CLUSTAL 2.1 multiple sequence alignment ENST00000380567.1 CGGACTGGCTGTGAGGCGGTCCTGCCTCGCTGCCTTCAGTCCCTAGTGTCTGGGTCCCCG ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 CCCTCCAGCCGCCTTTGAGTCGTGCCTGGGTCCTCGCCCTTGCCTCAGAACCGCGAAGAA ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 AGGAAGCTCGCGTGTTTGCTAGAAAACCTAGTTGGGAGTGCGAGGCAGAGAACGTTCAGC ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 ACCTTTGTTCCTCCCGAACCCTCGGGACAGAGGCAGGGTTCTGAGGGCAGGGATTCCCCC ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 TCGTCTTGGCCCCACCGCCCGGGCTGGGCACTAAACTCGGGCCGCGGCGGGGCGAGCGAG ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 GCGGGCTCCGGAGGGAGCTGACGCCTGATGATGGCGCAGTCCAACATGTTTACCGTGGCT ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 GATGTGTTGAGTCAAGATGAACTGCGCAAAAAGCTATACCAGACGTTTAAGGATCGGGGT ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 ATACTGGATACACTCAAGACACAACTTCGAAACCAGCTAATTCATGAGTTGATGCACCCT ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 GTATTGAGTGGAGAACTGCAGCCTCGGTCCATTTCAGTAGAAGGGAGCTCCCTCTTAATA ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 GGCGCCTCTAACTCTTTAGTGGCAGATCACTTACAAAGATGTGGCTATGAATATTCACTT ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 TCTGTTTTCTTTCCAGAAAGTGGTTTGGCAAAAGAAAAGGTATTTACTATGCAGGATCTA ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 TTACAACTCATTAAAATCAACCCTACTTCCAGTCTCTACAAATCACTGGTTTCAGGATCT ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 GATAAAGAAAATCAAAAAGCCATTAAGTCTGTGACTTAATCGCCAAGTCTCTTGGTAGTA ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 ATGTTAGCAGAATATAAATAAATTGGAGCACAAGATATTCTGGACTGCCCGCAAACTAGA ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 CCATCTCTACTGAAGTTCAGTATGGTTTTCTTATGCATTTTTTAAAAGAATTGGCAGAAT ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 ATCATCAAGCTAAAGAGAGTTGTAATATGGAAACTCAGACAAGTTCGACATTTAACAGAG ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 ATTCTCTGGCTGAGAAGCTTCAGCTTATTGATGATCAGTTTGCAGATGCTTACCCTCAGC ENST00000453312.1 ---------CTGAGAAGGTTGAGCTTATAGATGATCAGTTTGCAGAGGCTTACCTTCAGC ******** ** ******* ***************** ******* ***** ENST00000380567.1 GTATCAAGTTCGAATCTTTAGAAATAAAGCTAAATGAGTATAAGAGAGAAATAGAAGAGC ENST00000453312.1 ATATCAAGTTTGAGTCATTAGAAATAAAGCCAAATGAATATAAAAGAGAAATAGAGGAGC ********* ** ** ************* ****** ***** *********** **** ENST00000380567.1 AACTTCGGGCAGAAATGTGTCAAAAGTTGAAGTTTTTTAAAGATACCGAGATAGCAAAAA ENST00000453312.1 