CLUSTAL 2.1 multiple sequence alignment ENST00000377314.1 GGAAGGCAGAAGCAATCTCTGCCGAGAGAGTCAGCCGAGCGGCCGCGCGGAGAGGAGGGG ENST00000421970.1 ------------------------------------------------------------ ENST00000377314.1 CGGGCGGTCCCCAGGCGGGCGGGTGCAGGGCGCAGGGCGCCGACCTGCTGGAGAGGGGGC ENST00000421970.1 ------------------------------------------------------------ ENST00000377314.1 CCGGGCGCGAGGCGGAGTCCCGGCGCGCAGCCAGGCTGGTGGAGGCCCCCGGCAGGCTGC ENST00000421970.1 ------------------------------------------------------------ ENST00000377314.1 AGATTCCCTCCGGCTCCGGGAGCCGCAGCAGGACCGGCCAGGAGGCGCCATGGAGGGGAG ENST00000421970.1 -GATTCCCTCCGGCCCCGGGAGCCGCAGCAGGACCGGCCGGGAGGCGCCGCGGAGGGGAG ************* ************************ ********* ********* ENST00000377314.1 CCCCATCCCGGTGCTGACAGTGCCCACCGCGCCCTACGAGGACCAGCGGCCGGCCGGCGG ENST00000421970.1 TCGCATCCCGGTGCGGACAGTGCCCACCGCGCCCTGCGAGGACC---------------- * *********** ******************** ******** ENST00000377314.1 CGGGGGTCTGCGGCGACCCACCGGCCTCTTCGAGGGCCAGCGCAACTACCTGCCCAACTT ENST00000421970.1 -----------GGCGACCCACCGGCCTCTTCCAGGGCCAGCGCAGCTACCCGCCCAACTT ******************** ************ ***** ********* ENST00000377314.1 TATCCAGAGCGTGCTGTCGTCCATCGACCTGCGCGACCGTCAGGGCTGCACCATGGTGGT ENST00000421970.1 CATCCGGAGCGCGCTGTCGTCCGTCGACCTGCGCGACCGTCAGGGCCGCACCACGGGGGT **** ***** ********** *********************** ****** ** *** ENST00000377314.1 GGGCAGCGACGGCAGGTACTTTAGCAGGACGGCCATCGAGATCGTGGTGCAGATGGCCGC ENST00000421970.1 GGGCAGCGACGGCAGGTACTTCGGCAGGACGGCCGTCGAGGTCGGGGGGCCGATGGCCGC ********************* *********** ***** *** ** ** ********* ENST00000377314.1 GGCCAACGGG-------------------------------------------------- ENST00000421970.1 GGCCAACGGGGCGAGTGTCCGGATGCCCCTCGCTTCCCGCCGCGCCGCCGCCGCGCCCTC ********** ENST00000377314.1 -ATTGGACGACTGATTATTGGACAGAATGGCATCTTGTCGACACCTGCGGTCTCCTGCAT ENST00000421970.1 TATTGGACGACTGATTATTGGACAGAATGGCATCTTGTCGACACCTGCGGTCTCCTGCAT *********************************************************** ENST00000377314.1 TATCAGGAAGATCAAGGCAGCTGGTGGAATCATTCTAACAGCCAGCCACTGCCCTGGAGG ENST00000421970.1 TATCAGGAAGATCAAGGCAGCTGGTGGAATCATTCTAACAGCCAGCCACTGCCCTGGAGG ************************************************************ ENST00000377314.1 ACCAGGGGGAGAGTTTGGAGTGAAGTTTAATGTTGCCAATGGAGTGGAGATAGTGGACCC ENST00000421970.1 ACCAGGGGGAGAGTTTGGAGTGAAGTTTAATGTTGCCAATGGAG-GTATGTGGT----TC ******************************************** * * * ** * ENST00000377314.1 AGTGGATATCTATCTTAACCTCCTTCGGACCATCTTTGACTTTCATGCCATCAAGGGTTT ENST00000421970.1 AGTATATGCCT-TAATAATCAC-----GATT-TCTTTC-CTCTTATATTATTATAGTCTC *** ** ** * *** * * ** ***** ** * ** ** * * * ENST00000377314.1 GCTGACTGGACCCAGCCAACTGAAGATTCGCATTGACGCAATGCACGGAGTTATGGGACC ENST00000421970.1 