CLUSTAL 2.1 multiple sequence alignment ENST00000393977.3 AATTCCCCCAGCGAGGGAGGGAGGCCCCCGGCGGCCGGGAGCCTGCGAGCCGCGGCGGGA ENST00000450600.1 ------------------------------------------------------------ ENST00000393977.3 CCCGAGCGCACGCAGGGGCGCGGCGACGGCGGGGGCTAGTCGGGCTGCGGAGGCGGCCGT ENST00000450600.1 ------------------------------------------------------------ ENST00000393977.3 CGGGAGTGCGGAGCGCCTCGGACGAGGGTCCAACCGCCGGCAGGCACCAGAGGGCACGGC ENST00000450600.1 ------------------------------------------------------------ ENST00000393977.3 TGGCTCGGCACTGGGAGGGGCCCGGCGCTCGCAGCCCCCCACGCCCAGAGAGGATGCGGT ENST00000450600.1 -----------------------------------------------------ATGGAGT *** ** ENST00000393977.3 GCGCCCTGAGAGCCGGGTAGCCTCGGATAGCGGCGCTGCGTACGCGATGATGGATGAGCC ENST00000450600.1 --------------------------------------------------TGGAGGGGCA **** * ** ENST00000393977.3 GTGGTGGGAAGGGCGCGTCGCCTCGGACGTCCACTGCACCCTGCGCGAGAAGGAACTGAA ENST00000450600.1 GTGGTGGCGAGGGCAGCTGGCCGCCGACATTCACCAAGCACTTCGCTACAGGGAGCTGAA ******* ***** * *** * *** * *** * ** *** * * *** ***** ENST00000393977.3 GCTGCCCACCTTCCGAGCCCACTCCCCACTCCTGAAGAGCCGCCGGTTCTTCGTGGACAT ENST00000450600.1 GTTGCCCTCCTGTAAAGGCCAGTCCCCTCAATTAAGTCTCAGACGGTATTTTGCTGACTT * ***** *** ** *** ***** * * * * * **** ** * *** * ENST00000393977.3 --CCTGACCCTGCTGAGCAGCCACTGCCAG--CTCTGCCCTGCAGCCCGGCACCTGGCCG ENST00000450600.1 GATTTGCCACTG-TGAGCAATTGCTTCCATGCCTTTGCCCTTCTGCCCGCCATCTTGCTG ** * *** ****** ** *** ** ****** * ***** ** ** ** * ENST00000393977.3 TCTA-CCTGCTGGACCACTTCATGGATCGCTACAACGTCACCACCTCCAAGCAGCTCTAC ENST00000450600.1 TCTAGTTTACTGGACCTGTTCATGGACCGCTATGACATCTCTATCC---AGCAGCT---- **** * ******* ******** ***** ** ** * * * ******* ENST00000393977.3 ACCGTGGCCGTCTCCTGCCTCCTGCTTGCAAACGGAGTTTCGCTCTTATCGCCCAGGCTG ENST00000450600.1 ------GC-----------------------ATTGAGTTGCGCTTTC----------CTG ** * ***** **** * *** ENST00000393977.3 AAGTGCAGTGGCATGATCTCAGCTCATTGCAACCTCCACCTCCCAGGTTCAAGCAATTCT ENST00000450600.1 ------------------------------------------------------------ ENST00000393977.3 CCTGCTTCAGCGCCCCACCCCCCACCCACACCGCCCCAAGTAGCTGAGACTACAGGTAAG ENST00000450600.1 CCTGCTTC--------------------------------TAGC---------AAGTAAA ******** **** * **** ENST00000393977.3 TTCGAGGATCGGGAAGACCACGTCCCCAAGTTGGAGCAAATAAACAGCACGAGGATCCTG ENST00000450600.1 TTTGAAGAAAAAGAAGAAAGTGTGTCTAAGCTGGAGCAGCTCAACAGCCTGGGTTGTATG ** ** ** ***** ** * *** ******* * ****** * * ** ENST00000393977.3 