AAATTTGAGCAGAAACATGTCAAAAGTTGAAGTTCTTTAAAGATGCCAAGATAAAAAAAA ** ** * ******* ***************** ********* ** ***** ***** ENST00000380567.1 TTAAAATGGAAGCAAAAAAAAAGTATGAAAAGGAGTTAACCATGTTCCAGAATGATTTT- ENST00000453312.1 TTCAAATGGAAGTGAAAAGAAAGTGCGAGAAGGAATTAGTTGTCTTCCAGAATGATTTTT ** ********* **** ***** ** ***** *** * *************** ENST00000380567.1 GAAAAAGCTTGTCAAGCAAAATCTGAAGCTCTCGTTCTTCGGGAAAAGAGTACCCTTGAA ENST00000453312.1 GATAATGCTTGTCAAGCAAAATCTGAAGCCCTCATTCTTTATGAAAAGAGTATCCTTTAG ** ** *********************** *** ***** ********** **** * ENST00000380567.1 AGAATTCACAAGCACCAAGAGATTGAAACAAAAGAAATTTATGCTCAAAGGCAACTTTTA ENST00000453312.1 ATAAATGAAAAGCACCAAGAG--------------------------------------- * ** * * ************ ENST00000380567.1 CTAAAAGATATGGATTTGCTAAGAGGAAGAGAAGCAGAGCTGAAGCAAAGAGTTGAAGCT ENST00000453312.1 ------------------------------------------------------------ ENST00000380567.1 TTTGAATTGAACCAGAAGCTCCAGGAAGAAAAACATAAAAGCATAACTGAGGCACTTAGG ENST00000453312.1 -------TGAACCAGAAGCTACAG----AAAAACATAACAGCATGACTGAGG-ACTTGGA ************* *** ********** ***** ******* **** * ENST00000380567.1 AGACAGGAGCAGAATATAAAGAGTTTTGAGGAGACCTATGACCGAAAGCTCAAGAATGAA ENST00000453312.1 AGATGGGAGCAGAATACAAAGTCCCTTGAGGAGAGCTATGACAGAAAGCTCAGGAGCAAA *** *********** **** ********* ******* ********* ** ** ENST00000380567.1 CTTCTAAAGTATCAACTTGAACTGAAGGATGACTACATCATTAGAACTAATCGACTGATT ENST00000453312.1 CTTCTAAAGTATCAACTTGAACTAAAGGAGGACCACATCATTAGAACTAATGGACAGATC *********************** ***** *** ***************** *** *** ENST00000380567.1 GAAGATGAAAGGAAGAATAAAGAAAAAGCTGTTCATTTGCAAGAGGAGCTCATAGCTATT ENST00000453312.1 GAAGATGAAAGGAAGAATAAAGGAAAAGCTGTTTCTTTGCAAGTGGAGCTCCTAGCTATT ********************** ********** ******** ******* ******** ENST00000380567.1 AATTCAAAAAAGGAGGAACTCAATCAATCTGTAAATCGTGTGAAAGAACTTGAGCTTGAA ENST00000453312.1 AATGTAAAGAAGGAGGAACTCAATCAATCTGTAAATTGTATGAAAGAATTTAAGTTTCAG *** *** *************************** ** ******** ** ** ** * ENST00000380567.1 TTAGAGTCTGTCAAAGCCCAGTCTTTGGCAATAACAAAACAAAACCATATGCTGAATGAA ENST00000453312.1 TTAGGGTCTCTCAAAGCCCACTATTTGGCAATAACAAAACAAAAACGTATGCTTAATGAA **** **** ********** * ********************* * ****** ****** ENST00000380567.1 AAGGTTAAAGAGATGAGTGATTATTCACTACTAAAAGAAGAGAAACTGG-AGCTTCTGGC ENST00000453312.1 AAGGTTAAAGAGATGCGTGATTATTCACTACTAAAAGAAGAGAAACTGGGAGTTTCTGAC *************** ********************************* ** ***** * ENST00000380567.1 