CLUSTAL 2.1 multiple sequence alignment ENST00000376263.3 TAGGGCGCGACGGCGGGGAGGACGCGAGAAGGCGGGGGAGGGGAGCCTGCGCTCGTTTTC ENST00000447355.1 ------------------------------------------------------------ ENST00000376263.3 TGTCTAGCTCCGACCGGCTGAGGCGGCGCGGCAGCGGAGGGACGGCAGTCTCGCGCGGCT ENST00000447355.1 ------------------------------------------------------------ ENST00000376263.3 ACTGCAGCACTGGGGTGTCAGTTGTTGGTCCGACCCAGAACGCTTCAGTTCTGCTCTGCA ENST00000447355.1 ------------------------------------------------------------ ENST00000376263.3 AGGATATATAATAACTGATTGGTGTGCCCGTTTAATAAAAGAATATGGAAACTGAACAGC ENST00000447355.1 --------------------------------------------ATGGAAACTGAACAGC **************** ENST00000376263.3 CAGAAGAAACCTTCCCTAACACTGAAACCAATGGTGAATTTGGTAAACGCCCTGCAGAAG ENST00000447355.1 CAGAAGAAACCTTCCCTAACACTGAAACCAGTGGTGAATTTGGTAAACGCCCTGCAGAAG ****************************** ***************************** ENST00000376263.3 ATATGGAAGAGGAACAAGCATTTAAAAGATCTAGAAACACTGATGAGATGGTTGAATTAC ENST00000447355.1 ATATGGAAGAGGAACAAGCATTTAAAAGATCTAGAAACACTGATGAGATGGTTGAATTAC ************************************************************ ENST00000376263.3 GCATTCTGCTTCAGAGCAAGAATGCTGGGGCAGTGATTGGAAAAGGAGGCAAGAATATTA ENST00000447355.1 CCATTCTGCTTCAGAGCAAGAATGCTGGAGCAGTGACTGGAAAAGGAGGCAAGAATATTA *************************** ******* *********************** ENST00000376263.3 AGGCTCTCCGTACAGACTACAATGCCAGTGTTTCAGTCCCAGACAGCAGTGGCCCCGAGC ENST00000447355.1 AGGCTCTCCATACAGACTACAACGCCAGCATTTCAGTTCTAGACAGCAGTGGCCCCCAGC ********* ************ ***** ******* * **************** *** ENST00000376263.3 GCATATTGAGTATCAGTGCTGATATTGAAACAATTGGAGAAATTCTGAAGAAAATCATCC ENST00000447355.1 ATATATTGCATATCAGTGCTGATATCGAAACAATTGGAGAAATTCTGAAGAAAATCATCA ****** *************** ********************************* ENST00000376263.3 CTACCTTGGAAGAGGGCCTGCAGTTGCCATCACCCACTGCAACCAGCCAGCTCCCGCTCG ENST00000447355.1 CTACCTTGGAAGAGGGCCCGCAGTTGCCATCACCCACTGCAACCAGCCAGCTCCCGCTCG ****************** ***************************************** ENST00000376263.3 AATCTGATGCTGTGGAATGCTTAAATTACCAACACTATAAAGGAAGTGACTTTGACTGCG ENST00000447355.1 AATCTGATGCTGTGGAATACTTAAATTACCAACAATATAAAGGAAGGGACTTTGACTGCG ****************** *************** *********** ************* ENST00000376263.3 AGTTGAGGCTGTTGATTCATCAGAGTCTAGCAGGAGGAATTATTGGGGTCAAAGGTGCTA ENST00000447355.1 AGTTGAGGCTGTTGATTCATCAGAGTCTAGCAGGAGGAATTATTGGGGTCAAAGGTGCTA ************************************************************ ENST00000376263.3 