CLUSTAL 2.1 multiple sequence alignment ENST00000371927.3 TAACATCCAGGAGATATTCTAATACTTCTTATTTTCCAAGTACACACAAATTGGGGGTAG ENST00000453261.1 -------CA--AACTAGCCCAGTGCTGT--------CAAAT-----CAGATTAATGG--- ** * ** * * * ** *** * ** *** ** ENST00000371927.3 GGGGAAGGGCTAAGATGCTTAATAGTGGGCGTAGCCAGTTGTGGATAAATATCAAAAAGG ENST00000453261.1 ------------GGATGCTTTGTCCTGACTTT--CCAC----------ACACCAGAACGA ******* * ** * *** * * ** ** * ENST00000371927.3 GAATCCTAACATGAAGTATAAGTGGGATTTTCACCAAAACCCTATCCTTCCCCAGACTCC ENST00000453261.1 TTATT-TA--ATGAATTATTA-------TATGACCAA---CCTAA---TAAAAAGGATGC ** ** ***** *** * * * ***** **** * ** * * ENST00000371927.3 AGTGACAGTT-TAACGGTCAG-CTGCATCAAGGCTTGTGTACTGTGCAGTCTTAAAAGGC ENST00000453261.1 AA--ACAATCATACTAACTAGTCTTCTTC------TGTAAACAG---AGCCTTAAAGTTC * *** * ** ** ** * ** *** ** * ** ****** * ENST00000371927.3 ACCACTCCTGTCCATCTCGGTGAAATTG--ATGGTGGAGCAAAAGGGAGTTTAGGTGGTT ENST00000453261.1 ACTCCTACTGTAAGTGTTGTTCAGAATGTAATGGTTGAA--------------------- ** ** **** * * * * * * ** ***** ** ENST00000371927.3 CCGGTCTGGGGAGAAGACGTGCAGGGTTTCAGATGCGAAAGTCGCACCCAACCGCTTCAC ENST00000453261.1 --GGACTGGA------ATATGTAGTTTATCAG---------------------------- ** **** * ** ** * **** ENST00000371927.3 TCGGGCTCTAGGCCATCCGCAGGGGCCCTGCTTCCTTCCACCTGCGAGCTTTTTCTGCAG ENST00000453261.1 --GAGATCTATGCCA-----------CATATTTCT------------GCTGTTG--GCAG * * **** **** * * *** *** ** **** ENST00000371927.3 AATGCGGGAAGCCGCCGCCGCCGCCACAGAGGAGGGGGCGGAGGCAGAGGCGGAGGCGGC ENST00000453261.1 AATCTA-------------------ATAGAGTAAG-----AAGATAGAAATTTGTGGAAT *** * **** * * ** *** * ENST00000371927.3 ACCCAGGGGCCGGGGCAGGGGAGGCCGGGACCATCGCAGTGACAATTTATTT---TCC-T ENST00000453261.1 ACTCTGTGG-----------AAAGCTG---CCA-CATAAT--TAACTTACTTCTATCCGT ** * * ** * ** * *** * * * ** *** ** *** * ENST00000371927.3 GCAGCAGCGGCAGCAGGGACGGTTGCTGCAGGTTCGGGGTCGGCCGGCCTGCGCGTGGGC ENST00000453261.1 GTAATTGTGCCA--AAGGA--GT--CTTCAGGACCAGACTC--TTGGGATGTG---GAGA * * * * ** * *** ** ** **** * * ** ** ** * * * ENST00000371927.3 TTGCGAGGACGCTGTTCGTCCCCTGCGCTGGGGTGTCCGACAGCGAGGAGGAGAACGACG ENST00000453261.1 ATGCAAAATAATTATTCA--------------ATGTTC-------AGGATCAGCATGATC *** * * *** *** * **** ** * ** ENST00000371927.3 CACGGAGCCCGCGCGACTGGAACCAGCAAAGCTCCATCTGTCGGCAGAGGAGAAGGGGGA ENST00000453261.1 