CLUSTAL 2.1 multiple sequence alignment ENST00000398598.3 TGAGTTTCATTTCTTCGCGGCGCGGGGCGGGGCTGGGCGCGGGGTGAAAGAGGCGAAGCG ENST00000506077.1 ------------------------------------------------------------ ENST00000398598.3 AGAGCGGAGGCCGCACTCCAGCACTGCGCAGGGACCGCCTTGGACCGCAGTTGCCGGCCA ENST00000506077.1 ------------------------------------------------------------ ENST00000398598.3 GGAATCCCAGTGTCACGGTGGACACGCCTCCCTCGCGCCCTTGCCGCCCACCTGCTCACC ENST00000506077.1 ------------------------------------------------------------ ENST00000398598.3 CAGCTCAGGGGCTTTGGAATTCTGTGGCCACACTGCGAGGAGATCGGTTCTGGGTCGGAG ENST00000506077.1 ------------------------------------------------------------ ENST00000398598.3 GCTACAGGAAGACTCCCACTCCCTGAAATCTGGAGTGAAGAACGCCGCCATCCAGCCACC ENST00000506077.1 ------------------------------------------------------------ ENST00000398598.3 ATTCCAAGGAGGTGCAGGAGAACAGCTCTGTGATACCATTTAACTTGTTGACATTACTTT ENST00000506077.1 ---------------------------------------------------------GTT ** ENST00000398598.3 TATTTGAAGGAACGTATATTAGAGCTTACTTTGCAAAGAAGGAAGATGGTTGTTTCCGAA ENST00000506077.1 CATTCG---GAAC--------------------CGAAAA--------------TTGCCAA *** * **** * ** * ** * ** ENST00000398598.3 GTGGACATCGCAAAAGCTGATCCAGCTGCTGCATCCCACCCTCTATTACTGAATGGAGAT ENST00000506077.1 GTG--------------TGATTCAGCTTCTGCATGCAACC-TCAAATACTATATGGAGAT *** **** ***** ****** * *** ** * **** ******** ENST00000398598.3 GCTACTGTGGCCCAGAAAAATCCAGGCTCGGTGGCTGAGAACAACCTGTGCAGCCAGTAT ENST00000506077.1 GGTGATATGGTGGAGACAAATCAGGATACAGGGACCAAGAACCACCTGAACAGCCAGCAC * * * *** *** ***** * * * * * ***** ***** ******* * ENST00000398598.3 GAGGAGAAGGTGCGCCCCTGCATCGACCTCATTGACTCCCTGCGGGCTCTAGGTGTGGAG ENST00000506077.1 AGACAGAAGGTACACACCTGCACTGACCTCATCTACTCAC-GAGAGCCCTGGGCACGAAG ******* * * ****** ******** **** * * * ** ** ** * ** ENST00000398598.3 CAGGACCTGGCCCTGCCAGCCATCGCCGTCATCGGGGACCAGAGCTCGGGCAAGAGCTCC ENST00000506077.1 GAAAGCCTGGTCCT-------ATTGC--ACAAAGGGGATCAGAGCCTGGTCCAGAGCTCT * ***** *** ** ** ** ***** ****** ** * ******* ENST00000398598.3 GTGTTGGAGGCACTGTCAGGAGTTGCCCTTCCCAGAGGCAGCGGGATCGTGACCAGATGC ENST00000506077.1 GTGATGGAGGCTATCTAGGGAGTAGTCTTTCCTAGAGGCAGTGGTATTGTCAGAAGATGT *** ******* * * ***** * * **** ******** ** ** ** * ***** ENST00000398598.3 CCGCTGGTGCTGAAACTGAAGAAACTTGTGAACGAAGATAAGTGGAGAGGCAAGGTCAGT ENST00000506077.1 TCTTTGGTGCAGAAACTGAA-ACACTTTTGCATTAATGTCAGTATAGAGGAAAGGT-AAT * ****** ********* * **** ** * ** * *** ***** ***** * * ENST00000398598.3 TACCAGGACTACGAGATTGAGATTTCGGATGCTTCAGAGGTAGAAAAGGAAATTAATAAA ENST00000506077.1 TATCAGGACACCCAGATAGAGAC-------GTTTTGGACACA-------AAATCAATAAA ** ****** * **** **** * ** ** * **** ****** ENST00000398598.3 GCCCAGAATGCCATCGCCGGGGAAGGAATGGGAATCAGTCATGAGCTAATCACCCTGGAG