CLUSTAL 2.1 multiple sequence alignment ENST00000375495.3 ---------TACCTCTAGGCCTGGGAGGCATTGAGAAA----AAGGAAGTGGGTCCTGTT ENST00000439330.1 GTCAAATTTTACTTACAG-CTTCTTATACTATGTTAATTCTCATACAGGTGAGAAATTTT *** * ** * * * * ** ** * * *** * * ** ENST00000375495.3 CTGGTTCTTGCGACTATAGTCACCTCCCGAG--GCAAAT---------------GACCAC ENST00000439330.1 GTGAACCTAATCAATGTAGAAAAGTCCTCAGTGACAAATTTGGATGAAGAATGTGTCCAT ** ** * * *** * *** ** ***** * *** ENST00000375495.3 TGTCC--TGAGAGGACGTGGGTGAGGGGCAGATTTCTGC---CCCTTTGTCCGAAGAG-- ENST00000439330.1 TCTTCATCCAAAATTTCTCACTGGGAGGATAGCCTATGTAGGCAATGAATGTGAAAAAGT * * * * * * ** * ** * ** * * * *** * ENST00000375495.3 ------CCAAAAATGACCAAGTCCCTGGA-ATCAG---TGTCATTCAAGGACGTAACTGT ENST00000439330.1 CTTCCCTCAGAAGTCAC-ACATCTTCACACATCAGACTTTTCATTCTGGGGAAAAGCCCA ** ** * ** * ** * ***** * ****** ** * * ENST00000375495.3 A-GACTTCAGTAGGGATGAGTGGCAACAATTAGACCTTGC--TCAGAAA--AGCCTGTA- ENST00000439330.1 ACGAATGCAGAGAAAATGAG----AACGCTTTCACCCAGTAGTCAATATTCAGTTTGCAA * ** * *** ***** *** ** *** * *** * ** ** * ENST00000375495.3 CAGAGAAGTGATGCTGGAAAACTATTTCA-ACTTGATCTCAGTGGGATGTCAAGTTCCCA ENST00000439330.1 CAGAGAATTCACACCGAAGAGAAACCCTATATATGCACTGAATGTG--GGCAGGCCTTCA ******* * * * * * * * * * ** ** * ** * * ** * ** ENST00000375495.3 AACCAGAAGTCATCTTCAGCTTGGAACAAGAAGAGCCATGTATGTTGGATGGTGAGATCC ENST00000439330.1 T-CCAAAAGACACACTTGATTGCACATCAGAGAA----TATATAGTGGA----GAGAAGC *** *** ** * * * *** * * *** **** **** * ENST00000375495.3 CCAGTCAGAGCCGTCCAGATGGGGA---CATTGGTTTTGGACCTTTAC------AACAGA ENST00000439330.1 CTTTTGAATGCTGTTACTGTGGGAAAGCCTTTCATTCCAAATCCCAAGTGAATGAGCATG * * * ** ** **** * * ** ** * * * * ** ENST00000375495.3 GGATGTCT-------GAAGAAGTTTCTTTCCAGTCTGAGATTAATATTAATCTCTTCAC- ENST00000439330.1 GGAAAACCCACACAGGAGAAAAACCCTATACAGGCACAAAATG-TGTGAAGGTCTTCTCC *** * ** ** ** * *** * * * * * * ** ***** * ENST00000375495.3 AAGAGATGACCCATATTC---CATTTTAGAAGA-----ATTGTGGAAAGACGATGAACAC ENST00000439330.1 AAAAGAT--CCAATCTCCTTGCACACCAGAAGACTCATACTGTAGAGAGCTTATGTCTGT ** **** ** ** * * ** ****** * *** ** ** *** ENST00000375495.3 ACAAGAAAATGTGGAGAAAACCAGAACAAACCTTTAAGTCGTGTTGTCTTCATTA-ACAA ENST00000439330.1 ACTG---AATGTGGA-AAGGCC----TTTACTTACAAATTG----GTCTTGATTACACAT ** ******** ** ** ** * ** * * ***** **** *** ENST00000375495.3 GAAAACACTAGCTAATGACAGCATCTTTGAATATAAGGACATTGGGGAAAT--------- ENST00000439330.1 