AGCAGCCAGAACTTCACCCTCACCAAGAAGGAGCTGCTGAGCACAGAGCTGCTGCTCCTG ENST00000450600.1 ACTAATATGAATCTAGTATTAACAAAACAAAATTTGCTACATATGGAACTATTATTATTA * * *** * * ** ** * * **** * ** ** * * * ENST00000393977.3 GAGGCCTTCAGCTGGAACCTCTGCCTGCCCACGCCTGCCCACTTCCTGGACTACTACCTC ENST00000450600.1 GAAACCTTTCAGTGGAACCCCTGCCTTCCAACAGCCGCCCATTTCATTGAGTATTATCTC ** **** ******* ****** ** ** * ***** *** * ** ** ** *** ENST00000393977.3 TTGGCCTCCGTCAGCCAGAAGGACCACCACTGCCACACCTGGCCCACCACCTGCCCCCGC ENST00000450600.1 TCTGAAGCAGAACACAAAACAGGTCTTCA-TG--ACGGCTGGCCAATGATTTGCTTGGAA * * * * * * * * * ** ** ** ****** * * *** ENST00000393977.3 AAGACCAAA----GAGTGCCTCAAGGAGTATGCCCATTACTTCCTAGAGGTCACCCTGCA ENST00000450600.1 AAGACTAAATTCTAAATGGCC----AAATGTGCAGATTACTTCCTGGAAGTATCTTTGTA ***** *** * ** * * * *** ********** ** ** * ** * ENST00000393977.3 AGATCACATATTCTACAAATTCCAGCCTTCTGTGGTCGCTGCGGCCTGTGTTGGGGCCTC ENST00000450600.1 AGATTACGCCTTTCTAAAGTATGCACCTTTAGTAGCTGCTGCG---TATGT---GGCTTC **** ** ** ** * **** ** * ****** * *** *** ** ENST00000393977.3 C---AGGATTTGCCTGCAGCTTTCTCCCTACTGGACCAGAGACCTGCAGAGGATCTCAA- ENST00000450600.1 TGCGAGGATTATACTTCGTCTTTCTCCAACGTGGCCTACAAGACTGCATCG--TCTTACT ****** ** * ******** *** * * * ***** * *** * ENST00000393977.3 GCTATTCCCTGGAGCACCTCAGCAC-GTGTATTGAAATCCTGCTGGTAGTGTATGACAAC ENST00000450600.1 GCTTACTCTTGGGATTTCTTAGTGCAGTGTATTGAACAGCTATTGATCGCTCATGATAAT *** * *** ** ** * ********** ** ** * * **** ** ENST00000393977.3 GTCCTCAAGGATGCCG-TAGCCGTCAAGAGC---CAGGCCTTGGCAATGGTGCCCGGCAC ENST00000450600.1 GATGTGAAAGAAGCAAACAAACGGAGAGGGCAAGCAGGACCT--CAGT------CAGCAC * * ** ** ** * ** ** ** **** * * ** * * **** ENST00000393977.3 ACCCCCCACCCCCACTCAAGTGCTGTTCCAGCCACCAGCCTACCCGGCCCTCGGCCAGCC ENST00000450600.1 A------------ACT-AAGTG-TGTTCCAGA---AAGCCT-CCCAGCCCTCA--CGGCT * *** ***** ******** ***** *** ****** * ** ENST00000393977.3 AGCGACCACCCT-GGCACAGTTCCAGACCCCCGTGCAGGACCT-ATGCTTGGCC----TA ENST00000450600.1 AGT--TCATTTTCAGCA-ACCTCAATATCTCCATTAGACACCTCAGACCTCACTGCAGTA ** ** * *** * ** * * * ** * **** * * * * ** ENST00000393977.3 TCGGGACTCCTTG-CAGGCCCACCGTTCAGGGAGCCTGCTCT-CGGGGAGTACAGGCTCA ENST00000450600.1 TCGCCA-TCCTAGTCAGAACCACCAAGCTGTCAGCATATTGTATCGACCACACACACTTC *** * **** * *** ***** * * *** * * * * *** ** ENST00000393977.3 TCCCTCCACACCCCGTACCAACCGCTGCAGCCCTTGGATAT-GTGTCCCGTGCCC---GT ENST00000450600.1 ATCTTACACACTACAGACATGTC-CTGCTGGCTTCCAAGCTAGTGTTCAGGGCCTTGGGC * * ***** * ** * **** * * * * * **** * * *** * ENST00000393977.3 