CLUSTAL 2.1 multiple sequence alignment ENST00000373329.1 GCTTCGAAGATTGTTTCAGAAGCGTTGGGCGGGGCGTCCCTGAGAGAAATTAGAGTATTG ENST00000440222.1 ----------TTGCT-----ATCACTGA--------TTCC------AAATTTGATT-TTA *** * * * ** * ** ***** ** * ** ENST00000373329.1 TCATAGGCAACAGTCCAGAACTCAGGAGAATGAACTGAA-AATAAATGCT-----GTGTT ENST00000440222.1 TCTTTTGTTTTACTTT----CTT-------TTAACCACATGATAAGTGTCCCAGGATTTT ** * * * * ** * *** * **** ** * ** ENST00000373329.1 TTCAGAGAGTGCTTCACAGTTGA-CTGCAGGCATTCAGCTTTCTCTGGCATCATCTGGCG ENST00000440222.1 TTTCTAAAGAGCTTCAAAGTGAAACTGTAGACATT-----TTCTTTGCCTTTA---AAAG ** * ** ****** *** * *** ** **** **** ** * * * * ENST00000373329.1 TGAATAAAATGCTTCCTTCAGTTTCAACCAC-AGCTATTCA-GGTTTCCTGTGCTGGTTG ENST00000440222.1 CCAAAAAAGATCACCATCTGAGAGAAATTATGAGCCTTTCAAGGCCACCTGGGACAGA-G ** *** * * * ** * *** **** ** **** * * * ENST00000373329.1 TAAAAAAATTCT-CCAGAAGGGGCAAACTGCTTATCAGAGGAAAGGATCTGCTCAACTTT ENST00000440222.1 TGGAGAAATGATGCCAAAAA---CCAATTCCT----------AAGGA------------- * * **** * *** ** * ** * ** ***** ENST00000373329.1 TCTGCTCCATACCATGCATCACTGAATACATTTCATCTGCCAGTTCACCAGTTCCTTCT- ENST00000440222.1 ----CTTCAAA---------GTTGAAAA------ATGT-------------TTCCTTCAG ** ** * **** * ** * ******* ENST00000373329.1 AAGAGAACTTGTTCAAACTGCTCAAAAGACATTTTAAATCCAAAGGATGTGATTAGTGTC ENST00000440222.1 AAGAAAA-------GAACTGCT---GAGATA----AAA--CAAATGATGGCAAT----TC **** ** ******* *** * *** **** **** * * ** ENST00000373329.1 CAGCTGGAAGACACTACCTCTTGCAAAACTTTTTGCAGCCTATCTTGTCTTTCATCATAT ENST00000440222.1 CAATTA---------------TGCA----TTTTT----CCTA------CTTTC-TCATA- ** * **** ***** **** ***** ***** ENST00000373329.1 GAAGAAAAAAGAAAACCATTTGTTACCATATGTACTAATAGCATTTTGACCAAGTGCAGC ENST00000440222.1 ---------AGAAAAGTATTAA-----------ATTAATGTCTCTT-------ATGAAGG ****** *** * **** * ** ** ** ENST00000373329.1 ATGTGCCAGAAGACTGCTATTATTCAGTATGAAGTAAAATACCAAAATGTGAAACATAAT ENST00000440222.1 ATGGGTTCCTAGATTACATTTAA--AGT-TACAGTTTCATA--GAAAT---AATCATA-- *** * *** * * *** *** * *** *** **** ** **** ENST00000373329.1 CTTTGCAGTAATGCCTGCCTTTCAAAGTTTCACTCTGCTAACAACTTCATCATGAACTGC ENST00000440222.1 --TTGAAGTGAAGC----------AAATT----TCTG--AGCAGTCCCAT--TCAGTTGA *** *** * ** ** ** **** * ** *** * * ** ENST00000373329.1 TGTGAGAACTGTGGCACTTACTGTTACACCAGCTCTAGTCTGTCCCACATACTT-CAGA- ENST00000440222.1 AATAAAA----TAATAC--ACAGAAATAG----TCAAACACGTGCAAAATGTGTGCAGCC * * * * ** ** * * * ** * ** * * ** * *** ENST00000373329.1 TGGAAGGACAGTCTCATTACTTTAATAGTTCAAAGAGTATTACAGCATATAAGCAGAAAC ENST00000440222.1 TGGAAG--CACTCTGAATCCC---ACAATTCAGAGTGTGTT-----TTAT-----GAAAC ****** ** *** * * * * * **** ** ** ** *** ***** ENST00000373329.1 