CLUSTAL 2.1 multiple sequence alignment ENST00000378505.2 GTAGCGGCTGTTTGTTGACTTCCGGGAGCGCGGTTGTAGTTGATCTCCGGAGTTTCGCCA ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 TGCGGAACTTGGGGGCTTTCGCGGCCCGCGTCGGTGCGGAGTAGCTGCTTTAGCCCCGAC ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 CAAACCGTCCTCTACAGCCTCCTGGCCCCGGCGCAGGCTGCCCGTACTGCCCGTGGCATG ENST00000528178.1 -------------------------------------------ATATTT------GCA-- ** * *** ENST00000378505.2 AGGGAGCCGGAAGAGCTGATGCCCGATTCGGGTGCTGTGTTTACATTTGGGAAAAGTAAA ENST00000528178.1 ------------------------GATTCGGGTGCTGTGTTTACATTTGGGAAAAGTAAA ************************************ ENST00000378505.2 TTTGCTGAAAATAATCCCGGTAAATTCTGGTTTAAAAATGATGTCCCTGTACATCTTTCA ENST00000528178.1 TTTGCTGAAAGTAATCCTGGTAAATTCTGGTTTAAAAATGATGTCCCTGTACCTCTTTCA ********** ****** ********************************** ******* ENST00000378505.2 TGTGGAGATGAACATTCTGCTGTTGTTACCGGAAATAATAAACTTTACATGTTTGGCAGT ENST00000528178.1 TGTAGAGATGAACATTCT----TTTTTATT----TTATTTTATTTTAT---TTT------ *** ************** ** *** ** * * **** *** ENST00000378505.2 AACAACTGGGGTCAGTTAGGATTAGGATCAAAGTCAGCCATCAGCAAGCCAACATGTGTC ENST00000528178.1 ----ATT----TTA-TTATTATTATACTTTAAGTT-----TTAG--AGT--ACATGTGT- * * * * *** **** * **** * ** ** ******** ENST00000378505.2 AAAGCTCTAAAACCTGAAAAAGTG-AAATTAGCTGCCTGTGGAAGGAACCACACCCTGGT ENST00000528178.1 ----------------ACAATGTGCAGGTTAGTTACATATGTA------TACA------T * ** *** * **** * * * ** * *** * ENST00000378505.2 GTCAACAGAAGGAGGCAATGTATATGCAACTGGTGGAAATAATGAAGGACAGTTGGGGCT ENST00000528178.1 GT------------GCCATG---------CTGGTGT---------------------GCT ** ** *** ****** *** ENST00000378505.2 TGGTGACACCGAAGAAAGAAACACTTTTCATGTAATTAGCTTTTTTACATCCGAGCATAA ENST00000528178.1 -----ACACCCATTAA-------CTCGTCAT----TTAGC-------------------- ***** * ** ** **** ***** ENST00000378505.2 GATTAAGCAGCTGTCTGCTGGATCTAATACTTCAGCTGCCCTAACTGAGGATGGAAGACT ENST00000528178.1 -ATTAGGTA--TATCTCCTAAAGCTATCCCTCCCCCCTCCCC------------------ **** * * * *** ** * *** ** * * *** ENST00000378505.2 TTTTATGTGGGGTGACAATTCCGAAGGGCAAATTGGTTTAAAAAATGTAAGTAATGTCTG ENST00000528178.1 ---------------CCACCCCA-----CAA--CAGTCCCCAGAGTGTGA--------TG * * ** *** ** * * *** * ** ENST00000378505.2 TGTCCCTCAGCAAGTGACCATTGGGAAACCTGTCTCCTGGATCTCTTGTGGATATTACCA ENST00000528178.1 TGCCCCTT--------------------CCTGTGTCC---ATGTGTT------CTCATTG ** **** ***** *** ** * ** * * ENST00000378505.2 TTCAGCTTTTGTAACAACAGATGGTGAGCTATATGTGTTTGGAGAACCTGAGAATGGGAA ENST00000528178.1 TTCAATTCCCAC----------------CTATGAGTG-----AGAAT------ATGTGGT **** * **** *** **** *** * ENST00000378505.2 GTTAGGTCTTCCCAATCAGCTCCTGGGCAATCACAGAACACCCCAGCTGGTGTCTGAAAT ENST00000528178.1 GTTTGGTTTTTT------GTTCTTGAG-----ATAGTTTACTGAGAATGATG-----ATT *** *** ** * ** ** * * ** ** ** ** * * ENST00000378505.2 TCCGGAGAAGGTGATCCAAGTAGCCTGTGGTGGAGAGCATACTGTGGTTCTCACGGAGAA