CCCTGCATCCC----TTAGCATGCATATGGCCATTGCAGCTGAGCCCAGGCACTGCCTCG ENST00000450600.1 ACATGCAGACTAGTATTGGAATGTCACTGGCAATACCAGTAGAAGTTAAGCCTTGTCTGA * **** * ** * *** **** ** *** ** * ** ** ** ENST00000393977.3 CCACCACCTATGGAAGCAGCTACT---TCAGTGGGAGCCACATGTTCCCCACCGGCTGCT ENST00000450600.1 GTGTTTCTTATAACCGGAGTTATCAGATAAATAAACATTACCCTTGTATTACTTCGTGTT * *** * ** ** * * * ** * ** ** * ENST00000393977.3 TTGACAGATAGGCCACCTCCAGACCTCACGAGGAA--------GCCTTGGAGATGTGGGC ENST00000450600.1 TTGAAAAGT-GATTATGTGTGAAGCTGATAACTGACCCAGACTGCTTTGTGACTATGGGT **** * * * * * * ** * * * ** *** * **** ENST00000393977.3 AGAGGAAGAGGACACTG------AAGAGGAGAGCTCAGCCAAGTGAGGCAGCAGGAGGCC ENST00000450600.1 GAGCGTTTTGTAAACTTCTGTTCAAAAGGA-AGGGGATCTAAGTGA--CATCAGAA---- * * * *** ** **** ** * * ****** ** *** * ENST00000393977.3 ATCCCTGAAGAGCCTTGGAACGTGGAGGGTCTG--TGCTCCTTTTAA-ATAAAACTGACC ENST00000450600.1 -CTCTTCAGGTACC--AGCTCCAGGAAGA-CTGAATATCCCTTTTAATGCACCATGAATC * * * * ** * * *** * *** * ******** * * * * ENST00000393977.3 C----AGAGCAAAACAT-TCAATAACATACCTCACCCG---AGAGCA--TTCCTCT--GA ENST00000450600.1 CTGGGAGGACTAAGCAAATTAACAGTGTGTCAAATTCTGTTACAACAAATCCCTGTATGA * ** * ** ** * ** * * * * * * * ** * *** * ** ENST00000393977.3 GAAACGTCTGCCACGTGTGGCTAG-GGTACAAAAGGATGGCTTGGTGGCCGTCCCCCCAC ENST00000450600.1 CAAAAATGTTCAAGTCCTGGCTGATGGTCCAAA--TATTGC---GAAAATATTC---AAT *** * * * * ***** *** **** ** ** * * * * ENST00000393977.3 ACAGGGGCCCAGTGAATCGAGAAAGACTTGA-----------TAAGA---GGCCAGGAGA ENST00000450600.1 ACAA-----CAGAAAATTTGGGCAGACTCCAATTTGCCATTTTGAGATTTGACCTGTGGT *** *** *** * ***** * * *** * ** * * ENST00000393977.3 GTGGGAACTGGACACAGACCACTGATCTC-AAGCAT--GTCCAGTTTTTAGCATTAA--- ENST00000450600.1 ATAGCATCTGGGCCTAA--TGTTGGCTTCTAAGTAAAAGACTAAATGTTTACCTTATCTG * * * **** * * ** ** *** * * * * * ** * *** ENST00000393977.3 -AGACTTTTC---TATTCTTTGCTGATGGCA-GCTACACCGCTGA------AAAAGGAGG ENST00000450600.1 TGGACTTGCCAAACAGTCTTTTATGAAGGAAAGTTACAGTATTAATTTTTGAAAAGGTTT ***** * * ***** *** ** * * **** * * ****** ENST00000393977.3 GGCAGCCTGGCGTGTTCTCAGGACCCCCGGAGGATCCCATA-TTGGGT----GCTT---- ENST00000450600.1 TTTATTCTG-CAAATTTTTTTGTTCTACACATGATTTTAGAACTAAGTTTAAACTCATGA * *** * ** * * * * * *** * * * ** ** ENST00000393977.3 -TTCTTTCCCTGGCTCTATGCAGAGGGGCCTGAGTTGGTGTGTATG--CCTGAGTGTTTG ENST00000450600.1 ATTGTTATGCTATACCAATCTGCAGTAAAAAAAATTT-TTTAGATGATTCTATATAACTT ** ** ** * ** ** * ** * * *** ** * * ENST00000393977.3 