CTGCCAAACCACTTATATCTGTTCCTTGCAAACCATTGAAGCCCTCAGATGAAATGATTG ENST00000440222.1 T--CCAAAAGGATCACTTCTGCT--------ACGATTGTA----TCAACTTAATTGATCT ***** * * **** * ** **** * *** * ** **** ENST00000373329.1 AGACTACGAG-TGATTTGGGGAAGACAGAGCTTTTCTGCTCTATTAATTGTTTCTCTGCA ENST00000440222.1 TGGCAGCCTGATGATTTG------ACA----CTGTCTTCACTACC--CTGCTCCTTAGTC * * * * ******* *** * *** * *** ** * ** * ENST00000373329.1 TACAGTAAAGCTAAGATGGAATCTTCTTCAGTAAGTGTTGTTTCTGTGGTGCATGATACT ENST00000440222.1 T-CAGCGA-----------------TTACAATA------------GCAGTGCA-GAAAGC * *** * * ** ** * ***** ** * ENST00000373329.1 TCAACAGAGCTTCTTTCTCCAAAGAAAGATACGACTCCAGTTATAAGCAATATAGTGTCA ENST00000440222.1 TCA---------TTTTCT---------------ACTCT--------------TAGTGACT *** ***** **** ***** * ENST00000373329.1 TTGGCAGACACCGATGTTGCCTTGCCCA-TCATGAACACTGATGTCTTACAAGATACAGT ENST00000440222.1 TAGAAACCCGCTTCTGCTGCTCTGTCCAGTGACAGGCTCTG--GCCCCAACAGCTGCAGA * * * * * ** *** ** *** * * * *** * * * ** * *** ENST00000373329.1 TTCTTCAGTAACAG-CAACAGCAGATGTCATTGTGGATCTTTCTAAGAGTTCACCTAGTG ENST00000440222.1 GT-----GAGACAAATCACATCGAATGTT-TCCTGAGTCTTTCC-----TTTTCC----- * * *** *** * **** * ** ****** ** ** ENST00000373329.1 AACCCAGTAATGCTGTTGCTAGTAGTAGTACGGAACAGCCAAGCGTTTCACCATCTTCAT ENST00000440222.1 -ACCC--TGATACGGTTTCTT--------------CACCCAAATCT-----CATCTTGAA **** * ** * *** ** ** **** * ****** * ENST00000373329.1 CAGTA---TTCAGTCAGCATGCAATTGGTTCCAGTACAGAAGTACAAAAAGACAATATGA ENST00000440222.1 TTGTAGCTCCCGGGAGGGATGGGATTGGGA--GGGACTGG-GTA---GGAGACAAC-TGA *** * * * *** ***** * ** * *** ****** *** ENST00000373329.1 AATCTATGAAAATAAGTGATGAACTATGTCACCCAAAATGTACATCCAAAGTACAAAAAG ENST00000440222.1 AAC--ATGGGGGTGGGT-----------TCCCCCATACTGTTCTTGTG--GTA------- ** *** * ** ** **** * *** * * *** ENST00000373329.1 TTAAAGGTAAATCACGAAGTATTAAAAAATCTTGTTGTGCAGATTTTGAGTGTTTGGAAA ENST00000440222.1 ------GTGAAT----AAGTCTCACGAGACCTGATAGT----TTTTTGTTTTTTTGAGAC ** *** **** * * * * ** * ** ***** * **** * ENST00000373329.1 ACAGTAAAAAAGATGTGGCATTCTGTTATTCATGCCAGT-TGTTCTGCCAAAAATATTTT ENST00000440222.1 AGAGTA------------CACTCTATTGCCCAGGCTGGAGTGCAATGGCGCAA---TCTT * **** ** *** ** ** ** * ** ** * ** * ** ENST00000373329.1 AGCTGTGGAAGAGAGTCATTTGCAACCCACGGAACTTCTAATTGGAAAAAAACCCTGGAA ENST00000440222.1 GGCT------------CACT-ACAATC---------TCTGCCT---------CCCAGG-- *** ** * *** * *** * *** ** ENST00000373329.1 AAATTCAGAAAGCATGAAAAAAGTGAAATGCATTTGAAGTCATTGGAATTTTGGAGAGAA ENST00000440222.1 ---TTC---AAGC--------------------------------GATTCTTGG-----G *** **** ** * **** ENST00000373329.1 TACCAATTTTGTGATGGAGCTGTCAGTGACGATTTATCTATTCATTCGAAACAGATTGAG ENST00000440222.1 