CLUSTAL 2.1 multiple sequence alignment ENST00000394600.3 CGGGGCTGTAGGTAGGAGTTAAGTGG--GTA--GGATCCCTTAACCAGGGTTGTC---CG ENST00000425455.1 --------AAAGAAAAACTCAAGTGGCAGCAATGGA------AGCTGGAGGTACCACTCA * * * * * ****** * * *** * * * * * * * ENST00000394600.3 GTGCAGGTGGTGTGTGTTGTTTCGCCTAACGTGTCAGTGGCACAAATCACGCGAACTTCA ENST00000425455.1 GCACAT-TGGTGCCT-TTCTTGTGTCTCTGCCTTCGGGGGAAAAGATAAC-----TTTTC * ** ***** * ** ** * ** ** * ** * * ** ** ** ENST00000394600.3 TAAACATTGTGCGTTCGGAAGCCTTTCCAAGATGCATTTAATCCCTGCG-TGAGCCCACG ENST00000425455.1 TTGATACT------CCGGGA-------CATGCTACTT----TCTCAGCAATGAGAGCAG- * * * * *** * ** * * * * ** * ** **** ** ENST00000394600.3 TTAGGCATTCACGAAGGCATGTGCACTGTTCTCTCGGAAGCGGCTG-----GCCGGCTTC ENST00000425455.1 --AGGGGCTCA---AGTCACTGACATTGTCATCTTGGTTGTAGCTGCAGATAATGGGGTG *** *** ** ** ** *** *** ** * **** ** * ENST00000394600.3 C----CCTCCTCGCGCGCGGCTGTGGGTGC--AGGTCCTCACT-TCCCAGCCTCCCATGG ENST00000425455.1 TAGAATCTATTCA-GCATG-CCAAGGATGCTCAAGTTCCTATTGTCCTTGACATAAATAA ** ** ** * * ** *** * ** * * * *** * * ** ENST00000394600.3 GC---------CCAAGGCC--TTCTGGGCTCCAATTTGAGGCGAGCCAC---CCCA-GAT ENST00000425455.1 ATGTGACAAAGCTGAGGCTGATTCTGAGAA--AGTGTAAAAAAAGCTATTGGCTTATGAT * **** ***** * * * * * *** * * * *** ENST00000394600.3 CCGTAATTT-----TTCTGCAG-TGATTT---ATTTTTACCTTTCTGATTCCTTGACAAG ENST00000425455.1 GTGCTGTGTGAAGATTATGGAGGTGATGTTCAAACACTGCCTGTCTCTGCACTTG-CAGG * * * ** ** ** **** * * * *** *** **** ** * ENST00000394600.3 -GATATCCTAGCGGC------GAAACAACACC-------GTACTGGGAGTCAGAACGTCT ENST00000425455.1 CGATAATCTAATGGCTTTGGCAGAAGAACAACTGCAGAAATGTTGGAATTGAAAGCA--- **** *** *** ** **** * * *** * * * * * ENST00000394600.3 GGGTTCTAGTC-TTGACTGCCATTAAC--TAGCGGTATGACATTGGAGAAGCTTTTTTGA ENST00000425455.1 GAGCCCCACTGGTCCAGTGTAAGGAACAGTAATAGAGTCACAAAGGAAGAGGTCCTGTTA * * * * * * * ** * *** ** * * *** *** ** * * * * ENST00000394600.3 CC-CTTCTGGATTTCCGTTTCCTTTTCTGTAAAATGAGGAGCTTGGAA-GAT--CCGGAA ENST00000425455.1 CTACAGCTATAATTCAAAGAGGAATTTT---AAGAGAAGACTCTGTTCTGGTTGCTGGAA * * ** * *** ** * ** ** ** ** * * * **** ENST00000394600.3 AATGA-GGCCCATAGGAAACA-AGTGACTTGCTGAGTCCAGATAACACTGACTGTCAGAA ENST00000425455.1 AAAGTTGGGCAAAAGTACACTTAATG-TTTGATGAAAATGGA-AAAACAATCTGT--GAG ** * ** * * ** * ** * ** *** *** ** ** ** **** ** ENST00000394600.3 GTCTCGCTCTGTCTCCCCGGCTGGAGTGCAG--TGGCGTGATCTTGGCTCACTGCAACCT ENST00000425455.1 CCCTATCCCAGCATGGCAGAGGGAATTATAGGCTGGAGAGACCTT--CCTTCTGCAGGAG ** * * * * * * * * * ** *** * ** *** * ***** ENST00000394600.3 CTGT--CTCCCGGGTTCAAGAAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACA ENST00000425455.1 ATGAAATTCTTGAAGT--AGAA-----CCTGAGCTAAGGGCATGTGAAGTTTTGACTGGA ** ** * * **** **** * * * ** * **** * ENST00000394600.3 GGCATGTGCCACCACGCCCAGGAGAAACATGAACCAGAAGCT---ACTGAAGTTGGAGAA ENST00000425455.1 GGAA-GTATGAACAAGAACAGGAGAAAAGTCAAC-AGGATCTGAAAATAATAGAAGAAAA ** * ** * ** * ********* * *** ** * ** * * * ** ** ENST00000394600.3 CTTGCTACGATTTCA-----CACTATTTATAGGCAACTGCACAGT----CTGTGT-CA-- ENST00000425455.1 GTCAAAGGAACATCAAGAAACAC-ATTGGAAAGCCCGTGAGAAGTATGGCTGTGTGCAGT * * *** *** *** * ** ** *** ****** ** ENST00000394600.3 --AAGAAGAG--CATT---AAGACAGT---GGAGGCATGGGTTTTCATCTGCTTA---CC ENST00000425455.1 GGAAGGAGAGATCATTTCTAAAGTATTTAGAAAGAAAAGAACAAACATC--CTTAAAGCC *** **** **** ** * * ** * * **** **** ** ENST00000394600.3 CTGTG------TGGACAG---CTCAACTGTG-TGCCTGGCCCTGGCCAACAG--ATGT-- ENST00000425455.1 AAAAGAGAAAATGGAAAGAGATTCAAATGTACTTCCCAGTGATTATTAAAAGTGATGTTG * **** ** **** *** * ** * * ** ** **** ENST00000394600.3 ---GCTCACTGGGGCTGCTTTATCTCAGTATAGGCTTCTA----GTAACAAAAAAG---G ENST00000425455.1 ATGATCTGTTGGGGCCATTTTGAA-CATTATAGATACCTATGATGCATCACACGAGTGTG ****** *** ** ***** *** * * ** * ** * ENST00000394600.3 AAGAAGGACCA--------TGGAA------ATCTCAGT-----TATCTTCAACAAAATCT ENST00000425455.1 AACTAGAATTAGTACATTTTGGAGTGGGTGATATAAGTGCAAATGATGTTAACCTTGCTG ** ** * * **** ** * *** * * *** ENST00000394600.3 AAAAAGGTGGTAG----AAGTATGGATTGGA-ATGACTATTGAGGA-ACTGGCCAG--GG ENST00000425455.1 AAAGATTTGATGGTGTTATATATGGCTTTAATGTGAATACAGGCAATGTTATCCAACAGT *** * ** * * * ***** ** * *** ** * * * *** * ENST00000394600.3 CAATGGAAAAAAA----CACAGATTATGTAT-ATGAA----------GCTTTATTGAACA ENST00000425455.1 CAACTGCAAAAAAGGAGTAAAAATTAAACTTCACAAAATAATTTACCGTCTTGCTGGAGA *** * ****** * * **** * * ** * ** ** * * ENST00000394600.3 CT--------GATATTGACA-TAGATT------CACTG--GAAGCAGACTCACATTTAGA ENST00000425455.1 TTTGCAAGAGGAAGTGAGCAGCAGATTACCCTGCGCTGTGGAAGAGCACCCAG---TAGG * ** * ** ***** * *** **** ** ** *** ENST00000394600.3 TGAAG--TCTGGATCAAAGAAGTG----ATAAC-GAAGGCAGGGATGAAGTTAAAGTGGA ENST00000425455.1 TGAAGCGTCTATACTAGCTACCTTCTTTATAACAGAAGGGAAGAAAAAAGTTCCTGTGGA ***** *** * * * * ***** ***** * * * ***** ***** ENST00000394600.3 GTA------AATTAAAACAGGACAAAGTCAGAAAAAATAA--AGATG---CTGTAAGAAG ENST00000425455.1 TTGCTGCAGAGTCCAAAAGGGAC--AGTTAGAAAAAAAAATTAAATTAGCCTGTAAAGGA * * * *** **** *** ******** ** * ** ****** ENST00000394600.3 ------GCCCCAGGCAGATC--CAGCTTTATT--AACCCCA---AGGT----CCCCAGTT ENST00000425455.1 CATGTAATTTGGAAGGGATCATTAACCTCACTGAAACACCATAAAGATGACGTTTCAATT **** * * * * * *** *** ** * ** ** ENST00000394600.3 GTTA---CTATAATGGGCCATGTT---------GATCACG-------------------G ENST00000425455.1 GTCAAAACTGGAATGGATTGTGGTATCAATTTAGATGAAGAAAATATAGAATTTAAGGTG ** * ** ***** ** * *** * * * ENST00000394600.3 GAAAACGACATTACTTG------------ACAAATTTCG--------------------- ENST00000425455.1 GGAAATAAAATTGTTTGTTATAAAGAAAAGCAAATTTGAGCCAAGACTTTTTGGGATCCA * *** * *** *** ******* ENST00000394600.3 ------------------AAAAACTCAAGTGGCAG--CAGTGGAAACTG-------GAGG ENST00000425455.1 GGATTTTAAAATTACATTAAAAATGTAAATAACAAAACAAAAAAAAAAGACAAAGAGGGG ***** ** * ** ** *** * * ** ENST00000394600.3 CATCAC---------------TCAGCACA-----------TTGGTGCCTTTCTTGTCTCT ENST00000425455.1 CATTACATAATAGTAAATAATTCAATTCAAGGAGAAGACCTAAATACCCTAAATATATAT *** ** *** ** * * ** * * * * * ENST00000394600.3 CTGCCTT---CTGGGGAAA-----------AGATAACTTTTCTTGATACT--CCAGGACA ENST00000425455.1 GCACCTAACACAGGAGCAATCAGATTCACAAGGCAAGTTCT-TAGAGACCTACAAAGAGG *** * ** * ** ** ** ** * * ** ** * * ** ENST00000394600.3 TGCTGCTTTCTCAGCAATGAGAGCCAGAGGTGCT--CAGGTCACTGACATTGTCGTATTG ENST00000425455.1 TGTAGATTCCCACATAATAATAGTGGGAGACTTCACCACTCCACTGAGAGTATTAGATAG ** * ** * *** * ** *** ** ****** * * * ** * ENST00000394600.3 GTTGTAGCTGCAGATGATGGAGTGATGAAACAAACTGTAGAATCT--ATTCAGCA-TG-- ENST00000425455.1 ATCATTGAGGCAGAAAAT----TAACAAA--GATATGCAGGACCTGAACTCAGCAATGGA * * * ***** ** * * ** * ** ** * ** * ****** ** ENST00000394600.3 CCAAAGATGC---ACAGGTTCCTATTA---TCCTTGCCGTAAATAAATGTGACAAAGCTG ENST00000425455.1 CCAAATGGACCTGATAGACCTCTACAGAACTTTCTACCCCAAAACAACAGAATATACGTT ***** * * ** *** * * ** *** ** * * * * ENST00000394600.3 AGGCTGATCCTGAGAAAGTGAAAAA---AGAGCTGCTGGCTTACGATGTGGTATGTGAAG ENST00000425455.1 CTTTTCATCACCAAATGGTTCATACTCTAAAACTGACCACATA--AT-TGG-ACATAAAG * *** * * ** * * * * *** * ** ** *** * * *** ENST00000394600.3 A----TTATGGAGGTGATGTTCAAGCAGTGCCTGTCTC---CGCACTTACGGGCGATAAT ENST00000425455.1 CAATCTTCCACAAATGAAAAAGAACCAAAACC-ATCCCAAACACACTCTTGGATGACAGT ** * *** ** ** ** ** * * **** ** ** * * ENST00000394600.3 CTGATGGCTTTGGCAG--AAGC----AACAGTTGCTCT------TGCAGAAATGTTAGAA ENST00000425455.1 GCAATAAAAATAGAAGTTAAGACTAAGAAAATTGCTCAAAACCATGCAATTACATGGAAA ** * * ** *** * * ****** **** * * ** ENST00000394600.3 TTGAA-AGCA-GATCCC----------------AATGGTCCAGTGGAAGGAACAGTAATA ENST00000425455.1 TTAAACAACATGATCCCGAATCACTTCTGGGTAAATAATTAAATTAAAGCAGAGGTCAAG ** ** * ** ****** *** * * * *** * ** * ENST00000394600.3 GAGTCTTTC---ACAGACAAAGGAAGAGGT----CTTGTTACTA-----------CAGCT ENST00000425455.1 AAGTCCTTCTAAACAAACGAGAACAAAGATACAACATACCAGTATCCCTGGGACACAGCT **** *** *** ** * * ** * * * * ** ***** ENST00000394600.3 ATAAT----TCAAAGAGGAACTTTAAGAAA--AGGCTCTGTTCTGGTT------GCTGGA ENST00000425455.1 AAGACAGTGTTAAAAGGGAATTTCATAGCACCAGG---TGTCCACATCAAAAAGGCAGAA * * * *** **** ** * * *** *** * * ** * * ENST00000394600.3 AAATGTTGGGCAAA-AGTACG-CTTAATGTTTGA------TGAAAATGGAAAAACAATTG ENST00000425455.1 AAATCTTAAATTAATAATCTAACATCATAACTGAAAGAACCAAAGAAGCAAAAACAAAT- **** ** ** * * * * ** *** ** * * ******** * ENST00000394600.3 ATGAGGCCTATCCCAGCATG-------------------CCAGTG----------GGAAT ENST00000425455.1 -CAACACCAAATTCAGCAGAAAACAAGAAATAACCAAAATCAGAGCTGAATTGAAGGAAA * ** * ***** *** * **** ENST00000394600.3 TACAGGCTGGAGAGACCTTCCT-----TC------TGCAGGAGAAGAAATTCTTGAAGTA ENST00000425455.1 TAGAGACATGAAAGACCATTCAAAAGATCAATGAATGCAGGAGTTGGT-TTTTTGAA--A ** ** * ** ***** * * ** ******** * ** ***** * ENST00000394600.3 GAATCTGAGCCAA--GGGCAC--GTGAAGTTGTTGACTG--------GAGGAAATATGAA ENST00000425455.1 AAGTTATGACAGACTGGCCACTAGCTAGATTGATAAAGAAGAAAAGAGAGAAGATCCAAA * * * * ** *** * * *** * * *** * ** ** ENST00000394600.3 CAAGAACAG--GAGAAAGGTCAGGAGGAT-------CTGA--------AAATAATAGAAG ENST00000425455.1 TAAACACAATTAGAAAAGATGATGGGGATGTTACCACTGACCCCACAGAAATAAAAACAG ** *** **** * * * **** **** ****** * ** ENST00000394600.3 A------AAAGCGAAAGGAACACAAAGAAGCACAT----CAGAAAGCCCGTGAGAAGTAT ENST00000425455.1 ATATCAGAAACTATGAAAAACACCACTATGTACACAAACTAGAAAACCTA-GAAAAGAAT * *** * ***** * * * *** ***** ** ** *** ** ENST00000394600.3 ---------GGC-CATCTACTGT---------------GGAA--------------GAAG ENST00000425455.1 AAATTCCTGGACACATACACCCTCCCAAGACAAAACTAGGAATAGACAATATTCCTGAAC * * *** ** * **** *** ENST00000394600.3 AGATCAATTCTACGGTTTTTAGAAAGAAAAG-AACAAATACCCTTAAAGCCAAAAGAGAA ENST00000425455.1 AGACCAATTACAAGGTCCAAAATCGGATCAGTAATAAATAGCCTACCAACCAAAAAAGCC *** ***** * *** * ** ** ** ***** *** * ****** ** ENST00000394600.3 AAGGGAAAGA--GATTCAAATGTACTTTCTGT-GATTAT-TAAAGGTGA--TGTTGATGG ENST00000425455.1 CAGCACCAGATGAATTCACAGCTGAATTCTACCGGCTGTACAAAGAAGAACTGGTACCAT ** *** ***** * * **** * * * **** ** ** * ENST00000394600.3 TTCTGTTGAGGCCATTTTGAACATTATAGATA---------------------CCTATGA ENST00000425455.1 TTCTACTGAAACTATTCCAAAAATTAAGGAGGAAGGACTTCTCCCCAACTCATCCCATGA **** *** * *** ** **** ** ** **** ENST00000394600.3 