AAATCAAAGAACTTCGAGAGAACACTCAAACCACCATCAAGCTTTTCCAGGAATGCTGTC ENST00000447355.1 AAATCAAAGAACT--GAGAAAACACACAAACAACCATCACGCTTTTCCAGGAATGTTGTC ************* **** ***** ***** ******* *************** **** ENST00000376263.3 CTCATTCCACTGACAGAGTTGTTCTTATTGGAGGAAAACCCGATAGGGTTGTAGAGTGCA ENST00000447355.1 CTCATTTCACTGATAGAGTTGTTCTTATTGGAGGAAAACCCAATAGGGTTGTAGAGTGCA ****** ****** *************************** ****************** ENST00000376263.3 TAAAGATCATCCTTGATCTTATATCTGAGTCTCCCATCAAAGGACGTGCACAGCCTTATG ENST00000447355.1 TAAAGATCATCCTTGATCTTATTTCTGAGTCTCCCATCAAAGGACATGCACAGCCTTATG ********************** ********************** ************** ENST00000376263.3 ATCCCAATTTTTACGATGAAACCTATGATTATGGTGGTTTTACAATGATGTTTGATGACC ENST00000447355.1 ATCCCAATTTTTACGATGAAACCTATGATTATGGTGGTTTTACAATGGTGTTTGCTGACG *********************************************** ****** **** ENST00000376263.3 GTCGCGGACGCCCAGTGGGATTTCCCATGCGGGGAAGAGGTGGTTTTGACAGAATGCCTC ENST00000447355.1 ACCGTGGACGCCCAGTGAGATTTCTGATGCAGGGAAGAGGTGGTTTTGACAAAATGTCTC ** ************ ****** **** ******************** **** *** ENST00000376263.3 CTGGTCGGGGTGGGCGTCCCATGCCTCCATCTAGAAGAGATTATGATGATATGAGCCCTC ENST00000447355.1 CTGGTCGGGGTGGGCGTCCCATGCCTCCATCTAGAAGAGATTATGTTTATATGAGCCCTC ********************************************* * ************ ENST00000376263.3 GTCGAGGACCACCTCCCCCTCCTCCCGGACGAGGCGGCCGGGGTGGTAGCAGAGCTCGGA ENST00000447355.1 GTCGAGGACCACCTCCCCCTCCTCCCGGATGAGGTGGCCAGAGTGGTAGCAGAGCTCGGA ***************************** **** **** * ****************** ENST00000376263.3 ATCTTCCTCTTCCTCCACCA-CCACCACCTAGAGGGGGAGACCTCATGGCCTATGACAGA ENST00000447355.1 ATGTTCCTCTTCCTCCACCAACCACCACCTAG-GGGGGAGACCTCATGACCTATAACAGA ** ***************** *********** *************** ***** ***** ENST00000376263.3 AGAGGGAGACCTGGAGACCGTTACGACGGCATGGTTGGTTTCAGTGCTGATGAAACTTGG ENST00000447355.1 AAAGGGAGACCTGGAAACCGTTACGACGGCGTGGTTGATTTCAGTGCTGATGAAACTTGG * ************* ************** ****** ********************** ENST00000376263.3 GACTCTGCAATAGATACATGGAGCCCATCAGAATGGCAGATGGCTTATGAACCACAGGGT ENST00000447355.1 GGCTCTGCAATAGATACATGGAACGCATCAGAATGGCAGATGGCTTATGAACCACAGGGT * ******************** * *********************************** ENST00000376263.3 GGCTCCGGATATGATTATTCCTATGCAGGGGGTCGTGGCTCATATGGTGATCTTGGTGGA ENST00000447355.1 GGCTCCAGATATGATTATTCCTATGCAGGGTGTCATGGCTCATATGGTGATCTTGGTGGA ****** *********************** *** ************************* ENST00000376263.3 CCTATTATTACTACACAAGTAACTATTCCCAAAGATTTGGCTGGATCTATTATTGGCAAA ENST00000447355.1 