CAAAG---------ATGAGAAACTTTATGAATGCGGCAACTGTGGGAAAACCTTTACTCA *** **** * * * ***** ** **** *** ENST00000375495.3 --AGT-TCATGTAAACACACACCTGG-TTTCCTCA--AGAAAAAGACCCCATAACTGTAA ENST00000439330.1 GAAGTCTCACCTCAACATACATCTGAATTTTCACACTGGAGAGAAACCCAGTGTATGTAC *** *** * **** *** *** *** * ** ** * * **** * **** ENST00000375495.3 CTCG-TGTGGAAAGAATTTGGAGCCTA--TCA----TAACCTTATATAATAGAAACAATG ENST00000439330.1 CTGAACATGAAAAAGCCTTCAACCATAAGTCAAACTTAATCACACATTAAAAAGTTCATG ** ** *** ** * * ** *** *** * * ** * * * *** ENST00000375495.3 CAACAGAAAATTCTGATAAGACTATTGGAGATGGTGATATTTTCA---------CTCATT ENST00000439330.1 TTAGGGAAAAACTCAATGAATGCAGTGATTGTGGGAATTCTTTCAAGTCACAGCTCCATG * ***** ** * * ** *** ** ***** *** ENST00000375495.3 TGAATTC------TCATACAGAAGTGACTGCTTGTGAATGTAACCAATGTGGGAAACCTC ENST00000439330.1 AGAATCAACAAAGTCATGCAGGAGAGAGACCCTATGCATGCACTAAATGTGGGAAGGCCT **** **** *** ** ** * * ** *** * ********** * ENST00000375495.3 TGCATCATAAGCAAGCTCTCATTCAACAACAGAAAATTCATACTAGAGAGAGCCTCTATT ENST00000439330.1 T-CA--AAAAACCACATCTCCTTGCACGTCAGAAAACTCATATTGGAGCAAAA---TATG * ** * ** * * **** ** ** ******* ***** * *** * *** ENST00000375495.3 TGTTTTCTGACTACGTAAATGTTTTCTCCCCGAAGTCACATGCCTTTGCACAT--GAGAG ENST00000439330.1 TATGTCCTGAGTGTGAGAAGGCCTTCACATGCAAGTCAGTTTTGATTACATATCAAAGAG * * * **** * * ** * *** * ****** * ** ** ** **** ENST00000375495.3 TATTTGTGCTGAAGAAAAGCAGCATGAATGCCATGAATGTGAGGCAGTCTTCACTCAGA- ENST00000439330.1 AATTTACACTGGAGAGAAGCCTTATGAGTAGAGTGACTGTGGGAAAGCCTTCACACACAC **** *** *** **** **** * *** **** * ** ****** ** * ENST00000375495.3 --------------------------AGTCCCAGCTTGA-TGGCAGTCAGAGGGTTTATG ENST00000439330.1 ACACACACACACACACACACACACACACCACTAGCTTCAGCAGCAG-CAGCAAATTCACA * * ***** * **** *** ** * ENST00000375495.3 CAGGAA------------TATGCACTGAATATGAGAAGGATTTTTCCCTCAAGTCAAAC- ENST00000439330.1 CAGGAGAAAAGCCCTATGTATATACCGAGTGTGACAAGGCCTTCACCAACAAGTCAAGTT ***** *** ** ** * *** **** ** ** ******** ENST00000375495.3 --------CGTCAGAAAACTCCTTATGAGGGGAATTACTATAAATGCAGTGACTATGGAA ENST00000439330.1 TGAATAAGCACCAGATTACTCTTTCTCCAGCTAAACCTTATAAATGCAGTGACTGTGGGA * **** **** ** * * ** **************** *** * ENST00000375495.3 GAGCCTTTATCCAGAAGTCAGATCTGTTCAGATGC--CAGAGAATTCATTCTGGAGAAAA ENST00000439330.1 AAGGCTGCACCCAGAGATTAG--CTTTCAATATGCATCCAAGTATTCCTACCTAAAAGAA ** ** * ***** * ** ** * * **** * ** **** * * * * ** ENST00000375495.3 