TGC------TTCACAC-------GAGTGTG-----AACTAGAA---------TTAGT--- ENST00000425455.1 AGCAACATCCTGACACCCAAACCAGGTACAGATACAACAAAAAAAGAAAACCTCAGGCCA ** * **** ** *** * ** * ** ENST00000394600.3 ---ACATTTTGGAGTGGGTG---ATGTAAGTG-----------CAAATGATGTTAAC-CT ENST00000425455.1 ATAATATCCTTGA-TGAGTATCTATGAAAGAATCCCCACAAAACAAAAAACAAAAACATT * ** * ** ** ** *** *** **** * *** * ENST00000394600.3 TGC--------------------TGAAA----CATTTGATGGTGTT-ATATATGGCTTTA ENST00000425455.1 TGCAAACCAAATCCAGCAGCACATCAAAAAGCTATTTCATCATGTTCAAATA-GGCTTCA *** * *** **** ** **** * *** ***** * ENST00000394600.3 -ATGTGAATGCAGGCAATGTTA-TCCAAC--AGTCAGCTGCAAAAAAAGGAGTAA----- ENST00000425455.1 TACCTG---GGATGCAAGGTTGGTTCAACGTATGCAAATCAATAAATATGATTAATCACA * ** * * **** *** * **** * ** * * *** * ** *** ENST00000394600.3 -AAATTAAACTTCA--CAAAA-TAATTTAC-CGTCTTGTTGAAGATTTGCAAGAGGAACT ENST00000425455.1 TAAACAAAACTAAAGACAAAAGCCACATGCTCATCTCAATAGAGGC--AGAAGAGGCTTT *** ***** * ***** * * * * *** * ** ****** * ENST00000394600.3 GAGCAGCAGATT----ACCCTGTGCTGTGGAAGAGCACCCAGTAGGTGAGGCATCTATAC ENST00000425455.1 CAATA--AAATTCAACACCCCTTCATGTAAAA----ACTCAATAAACTAAGTGTGCA-AG * * * *** **** * *** ** ** ** ** * * * * * ENST00000394600.3 TAGCTACCTTCTCTGTAACAGAAGGGAA--GAAAAAAGTTCCTGTGGCTGGC----TGCA ENST00000425455.1 GAACATACTTCAAAATAATAAGAGCCATCTGTGACAAATCC--ACAGCCAACATCATACT * * **** *** * ** * * * ** * * ** * * * ENST00000394600.3 GAGT--CCAAAAG--GGA------CAGTTAGAAAA-----ACAAAAAAAA-----TTTAA ENST00000425455.1 GAATGGTCAAAAGCTGGAAGCATTCCTTTTGAATATTGGCACAAGAAAAGAATGCTCTCT ** * ****** *** * ** *** * **** **** * * ENST00000394600.3 ACTA--ACCCGTAATGGACATGTAATTTGGAAGGGCTCATTAACCTCATTGAAACACCAT ENST00000425455.1 CTTACCACTCCTATTCAACATATCATT-GGAAGTCCTGGCCAGA-TCAGTCAGGCAAGAG ** ** * ** * **** * *** ***** ** * *** * * ** * ENST00000394600.3 AAAGAT------GACATTTCAATTGTCAAAACGGGAATGGATTGTGGTCTCAGTTT--AG ENST00000425455.1 AAAGAAATAAAGGGCATCCAAATGG--AAAGAGAGAAAGTCTAAATATCTCTGTTTGTAG ***** * *** *** * *** * *** * * **** **** ** ENST00000394600.3 ATGAAGACA------ATATGGAA----------TTTCAAGTGGGAGAC------AGAATT ENST00000425455.1 ATGACATTATTCTAAATCTAGAAAACCCCATAGTCTCAGCCAGAAAACTCCTTCAGCATG **** * ** * *** * *** * * ** ** ** ENST00000394600.3 GT-TTGTTATGAAGAAAAGCAAATTCAAGCCAAGACTTCTTGGGATCCAGGATTTTAAAA ENST00000425455.1 GTACTGGTATAAAAACAGTCACAT--AGACCAA-------TGGAA--CAGAATAT--AGA ** ** *** ** * * ** ** * **** *** * *** ** * * * ENST00000394600.3 TTACATTAAAAATGTAAATAACTC ENST00000425455.1 GCCCAGAAAAAAGGTAGCAAACT- ** ***** *** ****