CCTATTATTACTACACAAGTAACTATTCCCAGAGATTTGGCTGGATCTATTATTGGCAAA ******************************* **************************** ENST00000376263.3 GGTGGTCAGCGGATTAAACAAATCCGTCATGAGTCGGGAGCTTCGATCAAAATTGATGAG ENST00000447355.1 GGTGGTCAGTGGACTAAACAAATCTGTCATGAGTAGGGAGCTTTGATCAAAATTGATGAG ********* *** ********** ********* ******** **************** ENST00000376263.3 CCTTTAGAAGGATCCGAAGATCGGATCATTACCATTACAGGAACACAGGACCAGATACAG ENST00000447355.1 CCTTTAGAAGGATCCGAAGATCGGATCATTACCATTACAGGAACACAGGACCAGATACAG ************************************************************ ENST00000376263.3 AATGCACAGTATTTGCTGCAGAACAGTGTGAAGCAGTATGCAGATGTTGAAGGATTCTAA ENST00000447355.1 AATGCACAGTATTTGCCGCAGAA------------------------------------- **************** ****** ENST00000376263.3 TGCAAGATATTTTTTCTTTTTTATAGTGTGAAGCAGTATTCTGGAAAGTTTTTCTAAGAC ENST00000447355.1 -----------------------TAGTGTGAAGCAGTATTCTGGAAAGTTTTTCTAAGAC ************************************* ENST00000376263.3 TAGTGAAGAACTGAAGGAGTCCTGCATCTTTTTTTTTTT---ATCTGCTTCTGTTTAAAA ENST00000447355.1 TAGTGAAGAACTGAAGGAGTCCTGCATCTTTTTTTTTTTTCAATCTGCTTCTGTTTAAAA *************************************** ****************** ENST00000376263.3 AGCCAACATTCCTCTGCTTCATAGGTGTTCTGCATTTGAGGTGTAGTGAAATCTTTGCTG ENST00000447355.1 AGCTAACATTCCTCTGCTTCATAGGTGTTCTGCATTTAAGGTGTAGTGAAATCTTTGCTG *** ********************************* ********************** ENST00000376263.3 TTCACCAGATGTAATGTTTTAGTTCCTTACAAACAGGGTTGGGGGGGGGAAGGGCGTGCA ENST00000447355.1 TTCACCAGATGTAATGTTTTAGATCCTTACAAACAAGGTTGGAGGGGGGAAGGGCATGCA ********************** ************ ****** ************ **** ENST00000376263.3 AAAA----CTAACATTGAAATTTTGAAACAGCAGCAGAGTGAGTGGATTTTATTTTTCGT ENST00000447355.1 AAAAAAAACTAACATTGATATTTTGAAACAGCAGCAGAGTGAGCCAATTTTATTTTTTGT **** ********** ************************ *********** ** ENST00000376263.3 TATTGTTGGTGGTTTAAA-AAATTCCCCCCATGTAATTATTGTGAACACCTTGCTTTGTG ENST00000447355.1 TATTGTTGGTGGTTTGAAGAAATTCCCCCCATGTAATTATTATGAACACCTTGCTTTGTG *************** ** ********************** ****************** ENST00000376263.3 GTCACTGTAACATTTGGGGGGTGGGACAGGGAGGAAAAGTAACAATAGTCCACATGTCCC ENST00000447355.1 GTCACTGTAACATTTGGGGGGTGGGACAGGGAGGAAAAGTAACAATAGTCCACATGTCCC ************************************************************ ENST00000376263.3 TGGCATCTGTTCAGAGCAGTGTGCAGAATGTAATGCTCTTTTGTAAGAAACGTTTTATGA ENST00000447355.1 TGGCATCTGTTCAGAGCAGTGTGCAGAATGTAATGCTCTTTTGTAAGAAACATTTTATGA *************************************************** ******** ENST00000376263.3 