ACCTTATGAGTACAGTGAATGTGAGAAAAACCTCCCTCAGAATTCAAACCTTAATATACA ENST00000439330.1 AATCTGCATGTTTCTTGAATATGAGAAAGCCTTCTCAGAGAAGTTGGATCTAAGTGTATG * * ** ***** ******* * ** * **** * * ** * * ** ENST00000375495.3 TAAAAAAATTCATACTGGAGGGAAACACTTTGAATGTACTGAATGTGGAAAAGCTTTCAC ENST00000439330.1 CTGTAGAATGCCTGCAGCAGAAAAACCATGTGAATATATTCA-TGAGCCAAG----TTAA * *** * * * * ** **** * ***** ** * * ** * ** * * ENST00000375495.3 AAGGAAATCAACACTAAGTATGCATCAGAAAA-------TCCATACAGGAGAAAAACCTT ENST00000439330.1 GAGGAGA--AGCCCTAAGAATGCATCAGAGCAGCATCTTTCCATATTTGC--ACGTCCTC **** * * * ***** ********** * ****** * * *** ENST00000375495.3 AT--------GTATGTACTGAATGTGGG-------AAGGCCTTTATCCGG--AAGTCA-- ENST00000439330.1 ACTATGTGGAGTATACACTGTTGGTGCCTCACCCTGATCCCCTTGACTGGCCAGGGCATC * **** **** *** * ** ** * ** * * ** ENST00000375495.3 CATTTTATCACACATGAAAGAATTCATACTGGAGAAAA-ACCCTATGAATGCAGTGACTG ENST00000439330.1 CATTTTCTAACTGCTGCAAG------TGCTGTAGCAAACAGCTTATACCTGTAACTTTTT ****** * ** ** *** * *** ** *** * * *** ** * * ENST00000375495.3 TGGGAA-AT--CCTTTA---TTAAAAAATCACAAC-TCCATGTGCATCAGCGAATT--CA ENST00000439330.1 CCAGAGCATTGCCTTTGGTTTTCCGTAGTGCCAACATGCCTGGAGATGGTTATACTACCC ** ** ***** ** * * **** * * ** ** * * * ENST00000375495.3 CACAGGAGAGAATCCC--------TTTATATGTTCAGAATGTGGGA-----AGGTCTTCA ENST00000439330.1 TCCTAGGGAGTAGCCAGTGAGTGATTTATAAA---AGGATACAAGAGCCCAAGTTCCTCC * * *** * ** ****** ** ** ** ** ** ** ENST00000375495.3 CTCA---CAAGACAAATCT-CA-------TTATACACCAGAAAATTC------------- ENST00000439330.1 CTCAAGGCAGAACAACTTTGCAGTGAAATTTACAATCCAGAGGCTCCTCCCCCTCTCCAC **** ** **** * * ** *** * ***** * * ENST00000375495.3 -------------ATACAGGAGAAAGACC---CTATATATGTA-CTGTGT----GTGGTA ENST00000439330.1 ACTCCTCTGCCCTGCATGGGGCCAAGGCTTGACTCTACATGAAACCACGTCCTTGTGATG * ** *** * ** ** *** * * ** *** * ENST00000375495.3 AGGCCT--TTACTGA--CAGGTCAAATCTCATTA-AG----CACCAAAAAATTCATACTG ENST00000439330.1 ACTCCTCTTTCCCTATCCTTCTCTTATTCCCTTACAGGTTCCACCATGAAGAACATA-TA * *** ** * * * ** ** * *** ** ***** ** **** * ENST00000375495.3 GAGAGAAACCTTATAAATGC-------AGCGACTGTG----GAAAATCATTCACCTGGAA ENST00000439330.1 AATCATATGCTTCCAGATGCCTTTCTTAGCCTCTGTGTATAGAAGGGAACCTGACCGGAG * * *** * **** *** ***** *** * * *** ENST00000375495.3 GTCTCGGCTCAGGATACATCAGAAGTGTCATACTGGAGAGAGACATTATGAATGCAGTGA ENST00000439330.1 ATGGTATCATAGAATTCAT-AGAA---CCCAACTGAGGAGAAATTGTTCAAGTTTAATCC * * ** ** *** **** * **** **** * * * * * * ENST00000375495.3 