CLUSTAL 2.1 multiple sequence alignment ENST00000379378.2 ------GCGGA---------------AGTGGCGGCGG-CGCCGGCCTGGCCTGGCCT-GG ENST00000422443.1 TCAGAGGCTGAGAATAGACACATCAAAGAGGTCACAGACACC--CTTACTCTCATCCAGG ** ** ** ** * * * ** * * ** * ** ENST00000379378.2 CTG-AGGGGAGGC-----------------GGCGGGCGG-GCGCGATGGCGGAGGCCGGG ENST00000422443.1 TTGTAGGTGTAACCATGATCTCATGATCTTGGCAGATGGAGAAAGATGGAGGAGGAGGGA ** *** * * *** * ** * ***** ***** ** ENST00000379378.2 CCACA--------GGCGCCGCCGCCCCCGGGCACTCCAAGCCGGCACG-------AAAAG ENST00000422443.1 GAATATTTCTGAGAACATCAATGCCTCCAGCAGCTCTGAGCTCATGTGTTCTTGTGTGAG * * * * *** ** * *** *** * ** ENST00000379378.2 AGCCTGG---GACTGCTCACCACCAAGTTC--GTGTCCCT------TCTGC----AGGAG ENST00000422443.1 ATCCAAGAGTGGCAGCTCTTCGGGGAGTTCCAGAATGCCTGTAGGGTCTGCCTTGAGGGG * ** * * * **** * ***** * * *** ***** *** * ENST00000379378.2 GCCAAGG---ACGGCGTGCTTGACCTC--AAGC--TGGCA-----GCTGACACCCTAGCT ENST00000422443.1 TTCAAAGGAGATAGCGGGGTTGGGTTCTGATGCATTGGTATCATTGCTGCAGCTGCTGCT *** * * *** * *** ** * ** *** * **** * *** ENST00000379378.2 GTACGCCAGAAGCGGCGGATTTACGACATTACCAATGTTTTGGAAGGTATCGGGCTAATC ENST00000422443.1 ATCCAGCAGGAAAGAAGACTGCAGGG---GGCCAGTGTCTC--ATGCTGCCGGCCCAGT- * * *** * * * * * * *** *** * * * * *** * * * ENST00000379378.2 GAGAAAAAGTCCAA---------GAAC-----AGC-ATC-----CAGTGGAAGGGTGTGG ENST00000422443.1 GGGAGTGAGCTCAGCTCACCACTGGGCTCCGGAGCTGTCAGGGTCAGAGGTAAGGGGTGG * ** ** ** * * *** ** *** ** * ** **** ENST00000379378.2 --GGCCTGGCTGCA-ATACCCGGGAGATTGCT--GACA---AACTGATTGAGCTCAAGGC ENST00000422443.1 TCAACTGAGTCCTACATGCATGTGAGGTTTCCTGGAGATGGAACAGGGAAGGCTTG-GGC * * * ** * * *** ** * ** * *** * *** *** ENST00000379378.2 AGAGATCGAGGAGCTGCAGCAGCGGG------------AGCAAGAAC-TAGAC-CAGC-A ENST00000422443.1 AGAGATGGAGGGCCAGAGACAGCAGGTGGGCTCTGGAGGGTGACGGCATAGACACAGCCA ****** **** * * **** ** * * * ***** **** * ENST00000379378.2 CAAGGTGTGGGTGCAGCAGAGCATCCGGAACGTCA-CAGAGGACGTGCAGAACAG-CTGT ENST00000422443.1 CAGGTGGTGAGCTC--CATGCCTCCTTGTTCACCAGCCTTGAAGGGGCCAGTCAGGCTGT ** * *** * * ** * * * * ** * * * * ** *** **** ENST00000379378.2 TTGG--------CCTAC-GTCACTCA-TGAGGACATCTG---CAGATGCTT------TGC ENST00000422443.1 TCAGGTGAATCTCTTACTGTTGCCCACTGGGGACTTCTGGGATGGGTGCCTGTGGGCTGC * * * *** ** * ** ** **** **** * *** * *** ENST00000379378.2 TGG-AGATACCCTCT---TGGCCATCC--------GGGCCCCATCAGGCACCAGCCTGGA ENST00000422443.1 TACCAGACAGGGTCTGTGTGGCCAGTATGGTAGGAGGGTGTCTCCAGCAA--AGCCT--- * *** * *** ****** *** * *** * ***** ENST00000379378.2 GGTGCCCAT--CCCAGAGGGTCTCAATGG----GCAG--AAGAAGTACCAGAT------- ENST00000422443.1 -CTACCCATGTCCTCATGAGTCACATAGGCCAAGCAGCTATGATGTTCCAGATGTTCTGC * ***** ** * *** ** ** **** * ** ** ****** ENST00000379378.2 -TCACCTGAAGAGTGTGAGTGGTCCCATTGAGGTTCT-GCTGGTGAA---CAAGGAG--- ENST00000422443.1 TTCCCCCACACCTTGTGC-TGGTCCGGTTTTTGCTCTTGCTTCTGCGGTTCCTCGATCTC ** ** * **** ****** ** * *** *** ** * ** ENST00000379378.2 -GCATGGAGCTCA-------------------CC--CCCTGTGGCTG----------TGC ENST00000422443.1 TGCCTTGAGCTCAGTCAGCTTGTCTGCAATCTCCAGCCCTATTGCAGCCAGGCCCCATGC ** * ******* ** **** * ** * *** ENST00000379378.2 CTGTGCCACCA--------CCTGAAGATTTG--CTCCAG-AGCCC--------------- ENST00000422443.1 CT-TTCCACTGATGCTGTTCTTGGATATTTTTTCTCCATTAGCCCTATGCCTTCCAATAC ** * **** * ** * **** ***** ***** ENST00000379378.2 ----------------ATCTGCTGTTTCT---ACAC--------------CT-CCACCTC ENST00000422443.1 ATTGGTAATGCTGTAAACCTGCGGTTTCTGGCACACAGATAGGATGTCAGCTGCCAGCTT * **** ****** **** ** *** ** ENST00000379378.2 T-GCCCAAGC---CTGCCCTAGCCCAGTCCCA----------GGAAGCCTCACG------ ENST00000422443.1 GAGGTCAAGCACGCTGTCCTTGGCC--TCCTACAGAAGTGGTGGGAGCTTGGTGGTGAGA * ***** *** *** * ** *** * ** *** * * ENST00000379378.2 --TCCAAATAGTCCTC--AGCTCACT-------CCCA----CTGCTGTCCCTGG----CA ENST00000422443.1 GTCTCAAATACTTCTCGTATCCCACTTAAGGTCCCCAGGGGCAGCAGTGCCTGTGGCCCA ****** * *** * * **** **** * ** ** **** ** ENST00000379378.2 G----TGC--------AGA-AGTCCAGGGAAT--------------------------GG ENST00000422443.1 GCCTCTGCTTCTCCTCAGCCAGGCCAGCTATTTTCATCTCTTATTTACATTTGTTCTAGA * *** ** ** **** * * * ENST00000379378.2 CT----GGCCC------AGCAGCTGAGATCACAGTG---AGT-----GGCG-----GCCC ENST00000422443.1 CTCCTGAGCCCGTCTCTACCTACTGAATTTAAAATGTTTAGTCATAAGACATATATACCT ** **** * * **** * * * ** *** * * ** ENST00000379378.2 TG-------------------------GGACTGATAG---CAAGGACAGTGGTG-AGCT- ENST00000422443.1 TTAAGTAAATTGGATATATGAAAATCTGGATTGACAAAAACAAAATCAATCGTATAACTT * *** *** * *** ** * ** * ** ENST00000379378.2 --CAGTTCACTCC--CACTGGGCCCAACA-ACACTGGACACCCGGCCACTGCAGTCTTC- ENST00000422443.1 TTCAAAACCCTTCATCATTGCATTTAAAGGACCTTGTAAAATATGCC-CTACTGTCTTTA ** * ** * ** ** ** ** ** * * *** ** * ***** ENST00000379378.2 ----TGCCCTGCT-------------------GGACAGC---------------AGCAGC ENST00000422443.1 AAGTTGTCTTAGTTTATTTAAAAATTATTTCAAAATAGTTTTTGAAATTCTGTAAACAGA ** * * * * ** * *** ENST00000379378.2 AGCAGC-AGCAGCAGCAGCA-----GCAGC----AGCAG----------CAACAGTAACA ENST00000422443.1 AGTACCTGGCCATGAATGCATACATGCACCTATAAATAGGCCTTATCTTCACCATTAA-A ** * * ** *** *** * * ** ** ** *** * ENST00000379378.2 GCAGCAGTTC-GTCCGGACCCAACCCTT---------------CTACCTC----CTTTGA ENST00000422443.1 AAGGCAAACCAGTCTGGATTTTAATTTTGATTTTTCGCATTTGCTATTTCAAATCACTAA *** * *** *** * ** *** ** * * * ENST00000379378.2 