ENST00000528178.1 TCC----AATTTCATCCATGTC-CCTACAAAGGACATGAACTCATCATTTTTATGG---C *** ** * ***** ** *** *** * * * ** * * ** ENST00000378505.2 TGCTGTGTATACCTTTGGGCTGGGACAATTTGGTCAGCTGGGTCTTGGCACTTTTCTTTT ENST00000528178.1 TGCATAGTATTCCATGGTGT-------ATCTG-------------TGCCACATTTTTTT- *** **** ** * * * ** ** ** *** *** *** ENST00000378505.2 TGAAACTTCAGAACCCAAAGTCATTGA-GAATATTAGGGATCAAACAATAAGTTATATTT ENST00000528178.1 ----AATCCAG--TCTA---TCATTGTTGGACATTTGGGTTGGTTC--CAAGTCTTTGCT * * *** * * ****** * * *** *** * * **** * * ENST00000378505.2 CTTGTGGAGAAAATCACACAGCTTTGATAACAGATATCGGCCTTATGTATACTTTTGGAG ENST00000528178.1 ATTGTGAATAGTGCCACA--------ATAA-ACATA-CGTGTGCATGTGT-CTTT----- ***** * * **** **** * *** ** **** * **** ENST00000378505.2 ATGGTCGCCACGGAAAATTAGGACTTGGACTGGAGAATTTTACCAATCACTTCATTCCTA ENST00000528178.1 ATAGCAGC-----------ATGATTTA--------------------------------- ** * ** * ** ** ENST00000378505.2 CTTTGTGCTCTAATTTTTTGAGGTTTATAGTTAAATTGGTTGCTTGTGGTGGATGTCACA ENST00000528178.1 ----------TAGTCCTTTG-GGTATATACCCAG--TGGTGGG--ATGCCGG--GTCAAA ** * **** *** **** * **** * ** ** **** * ENST00000378505.2 TGGTAGTTTTTGCTGCTCCTCATCGTGGTGTGGCAAAAGAAATTGAATTCGATGAAATAA ENST00000528178.1 TGGTATTTCTAGTTCTAGATCCCTGAGGAATTGCC----ACACTGACTTCCAC--AATGG ***** ** * * * ** * ** * ** * * *** *** * *** ENST00000378505.2 ATGATACTTGCTTATCTGTGGCGACTTTTCTGCCGTATAGCAGTTTAACCTCAGGAAATG ENST00000528178.1 TTGA-ACTAGTTTA-CAGT-----CCCACCAACAGTGTAAAAGTGTT-CCT------ATT *** *** * *** * ** * * * ** ** *** * *** ** ENST00000378505.2 TACTGCAGAGGACTCTATCAGCACGTATGCGGCGAAGAGAGAGGGAGAGGTCTCCAGATT ENST00000528178.1 T-CTCCACATC-CTCT-CCAGCACCTGTT--------------------GTTTCCTGACT * ** ** * **** ****** * * ** *** ** * ENST00000378505.2 CTTTTTCAATGAGGAGAACACTACCTCCAATAGAAGGGACTCT---TGGCCTTTCTGCTT ENST00000528178.1 ---TTTTAATGATTGCCATTCTAACTGGTGTGAGATGGTATCTCACTGTGGTTTTGATTT *** ***** * *** ** * * ** *** ** *** ** ENST00000378505.2 GT-TTTCTCCCCAATTCAGTCTTTCCACGATGTTCTGAGAGAAACCTCCAAGAGAGTGTC ENST00000528178.1 GCATTTCTCTGCA------TTTTTTCATG-TGTTTTTTGG-----CTGCATAA--ATGTC * ****** ** * *** ** * **** * * ** ** * **** ENST00000378505.2 TTATCTGAACAGGACCTCATGCAGCCAGAGGAACCAGATTATTTGCTAGATGAAATGACC ENST00000528178.1 TTATTT-------------TG-----AGAAG--------TGTCTGTTC------ATGTCC **** * ** *** * * * ** * *** ** ENST00000378505.2 AAAGAAGCAGAGATAGATAATTCTTCAACTGTAGAAAGCCTTGGAGAAACTACTGATATC ENST00000528178.1 --------------------TTTGCCCACTTT--------TTGATGGGGTTGTTTGTTTT ** * *** * *** * * * * * ENST00000378505.2 TTAAACATGACACACATCATGAGCCTGAATTCCAATGAAAAGTCATTAAAATTATCACCA ENST00000528178.1 TT--------------TCTTG-------------------------TAAATTTGTT-TGA ** ** ** **** ** * * ENST00000378505.2 GTTCAGAAACAAAAGAAACAACAAACAATTGGGGAACTGACGCAGGATAC-AGCTCTTAC ENST00000528178.1 