ATGTGGGAAAGCATTCATTCAGAAGTCAACAT----TAAGTATGCACCAGAGAATTCATA ENST00000439330.1 TTTAGGAAAAGACTTCCCACAAAAAGCGCTATAACATAAATTGATTCCAAACTCCTTATA * ** **** *** ** ** * ** *** * *** * * *** ENST00000375495.3 GAGGGGAAA-------AACCAT----ATGTTTGCACTGAAT---GTGGTA----AGGCCT ENST00000439330.1 AAAAAGGAATATGGAAAATTATGTAAATGCTTTTCCTGTTTTCTGTGAAATTTTAAGTAT * * ** ** ** *** ** *** * *** * * * * ENST00000375495.3 TCT------TCCACAAATCCCATTTTATTACACATGAG-AGAATTCATACTGGAGAGAAA ENST00000439330.1 TTTATAGTGTCAACAAACGAAGTTGTAGGACAACCAACTAGTATGTCTGATATGGACATA * * ** ***** ** ** *** * ** ** * * ** * * ENST00000375495.3 CCCTA---TGAATGCAGTATTTGTGGGAA-ATCCTTCACTA-AGAAATCACAGCTCCACG ENST00000439330.1 CCCTGAATTCAAGAGAATATGTTTCATAATACACTGCACAACAGAAGGTATAGT---ATG **** * ** * *** * * ** * ** *** * **** * ** * * ENST00000375495.3 TACATCAG-CAGATTCACA-CAGGAGAGAA----ACCCTATAGGTGTGCTG---AATGTG ENST00000439330.1 TGTTTTAAATATTTTTGTAATATGATATAATTGTACCTGTCAAATATGTTCCCTAGTGTG * * * * ** * * ** * ** *** * * ** * * **** ENST00000375495.3 GA---------AAGGCTTTTACTGACAGATCA-------AATCTCTTTACACAC-CAGA- ENST00000439330.1 TATTTCTAGCAAGAGATTCCACAATAAAACCATGATTTTGATTCCTTTATATATATAGGT * * * ** ** * * ** ** ***** * * ** ENST00000375495.3 ---AAATTCACAC-----TGGAGAGA-AACCTTATAAATGTAGTGACTGTGGGAAAG--- ENST00000439330.1 TCTGTTTTTATGTAAATGTGTAAATATAATCCTATCATACTAGCTTTTATTTCACAATAC ** * ** * * * ** * *** * *** * * * * ENST00000375495.3 ----------CCTTCACTAGGAAGTCAGGTC--TCCATATACATCA-GCAAT-------- ENST00000439330.1 TTTTTCTCTTCTTTCTGTAGACATTCATGTGAATGCCTAAACACAATGCTATTATTCTTT * *** *** * *** ** * * ** *** * ** ** ENST00000375495.3 CCCAT-ACTGG------AGAAAGGCAT-TATGAGTGCAGTGAATGTGGGAAAGCCTT--T ENST00000439330.1 CTTATTACTAGTACATAATAATTGGATATATTTATGGAGTACATGTGATA---CTTTGAT * ** *** * * ** * ** *** ** *** ***** * * ** * ENST00000375495.3 GCAAGAAAATCAACAC-TAATTAT-GCATCAGAG-AATTCATACA-----------GGAG ENST00000439330.1 ACACGCATA-CAACACATAATGATCAAATCAGGGTAATTGGTATATCCATCACCTCAAAC ** * * * ****** **** ** ***** * **** ** * * ENST00000375495.3 AGAAACCCTATATTTGTAAT--GAATGTGGGAAATCCTT-CATCCAGAAGTC---ACACT ENST00000439330.1 ATTTATCTTCTCTTTGTGTTTGGAATCTTGCAAGTCTTTTCTTCTTGATATTTTGAAATA * * * * * ***** * **** * * ** ** ** * ** ** * * * ENST00000375495.3 TAAA-TAGAC-----ACAGGAG--AATTCAT------ACTGGAGA--GAAAC-----CCT ENST00000439330.1 TAAAGTAAATGATTAACTGTAGTCACTTTATTGCGCTATTGAACACTAGAACTTACTCCT **** ** * ** * ** * ** ** * ** * * *** *** ENST00000375495.3 AT--GAATGCAGTGACTGTGGCAAGT------CTTTCATTAA------------------ ENST00000439330.1 ATCTAACTGTA-TGTTTGTATCCATTAACCAACCTCTATTTATCCCCCTTACCCTTCCCA ** * ** * ** *** * * * * * *** * ENST00000375495.3 ------GAAATC-ACAACTCCA---TGAGCATC------ATCGAATTCA--------CAC ENST00000439330.1 GCCTCTGATATCTATAATTCTACTCTTTACCTCTAGGAGATCGACTTTTTTAGCTACCAC ** *** * ** ** * * * ** ***** ** *** ENST00000375495.3 AGGAGAGAAACCAT---ATATATGTG---CTGAGTGTGGA--AAGGCCTTCACCATC--- ENST00000439330.1 GTGAGTGAGAACATGGGATATTTGTCTTTCTGTGCCTGGCTTATTTCTTTCTTTTTTTTT *** ** * *** **** *** *** * *** * * *** * ENST00000375495.3 -----AGATCAAATCTTATT---------------AAACAC-----CAGAAAATT--CAT ENST00000439330.1 TTTTGAGATGGAGTATCACTCTGTCACTCAGGCTGGAGTGCAGTGGCACAATGTTGGCTC **** * * * * * * * ** ** ** * ENST00000375495.3 ACTA-AACAGAAACCCTATAAGTGCA-GTGA----CTTGGGGAAAGCCTTAAA----CTG ENST00000439330.1 ACTGCAACCTCTGCCTTTCAGGTTCAAGCAATTCTCTTGCCTCAACCTCCCAAGTAGCTG *** *** ** * * ** ** * * **** ** * ** *** ENST00000375495.3 GAA------------GCCACAAC------------TCAGTATGCCT--------CAGAAA ENST00000439330.1 GGACTATAGGCCCATGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGCAT * * ***** ** * **** * *** * ENST00000375495.3 TCTG--ACAATGGGGAAGTAGA----GTGCTCCATGCC----ACAATT------------ ENST00000439330.1 TTCACCACATTGGTCAGGCTGATCTTGAACTCCTGGCCTCAGGCAATCCACCCACCTCGG * *** *** * * ** * **** *** **** ENST00000375495.3 ------ATGGTGTGGGGACTCAGAAGGTGA---------CCAAGGCCAACTTTCTTCTAT ENST00000439330.1 CCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCCCGACTTATTTC-AT * *** **** * **** ** ** ** **** *** ** ENST00000375495.3 CTAG--TTAGAAT---------------------TATGAACATCTGGAT--CAT------ ENST00000439330.1 TTAACATTAAGACCTCCACTTCCATTCATGTTGCTACAAATGACAGGATTTCATTCTTTT ** *** * ** ** * **** *** ENST00000375495.3 ATAGCTGATGTGTAGTTACACATATGGGGAGACACTTTTGAGAGTGTT-TAAGCAATG-- ENST00000439330.1 ATGGCTGA-ATAGCATTCCACA-ATAGTATCATTCTTATTAGATTTTAATATGTAGTACT ** ***** * ** **** ** * * *** * *** * * ** * * * ENST00000375495.3 TATAGTGGCCATCTTTGGTTACTTGATAT--TGGTGTTGTCAAGCT-CCTGCA--AATAA ENST00000439330.1 TTTAATCTTC-TTTTTATTTGCTCAACTTCCTCATCCTTTTATTCTACCTTCACTAATAC * ** * * * *** ** ** * * * * * * * ** *** ** **** ENST00000375495.3 TAGTAA------------AT-----GTGCAAGGAGATGA ENST00000439330.1 CTGCAATCCTCCCTACAGATCACCAGTGCAAACCGTCA- * ** ** ****** *