ACAGT---GACCC-----TTTGATGATAGACA----AGCAAGGTGCAGA------GGACC * * ***** *** *** ** **** * * ** ***** ENST00000377314.1 TTATGTGAGAAAAGTTCTGTGTGATGAGCTGGGGGCCCCAGCCAATTCTGCAATAAACTG ENST00000421970.1 TAGC-TCAGAAAAATTTAGTGAGGTGCCCAAAGTGATCCAACAAA----GAAGTGGCATG * * ****** ** *** * ** * * * *** * ** * * * ** ENST00000377314.1 -TGTTCCCCTGGAAGACTTTGGAGGGCAGCACCCTGACCCAAACCTGACATATGCAACGA ENST00000421970.1 ATGGGCTCATGAACCCATTT---GGGTGGTCTCTTGGTCC---CCTGT-----------A ** * * ** * *** *** * * ** ** **** * ENST00000377314.1 CTCTTCTGGAAGCAATGAAAGGAGGAGAATATGGATTTGGAGCTGCATTTGATGCTGATG ENST00000421970.1 CTCTTC----AGCA-TAAACTATTGA----ATAG--TTGATGCT-TATCTGATATGGA-- ****** **** * ** ** ** * *** *** ** **** ** ENST00000377314.1 GGGACCGTTATATGATCCTAG-GCCAAAATGGCTTCTTTGTGAGCCCTTCTGACTCCCTG ENST00000421970.1 AGGACTCTGA----ATTTTAACATTAAAACA--TACCCTGAAGGTCGTTGT------CTA **** * * ** ** **** * * ** * * ** * ** ENST00000377314.1 GCCATCATTGCTGCCAACCTCTCTTGCATTCCATATTTCCGTCAGATGGGGGTCCGCGGG ENST00000421970.1 AA---------TGACAATGACCCT--CATTTTACACATCAACAAATCAAAGGCCTGAGAG ** *** * ** **** * * ** * ** * * * * ENST00000377314.1 TTTGGGAGGAGTA-TGCCAACCAGCATGGCCCTGGACAGAGTGGCCAAATCAATGAAGGT ENST00000421970.1 GCTGAGT----TACTGCTGAAGGCCACAGGGTTGATCAG---GGTCAGATTAATGA---- ** * ** *** * ** * ** *** ** ** ** ***** ENST00000377314.1 CCCTGTATATGAGACCCCAGCTGGATGGAGATTCTTCTCAAATCTGATGGACTCAGGACG ENST00000421970.1 -TTTTTAGCCCAAATCC--------TGGGCTCTCTTTTT------------CCTACAGTG * ** * * ** *** **** * * * * ENST00000377314.1 TTGCAATCTGTGTGGGGA--AGAGAGCTTTGGCACTGGCTCTGACCACCTCCGAGAGAAG ENST00000421970.1 TTG-ACTTTCTCTCAAAATCATAGAATTGTTTCACTTTTTCTTAT--ATTCACAGCAATT *** * * * * * * * *** * * **** *** * ** ** * ENST00000377314.1 GATGGCCTGTGGGCTGTCTTGGTCTGGCTCTCCATTATTGCTGCCCGGAAGCAGAGTGTG ENST00000421970.1 TATAGTTTGAGGGTC--CTTAGT-----------------------GGAGG--GGGTG-- ** * ** *** *** ** *** * * *** ENST00000377314.1 GAGGAAATTGTCCGAGATCACTGGGCCAAATTTGGCCGCCACTACTATTGCAGGTTTGAC ENST00000421970.1 --GGATAT--------ATGTATGGAGTAAATTT-----------CTTTTAAAAATTGAAC *** ** ** *** ****** ** ** * ** ** ENST00000377314.1 -TATGAGGGGTTGGATCCCAAGACGACATATTATATCATGAGGGACCTGGAGGCCCTGGT ENST00000421970.1 ACACAAAAAAATAGG----GAGA--------------ATAAGAAA--TAGA--------T * * * * *** ** ** * * ** * ENST00000377314.1 CACAGACAAATCCTTCATTGGCCAGCAGTTTGCTGTGGGGAGCCATGTCTACAGCGTGGC ENST00000421970.1 AACATGTA-----CCCATTATCTTGT--TTTTCTATTTTG---CTTATCTTTTTTTTTCT *** * **** * * *** ** * * * * *** * ENST00000377314.1 GAAGACGGATAGTTTTGAATACGTGGACCCTGTGGATGGCACTGTGACCAAGAAACAGGG ENST00000421970.1 GAAGA------ATTTTAAA---GCAAATT------ATAGCACAA-GAACATTTCACA--- ***** **** ** * * ** **** ** ** *** ENST00000377314.1 CCTAAGGATCATTTTCTCGGATGCATCACGGCTCATCTTCCGGCTCAGTTCCTCCAGTGG