CCTCAGCTTCCCGA-GTAGCTG-------------------------------------- ** ** ** * ***** ENST00000373329.1 GGAAATAAAAAGTACCTAAAGCTTATAATTGAAAATATTTTATTTCTTGGAAAGCAGTGT ENST00000440222.1 --GAACCATAGGCACGCACCACC-ATGCCTGG------CTAATTTTT---------GTGT ** * * * ** * * ** ** * **** * **** ENST00000373329.1 TTACCCTTAAGAGGAAACGACCAGTCAGTTTCATC-TGTGAATAAAGGCAATTTTTTAGA ENST00000440222.1 TT----TTAATAG-AGATGG------GGTGTCACCATGTTGGCCAGGCTAGTCTT----- ** **** ** * * * ** *** * *** * * * * ** ENST00000373329.1 ATTGTTAGAAATGAGAGCAAAAGATAAAGGAGAAGAAACATTTCGACTTATGAATT-CAC ENST00000440222.1 -----------------------------------GAACTCCTGGCCTCGTGATCTGCCC *** * * ** *** * * * ENST00000373329.1 AAGTTGACTTCTATAACAGTACACAAATTCAAAGTGATATTATCGAAATAATAAAGACTG ENST00000440222.1 GCCTCGGCCTCC-----------------CAAAGTG---------------------CTG * * * ** ******* *** ENST00000373329.1 AAATGTTGCAGGATATTGTGAATGAGATCAATGACTCCTCAGCATTTTCAATCATATGTG ENST00000440222.1 AGAT--TACAGG--------CATGAG-CCACTG--CGCCCAGC-----CAA--------G * ** * **** ***** ** ** * **** *** * ENST00000373329.1 ATGAGACAATCAATAGTGCCATGAAAGAACAGCTTTCAATTTGTGTAAGATACCCACAAA ENST00000440222.1 ATCTGATGGTT-----TTACAAGGGGAAACCCCTTTCTCTT-------GGTTCTCAT--- ** ** * * ** * *** ***** ** * * * ** ENST00000373329.1 AATCATCAAAGGCTATCTTAATTAAGGAAAGATTCTTGGGTTTTGTTGATACTGAGGAGA ENST00000440222.1 -------------TCTCT--------------CTCTTG---CTTGCCACCATATAAGACA * *** ***** *** * * ** * ENST00000373329.1 TGACTGGGACCCACTTACATAGGACTATCAAAACTTATCTGCAGCAAATTGGAGTTGATA ENST00000440222.1 TGCCTTTTGCCTTCTGCCAT--GATTATGAGGCC---TCCCCAGCCACGTGGAACTG--- ** ** ** ** *** ** *** * * ** **** * **** ** ENST00000373329.1 TGGATAAAATACATGGCCAGGCCTATGATAGCACCACTAATTTGAAGATAAAATTTAATA ENST00000440222.1 TGAGTCCATTAAATCTCTTTTTCT----TATTAC--CTAGTCTCAGG-TATCCCTT---- ** * * ** ** * ** ** ** *** * * * * ** ** ENST00000373329.1 AAATAGCAGCAGAATTCAAGAAAGAAGAACCAAGAGCTTTATACATACATTGTTATGCAC ENST00000440222.1 ---TGCCAGCAGTGT-----GAAAAGGGACTAA--------TACACAC------------ * ****** * ** * * ** ** **** ** ENST00000373329.1 ACTTTTTGGATTTATCAATA-ATTAGGTTTTGTAAAGAAGTAAAAGAACTCCGAAGTGCT ENST00000440222.1 ----CCTGAATTCATTAGTTCATTCAGTCTT----------CAAGCAACCCTGCAGGA-- ** *** ** * * *** ** ** ** *** * * ** ENST00000373329.1 CTAAAAACTCTCAGTTCTTTGTTCAACACTATTTGTATGTCTGGGGAAATGTTGGCAAAT ENST00000440222.1 --AGAAATCACTAGTCCC------------ATTTGC-TGTAGGAGGAAA-GTGGGGG--- * *** *** * ***** *** * ***** ** ** ENST00000373329.1 TTTCGAAACATTTATAGGCTAAGTCAAAA---CAAAACATGCAAGAAACATATATCACAA ENST00000440222.1 -TCAGAGATGTTAAGTGACCTGCCCAAGGTTGCAAAGCAAGTAAGAGTCAAACCT----A * ** * ** * * * *** **** ** * **** ** * * * ENST00000373329.1 TCATGTTGGACAGTCCATGATCGTACATTACTATCTGTGATTGACAGTCTTCCAGAGATT