ACAAAATAAATTACTTAAACAACAACTGGAAGAGAGTAGAAATGAAAACCTGCGTCTCCT ENST00000453312.1 ACAAAATAAATTACTTAAATGACAAGTGGAAGAGAATAGAAATGAAAACTTGTGTCTCCT ******************* **** ********* ************* ** ******* ENST00000380567.1 AAACCGCCTAGCT--CAGCCGGCTCCTGAACTTG----------------CAGTCTTTCA ENST00000453312.1 AAATCATATATCTATTATCCACCTCCTGGGTTCAAGGAATTCTCCTGCCTCAGCCTTCCT *** * ** ** * ** ****** * *** *** * ENST00000380567.1 GAAAGAACTACGGA--AAGCCGAAAAG-----GCTA-----------TAGTGGTTG---- ENST00000453312.1 --AGTAGCTGTGGTGCATGCCTACAGGCATGCACCACCACATTCAGCTAATTTTTGTATT * * ** ** * *** * * * * * ** * *** ENST00000380567.1 ----AGCATG---AGGAGTTCGAAAGCTGCAGGC-AAGCTCTGCACAAACAACTGCAAGA ENST00000453312.1 TTTTAGTAGAGACAGGATTTC--ACGATGTTGGCCAGGCTGGTCTCAAACTTTT---AAC ** * **** *** * * ** *** * *** * ***** * * ENST00000380567.1 CGAAATTGAGCATTCTGCACAGCTGAAGG-CCCAGATT-CTAGG-TTACA-----AAGCT ENST00000453312.1 CAAAAGTGA----TCCACCCACCTTGGGCTCCCAGAGTGCTGGGATTACAGGCATAAGCC * *** *** ** * ** ** * ****** * ** ** ***** **** ENST00000380567.1 TCTGTAAAGAG---------TTTAACTACTCAGGTT--GCCG--ATT-TAAAA------- ENST00000453312.1 ACCGCACATGGCCTGCATGCTTTAGTAATTTATGTTATGTCAGCATTATAAAACTACGCT * * * * * **** * * * *** * * *** ***** ENST00000380567.1 TTGCAACTGAA---GCAAACTCAGAC-----AGCCCTAGAGAATGAAGTGTACTG---CA ENST00000453312.1 TTGTACCTGTAAGGGGAGGCTTAAATTGGGAAGATTTATAAAATTAAGATTACTGGATTA *** * *** * * * ** * * ** ** * *** *** ***** * ENST00000380567.1 ATC----CAAAGCAGTCT----GTG--ATCGA-----TCGT-----TCTGTCAATGGATT ENST00000453312.1 AACTCTGCTAACCTGCCTCTAGGTGGTATCCAGGCTTTCCTGGGCCTCTGTCTGCTGATT * * * ** * * ** *** *** * ** * ****** **** ENST00000380567.1 AATAAATGGCAATGTGGTGCCTTGCAATGGTGAGATA-AGTGGGGATTTCTTGAACAATC ENST00000453312.1 GG-GTTTGGCCACTGGACACAC--CAACCTCCACATATAGTGG-----CCTTAGACTGGC **** * * * *** * *** ***** *** ** * ENST00000380567.1 C------TTTTAAA--CAGGAAAACGTTCTAGCACGTATGGTTGCATC----AAGGAT-- ENST00000453312.1 TGCTGCATCTCAAGGCCAAGTGAG-GTCATAGTGTCTGTGATGGCCTCTTCCAATTGTTC * * ** ** * * ** *** * ** * ** ** ** * ENST00000380567.1 --CACAAATTATCCAACTGCATGGGTGGAGGGTAGTTCCCCTGATTCTGACCTTGAGTTT ENST00000453312.1 TTCACCACCTCCCTCTCTCCA---GTGCTGAGAATTTCTCCCTTCTCTGATCTTCCATTC *** * * * ** ** *** * * * *** ** ***** *** ** ENST00000380567.1 GTAGCCAATACTAAGGCAAGGGTCAAAGAGCTTCAGCAAGAGGC----CGAACGCTTGGA ENST00000453312.1 CCAAAGAGTGCTAACACTGTGGCCCTGTTACTCTCCCAGGGAACACTGCCATTATTTGTG * * * **** * ** * ** ** * * * * *** ENST00000380567.1 AAAGGCTTTCAGAAGTTACCATCGGAGAGTCATTAAAAACTCTGCCAAAAGCCCACTAGC