ENST00000506077.1 GCTCAACATGTCATTGCTGGG-AAGAGATGGGAATTAGTCATGAGCTTATCAGTCTAGAG ** ** *** *** ** *** *** ******** *********** **** ** *** ENST00000398598.3 ATCAGCTCCCGAGATGTCCCGGATCTGACTCTAATAGACCTTCCTGGCATAACCAGAGTG ENST00000506077.1 ATCAGCTCCCCACAC-------------------TAGACATTCCTGGTATGAGTCAAGTG ********** * * ***** ******* ** * **** ENST00000398598.3 GCTGTGGGCAATCAGCCTGCTGACATTGGGTATAAGATCAAGACACTCATCAAGAAGTAC ENST00000506077.1 GCTTGGGGCTATCAGACCACTGACCTTGCACATCAGATCAAGGCACTCG---AGGATGAC *** **** ***** * ***** *** ** ******** ***** ** * ** ENST00000398598.3 ATCCAGAGGCAGGAGACAATCAGCCTGGTGGTGGTCCCCAGTAATGTGGACATCGCCACC ENST00000506077.1 CTCTGTAAGCAGGAGACAATCCACTTGGTGGCTGCCCTCAGTTACATGGACATCCCCACC ** * ************* * ****** * ** **** * ******** ***** ENST00000398598.3 ACAGAGGCTCTC-AGCATGGCCCAGGAGGTGGACCCCGAGGGAGACAGGACCATCGGAAT ENST00000506077.1 ACAGAAGCACTAGAATATGGCTCGGGAGGTGGACAGCAAAGCAGGCAATACCATAGTTAC ***** ** ** * ***** * ********** * * * ** ** ***** * * ENST00000398598.3 CTTGACGAAGCCTGATCTGGTGGACAAAGGAACTGAAGACAAGGTTGTGGACGTGGTGCG ENST00000506077.1 CTGGACAAAGCCTGTTCTGGTGGACAAAGGTGCCAAAGTCAAGTTCCTTGATGCGGTATA ** *** ******* *************** * *** **** * * ** * *** ENST00000398598.3 GAACCTCGTGTTCCACCTGAAGAAGGGTTACATGATTGTCAAGT-GCCGGGGCCAGCAGG ENST00000506077.1 AAACCTGGTATACCAA-TAGCCATGGGCT-CATCACTGAGGACTAGATAGGATCACCAGG ***** ** * *** * * *** * *** * ** * * * ** ** **** ENST00000398598.3 A-----GATCCAGGACCAGCT---GAGC--CTGTC-CGAAGCCCTGC-AGAGAGAGAAGA ENST00000506077.1 TCTACTGGTTTAGTGTTACTCCCAAAGTAACTGTCACATATCACAGCTAGACAATAAGGT * * ** * ** ***** * * * * ** *** * * * ENST00000398598.3 TCTTCTTTGAGAACCACCCATATTTCAGGGATCTGCTGGAGGAAGGA----AAGGCCAC- ENST00000506077.1 TCTGGTTT-----TCAC--GTTTGTCAGTG---TGCAGGATCAAGGGTTCTGAACCTATT *** *** *** * * **** * *** *** **** * * * ENST00000398598.3 GGTTCCCTGCCTGGCAGAAAAACTTACCAGCGAGCTCATCACACATA----TCT-GTAAA ENST00000506077.1 GGCAGCTCTACTGACACTGA---CCAACAGCTAGTTCATCACAAGAAGAGCCCTAGCATA ** * *** ** * * **** ** ******** * ** * * * ENST00000398598.3 TCTCTGCCCCTGTTAGAA-AATCAAATCAAG------GAG--ACTCACCAGAGAA-TAA- ENST00000506077.1 ACT-TATTTCCCTTAGTATAATTATTCCAAGACTTCTGAGCCACTCTCCAAAAAAGTAAA ** * * **** * *** * **** *** **** *** * ** *** ENST00000398598.3 -CAGAGGAGCTACAAAAGTATGGT---GTCGACATACCGGAAGACGAAAATGAAA---AA ENST00000506077.1 TCAAGGGAA----AAAAGCACAACAGGGCTAATG-ACTGGAAGGCATCACCAACAGCTAC ** *** ***** * * * ** ***** * * * * * ENST00000398598.3 ATGTTCTTCCT---GATAGATAAAGTTAATGCCTTTAATCAGGACATCA-CTGCTCTCAT ENST00000506077.1 ATTTTCCACTCCGAAACACATAGGCTCCATG--TTTGAGCCAAAGGTCAGTTAATCTGAC ** *** * * * *** * *** *** * * * *** * *** * ENST00000398598.3 GCAAGGAGAGGAAACTGTAGGGGAGGAAGACATTCGGCTGTTTACCAGACTCCGACACGA