TTCTTACTCTGAG---ATGGGTCCATACACACCTAACCCTTCATC--------------- * * * * * *** *** * * * * ** * ENST00000371927.3 GGAGGCACGGCCGAGGCAAACGAGCGGACGCCTCGTCGCCGGGTGCCGGTAT-CAC-CCC ENST00000453261.1 -----CAAAACTGAA-----------------TTATTGTCCAGCATTGATCTTCACACTC ** * ** * * * * * * * * *** * * ENST00000371927.3 GCTGCAACGCCTTCCAGCAAAAGCCACCGCGGCCCGGGTTGCAGCAGCCGGACGGATGCC ENST00000453261.1 ACTGT---TCCTATCAGCTCGTGCTGCCAGAGGCT--GTTGTCATTGTCTGTT---CATC *** *** **** ** ** * * **** * * * * ENST00000371927.3 AAGGCCACACGGCAGCCACGGGGGCAGCCGTCGCAGTCGCCGTCCCACACGGGCTGCGGA ENST00000453261.1 AAAGC------------ATAAAGACATGCATGGCA----TCTCCCC------GCT----- ** ** * * ** * * *** * *** *** ENST00000371927.3 CACCAAGGGTTGCTAATGAAGTGATTGAGAAGAAACAGTGAACATCCTCATTTCACAGAT ENST00000453261.1 TACCA---GTTC----TGGCACGTTTGGG---------------------CTTTCCAGCT **** *** ** * *** * ** *** * ENST00000371927.3 AAGACAACATGGATCAGCCTTTTACTGTGAATTCTCTGAAAAAGTTAGCTGCTATGCCTG ENST00000453261.1 GAC-CACCAAGGA---GCCCAG-GCTGTTTAGTTTATGTAAGTGTATGTTGGTAAA---A * ** ** *** *** **** * * * ** ** ** * ** ** ENST00000371927.3 ACCATACAGATGTTTCCCTAAGCCCAGAAGAGCGAGTCCGTGCCCTAAGCAAGCTTGGTT ENST00000453261.1 AACATAAAAATAAT----TATGCT---------GGATCTG------AGGTGA-TATGTTT * **** * ** * ** ** * ** * * * * ** ** ENST00000371927.3 GTAATATCACCATCAGTGAAGACATCACTCCACGACGTTACTTTAGGTCTGGAGTAGAGA ENST00000453261.1 CTAATATTAGCATCATCAA---CATCA------GACG---CCT---GCCT---------A ****** * ***** * ***** **** * * * ** * ENST00000371927.3 TGGAGAGGATGGCGTCTGTGTATTTGGAAGAAGGAAATTTGGAAAATGCCTT-TGTTCTT ENST00000453261.1 TGGGCATGTGGTTGCCTG-ATTTTCTTAAGATG----TTTCAGAAATGACTGATATTTTA *** * * * * *** * ** **** * *** ***** ** * ** * ENST00000371927.3 TATAATAAATTTATAACCTTATTTGTAGAAAAGCTTCCTAACCATCGAGATTACCAGCAA ENST00000453261.1 GATGAGAAAGTTTTA----TATTTATTGCA---CTTGCACATT-TAGAAATTTCC----- ** * *** ** ** ***** * * * *** * * * ** *** ** ENST00000371927.3 TGTGCAGTACCTGAAAAGCAGGATATTATGAAGAAACTGAAGGAGATTGCATTCCCAAGG ENST00000453261.1 -------TTTTTGG---GCTGGTCTGTCTCAAGAGTGTTAA----ATTA-ATACCTA--- * ** ** ** * * **** * ** *** ** ** * ENST00000371927.3 ACAGATGAATTGAAAAACGACCTTTTAAAGAAATATAACGTAGAATACCAAGAATATT-T ENST00000453261.1 -TTAATGAATTCGAATAC---------------TATGAC-CAG---ATCAAGTGTACTAT ******* ** ** *** ** ** * **** ** * * ENST00000371927.3 GCAAAGCAAAAACAAATATAAAGCTGAAATTCTCAAAAAATTGGAGCATCAGAGATTGAT