ENST00000453312.1 GATACCCTGAATAAGTCACCCT-------TTATTAAAAA-TTTCTTAGATGACC-TTGAC * * * * **** *** * * ******** * * * * * ** * * ENST00000380567.1 AGCAAAGAGCCCACCATCT-CTGCACTTGCTGGAAGCCTTCAAAAACATTACTTCCAGTT ENST00000453312.1 TGTGG-GAGCCTTCTGCCTTCTGC-----CTGGA-----TCCCAACTGCTGCTGACAGAT * ***** * ** **** ***** ** ** * ** *** * ENST00000380567.1 CCCCGGAAAGACATATTTTTGGAGAGGACAGAGTTGTC-TC--TGAGCAGCCTCAAGTGG ENST00000453312.1 GCACAGAT---CATATT-----GGATCTTGGGGCTGTCATCAACAAGTAGACT-AGGTAG * * ** ****** ** * * **** ** ** ** ** * ** * ENST00000380567.1 G----CACACTTGAAGAAAGGAATGACGTCGTGGAAGCACTGACAGGCAGTGCAGCCTCG ENST00000453312.1 AGAGCCACTTCTGTGCATGGTAGAGA----ACAGAAACAGTATT--TCAAATTAATTTGA *** ** * * * ** *** ** * ** * * ENST00000380567.1 AGGCTCCGCGGGGGCACTTCCTCCAGACGCCTCTCTTCCACACCCCTTCCAAAAGCAAAA ENST00000453312.1 GGACTTAAAAGAGTTATTTTTTTTCTGTACC---ATTATGCATTCCA-CCACCAGTGAAT * ** * * * ** * ** ** ** ** *** ** ** ENST00000380567.1 AGAAGCCT-------CGAAAGTGAAATGTATCTGGAAGGTCTGGGCAG--ATCACACATT ENST00000453312.1 GAATTCCTGTCTTTCCTTCAGCAAA--GCATTTGTCATGTTTTAAAAACAATTTCACAGT * *** * ** ** * ** ** * ** * * ** **** * ENST00000380567.1 GCTTCCCC-------CAGTCCTTGTCCTGACAGAATGCCCCTACCATCACCCACT-GAGT ENST00000453312.1 TCTAGCAAATATAGACAGGCCATATCTC-----ATTGTTTTAACTGTCACTCCCTTAAGG ** * *** ** * ** * ** ** **** * ** ** ENST00000380567.1 CTAGGCACAGCCTCTCCATCCCTCCTGTCT-CCAGCCCTCCGGAGCAGAAAGTGGGTCTT ENST00000453312.1 ATATACA-AGATTGAGCATCTTTT-TGTTTGCTTGCCATCTG----------TGTATCTT ** ** ** * **** * *** * * *** ** * ** **** ENST00000380567.1 TATCGAAGACAAA-CTGAACTTCAAGACAAAAGTGAATTTTCAGATGTGGACAAGCTAGC ENST00000453312.1 CATTGATGAGGTATCTG---CTCAGCTCTTTACCCATTTTT--AAT-TGGATAGTCT--C ** ** ** * *** *** * * * **** ** **** * ** * ENST00000380567.1 TTTTAAGGATAATGAGGAGTTTGAATCATCTTTTGAAT--CTGCAGGGAACA----TGCC ENST00000453312.1 TCTTACTGTT------GAGTTTCAATATTTCTTTGCATATTTTCAGAGCAAAGTCTTGCT * *** * * ****** *** * **** ** * *** * * * *** ENST00000380567.1 AAGGCAGTTGGAAATGGGCGGGC-TTTCTCCT---GCCGGGGATA-----TGTCTCATGT ENST00000453312.1 TAGA---TCTGTAATTTGCAGATATTTCTCCTCAGACTGTGGCTTATCTTTGTTTCCTGA ** * * *** ** * ******** * * ** * *** ** ** ENST00000380567.1 GGACGCTGC-TGCAGCTGCTGTGCCCCTCTCATATCAGCACCCAAGTGTAGATCAGAAAC ENST00000453312.1 CAAGATTTTATGCAG--AGTATAAACTTTTAATATGAGA----AGGCCTACATTGTTAAT * * ***** * * * * * **** ** * * ** ** ** ENST00000380567.1 AAATT-----GAAGAACAAAAGGAAGAAGAAAAAATACGGGAACAGCAAGTGAAAGAACG