GCCCATCAAG-------GCA-------------GACCCCACAGG----TGTTTT------ ENST00000422443.1 AAGTATCAAGAAGTTGTGCATTTCTGCATTTGAGGTACTACATGACTGTGCTTTTGTTGA ****** *** * * *** * ** *** ENST00000379378.2 ------GGAACT----------------------CCCCAAAGAG------CTGT-CAGAA ENST00000422443.1 GGTGAAGGAAATATGCATTACTAAGATGAATTTACCCTACAGAAGGAAAACTCTATAGGA **** * *** * *** ** * ** * ENST00000379378.2 ATCTTTGATCCCACACGAGAGTGCATGAGCTCGGAG-----CTGCTG----------GAG ENST00000422443.1 ATTTCCTCTGCATCACCAAAAC-CATGAACTTTCTGGCCCCCTACTGTTATTTAAAAAAA ** * * * *** * * ***** ** * ** *** * ENST00000379378.2 GAGTTGATGTCCTCAGAAGTGTTTGC-----------CCCTCTGCTT-----------CG ENST00000422443.1 GAGCTCATTCCAACAGAGTTGCTGACATTGAACTCAATTCCTTGCATGTAAGGGTCCATG *** * ** * **** ** * * * *** * * ENST00000379378.2 TCTTTCTCCACCC--------CCGGGAGACCACG--------ATTATATCT---ACA-AC ENST00000422443.1 TCTTTCACTAACTGGTTAGGGCTAGGGGAGCATATAATGTATATAATACCTGTCACAGAC ****** * * * * ** ** ** ** *** ** *** ** ENST00000379378.2 CTGGA-----CGAGAGTGAAGGTGTCTG---TGACCTCTTTGATGT--------GCCTGT ENST00000422443.1 CAGGAAACTGCAAAAGGAAAAACTCTTGAAGTGACTACTTTTAAGTCAATTGGAATTGAT * *** * * ** ** ** **** **** * ** * ENST00000379378.2 TCTC-------AACCTCTGA-----CTGACA-GGGAC--ATGCCC------------TGT ENST00000422443.1 TCTTTCAGCAGAATCTCAGAAAAAGCAAACATGAAACTAATGACCCTGAAAAATTTTTGT *** ** *** ** * *** * ** *** ** *** ENST00000379378.2 GTGGCTG-----GGACCCAGACTGTCTGACCTGGGGGTTGCCTGGGGACCTCTCCCACCC ENST00000422443.1 ATAGTTTCCTTTGGTCATAGTCCTATTGGCACAATCTCAGCCTTCAG-CTTTTCATGTCC * * * ** * ** * ** * **** * * * ** ** ENST00000379378.2 -----GACCCCTACAG------AGCT--TGAGAGCCACAGAC--------GCCTGGCTTC ENST00000422443.1 TTGGTGGATTGTGTAGTTATGTAGTTAATCATAATTATGAATTTATTGTTATCTGAACTT * * ** ** * * * * * * *** * ENST00000379378.2 TCCG-----GCCTCCCCT----------CACCGCACAGTTCT----GGCCACAGCTC--- ENST00000422443.1 TCCTTTTGTGCATTACCTGCTATCTCAATACTGTAT-GTTTTAAAGGGCCACATCCCAAA *** ** * *** ** * * *** * ******* * * ENST00000379378.2 ------CCGCTCCTGTGC----TGGCACTTC----TGT-----GCTC---------GCAG ENST00000422443.1 AAGAACCCCATCCTTTGCCCCCTACCATTTCAGCCTGTTAAAAACTCTTTTTTTTAATAT ** **** *** * ** *** *** *** * ENST00000379378.2 AGCAGGGGAAC-AGGACTCA------GCCCCCATCAC-----CGTGG----------AGC ENST00000422443.1 GGCAGACTAGTTACTATTTATTTGATGATCTCATTATGTTTATTTGATATTCTCATTAAC **** * * * * * * * *** * ** * * ENST00000379378.2 CAAAGTGTTTGCTTCTCCCTT---------TCTGCGG---CCTTC--------------- ENST00000422443.1 TATGTTGTTTGCATCTTTCCTGGTTAAAAGTTCACAGGAACATTCTAAATTGAAAATACA * ******* *** * * * * * * *** ENST00000379378.2 ----------GCCAG-------------------------CCCAGGCTCGGCTGCCA--C