ENST00000440222.1 GCCTGATTCCCAAGCC--GGT-GTA-ATCACTGTGTTCAGTTTGCAG----CCAAAGG-- * ** * ** ** * * *** ** *** * * ** *** *** ** ENST00000373329.1 ATTGAAACATTGGAAGTTATAGCAA-GCCATTCTTCAAATACAAGTTTCGCCGATGAATT ENST00000440222.1 GATGAAG-ATCTGAGGCTCCTGTGATATCATGGATCATCTATA---TTTGCTGA-GATAA **** ** ** * * * * *** *** ** * ** ** ** ** ENST00000373329.1 GAGTCATTTGCTGACATTGGTTTCCAAATTTGAATTTGTCTTTTGTTTGAAATTCCTGTA ENST00000440222.1 AAATGATGTGCTA-----------CTAATTTAATCTCATCTGTA----AGAACTTTTCTT * * ** **** * ***** * * *** * ** * * * ENST00000373329.1 TCGAGTGCTGAGTGTTACAGGAATTCTTTCCAAAGAGCTTCAAAATAAAACCATAGACAT ENST00000440222.1 TC------CCAGAGTTATGATGTCTTTTATCAGGATGGTTAGACAT----CCAC--GTAT ** ** **** * ** ** * ** * ** *** ** ENST00000373329.1 TTTTTCTTTG-TCTTCAAAAATAGAAGCAATTTTGGAATGTTTATCATCTGAAAGAAATG ENST00000440222.1 GGTTCCGAAGCTCCTGCTGAATAGGGCGGGCCATGGAATGTCTG--GTTTG--------- ** * * ** * ***** ******** * * ** ENST00000373329.1 ACGTATACTTTAAAACAATCTGGGATGGAACAGAGGAAATATGTCAAAAAATAACCTGTA ENST00000440222.1 ---------TTG-------CTGGGATGGCATAAAGGGCATACACTGAA---------GTG ** ********* * * *** *** ** ** ENST00000373329.1 AAGGTTTTAAAGTTGAAAAACC----TTCTCTTCAGAAAAGAAGAAAAATTCAGAAATCA ENST00000440222.1 AA-------ATGCTGACAAACCATTCCTCTGTTCTTAAAAAAATAAAAAAT--------- ** * * *** ***** *** *** **** ** ***** * ENST00000373329.1 GTAGATCTTGGCAATTCAGATAATATGTTTTTTCCTACTTCAACAGAAGAACAATATAAA ENST00000440222.1 GTG---CCTGGC----TAAACAAACTGT----------------GGAATATTAATATAAT ** * **** * * ** *** *** * ******* ENST00000373329.1 ATTAATATCTATTACCAAGGATTAGATACTATATTACAAAATTTAAAGTTATGTTTTTCG ENST00000440222.1 GG-AATA-CTACT--CAGCGATAAAA---------AGGAA---CAAGGTACTGATTCTTG **** *** * ** *** * * * ** ** ** ** ** * * ENST00000373329.1 GAGTTTGATTATTGCAAAATAAAGCAAATTTCAGAACTGTTATTTAAATGGAATGAACCA ENST00000440222.1 TAG-----------CAACATGGA-TGAATCCCAACAGTCTTA----------------CA ** *** ** * *** ** * * *** ** ENST00000373329.1 TTAAATGAAACAACAGCAAAACATGTTCAGGAATTTTATAAACTTGATGAGGACATTATC ENST00000440222.1 CTGGGCAAAATAA----AAAGCCTGAC----------ACAAA-------AGGGCA----- * *** ** *** * ** * *** *** ** ENST00000373329.1 CCAGAACTTAGATTTTATCGACATTATGCAAAGCTTAACTTTGTCATAGATGATAGTTGC ENST00000440222.1 -CAGAGC--AAAT------GACTTTATATGAAATTC----------TAGA--AAAG---- **** * * ** *** **** ** * **** * ** ENST00000373329.1 ATAAACTTCGTCAGTCTCGGCTGTTTGTTTATTCAGCATGGTCTTCACAGTAATATTCCT ENST00000440222.1 ACAAACTTAGT--GTAT------------TATTGTGCTAGGGCT--ACCATGA------- * ****** ** ** * **** ** ** ** ** * * ENST00000373329.1 TGTCTCTCAAAGCTATTATATATTGCTTTGTCTTGGCCAATTACTTCAGCAAGTACTGAG ENST00000440222.1 -------CAAAG-TACCAAAGACGG-------------GGTGGCTT----AAACAGCAGA ***** ** * * * * * *** ** * ENST00000373329.1 AACTCATTTTCTACCCTGCCTCGTCTTAAGACATATTTATGTAATACCATGGGACAAGAG ENST00000440222.1 AATTTGTTTCCT-------------------CACAGTTCTG---------GAGGCCAG-- ** * *** ** ** * ** ** * * * ** ENST00000373329.1 AAGCTTACTGGCCCAGCCCTAATGGCTGTTGAGCAGGAGTTGGTAAATAAACTAATGGAG ENST00000440222.1 AAGCCT----------CTATCAAGG-TGTTG-GCAGGGGT-GGTTTCT----TCGTAGGC **** * * * * ** ***** ***** ** *** * * * * ENST00000373329.1 CCTGAAAGACTCAATGAAATTGTGGAAA--AGTTTATCAGTCAGATGAAAGAAATATAAT ENST00000440222.1 CCCT-----CTCCTTGGC-TTGTAAATGGTAGTTT-TCTCCCAG---------------- ** *** ** **** * ***** ** *** ENST00000373329.1 ACATGCTCATTTGAACTTACCTAAAAGACTTGTATTTCCATTGGGATGTTTTCATTTCAA ENST00000440222.1 -TGTTTCCACGTGGTTGTCCCTCTGTG---TGTATCT--------GTGTCCTAATTTC-- * ** ** * *** * ***** * *** * ***** ENST00000373329.1 AATTGTTCAAAATTCAAAAGACACAGAACGATAAACAGTGAAGTCTCCTTCCCTCCTTTA ENST00000440222.1 --CTCTTC----TTATAAAGACACCAGGC-----ATATTGGA-TTAGGTTCCACCCTAAG * *** ** ******** * * * ** * * **** *** ENST00000373329.1 GAACTCATTTTCTCTTCCCAAAAAGTGTTATCTTTTCCTTAAATATCC---CTCTAGAGG ENST00000440222.1 GATCTCATTTT-----------AAG-GTAATCACCTCTTTAAAGACCCAACCTCCAAA-- ** ******** *** ** *** ** ***** * ** *** * * ENST00000373329.1 TATTTTTCCTAAGTGGTATTGTACGGTGTATACTGTTCTTCAGCTTGTCTTCTCTGTGTA ENST00000440222.1 TAC--------AGTCACATTTTGCAGT----ACTAGGGATTAG---GACTT-------TA ** *** *** * * ** *** * ** * *** ** ENST00000373329.1 ACATATTTTTGAGATTGTCCCATGTCGTTACATGAAGAGTTTCTTGATTCTTGGTCTATA ENST00000440222.1 ACATAT-----GGATT-----------TTG---GAAGAAC------ACAATTAGCCCACA ****** **** ** ***** * ** * * * * ENST00000373329.1 ATTGCAGATGTTATTGTATGAATGTACCATAATATATTTGAGCAGTCCCTGCTGACATTT ENST00000440222.1 AC-ACCTAGACTATGGTGAAAATA-AGCAGAAT-------AGTGGTTGCCTCTGGGAGGA * * * *** ** *** * ** *** ** ** * *** * ENST00000373329.1 TTTTCCTAACCTTTTGCTATTATAAATAATGATTCATTTTATAACCTTTTATATAGGTCA ENST00000440222.1 GTGT---GGGTTAGGGATATACTAGGAAGTGGTT---TGGGAGACTTTCTG--------- * * * * *** ** * ** ** * ** ** * ENST00000373329.1 CATTGCACATGAGTGAGTTTACTGTAAGCTGGAAATCTAAAGTTAGAATTACTAGGTTAA ENST00000440222.1 --------------GGGTTGATGGAAAATTGG--ATTTGGTGATAGGGTT--TGGGTTAT * *** * * ** *** ** * * *** ** * ***** ENST00000373329.1 GATATGTGCATTTTTACTTTTGATAGATATTGGCAAGTTGCCATCTATAAGGATTGTGCC ENST00000440222.1 AA-AAGT---TATCTACATTTG-------TTGCCCGGGCGCGAT------GGCTCATGCC * * ** * * *** **** *** * * ** ** ** * **** ENST00000373329.1 AGT--TTACAGTCCCACCCACAATGC--ATGAGAGTGCCT-ATTAAATCTTTGTAAGTGT ENST00000440222.1 TGTAATCCCAGCCCT--CTGGGAGGCCGAGGTGGGTGGATCACGAGGTC-----AAGAGA ** * *** ** * * ** * * * *** * * * ** *** * ENST00000373329.1 TA ENST00000440222.1 CT