ** ENST00000370651.2 AGTAGGTGCCATTGGTCATTCTGCAGTGCACTGCAACCATTGTTTCCCCTAGTGCCCTCT ENST00000420305.1 ---AGGTATC------------------CGCTG----------TCCCTCTAG-------- **** * * *** * ** **** ENST00000370651.2 TTTCCCTAGGGCATTGCTCTCCTATTCCCACGCCTTAACACAGCTCTATACCTAGAAGCA ENST00000420305.1 -----CTGGAG--TTGC------------------------------------AGAA--- ** * * **** **** ENST00000370651.2 GCCAGCCCAGGCATGCAGTCACATTTAATCACATCCCCCTTCTAGAGTGCTTCAAAATGA ENST00000420305.1 ------TCAAACATGTG---AAGCCTAATTA----------------------------- ** **** * **** * ENST00000370651.2 TGTAGTCCCTCAACTTGGCTAAAGAATCTCAATCTCTTGAAATTTATTTTTTTAATGTCA ENST00000420305.1 -----------AACTTGGC----------CTATTACCTAGAACCAACTC----------- ******** * ** * * ** * * ENST00000370651.2 TATTCATCTGGTAAATATCTACTGTTTGCCAGGCATTTAAGAATATGGCAAAGAACATAA ENST00000420305.1 ----CAATTG------AGCTACAAGCTACTAG----CTAAG------------------- ** ** * **** * * ** **** ENST00000370651.2 AAGATGGTGTCACCAGATTTTGGTCACCAATGAGTACCCGACCCGTTGCCATGATTAAGA ENST00000420305.1 ------------CCA-ATCCTAG------ATGAGT-CAAAGCCTA----CATCACTGAGA *** ** * * ****** * ** *** * * *** ENST00000370651.2 GAGAATGCTTTCTATTGGAGTTTCAGGAAATATAATTTGAGAATACTTTAAAGGGAAGTG ENST00000420305.1 AA------------TTGAAGCTT------------TTTG--------CTA---------G * *** ** ** **** ** * ENST00000370651.2 GAAGTATAAGTGAATGATATTTTTCTTTTACATGTAAACAATGAAGTTATTTCAAAGTTA ENST00000420305.1 GAAGCA------------------CTATTGC-----AGCAAT-------------AGCTA **** * ** ** * * **** ** ** ENST00000370651.2 AGTTTTAAACAAAATACATGAAGTAGTGTCTGCCATACATGTTAATATTCTACATTCTTG ENST00000420305.1 AGT---------AGTACA----------------------GTTAG--------------- *** * **** **** ENST00000370651.2 CTTCCTTAAATTAATATGTTTGTGTGTATATATGTGCCTCACACCTGAATTGAAAATTAA ENST00000420305.1 ---CCTT---TCAACA--------------------------ACTTGAAT---------A **** * ** * ** ***** * ENST00000370651.2 AGACTGGTTTAAAAGTGGTTTAAAAGTGACATTTAATGTTTCTCCATTACGTTTGGGGTA ENST00000420305.1 AGATTG---TGAAA----TGCAGAAATA----CTAAT---------TTATG--------A *** ** * *** * * ** * **** *** * * ENST00000370651.2 ACCAGCCTAAGTGGAATCTTGGAAGGAAAGTAAGGGAAAAACTTGTATTTGCCTTCAATG ENST00000420305.1 AC-------------ATTTTGAAAA-----------------------------TC---- ** ** *** ** ** ENST00000370651.2 AATTAAACCAGTGATATGTGTTAACGTATGAATGAAAGGATTGATGGTGATTTTATAATT ENST00000420305.1 -------CCAG--------GTTA---------------GATT--------------AATT **** **** **** **** ENST00000370651.2 ATATATATTGCCGCAGTAACCAGTTAATAAATTGATAGCTACCATTT ENST00000420305.1 -----TATTGC-------ACT--TTATTA--TTCCTAA--------- ****** ** *** ** ** **