TTTTTAAAATAAATTTAGTGAACC---------------TATTTTTGGTGGTCATTTTT- ENST00000447355.1 TTTTTAAAATA--TTTAATTAACCCCAAAAAAGAAGACATACAAATGGCAAACAGGCATA *********** **** * **** ** *** ** * ENST00000376263.3 --------TTTTTAAGAC----AGTCATTTTA-AAATGGTGGCTGAATTTCC-------- ENST00000447355.1 AGAAAAGGTATGCAACATCACTGATCATCACAGAAATGCAAATCAAAACTACAATGAGAT * * ** * **** * ***** ** * * ENST00000376263.3 --CAACCCACCCC---CAAACTA---------------------AACACTAAGT-TTAAT ENST00000447355.1 ATCATCTCACTCCAGTTAAAATAGCTTTTATCCAAAAGACAGGCAATAACAAATGCTGGT ** * *** ** *** ** ** * ** * * * ENST00000376263.3 ----------------------TTTCAGCTCCTCTGTTGGACATATAAGT--GCA-TCTC ENST00000447355.1 GAGGATGTGGGGAAAGGGAACCTTCTTACACTGTTGTTGGGAATGTAAATTAGTAATCTC ** * * ****** ** *** * * * **** ENST00000376263.3 --TTGT--TGGACATAGGCAAAATAA-----CTTGGCA--AACTTA----------GTTC ENST00000447355.1 ATTTGCAATAGCCATAAATAAAATTAAATACCTAAGTATTAACCAAAGAAGGGAAAGATC *** * * **** ***** * ** * * *** * * ** ENST00000376263.3 T------GGTGATTTCT-------TGATGG------------------TTTG-------G ENST00000447355.1 TTTATAAGGAAAACTGTAAAACACTGATGAAAGAAATGGAAGACAACATTTACAAAATAG * ** * * * ***** *** * ENST00000376263.3 AAGTCTATT------------GCTGGGAAGA--AATTCCATCATACATATTCATGCT--- ENST00000447355.1 AAATCTATTTCATGTTTATGGACTGGAAAAATCAATACTGTTA-AAATGTCTATACTACC ** ****** **** ** * *** * * * * ** * ** ** ENST00000376263.3 TATAATAAGCTGGGGATTTTTTGTTTGTTTTTGC--AAATGCTTGCCCCTACTTTTCA-- ENST00000447355.1 CAAAGCAATCTATAGATTCAATGCT-ATTCCTATCAAAATACCAATGAC-ATTCTTCACA * * ** ** **** ** * ** * **** * * * * **** ENST00000376263.3 ------------ACAATTTT---------------------------------------- ENST00000447355.1 GAAATAGAAAAAATAATCCTAAAATTTATATGGAACCACAAAAAAACCAAAATACCCAAA * *** * ENST00000376263.3 -CTATGTTAGTTGTGAAGAACTAAGGTG--GGGAGCA-------------------GTAC ENST00000447355.1 GCTATCTTAAGCAAAAAGAAGAAAACTGAAGGAATCATATCACCTGACTTCAAATTATAC **** *** ***** ** ** ** * ** *** ENST00000376263.3 TACA-AGTTG-AGTAA-----------TGGTATGAGTATATA------------------ ENST00000447355.1 CACAGAGCTATAGTAACCAAAACAGCGTGGTACTAGTATAAAAACACATAGACCAATGGA *** ** * ***** ***** ****** * ENST00000376263.3 --------------CCAGAA------TTCTG-ATTGGCAGCAAGTT--TTATTAA----- ENST00000447355.1 ACAGAATAGACAACCCAGAAACAAACCCATGCACCTACAGTGAACTCATTTTCAAGAAAG ****** ** * *** * * ** * ** ENST00000376263.3 ----TCAGAATA-ACACTTGGTTATGGA----------AGTGACTAATGCTGAAAAAATT ENST00000447355.1 GTGCCAAGAACAGACATTGGGGAAAAGACAGTATCATTGATAAATGGTGCTGGAAAAACT **** * *** * ** * ** * * * ***** ***** * ENST00000376263.3 