ENST00000421970.1 CCCAA-----ATATTTTTGTATGCATC--------TCT-------------------TAA ** ** ** ** * * ******* *** * ENST00000377314.1 TGTGCGGGCCACCCTCAGACTGTACGCAGAGAGCTACGAGAGGGATCCCAGCGGCCATGA ENST00000421970.1 AAAGAAAGACACATT---GCTGCATG-ACCGTGCTAACATA-----CCTAACAATAATAA * * *** * *** * * * * **** * * ** * * ** * ENST00000377314.1 CCAGGAGCCACAGGCAGTGCTGAGCCCTCTCATAGCCATCGCACTGAAAATATCCCAGAT ENST00000421970.1 CA------------------TTAATTCTCCAAT----ATCAC-CTGAAAA-----CTAAT * * * *** ** *** * ******* * ** ENST00000377314.1 TCATGAGAGAACTGGCCGGAGGGGACCCAC--TGTCATCACCTGAATAGAGGAAAGATCA ENST00000421970.1 CTATAGTCAAATTTTTCA-ATAATCCCCAAAATATTATTATTT--ATAGCTGTT---TTA ** ** * * * **** * * ** * * **** * * * ENST00000377314.1 CTCACCAGGGCCAAAGAGAGTGCTCAGCGGGAGATGCTTCACTGATGCCTT--CTTGCTA ENST00000421970.1 TTCA--------AATCAGGATAC--ATCTAAGGATGCC------ATGCATTTGCTTGGCA *** ** ** * * * * ***** **** ** **** * ENST00000377314.1 CCTGT-TTGTGCCTCTTATGACTTTGGAAAAACAAAAGATATTTTGCTTTTGGGGGATAG ENST00000421970.1 AGTCTCTTAAATCTCTTTTAA-TCTAGAATGCTGAG------TTTGCAT----------G * * ** ***** * * * * *** * ***** * * ENST00000377314.1 AGGGTGGGTGGGAAAAGAAAAAAAATCCATT-TGGTTTTGGTTTTGTCCTATTCCTC--- ENST00000421970.1 AATGTGGGTAGGAGCCAAATTTTAACCAGCAACAGTTACCATTATAAATTATTCCTCATC * ****** *** ** ** * *** ** * ******** ENST00000377314.1 -CAAATGCAGCAGGGCCTTTAGTTGTCTGTTAAAGCTGCACTATAATTTGGTATCTACAT ENST00000421970.1 CCAGGCAAAGCAGTGCATT-------CTG--AAGGG------AAAACTTATTATCTATCC ** ***** ** ** *** ** * * ** ** ****** ENST00000377314.1 TTTATCACACAAAGGAACCTCCCCTTTTGACAACAACTGGGCTAGGCAGCTGTTAATCAC ENST00000421970.1 CTCCTTGTAGA----------CGTTTTACACGTTATCCAAACAAGAAAG-TGT-ATTCAT * * * * * *** ** * * * ** ** *** * *** ENST00000377314.1 AACATTTGTGCATCACTTGTGCCAAGTGAGAAAATGTTCTAAAATCACAAGAGAGAACAG ENST00000421970.1 G----TTGAATATT--------TAAA--AAACAATATTGTAA--CCACAAAGCAGAA--- *** ** ** * * *** ** *** ***** **** ENST00000377314.1 TGCCAGAATGAAACTGACCCTAAGTCCCAGGTGCCCCTGGGCAG--GCAGAAGGAGACAC ENST00000421970.1 ------AACTAAACCA---CCAAACCACAAAGG----TAGACAACAATAGAGGAAGA--- ** **** * ** * ** * * * ** *** * *** ENST00000377314.1 TCCCAGCATGGAGGAGGGTTTATCTTTTCATCCTAGGTCAGGTCTACAATGGGGGAAGGT ENST00000421970.1 ---------AGAGAACAAATTATCTA------CAAAGT---------AACCAGAAAACA- *** * ****** * * ** ** * ** ENST00000377314.1 TTTATTATAGAACTCCCAACAGCCCACCTCACTCCTGCCACCCACCCGATGGCCCTGCCT ENST00000421970.1 ---ATTAGCAAAATGGCAGGAGTAAGTCTT----TTACTATCAA--TAATAACCTTGCTG **** ** * ** ** ** * * * * * ** ** *** ENST00000377314.1 CCCCCATCCCATCCCCAACATCCCTGTACCACCTTCTCTCACATCTTCTAAAGCTTTGTA ENST00000421970.1 -------------------GTACATGGGTTAAACTGTCCAA-----TCAAAAGAT--GTA * * ** * * ** * ** **** * *** ENST00000377314.1 CAAATCACAATGGTGCACTTCCAACAAAATATATCAATAGGTGTTTTCCTCTCTTATTTT