GTTCA-----------------------TTGTAGAAT-----CTGGATATTAGCCCTT-- ***** *** *** * ***** *** *** ENST00000378505.2 TGAAAACGATGATAGTGATGAATATGAAGAAATGTCAGAAATGAAAGAAGGGAAAGCATG ENST00000528178.1 --------------------------------TGTCAG--ATGA-----------GTAGG ****** **** * * * ENST00000378505.2 TAAACAACATGTGTCACAAGGGATTTTCATGACGCAGCCAGCTACGACTATCGAAGCATT ENST00000528178.1 TTGCTAAAATTT-TC---------TCCCATTTTGTAG---GTTAC--CTGTT----CACT * ** ** * ** * *** * ** * *** ** * ** * ENST00000378505.2 TTCAGATGAGGAAGTAGAGATCCCAGAGGAGAAGGAAGGAGCAGAGGATTCAAAAGGAAA ENST00000528178.1 CT--GATG-----GTAG---TTTC------------------------TTT--------- * **** **** * * ** ENST00000378505.2 TGGAATAGAGGAGCAAGAGGTAGAAGCAAATGAGGAAAATGTGAAGGTGCATGGAGGAAG ENST00000528178.1 TGCTGT-------------GCAGAAGCTCTTTAGTTTAAT-------------------- ** * * ****** * ** *** ENST00000378505.2 AAAGGAGAAAACAGAGATCCTATCAGATGACCTTACAGACAAAGCAGAGGTGAGTGAAGG ENST00000528178.1 -------------TAGATCCCATTTGTCAATTTT--------------GGCTTTTGTTGC ****** ** * * ** ** ** * ENST00000378505.2 CAAGGCAAAATCAGTGGGAGAAGCAGAGGATGGGCCTGAAGGTAGAGGGGATGGAACCTG ENST00000528178.1 CATTGC----TC--TTGGTGTTTTAGA-------CATGAAGTCCTTGCCCATG---CCTA ** ** ** * ** * *** * ***** * *** *** ENST00000378505.2 TGAGGAAGGTAGTTCAGGAGCAGAACACTGGCAAGATGAGGAGAGGGAGAAGGGGGAGAA ENST00000528178.1 TG-----------TCCTGAATGGTTTTCTTCTAGGGTTTT-------------------- ** ** ** * ** * * * ENST00000378505.2 AGACAAGGGTAGAGGAGAAATGGAGAGGCCAGGAGAGGGAGAGAAGGAACTAGCAGAGAA ENST00000528178.1 ---TATGGTTATAGGTCCAATGTTTAAGTCT------------------TTAAC------ * ** ** *** **** * * * ** * ENST00000378505.2 GGAAGAATGGAAGAAGAGGGATGGGGAAGAGCAGGAGCAAAAGGAGAGGGAGCAGGGCCA ENST00000528178.1 ---------------------------------------------------------CCA *** ENST00000378505.2 TCAGAAGGAAAGAAACCAAGAGATGGAGGAGGGAGGGGAGGAGGAGCATGGAGAAGGAGA ENST00000528178.1 TCTT-------------------------------------------------------- ** ENST00000378505.2 AGAAGAGGAGGGAGACAGAGAAGAGGAAGAAGAGAAGGAGGGAGAAGGGAAAGAGGAAGG ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 AGAAGGGGAAGAAGTGGAGGGAGAACGTGAAAAGGAGGAAGGAGAGAGGAAAAAGGAGGA ENST00000528178.1 ----------GAATT--------AATTTT------------------------------- *** * ** * ENST00000378505.2 AAGAGCGGGGAAGGAGGAGAAAGGAGAGGAAGAAGGAGACCAAGGAGAGGGGGAAGAGGA ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 GGAAACAGAGGGGAGAGGGGAGGAAAAAGAGGAGGGAGGGGAAGTAGAGGGAGGGGAAGT ENST00000528178.1 -------------------------------------------GTATA------------ *** * ENST00000378505.2 AGAGGAGGGGAAAGGAGAGAGGGAAGAGGAAGAGGAGGAGGGTGAGGGGGAAGAGGAGGA ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 AGGGGAGGGGGAAGAGGAGGAAGGGGAGGGGGAAGAGGAGGAAGGAGAAGGGAAAGGGGA ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 GGAAGAAGGGGAAGAAGGAGAAGGGGAGGAAGAAGGGGAGGAAGGAGAAGGGGAGGGGGA ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 AGAGGAGGAAGGAGAAGGGGAGGGAGAAGAGGAAGGAGAAGGGGAGGGAGAAGAGGAGGA ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 AGGAGAAGGGGAGGGAGAAGAGGAAGGAGAAGGGGAGGGAGAAGAGGAGGAAGGAGAAGG ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 GAAAGGGGAGGAGGAAGGAGAGGAAGGAGAAGGGGAGGGGGAAGAGGAGGAAGGAGAAGG ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 GGAAGGGGAGGATGGAGAAGGGGAGGGGGAAGAGGAGGAAGGAGAATGGGAGGGGGAAGA ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 GGAGGAAGGAGAAGGGGAGGGGGAAGAGGAAGGAGAAGGGGAAGGGGAGGAAGGAGAAGG ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 GGAGGGGGAAGAGGAGGAAGGAGAAGGGGAGGGGGAAGAGGAGGAAGGGGAAGAAGAAGG ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 GGAGGAAGAAGGAGAGGGAGAGGAAGAAGGGGAGGGAGAAGGGGAGGAAGAAGAGGAAGG ENST00000528178.1 ------------------------------------------------------------ ENST00000378505.2 GGAAGTGGAAGGGGAGGTGGAAGGGGAGGAAGGAGAGGGGGAAGGAGAGGAAGAGGAAGG ENST00000528178.1 --------------AGGTGTAAGG------------------------------------ ***** **** ENST00000378505.2 AGAGGAGGAAGGAGAAGAAAGGGAAAAGGAGGGGGAAGGAGAAGAAAACAGGAGGAACAG ENST00000528178.1 ------------------AAGGGA------------------------------------ ****** ENST00000378505.2 AGAAGAGGAGGAGGAAGAAGAGGGGAAGTATCAGGAGACAGGCGAAGAAGAGAATGAAAG ENST00000528178.1 ------------------------------TC------CAGTT----------------- ** *** ENST00000378505.2 GCAGGATGGAGAGGAGTACAAAAAAGTGAGCAAAATAAAAGGATCTGTGAAATATGGCAA ENST00000528178.1 --------------------------TAAGC------------TTTCT-ACATATGGCTA * *** * * * * ******* * ENST00000378505.2 ACATAAAACATATCAAAAAAAGTCAGTTACTAACACACAGGGAAATGGGAAAGAGCAGAG ENST00000528178.1 GC---------------------CAGTT-------------------------------- * ***** ENST00000378505.2 GTCCAAAATGCCAGTCCAGTCAAAACGACTTTTAAAAAACGGGCCATCAGGTTCCAAAAA ENST00000528178.1 -TTC------CCAG------------------------------CATCATTTATTAAATA * * **** ***** * *** * ENST00000378505.2 GTTCTGGAATAATGTATTACCACATTACTTGGAATTGAAGTAACAAACCTTAAATGTGAC ENST00000528178.1 G----GGAAT----CCTTTCCCCATTGCTTGTTTTT------------CTCAGGTTTG-- * ***** ** ** **** **** ** ** * * ** ENST00000378505.2 CCGATTATGGCCAGTCAGACAATT-TAAATGCCTTGCATATAACGGGCACTCATTACGTG ENST00000528178.1 ----TCAAAG---ATCAGATAGTTGTAGATA---TGC--------GGC-TTTATTTC--- * * * ***** * ** ** ** *** *** * *** * ENST00000378505.2 TTATTAAATTGATTTTATGTCAATTATTTTATGTGTAGTAAAAAAAAAAGCAACTGATGC ENST00000528178.1 -TGAGGGCTCTGTTCTGT-TCCATTGATCTATAT-------------------------- * * ** * * ** *** * *** * ENST00000378505.2 AGCTGTGTTAAGGAGCCAAAGACAATAGGAGGCACTGGTAAATTTTGGCCTCTCTCAAAC ENST00000528178.1 --CTCTGTTGTGGTACCAGTATCA--------TGCTG-----TTTTGGTT--------AC ** **** ** *** ** *** ****** ** ENST00000378505.2 TAAAATTTTCGTGTATTTCCCCCCCAAATTATAAAAACATAACTAGAAAATATTAAAAGG ENST00000528178.1 TGTAGCCTT---GTAGT---------------------ATAGTTTGAAG----------- * * ** *** * *** * *** ENST00000378505.2 TCATATCAGATTATTAACATTATATATTCATTAAAGGCAGCTTTAGGAAACAGGAATATA