GATTATTTTTAT-TAGATAA-----------------TTTCTCACC---TATAGAC---- ENST00000447355.1 GGATATCCATATGCAGATGAATGGAGCTATACCCCTATCTCTTGCCAAATACAAACATCA * *** *** **** * * *** ** ** * ** ENST00000376263.3 ----------------------------------TTAAACTGTCAATTTGCT-------- ENST00000447355.1 AATCAAAATGGATAAAAGACTTAAAACTAAGACCTCAAACTATGAAACTACTAGAAGAAA * ***** * ** * ** ENST00000376263.3 ---CTAGTG----TCTT------ATTAGTT--------AAACTTT---GTAAAA---TAT ENST00000447355.1 ACATTGGGGAAAATCTCCAGGACATTGGTCTGGGCAAAAAATTCTTGAGTAAGACCCTAT * * * *** *** ** *** * * **** * *** ENST00000376263.3 A---------------------------------------TATATACTT-----GTTTTT ENST00000447355.1 AAGCAGAGGCAACCAAACCAAAAATGGACAAATGGGATGATATCAAGTTAAAAAGCTTCT * *** * ** * ** * ENST00000376263.3 CCATTGTATG------------CAAATTGAAA-----------------GAAAAAGATGT ENST00000447355.1 GCACAGCAAAGGAAACAATCAACAAAGTGAAGAGACAACCCACAGAATGGGAGAAAATAT ** * * **** **** * * ** ** * ENST00000376263.3 ------ACCATTTCTCTG--------TTG----------TATGTTGG-----------AT ENST00000447355.1 TTGCAAACTACCCATCTGACAAGGGATTAAAAACCAGAATATATAAGGCACTCAAACAAC ** * **** ** *** * * * ENST00000376263.3 TATGTAGGAAATGTTTGTGTA---CAATTCAAAAA--AAAAAAAGATGAAAAAAG---TT ENST00000447355.1 TCTATAGGAAATAATCTAATAATCTGATTTAAAAATGGACAAAAGATTTAAATAGACATT * * ******** * ** *** ***** * ******* *** ** ** ENST00000376263.3 CCT-----GTGGATGTTT--------------------------TGTGTAGTATC--TTG ENST00000447355.1 TCTCAAAAGAAGACATACAAATAGCAAACAGGCATAAGAAAAGGTATGCAACATCACTCA ** * ** * * ** * *** * ENST00000376263.3 GCATT--------------------TGTATTGA---------------TAGTTAAAAT-- ENST00000447355.1 TCATCAGAGAAACACAAATCAAATCTACAATGAGATATCATCTCACTCCAGTTAAAATGG *** * * *** ********* ENST00000376263.3 -TCACTTCCAAATAA------ATAA--AACACCCATGATGCTA------------GATTT ENST00000447355.1 CTTTTATCCAGAAGACAGGCAATAACAAATGCTGGTGAGGATATGGAGAAAAGGAAACCT * **** * * **** ** * *** * ** * * ENST00000376263.3 ------------------GATGT------GTGC--CCGATTTGAACAAGGGTT----GAT ENST00000447355.1 TCTTACACTGTTGGTGGGAATGTAAATTAGTACAACCACCATGAAAAACAGTTTGGAGGT **** ** * ** **** ** *** * * ENST00000376263.3 T--------------------GACACC-TGTAA------AATT----TGTTGAA-ACGTT ENST00000447355.1 TCCTCAAAAAACTAAAAATAAGCTACCATATGATCCAGCAATCCCACTGTTGAATATATA * * *** * * * *** ******* * * ENST00000376263.3 CCTCTTAAAAGGAAAT----ATAGTAA--------------TCTTATGT----------- ENST00000447355.1 CCCCCAAAAAGGAAATCAGTATATCAAAGAGATATCTGCACTCCCAAGTTTGTTTGAGCA ** * ********** *** ** ** * ** ENST00000376263.3 ---------------------- ENST00000447355.1 CTGTTTACAATAGCCAAGATTT