ENST00000453261.1 ATATAACAACAACAA------------------CAAAAAG--AAAGCA--AGTGGTGCAT * * *** ***** ****** **** ** * * ** ENST00000371927.3 AGAGGCAGAAAGGAAGCGGATTGCTCAGATGCGCCAGCAGCAGCTAGAATCGGAGCAGTT ENST00000453261.1 GGAGGAAGGAAAGAAGTAGA------AAA-----CAGAGGGAGGGAGAA--AGAAAGGGT **** ** ** **** ** * * *** * ** **** ** * * ENST00000371927.3 TCTGTTTTTCGAAGATCAACTCAAGAAGCAAGAGTTAGCCCGAGGTCAAATGCGAAGTCA ENST00000453261.1 -----------AAGAGGA----AAGAAGCCAGAAAGAA---AAGGAGAAA---GAACTTC **** * ******* *** * *** *** *** * ENST00000371927.3 GCAAACCTCAGGGCTGTCAGAGCAGATTGATGGGAGCGCTTTGTCCTGCTTTTCCACACA ENST00000453261.1 ACAAAT---AAGAATCTCA-ATTAGACTGA------------GCACAGAATTTCAACAAA **** * * * *** * *** *** * * * **** *** * ENST00000371927.3 CCAGAACAATTCCTTGCTGAATGTATTTGCAGATCAACCTAATAAAAGTGATGCAACCAA ENST00000453261.1 ACAAAAATATT-----CTAAAAGAATT-------------GAGAAAAATAACTGAA--AA ** ** *** ** ** * *** * **** * * ** ** ENST00000371927.3 T-TATGCTAGCCACTCTCCTCCTGTAAACAGGGCCTTAACGCCAGCTGCTACTCTAAGTG ENST00000453261.1 TGTATG------ATTTTTCTACC--------------AAAGTAAACTACTATTCAAGG-- * **** * * * ** * ** * * ** *** ** * * ENST00000371927.3 CTGTTCAGAATTTAGTGGTTGAAGGACTGCGATGTGTAGTTTTGCCAGAAGATCTTTGCC ENST00000453261.1 ------AAGATTTAG------------------ATATA----------AAGACATTT-TC * ****** * ** **** *** * ENST00000371927.3 ACAAATTTCTGCAACTGGCAGAATCTAATACAGTGAGAGGAATAGAAACCTGTGGAATAC ENST00000453261.1 ACATA--GCTAAAATTCAGAGGGGTTATTGC--TAATCTGAATAAA--------GGACCT *** * ** ** * ** ** * * * * ***** * * * ENST00000371927.3 TCTGTGGAAAACTGACACATAATGAATTTACTATTACCCATGTAATTGTGCCAAAGCAGT ENST00000453261.1 TCTACAGAGAATTCCCAAATAAGGAA-------------ATACAA----GGCAGAAAGAT *** ** ** * ** **** *** ** ** * ** * * ENST00000371927.3 CTGCGGGACCAGACTATTGTGACATGGAGAATGTAGAGGAATTATTCAATGTTCAGGATC ENST00000453261.1 ------AACCTGA--ATTGGAACA-AGAAATGACAAACAAATAACCTGA----------- *** ** **** *** ** * * * *** * * ENST00000371927.3 AACATGATCTCCTCACTCTAGGATGGATCCATACACATCCCACTCAAACTGCAT-TTTTA ENST00000453261.1 AATAT---------AC------ATGAATAAATATATATACTAATTAAA-TATATATTTTA ** ** ** *** ** *** * ** * * * *** * ** ***** ENST00000371927.3 TCCAGCGTTGATCTTCACACTCACTGTTCCTATCAACTCATGTTGCCAGAGGCCATTGCC ENST00000453261.1 T-----ATTAAT-TAGATA-----TATATTTATAAA----TATAAATAAA---CATTGA- * ** ** * * * * * *** ** * * * * ***** ENST00000371927.3 