ENST00000506077.1 GATGACACTGCAGACTGTAATGGCTTCAAA-ATTGTGCTGTCT-CCCGACT--GGCCCTG * * * * ****** ** * * *** ***** * ** **** * * * ENST00000398598.3 GTTCCAC--AAATGGAG-TACAATAAT-----TGAAAA----------CAATTTTCAAGA ENST00000506077.1 TCTATACTCAGGGGAAGATGCAATGTTGCTCATGACAAGTGTTCTTTCCACTTGTCTAGG * ** * * ** * **** * *** ** ** ** ** ** ENST00000398598.3 AGGCCATAAAATTTTGAG----TAGAAAAATCCAGAAATTTGAAA-ATCAGTATCGTGGT ENST00000506077.1 ACATTATTGTGTCTAGTGGCTCTAAAGGCATCTAGTGAA--GACATATCAGTGTCCAGCT * ** * * * * ** * *** ** * ** * ****** ** * * ENST00000398598.3 AGAG------AGCTGCCAGG-CTTTG--TGAATTACAGGACATTTGAGACAATCGT--GA ENST00000506077.1 ACAACCTTCTGGCATTTAGGTCTTCGCTTTATGTAGGGGAAATTTGGGGGTAGCATCCGA * * ** *** *** * * * ** *** ***** * * * * ** ENST00000398598.3 AACAGCAAATCAAGGCACTGGAAGAGCCGGCTGTGGATATGCTACACACCGTGA------ ENST00000506077.1 GACA-----CCACAGCTTTGGGGGA------TATCTAAGTACAAGATACCATGAGCCCAT *** ** ** *** ** * * * * * * * *** *** ENST00000398598.3 CGGATATGGTCCGGCTTGCTTTCA--CAGATGTTTCGATAAAAAATTTTGAAGAGTTTTT ENST00000506077.1 TGAGTATAGGGGGACATAATTTTAGCCAGAAAC----ACAAAGTACTTCTCAG------- * *** * * * * *** * **** * *** * ** ** ENST00000398598.3 TAACCTCCACAGAACCGCCAAGTCCAAAATTGAAGACATTAGAGCAGA---ACAAGAGAG ENST00000506077.1 TAGCATCCCCACCAGT-CTATGTTCAGGTAGGAGAGCTTCTACATGAACTCACAGGACAG ** * *** ** * * * ** ** ** * * * *** ** ** ENST00000398598.3 AGAAGGTGAGAAGCTGATCCGCCTCCACTTCCAGATGGAACAGATTGTCTACTG----CC ENST00000506077.1 AGAACACTCACCTACAAGGCACCATGGTTTTTAGA--ATACAACCTTTGCAATGGAGACT **** * * ** ** *** *** * * * ** * ENST00000398598.3 AGGACCAGGTATACAGGGGTGCATTGCAGAAGGTCAGAGAGAAGGAGCTGGAAGA-AGAA ENST00000506077.1 AAGATCAAGAAAGTAGGA-TACAGTTCATATCCTCAAAGATCAAGTGTCAGATAACAGTG * ** ** * * *** * ** * ** * *** *** * * * ** * ** ENST00000398598.3 AA--GAAGAA-GAAATCCTGGGATT--TTGGGGCTTTCCAGTCCAGCTCGGCAACAG-AC ENST00000506077.1 TATCAAAGAATGAAGTCATGAAACAGGTTAAGACATGCCACACCACTTAAAGTACAGTAC * ***** *** ** ** * ** * * * *** *** * **** ** ENST00000398598.3 TCTTCCATGGAGGAGATCTTTCA--------GCA-----------CCTGATGGCCT--AT ENST00000506077.1 TCTAAAAT--ATGAGATCGTTTACATGAGAAGTAGGATACAATTTCCTGATACTCTGAAT *** ** * ****** ** * * * ****** ** ** ENST00000398598.3 CACCAGGAGGCCAGCAA-GC-GCATCTCCAGCCACAT-----CCCTTTGATCATCCA--- ENST00000506077.1 CACAAAGAAAATAGAAATGCTGCAATGCAGAACAAGTAGTTGCATTTTAGTCACTCAAAC *** * ** ** ** ** *** * ** * * *** *** ** ENST00000398598.3 -GTTCTTCAT----GCTCCAGACGTACGGC-----------CA--GCA------------ ENST00000506077.1 TGTTCT-CATTTTGGTTCCACAAGTGTAGCATAGAAAAAGACAATGCATTAAGGCATTTG ***** *** * **** * ** ** ** *** ENST00000398598.3 GCTTCAGAAGGC----CATGCTGCAGCTCCTGCAGGACAA----GGACACCTAC----AG ENST00000506077.1 GTTTCTGGATACTATCCATGGCACAGGCCACGTGGTTCAAATATGGACTCTTCTTTTGGG * *** * * * **** *** * * * *** **** * * * ENST00000398598.3 CTGGCTC--CTG---AAGGAGCGGAGCGACACCAGCGACAAGCGGAAGTTCCTGA---AG ENST00000506077.1 ATGGTTCATCTGTCAGAGGTATAGATCAACATAAGGAATA-GCGT---CTCATGATGCAA *** ** *** *** ** * *** ** * * *** ** *** * ENST00000398598.3 GAGCGGCTTGCACGG-CTG------ACGCAGG-----CTCGGCGC---CGGCTTGCCCAG ENST00000506077.1 AAGTGGCATA-ACGGACTGCAGAAAATGTGAATAGTACCAGGAGCTAACAGCACACTTAT ** *** * **** *** * * * ** ** * ** * * ENST00000398598.3 TTCCCCGGTTA-------ACCACA--CTCTGTC----CAGCCCCGT-----AGA------ ENST00000506077.1 TTTCTGTATCATATTTAGAATATAATTTCTATCATATCATCCTTATTAATCAGAACATTA ** * * * * * * *** ** ** ** * *** ENST00000398598.3 -----CGTGCACGCACACTGTCTGCCCCCG--TTCCCGGGTAGCCACTGGACTGACGACT ENST00000506077.1 AGTTTCATACAGAATTATTTTCGGTTCTAGACTTCCAAAGAGTTCTCTGTTGTAAGGGCT * * ** * * ** * * * **** * * *** * * * ** ENST00000398598.3 TGAG----------TGCTCAGTAGTCAGACTG--GAT--AGTCCGTCTCT--GCTTATCC ENST00000506077.1 TGAACAAAGCAGTCTATCCAGT-GTTGAATTCCTGATCAAGTCAATCTTGAAGCATGCTA *** * **** ** * * *** **** *** ** * ENST00000398598.3 GTTAGC-CGTGGTGAT--------TTAGCAGG--------------AAGCTGTGA----- ENST00000506077.1 GACAACTCACAGTAATAGGAAATGTTAACGAGCTTATTTCTAAGCAAACCTTTAATCCAG * * * * ** ** *** * * ** ** * * ENST00000398598.3 -------GAGCAGTT--TGGTTTC---TAGCATGA----AGACAGAGCCCC---AC---C ENST00000506077.1 TACCACTGGGCAATTAACACTTTCAGATGGAACAACTTCAAATGGAACCTTTTGACAGGC * *** ** **** * * * * * * ** ** ** * ENST00000398598.3 CTCAGATGCACATGA--GCTGGCGGGA-------TTGAAGGAT------GCTGTCTTC-- ENST00000506077.1 CCCAGC--CCTGTGATTGCTGCCAGGAAATTATGCTGAAGAATCACTCTGTAGCCTTCTA * *** * *** **** * *** ***** ** * * **** ENST00000398598.3 --GTACTGGG-AAAGGGATTTTCAG-----------CCCTCAG---------AATCG-CT ENST00000506077.1 AAGTATCAAACAAAAAGTCTTTCTGATTGGACAAATCCCTCAATTCATCATCAACCAACT *** *** * **** * ****** ** * ** ENST00000398598.3 CC-ACCTTGCAGCTCTCCCCT------------TCTCTGTATTCCTAGAAA--------- ENST00000506077.1 CTTAATTCAGAGCTGTTCCCTAAGAAGGAAACCTGTCTCAACTTCCAGGAAACCATGTTT * * * **** * **** * *** * * * ** ** ENST00000398598.3 ----------CTGACACATGCTGAACAT----CACA-GCTTATTTCCTCATTTTTATAAT ENST00000506077.1 GAAGCTCAACCTAAGACCAGCAGGGCACAGGGCACATGCTCACTTTGTCAGATGTAGGTT ** * ** ** * ** **** *** * ** *** * ** * ENST00000398598.3 GT-------------CCCTTCACA-AACCCAGTG--TTTTAGGAGCATGAGTGCCGTGTG ENST00000506077.1 GTGCCAGTGGGTCAGCTCTACACACAGCACAGAGGATGCTGGGCCCTTGAATTTGATCTT ** * ** **** * * *** * * * ** * *** * * * ENST00000398598.3 TGTGCGTCCTGTCGGAGCCC-------------TGTCTCCTCTC---TCTGTAA----TA ENST00000506077.1 CAC-TATCCAAAGGGAGTCCATGGCAGAGAAAATGGAACACCTCAGATCTGAGAACCATA *** **** ** ** * *** **** * ** ENST00000398598.3 AAC-TCATTTCTAGCAGA------------CA- ENST00000506077.1 AACGTGGAGGCCAGGGAAGTGGGGAAAGAGCAT *** * * ** * **