ENST00000422443.1 AATATAGTATGTCAGAGATTATGGCATGTGGAAAGCACTTTTCTGAATTAACTGAGAGTC * *** * * * *** * * ENST00000379378.2 CCAGTGGCACAGAACCGAGGAGCTGCCATT--------------ACCCCCCATAGGGGGC ENST00000422443.1 TTTGTAGTATGAATGCAAAGAGTGGGGATTCTTGAGTCAAAAGAATTGTTTTCAAATCTC ** * * * * * *** * *** * * * ENST00000379378.2 AGTGTCTTG--TTCCTGCC--AGCCTCAGTGTC----TTGCT-----TCTGCCAGCTCC- ENST00000422443.1 AGTGTTTCAATTTCCTACCTTAGTGACAATATGCAAGTTACTGAACTTCTCTTAGCTTTC ***** * ***** ** ** ** * * ** ** *** **** ENST00000379378.2 ---TTCCC--CTAGGAGGGAAGGGTGGGG-------------TGGAACTGG--------- ENST00000422443.1 CTATTCCCATCTGTGAAAGAGTGATAATAATTTATAGACTTATGGAACAGATGAATAACA ***** ** ** ** * * ****** * ENST00000379378.2 --GCACATGCCAGCACCACTTCTA-GCTTCCTTCGCTATC-------------------- ENST00000422443.1 AAATATATGTGAAAGTGCCTGACATGTTTTAATGGATATTGAATGAAAGTAATAATAAAA * *** * ** * * ** * * *** ENST00000379378.2 ---CC------------------------CCACCCCCTGACCCTCC------AGCTCCTC ENST00000422443.1 TAACTGGGACAAGGCGGGTATAAAGAGAACCAGACTATGATAGTCCCTAAAGGGCTCTTT * *** * *** *** **** * ENST00000379378.2 CTGGCCCTCTCACGT--GCCCACTTCTGCTGGGCCTTTAGCCCTAGAACCTGCAGGTGGT ENST00000422443.1 TT---CCACTTAAATAAGAAAACATGTGTAAAGTCACTAGC---AGAGTGCTCAGG--AC * ** ** * * * ** * ** * * **** *** **** ENST00000379378.2 GGGGGCGGCTACCAAGAAGGA--------------ACAGAG-GTCTCTGGGGAGGAGTCT ENST00000422443.1 ATGGTTGACTATCAAGGGATGTTAGTTCCTCCTTCACAGAACATTTCCAGTTACATCTTT ** * *** **** ***** * ** * * * * ENST00000379378.2 G---GGTGGTCCAGCCCTGATGATTGGCCCCACCTCCTGCTGCC------CCATAACCCT ENST00000422443.1 GTTTGGTGTTCCGAACTGAAAAGATGTGTATGTATTCTTGTGTCAACATTCAATAACCAG * **** *** * * ** * ** ** * * ****** ENST00000379378.2 CT-CTTCATTTCG--GCTTTTT--CATT------TACCC---TCATTTAGAGCCATT--- ENST00000422443.1 TTGCCTTGTTGCAATGCTTCTTAACATTAGTGTGTATGCAGATCACCTGGGAATGTTGTT * * * ** * **** ** **** ** * *** * * ** ENST00000379378.2 ---TGCAGA----GATTTAG-------------------AAAGATTTACAGTAACGAATG ENST00000422443.1 AAATGTAGATTCTGACTCAGGAGGTCTGGGATGGAGCCGAAAATTCTATATTTTCAAAAG ** *** ** * ** *** * ** * * * ** * ENST00000379378.2 ----------GATTCCTATA--------------------TAAAG--------------- ENST00000422443.1 TCTCATAGCCGATTCCTATAAAGTTGGTCCAGTCGAATAGCAAAGCCTTAATAGGCCAGG ********** **** ENST00000379378.2 ---ATTATTTTTATACTTTTTGCAGCA-----------AAAG-----------GAAATTG ENST00000422443.1 CGTATTCTCTCTTCGTTCCTTGCATTATCTGATTTCGTAAAGCTAATAGTGTAAAGATGG *** * * * * ***** * **** * ** * ENST00000379378.2 TAATATT-TGTACAGTGTTCAAGTGAATAAAAACCATGCCTAAGGCTA ENST00000422443.1 TATTATTCTACACATTTTACAAATGAG-AAAGTTTTAACCCACAGAGG ** **** * *** * * *** *** *** ** * *