ATTGTTTGCTCACCAAAGCATAAAGACACTGGCATCTTCAGGCTCACCAATGCTGGCATG ENST00000453261.1 --------------ACAGTATAAA-ATA-TAATATCT-----------AAT--------- * ** ***** * * * **** *** ENST00000371927.3 CTTGAGGTTTCTGCTTGTAAAAAA-AAGGGCTTTCATCCACACACCAAGGAGCCCAGGCT ENST00000453261.1 -TTGAGGAG---AAATGTGAAAATTAAATATTTTAAATAATATACAATAGGG--TAGGT- ****** *** **** ** *** * * * ** * * * *** ENST00000371927.3 GTTCAGTATTCAGAAATTCCTTTCTGGGATAATTTCTGGCACTGCTTTGGAGATGGAGCC ENST00000453261.1 ----GGTAATCAGAA--TCAATTATTAGAC-----TCGACAC------------------ *** ****** ** ** * ** * *** ENST00000371927.3 CCTGAAAATTGGCTATGGACCAAATGGATTCCCACTCTTGGGGATCTCTAGGTCATCATC ENST00000453261.1 -----------ACTATG---------------CATT-------ATTTCCAAATCA----- ***** ** * ** ** * *** ENST00000371927.3 ACCATCTGAACAGCTCTGAGAGAGACAAGAAGTGGAATGGAGAAGGTGATTAGGTAATCC ENST00000453261.1 ---------------------GAAATAAAAAA-GGAAAAAAAAAACC--TCTGCTAATC- ** * ** ** **** * ** * * ***** ENST00000371927.3 AAGAATTGCCAGGCGAACAATTGTGAAAATCTTTCATAGAGTTCCCGATGAAAACAACTC ENST00000453261.1 AAAAGT-------------------AATATACTTAAAAGGA--------GAAAAGGAC-- ** * * ** ** ** * ** ***** ** ENST00000371927.3 TTTCTTGTTAGCCATTATCTCTGCCTTTCCTTTCTAAAGAAAAACACGTCATTTCATCTT ENST00000453261.1 -----------------------------------AAATAAAAATA---------ACCTG *** ***** * * ** ENST00000371927.3 GATTATCAGTTTCTCAAGTACTCATGGATGTGAGGCCAGGTACCCTGTCACCTTGGCTCT ENST00000453261.1 GGT------------AAATA-----------AAAATCAGATATA-TGTTA---TAAAATT * * ** ** * *** ** *** * * * ENST00000371927.3 GTTTGGGATGCAATGTTGTGTTTGTCACCACTTCCCATTCCCCAAAAGCATCTTTAACAT ENST00000453261.1 ATGCCAAATATA-TAGTGCACATGACACAA--TCAAGTTAATTAAAATCATCTATTAAAT * ** * * ** ** *** * ** ** **** ***** * * ** ENST00000371927.3 AGACCATTCATTCTTCAGATTCAAAATGCTTAAGCTGAACTAACCTCAAAGGGCCCTCAT ENST00000453261.1 GG--CAGT-ATGTATCAGAGTGTATTTGTTTAA--------AATCACA---------TGT * ** * ** ***** * * ** **** ** * ** * ENST00000371927.3 TAATTTACAGACATTTGAATAACACCCATATTCATTTCTGCTACTGAACCAAAGCCTTTT ENST00000453261.1 T--TTTACAGATAT-------ATACCTA-----------------GAACACAA------T * ******** ** * *** * **** ** * ENST00000371927.3 CCAAAAAAATCATCTAGCAAACTGTTTTTGCCAGGCCAAATATTAACAGGTATATATATT ENST00000453261.1 GGGAAGGAGAGATTCA--AAG----TTTTG-----------------AAGAATATATACT ** * ** * ** ***** * * ******* * ENST00000371927.3 TGCATACATAAATATTTACCTCTATGTCTTGTGTGTTTTTGTTA---TGAGACAGAGTCT ENST00000453261.1 -GGGTATATAAAAACCAAACT--AAAACTTGGTTGGTTCTATTAATATCAAACAAAATTT * ** ***** * * ** * **** ** ** * *** * * *** * * * ENST00000371927.3 CACTCTGTCGCCCAGGCTGGAGTGC-AGTGG-CACAGTCTCAGCTCACTGCAACCTCCAC ENST00000453261.1 ---TCTGTCACC-----TGAAATATTAATAAATATAATAAAAGACCACTAAA-------- ****** ** ** * * * * * * * ** **** * ENST00000371927.3 CTCCCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCGAGTAGCGAGGACTACAGGCGTG ENST00000453261.1 ---------TTATGGAATACTC------------------TGACAA------------TG * * * ** *** * * * ** ENST00000371927.3 CACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTTACCCTGTTGGC ENST00000453261.1 GAACACCATAT--AGC----------------AGCAGAAATAAA-----------TTAAT * ***** *** ** *** ** ** ENST00000371927.3 CAGGGTGGTCTCGAATTCCTGACCTCTGATGATCTACCCGCCTGGACCTCTCAAAGTGCT ENST00000453261.1 CAGAG----CTAGAAGT--TGAA---TAACAATATACATTGCCGAA-------------- *** * ** *** * *** * * ** *** * * * ENST00000371927.3 GGGATTACAGACATGAGCCACTGTGCCCTGCCTCTGTTTTGTGTATTTACATAAATACAT ENST00000453261.1 -GGATTA---ACATAA----TTATACC--------ATTATATGAATGTATA-AAACA--- ****** **** * * * ** ** * ** ** ** * *** * ENST00000371927.3 GTCTCCAGAGCTTTAAATTCTTCTTAAATTTTAAAACTAGAACTAAACCAGACATTGAGA ENST00000453261.1 GT----AAAAAT--AAATTTTT----AATTTTAT-------------CTAGATAATGAGG ** * * * ***** ** ******* * *** * **** ENST00000371927.3 GGACCCAGAAATATACCCTGACTAACGTGGGTGGAATTTCATTTGGCTTGACTCTTTGGT ENST00000453261.1 GTGTCTTGAAATAAA---TGTTTAATGTA------------------------CTATACT * * ****** * ** *** ** ** * * ENST00000371927.3 GAAAAAAAAAAAAATCAGGCTCTCAAGGACTCAATTTGGTGAACCAATGCCAAATAGAAA ENST00000453261.1 GGGGAGCATCAATAGTAG--TTTTAATGATTTCTTTACCTGGGTGGGTACC---CAGGTA * * * ** * ** * * ** ** * ** ** * ** ** * ENST00000371927.3 AATGTTCTTGACATTTTCCCCAAAATAGATGTCTAAAGATTTTGCACTTCAAATTGGTAC ENST00000453261.1 ATTGTT----ACATTCTTCTCTA------TGCCT------TTTATATATCAG-------- * **** ***** * * * * ** ** *** * *** ENST00000371927.3 TTTATGTATTAAAAGTGATATTGAAACTAAATTCCTACCCAATTAGTTGAAAAATATGAA ENST00000453261.1 -TTACAGATCAG----------GGAAC--AAT-------------GT--AATAATTTAAA *** ** * * *** *** ** ** *** * ** ENST00000371927.3 AAAAGCAATTGCTAGAGAATGCAATTTATTAAATGTTGGTGGTCTTTTAAAAAATGAATT ENST00000453261.1 