ENST00000421970.1 -GAATGGCTG-AGTGGATCAACAACAAGATCCAAC--TAGATGCTGCCTAC--------- *** * *** * ****** ** * * *** ** * * * ENST00000377314.1 GTAAATAGTATTATTTT--AGCTATTAAGCTGGATACCTTCTTTCAAATTCAGCCATTCA ENST00000421970.1 ---AAGAGACCCATTTTTAAACTTTAAGAATAGGCATATACTG--AAAGTAAA------- ** ** ***** * ** * * * * * * ** *** * * ENST00000377314.1 GTTGTAAAGTTGGGAAGAAGTTTCTTGACAAGACTCTGCAATTAAATGCTTAAAATTTGG ENST00000421970.1 --TGGATAG--AAGGAGATATTCCATGAAAACAG---ACAGTTA-----CCAAAAGAGAG ** * ** * *** ** * *** ** * ** *** **** * ENST00000377314.1 AGGGGATCCTTCCTTGATTACATCAAGTATGTTGGTACATGGGTTT---ATACAAGTTCC ENST00000421970.1 CAGGGATGCCT--ATACTTATATCAGATA-------AAACAGACTTCCAGTAAAAAGCTG ***** * * * *** **** ** * * * ** ** ** ENST00000377314.1 TCTTGAGAAGGCAAAAAGACCACCATGTGTGAGAGCTCTTTGACTTGGCCAATAGGGGCC ENST00000421970.1 TTCCAAGAGACAAAGAAGGTCA-------TGA------TTTAA--TGATAAAGAGG---T * *** ** *** ** *** *** * ** ** *** ENST00000377314.1 TATCTTAATGCACTTGTTTGGACA---CATTTCTGATCTTATTTGTAAAGGCTGCAAAAG ENST00000421970.1 CATCTTA------TCAAGAGGACATAACAATTGTAAACATATATGCA-----TCCAAAAT ****** * ***** ** ** * * * *** ** * * ***** ENST00000377314.1 GAGAGGA-TGAAATGCTGTAAAAGTAGGAAATGAAGTGGAAGCTGGAAGAAAATGTAATT ENST00000421970.1 TGAAGCACTTAAATA-TGTAAA-GCAAATATT--AGTGGACA-TGAAGGAAGAAATA--- ** * * **** ****** * * * * ****** ** * *** * ** ENST00000377314.1 GGTGGTACAGCTATGGGCCAGATGGTGGAGGGGAGGGTGGGGACCCCTGCCGGCAA--GC ENST00000421970.1 -----TACAGCAATATAACAC-TAAT--AGGGGACT-TCAGTACTCC-ACTTGCAACAAT ****** ** ** * * ****** * * ** ** * **** ENST00000377314.1 AGAGTGTCACAGCTGGCTTTCCTCACTTGGGAAAAGGGTACTGCCGGTCTAGCAGCCTCC ENST00000421970.1 GGAGAGAT-CAACCAGACAAAA--AATTAACAAGACAACACTA----------AATTTGA *** * ** * * * ** ** * *** * * ENST00000377314.1 TCTGTACTCAGCCAGGACACCCAGCGCGTGGGACCTGTTTGTGTCTGTTTTGCTTCCTTG ENST00000421970.1 ACTATACT---TCAG---ACCAAATG-----GACCTACCAG-ACCTACATT-CATCC--A ** **** *** *** * * ***** * ** ** * *** ENST00000377314.1 GGAACGGCACAGTCACTCACCCTGCCATTTGCGGAAATGACCTGGTGCACTTTGACTGTT ENST00000421970.1 ACAACAGCAGAAT-ATACATTCTTCT-CTAGC----AT-ACATAGAACATTCTCCAGGAT *** *** * * * ** ** * * ** ** ** * * ** * * * * ENST00000377314.1 AAGCAATGCGTTATTGCTGTAG--TCAAGGTTAGTGCAAGCAAGGAAAC---ATTCCCAG ENST00000421970.1 AGACCATATGTTAG-GCCACAAAATAAACCTTAACAAATTCAAAAAGATTGAAGTCAC-G * * ** **** ** * * ** *** * *** * * * ** * * ENST00000377314.1 TAAGGTATTTGTTTCCATTTTCTGTC-TGTGCTTCTG----TCAGAAACTTG-------C ENST00000421970.1 TCTAGTATT-GTTTCCAACCACAATGGTGTGAAGCTAAAAATCAATAACGGGAGGAATCT * ***** ******* * * **** ** *** *** * ENST00000377314.1 TAGGACATTTA-------GTGGCCAATAAAAAAGAAATTCCTAATTTCAACCTTA----- ENST00000421970.1 TGGAAAATTTACAAATATGTGGAAACTAAACAACATGCTTATGAT---GAACTAATGGGT * * * ***** **** * **** ** * * * ** * ** *