CLUSTAL 2.1 multiple sequence alignment ENST00000372839.3 GGAGCTACCGCCACCGCCGCCGCCGATTCCGGAGCCGGGGTAGTCGCCGCCGCCGCCGCC ENST00000445359.1 ------------------------------------------------------------ ENST00000372839.3 GCTGCAGCCACTGCAGGCACCGCTGCCGCCGCCTGAGTAGTGGGCTTAGGAAGGAAGAGG ENST00000445359.1 ------------------------------------------------------------ ENST00000372839.3 TCATCTCGCTCGGAGCTTCGCTCGGAAGGGTCTTTGTTCCCTGCAGCCCTCCCACGGCAG ENST00000445359.1 ------------------------------------------------------------ ENST00000372839.3 AGTCTCCAGAGATTTGGGCCGCTACAAAAAGTGCATTTTGCCCATTCGGCTGTGGATAGA ENST00000445359.1 ------------------------------------------------------------ ENST00000372839.3 GAAGCAGGAAGAGCACTGGACTTGGAGTCAGGGAATGACAATGGATAAAAGTGAGCTGGT ENST00000445359.1 -------------------------------------ACAATGGATAAAAGTGTGCTGGT **************** ****** ENST00000372839.3 ACAGAAAGCCAAACTCGCTGAGCAGGCTGAGCGATATGATGATATGGCTGCAGCCATGAA ENST00000445359.1 ACAGAAAGCCAGGCCCGCTGAGCAGGCTGAGCGCGGTGATGATGTGGCTGCAGCCGGGAA *********** * ****************** ******* *********** *** ENST00000372839.3 GGCAGTCACAGAACAGGGGCATGAACTCTCCAACGAAGAGAGAAATCTGCTCTCTGTTGC ENST00000445359.1 GGCAGCCATGCCACAGGGGCATGCGCCCCCAGCTGAAGACAGCAATCTGCCCTCTGCCGC ***** ** *********** * * * ***** ** ******* ***** ** ENST00000372839.3 CTACAAGAATGTGGTAGGCGCCCGCCGCTCTTCCTGGCGTGTCATCTCCAGCATTGAGCA ENST00000445359.1 CTACAAGAATACGGTGGG-GCCCACTGTTCTTCCTGGATTCTCATCTCCAGCACTGAGCA ********** *** ** **** * * ********* * ************ ****** ENST00000372839.3 GAAAACAGAGAGGAATGAGAAGAAGCAGCAGATGGGCAAAGAGTACCGTGAGAAGATAGA ENST00000445359.1 GAGAACAG-GAGGAATGAGA---AGCAGCAGATGGGCAAAGAGTACCATG-GAAGACAGA ** ***** *********** ************************ ** ***** *** ENST00000372839.3 GGCAGAACTGCAGGACATCTGCAATGATGTTCTGGAGCTGTTGGACAAATATCTTATTCC ENST00000445359.1 GGCAGAGCTGCTGGACATCTGCAATGAGGTTCCGGAGCTGTTGGACAAGTCTCTTATTCC ****** **** *************** **** *************** * ********* ENST00000372839.3 CAATGCTACACAACCAGAAAGTAAGGTGTTCTACTTGAAAATGAAAGGAGATTATTTTAG ENST00000445359.1 CCATGCTACACAACCTGAAAGCAAGGCGTTCTCCTTGAAAATGAAAGGAGATTGTTTCGG * ************* ***** **** ***** ******************** *** * ENST00000372839.3 GTATCTTTCTGAAGTGGCATCTGGAGACAACAAACAAACCACTGTGTCGAACTCCCAGCA ENST00000445359.1 GTATCTTTCTGGGGTGGCGTCTGGAGACAATAAACAAACCACACTGTTGAACTCCCAGCA *********** ***** *********** *********** *** ************ ENST00000372839.3 GGCTTACCAGGAAGCATTTGAAATTAGTAAGAAAGAAATGCAGCCTACACACCCAATTCG ENST00000445359.1 GGCTTACCAGGAAACATCTGAAATTAGTAAGAAAGATATGCAGCCTACACACCCAATTCG ************* *** ****************** *********************** ENST00000372839.3 TCTTGGTCTGGCACTAAATTTCTCAGTCTTTTACTATGAGATTCTAAACTCTCCTGAAAA ENST00000445359.1 ACTGGGCCTGGCACTTAATTTCTCAGTCTTTTGCTACGGGATTCTAAACTCTCCTGAAAA ** ** ******** **************** *** * ********************* ENST00000372839.3 GGCCTGTAGCCTGGCAAAAACGGCATTTGATGAAGCAATTGCTGAATTGGATACGCTGAA ENST00000445359.1 GGCCTGCAGCCTGGCAAACGTGGCATTTGATGAAGCAATTGCTGAGTTGGATACACTGAA ****** *********** ************************ ******** ***** ENST00000372839.3 TGAAGAGTCTTATAAAGACAGCACTCTGATCATGCAGTTACTTAGGGACAATCTCACTCT ENST00000445359.1 TGAAGAGTCTTATAAAGACAGCACTCCCACCATGCAGTGACTTCGGGACAATCTCACTCT ************************** * ******** **** **************** ENST00000372839.3 GTGGACATCGGAAAACCAGGGAGACGAAGGAGACGCTGGGGAGGGAGAGAACTAATGTTT ENST00000445359.1 GGGGACATCGGGAAACCAGGGAGATGCAGGAGATGCTGGGGAGGGAGAGAACTG-TGTCT * ********* ************ * ****** ******************* *** * ENST00000372839.3 CTCGTGCTTTGTGATCTGTTCAGTGTCACTCTGTACCCTCAACATATATCCCTT-GTGCG ENST00000445359.1 GCCATGCCTCACAATCTGTTCAGTGTCACCCTGTACCATCCACGTAAATCCCTTTGTGTG * *** * **************** ******* ** ** ** ******* *** * ENST00000372839.3 ATAAAAAAAAAAAAAAAAAAAAAAAGAGAATCGTACGTCGACTTTCGATTTTTCACAGCC ENST00000445359.1 ATTAAAAAAAAAAAA------------GAATTGTACATTGTCTTGCGATTTTTCACAGCC ** ************ **** **** * * *** *************** ENST00000372839.3 TCAGCCTAGGAAAAATGGTTCATGGGATAAACAGCTGGTATTTGTATCTAAAACTCAGAT ENST00000445359.1 TCAGCCTAGCAAGAATGGTTCGTGGGATAAACAGCTGGCACTTGTATCTAAAACCTAGAT ********* ** ******** **************** * ************* **** ENST00000372839.3 TGGTCACATAAATGCCACGGCATTCCGAAGTTTTGATTTTGATTAACATTGACAGGATTA ENST00000445359.1 TGGTTGCATAAACACCATGGCATTCTGAAGTTTTGGTTTTGATTGACATTGGCAAGATTA **** ****** *** ******* ********* ******** ****** ** ***** ENST00000372839.3 CTGTGTGTTTAATTTTTTAAAAACTGAACACTGTGATTATGGGGTTTTGTAATTTAGCAG ENST00000445359.1 CTGTGTGTTTAATTTTCTTAAAGCTGAGCACTGTGGTGATGGG-TTTTGTAATTCAGCAT **************** * *** **** ******* * ***** ********** **** ENST00000372839.3 AACTCTTACTGGTAGAAAAAATAGACCTGAATTATGTGTAACTTTTTGGAAGGTTTAATC ENST00000445359.1 AATTCTTACTGATAAGAAAAATAGACCTGAATGTTATGTAACTCTTTGGAAAGTTTAATC ** ******** ** **************** * ******* ******* ******** ENST00000372839.3 TGATATCAAAATAATCATTGAAATACAATTCCATTGTAAAGTTGTACAGAAAGTTATAGA ENST00000445359.1 CAATATTAAAATAGTCACTGAAATACAATTTCATTGTAAAGTTGTACAGAAAGTTACAGA **** ****** *** ************ ************************* *** ENST00000372839.3 GATTATATTGTGATGCTGGAACTTGGAGTGAGACACACATCATTTGGCATTTGAGTTGAA ENST00000445359.1 GGTTATGTCGTGATGCTGGGATGTGGAGTGAGACAC-CATCATTTGGCATTCAAGTTTAA * **** * ********** * ************* ************** **** ** ENST00000372839.3 TGGTAATTCACAGTAATGCTGCCGTTGTTCGGGACTTAAAGACACTTGACCTGTTTGGGC ENST00000445359.1 TGGTAATTCACAGTGATGCTGCC--TGTTCAGAGCTTATAGACACTGGACCTGTTTGGGC ************** ******** ***** * **** ******* ************* ENST00000372839.3 TGTTGCCACTTAAAAGTTCATGACCACAAATGTCCACAGTGTCTTCCTCTGAGGAAACTC ENST00000445359.1 TATTGCCACTCAAAAGTTCATGACCACAAATGTCCACAGCGTCTTCCTCTGAGGAAATGC * ******** **************************** ***************** * ENST00000372839.3 GAATCCTGAAATGGAAATTCTTTGTGGCAGATAACTGGCTTATGACACCTTGAAAAGTTC ENST00000445359.1 AAATCCTGAAGCTGAAATTCCTTGTGACAGATAACTGGCT-GTGACACCTTGAAAAGTTC ********* ******* ***** ************* ****************** ENST00000372839.3 AAGTGCTCATATAACACACCACACTGAACCCCCTTTCCTACAGCAATATGTTCACTATGT ENST00000445359.1 TGGTGCTCATATGACACACCTGACTAAACCCCCCTTCCTACAGCAATAGG---AATATGT ********** ******* *** ******* ************** * * ***** ENST00000372839.3 TACCAATTTGCAACTTGTGCTTCAATAGTGGAATCTACTTTCATTGTTAACACTGAGCTA ENST00000445359.1 TACTGATTTGAAACTTGTGCCTCAATAATGGAATAGTTTTTCATTGTTAACACTGAGCTA *** ***** ********* ****** ****** ********************** ENST00000372839.3 AAGAAAAAAA-GCCGTGTGTTTTATGAATGACCTTATCTGTTTCCTGG------------ ENST00000445359.1 GTGCTGTAAATGCTGTCTGTTTTATGAATGCTCTTTTCTGTTTCCTGGCTAATATCTCCT * *** ** ** ************* *** ************ ENST00000372839.3 ------------------------------------------------------------ ENST00000445359.1 TCTTTTTTTTTTTTTTGGTGTGAGGAATTTAATAAGATAATGCATACAAAGTGCTCAGAA ENST00000372839.3 ------------------------------------------------------------ ENST00000445359.1 CCCCAGCAGATACACGGCATTCACTGAGTGTTAGCCAGTCTCATTATAGCACAGATGTCC ENST00000372839.3 ---------------------------------ATAATACCTTTAAGAATAATGTCCTGA ENST00000445359.1 CTTCCCCCACATGCCTTTGCCCCACATTCCTGGATAATACCTTTAAGAATAATGTTCTGA ********************** **** ENST00000372839.3 GTCAGGCGTGGTGGTGCGTGCATCTAGTCCCAACTATTTGGGAGGCTGAGGCAGGAGGAT ENST00000445359.1 GTCAGGCATGGTGGTGTGTGCCTGTGGTTCCAAATACTTGGGAGGCTGAGGCAGGAGGAT ******* ******** **** * * ** **** ** *********************** ENST00000372839.3 CGCTTGAGCCCAGGAGTTTAAAGCTGCAGTGCCCTGTGGTTGCACCTGTGAATA---ACT ENST00000445359.1 CACCTGAGCCCGGGAGTTTAAGGCCATAGTGTCCTGTGGCTGCCCCTGTGAATAGCCACT * * ******* ********* ** **** ******* *** ********** *** ENST00000372839.3 GCACTCCAGCCTGGGCAACATAGCGAGACCTCATCTCCAAAAAAGAAAACAAAAAACAAA ENST00000445359.1 GCACTCCCACATGGGCAACATAGCAAGACCTTGACTCCAACAAA----ACAGAAGA---- ******* * ************* ****** ****** *** *** ** * ENST00000372839.3 AAAAGGAATGATGTTCTGTAGAGATGGCCTTTCACTTGAGGAGTACTCAGTTTTCAGGTT ENST00000445359.1 ----------ATGTTCTGTAGAGATTGCCTTTCACTTCAGGAGTGCTCAGTTTTCATGTT *************** *********** ****** *********** *** ENST00000372839.3 CTTCCTAGCTCGGGGCTTTTAAATTTTGAAATCTAAACATTCTTTCCCACCATCCTTTTT ENST00000445359.1 CTTCCTAGATTGGGGCTTTTA---TTTATTATTATATTATGTTTT------ATTTTATTT ******** * ********** *** ** * ** *** ** * *** ENST00000372839.3 GACTGTTGACCTTGGTTTTCTCTTCTAAGTTTCTGTCCCTCTGCTTCCTTACTTTTTTTC ENST00000445359.1 ACTTATTCA--TTAAT---------TAA-------------------------TTAGTTA * ** * ** * *** ** ** ENST00000372839.3 CTTTTTGAATTCTATCTTTATCTGTCTTTTGTTCACTTTTTAATGCTATATATGGGCAGG ENST00000445359.1 ATTTTGAGACAGGGTCTCCCTCTGCG----GCCCA-------------------GGCTGG **** * *** **** * ** *** ** ENST00000372839.3 GGTGAGAGACATTACTGAGCACCTTGGTGAGCAAGCCTGGCTTTAAAGATTGGAGAAGAG ENST00000445359.1 AGTGCGG-----------------TGGCA--CAATCTTGGCTC-----ACTGCA-----A *** * *** *** * ***** * ** * ENST00000372839.3 CTTCTGGCACCAGAACCCTGTCT-TCCTCCAGTTCTCAACA--CGGTGTTGCTCTTCAGT ENST00000445359.1 CCTCTGCCTCCTGGGTTCAAGCAATTCTCCCGC-CTCAACCTCCTGAGTAGCT----GGA * **** * ** * * * * **** * ****** * * ** *** * ENST00000372839.3 CATACCGGAATCTGAATCAAAAAAGTATTTTTAAATATCCATGATTTCTCCCTGTATTGA ENST00000445359.1 ATTACAGGCACGTGACACCAAAGGCCACCT---AATTTTTGTATTTTTAGTAGAGATGGG *** ** * *** * *** * * *** * * *** ** * ENST00000372839.3 GGCTAGCCCTGATCATGCTTTTTGTGCCTGTCACCAGGTCTCCCAAGTGCACTCATCCAG ENST00000445359.1 GATTTATCTT--TTTTTTTTTTTTTTTTTGAGATGGAGTCTT----GCTCTGTCGCCCAG * * * * * * ***** * ** * **** * * ** **** ENST00000372839.3 GTCAGTGCTCAGATGTGTTTAAGGAGACCCTATATTCAGGGAAGTTGCGTGAACACTGCA ENST00000445359.1 GCTGGAGTGCAG-------TGGCGAGATCTCG-----------GCT-------CACTGCA * * * *** * **** * * * ******* ENST00000372839.3 GTGGGGAGAATTGAGAATAGTCAGGCCTATCAGTCTCACAGAATCACCCCTCTACCTTTG ENST00000445359.1 ------------------AGCTCCGCCTCCCGGGTTCA---GGCCATTCTCCTGCCTC-A ** **** * * *** ** * ** *** ENST00000372839.3 ATATTCCACTTAGCTGTAGAGTCCATCTGTTTGTCCATC-TGCTGAAATGAGAAAAGAAA ENST00000445359.1 GCCTCCTGAGTAGCTG-GGATTACAGGTGCGTG-CCACCATGCCCAGCT--------AAT * * ****** ** * ** ** ** *** * *** * * ** ENST00000372839.3 AATTTATGCACTGATTTAAAACAAACCAAAAAAAAAGAAAAAAACAAAAAAAAAAATCCC ENST00000445359.1 ATTTTGT------ATTTATAATAGAG-ATGGGGTTTCACTATGTTGGTCAGGCTGGTCTT * *** * ***** ** * * * * * * ** ENST00000372839.3 TCCTTTCTAGCTGAACAAAAATGTGCAGTTAATACTTGGCGCTTGAAAATGCAGTAGTGA ENST00000445359.1 GAACTCCTGACCTCGTGATCTTCCCC-GT-----CTTGGCCTCCCAAAGTGCTGGGATTA * ** * * * * ** ****** *** *** * * * ENST00000372839.3 ATGTGGAACCAAGCCTG--TCTGTATATCTGGTAGCTCTTTTCTTGCTTTGTTTTTTCTT ENST00000445359.1 ---------CAGGCATGAGTCACTGTGCCTGG---CCTTTTGTTCACTTTTTTTTTTTTT ** ** ** ** * * **** * *** * **** ****** ** ENST00000372839.3 ACCAGTATTCTGCCTAACGTTTGCTTCTGTGAT---GGTTATATTGCCTAGCAAGCACAC ENST00000445359.1 --------TGAGACAGA-----GTCTCTGTCACCCAGGCTGGAGTGC--AGTG-GTGCAA * * * * * ***** * ** * * *** ** * ** ENST00000372839.3 CCGTGGTTGTGAAAATAGTATAGCAAAAAAGAAAAATCCCCGGTTATTGATGTACTAGAT ENST00000445359.1 TCTCGGCT----------CACTGCAAG----------CTCC--------ACCTCCCAGGT * ** * * **** * ** * * * ** * ENST00000372839.3 TTGTGTATGTCTTTTAAACAGTTCTAGTTTCACCTTACACAGAATAATCAGGAA---AAG ENST00000445359.1 TTACGCCATTCTCCT-----GCCTCAGCCTCCC--------GAGTAGCTGGGACTACAGG ** * *** * * ** ** * ** ** *** * * ENST00000372839.3 TGTAAAAATTCAAAAGTGAAATAAAAATTTTATCAGTTAGTTGCCTGT------GAA--- ENST00000445359.1 CGCCCACCACCAAGCCTGGA-TAATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGTATTT * * *** ** * *** **** * ** ** * * * *