GAAACTAATTT------AATAGTATTTG--GGATTTCTTTGG-CTTATATAAGAC---TT *** **** *** **** ** * *** *** ** ** * ** ENST00000371927.3 CCTCTTGTAGCCAGTGAGATCAGTTATTTATTTATTTATTTTAATAGTAACAAGGTCTCA ENST00000453261.1 TTTCTGGGAA----TGATAATA-TTACTGGCTT-TGTGTGATGAAAG-AATAAATCATTA *** * * *** * * *** * ** * * * * * ** ** ** * * ENST00000371927.3 CTAT-ATTGTCCAGGCTGATCTTGAACTCCTGGCCTCAAGCTGTCCTCCCATCTCAGCTT ENST00000453261.1 TTATCATCATA-AGGTTGATTTGGAAAT----------AGC-ATTTTTTCCCCTCAA--- *** ** * *** **** * *** * *** * * * **** ENST00000371927.3 CCCAAAGTGCTGAGATTATAGGCATGAGCCACCATGCCTGGCTAGTTAATGGTTATTAAG ENST00000453261.1 -CCACA--GCTG---------GC-TGA---ACCTTGTCTAATTGGTAAATT-CCAGGATG *** * **** ** *** *** ** ** * ** *** * * * ENST00000371927.3 TAATACAAACATTTCTGTGAATTCCACCAGATCATTGACTTTGGCATAGTTCACTTAAGA ENST00000453261.1 TATTGCTGTCCTTTTGAAGAA----GTCACATCATTTATTTT-----------CTGTGGA ** * * * *** *** ** ****** * *** ** ** ENST00000371927.3 CTTTGTTTGATAAAATAAATCTCTTTCACTCTAATTAGGAAGCATTTTTGGGATCCTGAT ENST00000453261.1 C------------ATTAATTTTATTTC---------------CAGTTTT----TCTT--- * * *** * * **** ** **** ** * ENST00000371927.3 TAATGCTCTAATATTGTGGGGCCAAAAAATATGTGGAACGTGGCCCTGCAGTTAGATGAG ENST00000453261.1 -----CTCTAGTAAT-TGGAG------AATCT-TGAAGTCTGGCCC----ATTAT-TCAT ***** ** * *** * *** * ** * ****** *** * * ENST00000371927.3 CTGAGATCACTATAGTACTATATAGCGCTCTAAATCCTAAATGCTAGATCACTGTAATAC ENST00000453261.1 CTGGGATT----------TATAAATCCTTCTACAGCTTGCA--CT--ACCTTTCTAAGTT *** *** **** * * **** * * * * ** * * * *** ENST00000371927.3 TGTACAGATCAGCCACTTGCTGGCTTGTGACTCTGGGCCATTTACTTCACCTCTCAAAAG ENST00000453261.1 TGAAC-------CTACTTTCGAGGGTATATATCC-------TTCCTTC-CCCCACAA--- ** ** * **** * * * * ** ** **** ** * *** ENST00000371927.3 GCATATTTAAAGTGAGGAAAATAATAAGTTTATTTTGGAAATTCAGTTAGATGATGCAAA ENST00000453261.1 ----CTCT--------GAAAATATGTAGCT-------GAAAGAGAGCCA--------AAA * * ******* ** * **** ** * *** ENST00000371927.3 TTGTTTACTGTAATTTCTAGCATGTAGTTCGTGCTCCATGCATTTAACTGTTATTACAGG ENST00000453261.1 TC-----------TTTCT---------------CTC-------TCAA-----ACTACAAG * ***** *** * ** * **** * ENST00000371927.3 TTGTATTAGTATCACATTAAATTACCCACTGAAGTGAAAGTGAAACCAGAATGCTGTCAA ENST00000453261.1 TC---CCAGTTTTA---------------------------------------------- * *** * * ENST00000371927.3 CGATT ENST00000453261.1 -----