CCTTGCGAGGCACAGTGGGTGGCTGTCTTGCCTT-TGTTTTCGAACC-----TAAAACCA ENST00000450600.1 CCTCTC-ATAAATAGTA--TAGGTATCTGGATTTATATACTAAAATTAATGGTGGAGTAG *** * * * *** * * * *** * ** * * * ** * * ENST00000393977.3 TTTTCAGCCTTTTAGA--TATG-TCATG--TGCTGCTGCTTCCCGAAGTGGTCTTGCTTT ENST00000450600.1 ATCTCTTATTTTTAAAATCACGGTCATAATTTTTCTTTTTTCCCCAAGTGATC--AACCT * ** ***** * * * **** * * * ***** ***** ** * ENST00000393977.3 CTGTTTCGTAAGATGTCTTGTTTACACACTGTA-TCAGGGATTTGGTGATACTTGAAAAT ENST00000450600.1 CAAATTTTTAGAA----TTAAA-ACACATTTAACTCAGGGAATTTGTACTACTTGGAAAC * ** ** * ** ***** * * ******* ** ** ****** *** ENST00000393977.3 TC----CTTTGGAGAAAAAAAC-----AAATTTAATTGC-CACACTGCCTGTCCCACATG ENST00000450600.1 ACTTAACTGTAATGCAACAAGCCTTGGAAATGTTATAGTGTGAACTACCTTTATAACATA * ** * * ** ** * **** * ** * *** *** * **** ENST00000393977.3 ------AGGGCTGTTAATTTGGAAC----CCAAGTTTGAACCCAACTTGTGATGGACCCG ENST00000450600.1 GATTAAAATACTCTTGCTAGGGTGTGTTTTCAAATAAGAACATAA--TATTATAGCTCAG * ** ** * ** *** * **** ** * * ** * * * ENST00000393977.3 CAGGTAACCACAGAGCTTCCTTTTTG-AAGGCATATGGTTGGAGAGAACCATTTTCCCAG ENST00000450600.1 AATGAAGTGGTAGTTCCTGTGTTTCATAATACATATG--TAGGTTTTGCC--TTTCTCAG * * * ** * * *** ** ****** * * ** **** *** ENST00000393977.3 C----TCTCGGTTCCGGA---AGATTCCACGTCTT--GGAGGCTGTGTT---------CA ENST00000450600.1 TGCAATCTGTGATTTATACTCAGAATCGACATTCTTAAAAAGTTATTTCAAGGGAAGGCA *** * * * *** ** ** * * * * * * * ** ENST00000393977.3 CCACTAGAACTTTAATAACT--ACCCAGGGAGGGAG-AAGCTCGTTGAAAGGAAGACAAA ENST00000450600.1 TAACT--AACTGTAAGAGGTTGGTGCTAGAATAAAGTAGGTTTATTTTGGAGGGGACCGT *** **** *** * * * * * ** * * * ** * *** ENST00000393977.3 GATTTAAACAGTTCCCACCTCTCTC-----CACCACATACTTAC----AGGGCATGAGTT ENST00000450600.1 GGCCAGGGAAGTTCTCAGGTTGTGCTAGAGCAGCACTTTGTTATGTGGAAGACACGTTTT * ***** ** * * ** *** * *** * * ** * ** ENST00000393977.3 TAACCCAGTCTAGGCTTTGAGTGTGGCTGAT--AGCGAAG--GATAGCAATGTGGA--AA ENST00000450600.1 TTAAGCAACCT-----TTGAAGCCAGCTAGTCCGTCTAAGCAGGCAAAGGTACAGACTAA * * ** ** **** *** * * *** * * * ** ** ENST00000393977.3 ATTTGCTTAGTCCCACCTGTATTTGGGGAG---TGGGA-TGTACATGGGCGTTTGA---T ENST00000450600.1 ATTTCAGTAG--CTACTTTCATTGGATTGACCCTGCAACTGCCCTGGGACATTTCACTGT **** *** * ** * *** * ** * ** * ** * *** * * ENST00000393977.3 ACCACCATTGATAGGCAAGCGAC--TGGTTGG-ATCA----AAAGCCAGTATTTAGGGAT ENST00000450600.1 ACTGGTATTAACTG-CAAACAGCAATAATTGTCATTACAGCAAGGGCAGT--TTGGGGGT ** *** * * *** * * * *** ** * ** * **** ** *** * ENST00000393977.3 ------CTGCAGCGAGAGGGCCCTCAGG-----AAGACTC-TTGTAACCATGTGCAATAT ENST00000450600.1 AAAGCATTTTGGAGGAATAACCTTAAAAGGTTAAAAAGTCACTGTAATAACTGATAAAGT * * * * ** * * ** * ** ***** * ** * ENST00000393977.3 GTTTTTATTCTGACTCGC-----------------AGCTTGTGCTCAGCATGTTCTTTGG ENST00000450600.1 GTATACATTGTG-CTCGTTTCTGTGGGGGAAGAAAGATTTGTTGGAGGGAAGCTTTCTGG ** * *** ** **** **** * * * * * *** ENST00000393977.3 TTTAGT--TTGG--GGTTGGG-------GGACACATTGTTCACCCAG-CAGAACTGGGAG ENST00000450600.1 TTTAAAAATTAGTAAGCTATGTCTTTTTATGTGTGTTTTTTTTTAAGATAGCACTTGAA- **** ** * * * * ** ** ** ** *** * * ENST00000393977.3 GTGCAAAGGAC----CGTGGAAGCAATTT--TTGT-----TTTGT-TTGAGGA-ATACCT ENST00000450600.1 -TAGAAGGGAATCTGCATGGCAGATATGTGACTGTCACAATATGCATTGAAGACAAGCTT * ** *** * *** ** ** * *** * ** **** ** * * * ENST00000393977.3 GTCTTGGATTCCTTAGCCCCTTGCC--AGTCCTGGAGACTGTGGCAGGGGCC---GCCAG ENST00000450600.1 ACTATAAAGATGTGGGTATGCAGCAGGAGTCTCAGTAATCAAGCCAGTGGCCTTTGTTAG * * * * ** **** * * * *** **** * ** ENST00000393977.3 GAAGGCAGCTGTCT-------GCTGCTGAGT----CAGATCG-----------GAAGGTG ENST00000450600.1 GAAGGGAAGGGGCTCAACACAGTGATGGAGTGATCCAGATGGCTTCCGGGGATGAATGTG ***** * * ** * **** ***** * *** *** ENST00000393977.3 G-TGAATCTTTCCAG--AGCA-----GCT--GAAAA------TCTCAGCATGGAGACAGT ENST00000450600.1 GGTGGGTAGCTTCTGCCAGCATGAATGCTTAGAAAAATATGCTTTCCTTAAAAAGAAAAT * ** * * * * **** *** ***** * ** * *** * * ENST00000393977.3 AAG----AAAAGAGACGGGGTGTGGATAAGACTCTGCCACCGTGTCACACTAGCATAGGA ENST00000450600.1 AACTTTTAGAGTACATAGGGCATA-ATGTGGATTTATTAGTCTGGTAGA-TAAAATGAAA ** * * * * *** * ** * * * * ** * * ** ** * ENST00000393977.3 GGCTGC----------ACGTTCATTTGTTGTTGTTTTT-----------TTTTCCTTTG- ENST00000450600.1 AAGCACTCAGGTAAGAACACCCACTCATGGCAGTTTTTAAGCATGAAAATTGTTTTTTGA * ** ** * * * ****** ** * **** ENST00000393977.3 -----CCAACCTCCGTTCTATTTATGT--GCAAGCAGTTTGGATTCA---AGTTCTTGTA ENST00000450600.1 AAGTACCATCACTTTTCCTTTTTAAAGAAGCCTGCTAATTGGATTTTGGTAGTTCTTACC *** * * ** **** ** ** ******* ******* ENST00000393977.3 TC---------TGT-CTGTTCTGGGACCTGGGGATT---GTGAGGGT---TCCCTCACAG ENST00000450600.1 TCAAGAAAACTTGAATTGTTTGGGGGAAAGTAGGCTCAAAAGAGAATATATCTTTCACAT ** ** **** *** * * * *** * ** ***** ENST00000393977.3 CCA-GCACGACCCCCAGAAA----GAGGCG----TCCCACAAT--AAACACGTCACC--T ENST00000450600.1 TCACATTCAGAACTCAGCAACCTGGAGTCCAATTTTCCGTATTTTAACTACCTCAGTAAT ** * * *** ** *** * * ** * * ** ** *** * ENST00000393977.3 GCTCT-----TGATCTCTCA---------- ENST00000450600.1 GGTATGAATGTGAGATATTGGGATGGAGAT * * * *** * *