ENST00000528178.1 -----TCAGGT----AGCGTGATGCCTCCA---------GCTTT---------------- **** * * * * ** * ** ***** ENST00000378505.2 CTACAAGAGTGTTTTGTTTGTGTATACAAATCATTCCATTTTTAAATGGCACAGATGCTT ENST00000528178.1 ----------GTTCT-TTTG-GCTTAGGATTGATT-----------TGGC---GATGT-- *** * **** * ** * * *** **** **** ENST00000378505.2 AAGGGCTATAAAAACTTCTAATTTCTTATAAATATGTTAGCACTTTTTTTAAGTTA-GTG ENST00000528178.1 --GGGCCCT-----TTTTTGGTTCCATATGAACTTTAAAGTAGTTTTTTCCAATTCTGTG **** * ** * ** * *** ** * ** * ****** * ** *** ENST00000378505.2 ATTACAGTTTACCTACTGTATAGAATAATTTTCTAATAATGGATGGTATTCTAAAACTCA ENST00000528178.1 AAGAAAGTC-----ATTG------GTAGCTT---GATGG-GGATGGCATT----GAATCT * * *** * ** ** ** ** ****** *** * ** ENST00000378505.2 ATTGAGGCATTCACATTTTAAAGAAAGTATTGTCTTTCACCTTTTATGTGTTCTTTTTGC ENST00000528178.1 ATAAA-----TTACCTT----GGGCAGTATGGCCATTTTCACGATATTGATTCTTCCTAC ** * * ** ** * ***** * * ** * *** ***** * * ENST00000378505.2 AAAAATCTACAAA-GTGACAGCTGTGTTCAGAGCTTAGATCCCAAAAACGTGATCTCTTT ENST00000528178.1 ------CCATGAGCATGGAA----TGTTC-----TTCCATTT---GTTTGTATCCTCTTT * * * ** * ***** ** ** ** ****** ENST00000378505.2 TAGTTACTATCTGGGCAGATGGTAGTATATCTAATGAAATGGTGATTAATTTAAATGTAT ENST00000528178.1 TATTTCCT---TGAGCAG-TGGT----------------TTGTAGTT--CTC-------- ** ** ** ** **** **** * ** ** * ENST00000378505.2 AATCTGGAAATATGTAAAACTTGAAGTATTTTTTGTCCAGGCAAAGGTACTCATTGGGCC ENST00000528178.1 ---CTTGAA-------------GAGGCCCTTCATGTCCCTTGTAAGGTGG--ATT---CC ** *** ** * ** ***** ***** *** ** ENST00000378505.2 TCAGTTTCTTCATCTCTAAAATGGAGTGGATGAGATGATGTGATAACTGCAGTCCCTTCT ENST00000528178.1 TAGGTATTTTATTCTCT---TTGAAGCAATTGTGA--ATGGGA--------GTTC----- * ** * ** ***** ** ** ** ** *** ** ** * ENST00000378505.2 AACTCTTAAATTCTTTTCATTCTCACAGATTCACTCTATCATTATTGTTATTCATGTA-A ENST00000528178.1 -ACTCATGA-----TTTGGCTCTCTG--------TTTGTC-----TGTTGTTGGTGTATA **** * * *** **** * * ** **** ** **** * ENST00000378505.2 GAAACGTTTTAGGGAGAAAAATTACACTTTAAAATTAATTTAGTTTTCTATACAGTTGTT ENST00000528178.1 AGAATGCTT--------GTGATTTTAGT---ACATTGATTTTGTATCCTG-AGA------ ** * ** *** * * * *** **** ** * ** * * ENST00000378505.2 TTCTTTACTCTTGAAAAGTTA--TGACAGCTTTAACGTCTCTTGTCTTCTGTAATTTTTT ENST00000528178.1 --CTTTGCT-----GAAGTTGCTTATCAGCTTAAG---------------GAGATTTTGG **** ** ***** * ****** * * ***** ENST00000378505.2 ATTTCTAAACTCCTATCATTTCCAAGCTTTAACTGTACTTTATCAGAGCCTTCATTTCTG ENST00000528178.1 G---CTGAGACAATGGGGTTTTC------TAGATATAC--AATCAGA-CAATCA------ ** * * *** * ** * *** ****** * *** ENST00000378505.2 GTATGTGTTATATGCCCTCAATGTATTCACTGACTGTTCTGTAATTTCAGTTTGTCTGTT ENST00000528178.1 ------GTTA-ACA-----AGGATACCCAGGAATTG-------AACTCAGCT---CTGCA **** * * ** ** * ** * **** * *** ENST00000378505.2 CCTTGTCAGAATGTTTCAAGTAAAATAAAAAATTAAATGT ENST00000528178.1 CCAAGC--GGACCT---------AATAGACATCTACAG-- ** * * * * **** * * ** *