ENST00000453312.1 TAATTTTTCTGTTATGGATAAGCTTTGGTGTCATATATTAAAACT-CATGACCAAACCCA **** * * *** * *** *** ** * ** * ENST00000380567.1 AAGGCAGAGAGAAGAAAGAAGGCAGAGTAACCTACAA---GAA--GTTTTAGA----AAG ENST00000453312.1 AGGTCACATAGGTCTCTTTCTGTGGTTTCTTCTATAATTTGAATAGTTTTACACTTTAAG * * ** * ** * * * *** ** *** ****** * *** ENST00000380567.1 ----GGAACGAAGAGAACTAGAAAAACTGTATCAGGAAAGGAAGATGATTGAAGAATCAC ENST00000453312.1 TCTCAGAACTATGTTGA---GAAAAATTTTGTGTAAGTTGTAAAATG--TGC--CATCTC **** * * * ****** * * * * ** *** ** *** * ENST00000380567.1 TGAAGATTAAAATAAAAAAGGAATTAGA--AATGGAAA----ATGAATT--AGAAATGAG ENST00000453312.1 TGTTCATTTCATTGCCTGTGGTTTCCGGTTAATGGTCTCTTCATCATTTTCAGCAAAAAA ** *** * * ** * * ***** ** * ** ** ** * ENST00000380567.1 TAATCAAGAAATAAAAGACAAATCTGCTCACAGTGAAAATCCTTTAGA-GAAATACATGA ENST00000453312.1 CAAACAACAACAAAAA---AAACCCAGG-ATAATAGCAGCATTTCAGATGGAAT-TTCCA ** *** ** **** *** * * * * * ** *** * *** * ENST00000380567.1 AAATCATCCAGCAGGAGCAAGACCAGGAGTCGGCAGATA---AGAGCTCAAAAAAGATGG ENST00000453312.1 AAATGATGGTGCTG-AACAA--TCTGAAGTCTGCTTTTATTTGGTGCCTTAG---GCCAG **** ** ** * * *** * * **** ** ** * ** * * * ENST00000380567.1 TCCAAGAAGGCTCCCTAGTGGACACGCTGCAATCTAGTGACAAAGTCGAAAGTTTAACAG ENST00000453312.1 TCAGGAGAGAATGCATAGCTGCCCCACCATGACCACCTGG---GTCCTGCAGTTCTGCCG ** ** * * *** * * * * * * ** * **** * * ENST00000380567.1 GCTTTTCTCATGAAGAACT--AGACGACTCTTGGTAACCATGTTTGCTGCCCA-GCTTCT ENST00000453312.1 GCAGC-CAGACGGGGCACATGAGACTACCTTTTCTGACCCTGGGAGG-GCCCACGTGTTC ** * * * * ** **** ** ** * *** ** * ***** * * ENST00000380567.1 AACTTACATACCGTGAGAAGTTACGTAACATTTACTCCTTTGTAAA-----------TGT ENST00000453312.1 AA--TGCATGCCACCTGAGGACAAGAGCTACCTTCTCCTCAGCACAGACCCCAGCCATAC ** * *** ** ** * * * * * ***** * * * * ENST00000380567.1 TTCCCTATCATCAGACAAAACTCAATAAAAATGTGTGTAATCCAATGTGGGTTTTTTTTT ENST00000453312.1 TGCCTCACTCCAGGACAGTAGGAGGCAGAAATAAGTGAAAACC----TTCCTCTAACTGC * ** * **** * * **** *** ** ** * * * * ENST00000380567.1 CCATAATTA-------ATTTTGATACCATAGTGTGTGAA-CCAAGAATAA---------- ENST00000453312.1 TGAGGATCAGGGGCCCACTAGAAGGCCTTTGTGTGGAAAATTAGAAACAAAAAAATCCTA * ** * * * * ** * ***** ** * ** ** ENST00000380567.1 ----TCTAGT-CACGTGAAACCTCTTCTCCAGTCATAGTATTTCTCATTCATTATAATAA ENST00000453312.1 CAGCTCTAGTGCACCCCAAGGTCTTTCCCCACACCCAAGGTGTGATGGCCACAATGCCAG ****** *** ** *** *** * * * * ** ** * ENST00000380567.1 AAGTA-AC----------TGGCTTT-TAA-------- ENST00000453312.1 GTGTGCGCCAAGGCCTCGTGGCCTTGTGACACAACTA ** * **** ** * *