CLUSTAL 2.1 multiple sequence alignment ENST00000399688.3 AGTCTCCGCCCATACCCCTCCGGGTTAGGCGGCTGTAGCGGAGCTCGAAAAGAGTGGCGC ENST00000430406.1 ------------------------------------------------------------ ENST00000399688.3 AGGGTCGCGCGGCCCCGCCTCCTTCCCCGCCCAGCGAAGCTCTCTGACCACCCCTCTTTT ENST00000430406.1 ------------------------------------------------------------ ENST00000399688.3 CTAGAGTTCTGCCTCGCTTCCCGGCGCGGTCGCAGCCCTCAGCCCACTTAGGATAATGGC ENST00000430406.1 ------------------------------------------------------------ ENST00000399688.3 GACAGCTGAGGTACTGAACATTGGTAAAAAATTATATGAGGGTAAAACAAAAGAAGTCTA ENST00000430406.1 -----------------------------------------------CAAA----GTCCA **** *** * ENST00000399688.3 CGAATTGTTAGACAGTCCAGGAAAAGTCCTCCTGCAGTCCAAGGACCAGATTACAGCAGG ENST00000430406.1 TAAATTATTAGATAGTCCAGAAAAAATCCTCCTGCAGTTCAAGGACCAGATAACAGCAGG **** ***** ******* **** ************ ************ ******** ENST00000399688.3 AAATGCAGCTAGAAAAAACCACCTGGAAGGAAAAGCTGCAATCTCAAATAAAATCACCAG ENST00000430406.1 AAATGCAGTTAGAAAGAATCACCTGGT---AAAAGCTGCAATCTCAAATAAAATTACCAG ******** ****** ** ******* ************************ ***** ENST00000399688.3 TTGTATTTTTCAGTTATTACAGGAAGCAGTTACCTCATATAAGTCAAATCGTATTAAAAC ENST00000430406.1 TTGTGTTTTTCAGTTGTTACAGGAAGCAA---------------------GTGTCAAAAC **** ********** ************ ** * ***** ENST00000399688.3 TGCCTTCACCAGAAAATGTGGGGA----GACAGCTTTCATTGCACCGCAGTGTGAAATGA ENST00000430406.1 TGCTTTCACCAGAAAATGTGGGGAAACAGACAGCTTTTGCTGCTCCCGAGTGTGAAATGA *** ******************** ********* *** ** ************ ENST00000399688.3 TTCCAATTGAATGGGTTTGCAGAAGAATAGCAACTGGTTCTTTTCTCAAAAGAAATCCTG ENST00000430406.1 TTCCAACTGAATGGGTTTGCAGAAGAATAGCAACTGATTCTTTTTTCAAAAGAAATCCTG ****** ***************************** ******* *************** ENST00000399688.3 GTGTCAAGGAAGGATATAAGTTTTACCCACCTAAAGTGGAGTTGTTTTTCAAGGATGATG ENST00000430406.1 ATGACAAGGAAGGATATAAGTTTTACCCACCTAAAGTGGAGATGTTTTTCAAGGATGATG ** ************************************* ****************** ENST00000399688.3 CCAATAATGACCCACAGTGGTCTGAGGAACAGCTGATTGCTGCAAAATTTTGCTTTGCTG ENST00000430406.1 CCAGTAATGACCCAGAGTCATCTGAGGAACAGCTAATTGCTCCAAAATTTTGCTTTGGTG *** ********** *** ************** ****** *************** ** ENST00000399688.3 GACTTCTTATAGGCCAGACTGAAGTGGATATCATGAGTCATGCTACACAGGCTATATTT- ENST00000430406.1 AACTTCTCATAGGCCAAACTGAAGTGGATATCATGTCATATACTACATAGGCTCTTTTTT ****** ******** ****************** ** ***** ***** * *** ENST00000399688.3 GAAATACTGGAGAAATCCTGGTTGCCCCAGAATTGTACACTGGTTGATATGAAGATTGAA ENST00000430406.1 GAAATACTGGAGAAATCTTGGTTGCCCCAGAACTGTATGCTGGTTGATATGAAGATCAAA ***************** ************** **** ***************** ** ENST00000399688.3 TTTGGTGTTGATGTAACCACCAAAGAAATTGTTCTTGCTGATGTTATTGACAATGATTCC ENST00000430406.1 TTTGGTGTTGATGTAACCCCTAAAGAAATTGTTCTTGCTGATGTTATTGATAATGATTCC ****************** * ***************************** ********* ENST00000399688.3 TGGAGACTCTGGCCATCAGGAGATCGAAGCCAACAGAAAGACAAACAGTCTTATCGGGAC ENST00000430406.1 TGGAGACTCTGGCCATCAGTAGATGGAAGCCAACAGAAAGACAAACAGCCTCATCAGGAC ******************* **** *********************** ** *** **** ENST00000399688.3 CTCAAAGAAGTAACTCCTGAAGGGCTCCAAATGGTAA-AGAAAAACTTTGAGTGGGTTGC ENST00000430406.1 CTCAAAGAAGTAACTCCTGAAGGGCTCAAGATGGTTATAGAAAAACTTAGAGTGGGTTGC *************************** * ***** * ********** *********** ENST00000399688.3 AGAGAGAGTAGAGTTGCTTTTGAAATCAGAAAGTCAGTGCAGGGTTGTAGTGTTGATGGG ENST00000430406.1 AGAGAGAGAAGAGTTGCTTTTGAAATTAGAAAGTCCGTGCGGGATGGCAGTATTGGTAGG ******** ***************** ******** **** ** * * *** *** * ** ENST00000399688.3 CTCTACTTCTGATCTTGGTCACTGTGAAAAAATCAAGAAGGCCTGTGGAAATTTTGGCAT ENST00000430406.1 CTCTACTTCTGATCTTGGCCACTGTGAAAAAATCAAGAAGGCCTGTGGAAATCTTGGCAT ****************** ********************************* ******* ENST00000399688.3 TCCATGTGAACTTCGAGTAACATCTGCGCATAAAGGACCAGATGAAACTCTGAGGATTAA ENST00000430406.1 TTCCTGAGAACTTCAAGTAACATCTGTGCATAAAGGACCAGATAAAACTCTGCGGATTAA * * ** ******* *********** **************** ******** ******* ENST00000399688.3 AGCTGAGTATGAAGGGGATGGCATTCCTACTGTATTTGTGGCAGTGGCAGGCAGAAGTAA ENST00000430406.1 AGGTGAGTGTGAAGGGGATGGCATTCCCACTGTGTTTGTGGCAGTGGCAGGCAGAAGAAA ** ***** ****************** ***** *********************** ** ENST00000399688.3 TGGTTTGGGACCAGTGATGTCTGGGAACACTGCATATCCAGTTATCAGCTGTCCTCCCCT ENST00000430406.1 TGGTTTGGGACCAGTGACGTCTGGGAACACTGCATATCCAGTTATCAGCTGTCCTCCGCT ***************** *************************************** ** ENST00000399688.3 CACACCAGACTGGGGAGTTCAGGATGTGTGGTCTTCTCTTCGACTACCCAGTGGTCTTGG ENST00000430406.1 CA-AGCAGACTGGGGAGCTCAGGATGTGTGGTCTTCTCCTCGACTACCCAGTGGTCTCAG ** * ************ ******************** ****************** * ENST00000399688.3 CTGTTCAACCGTACTTTCTCCAGAAGGATCAGCTCAATTTGCTGCTCAGATATTTGGGTT ENST00000430406.1 CTGCTCAACCACCCTTTCTCCAGAAGGATCAGCTCAGTTTGCTGCACAGATATTTGGGTT *** ****** *********************** ******** ************** ENST00000399688.3 AAGCAACCATTTGGTATGGAGCAAACTGCGAGCAAGCATTTTGAACACATGGATTTCCTT ENST00000430406.1 AAACAATCATTTGCTGTGGGGCAGACTGTGAGCAAGCGTTTTGAACACATGGATTTTCTT ** *** ****** * *** *** **** ******** ****************** *** ENST00000399688.3 GAAGCAGGCTGACAAGAAAATCAGAGAATGTAATTTATAAGAAAGAATGCCATTGAATTT ENST00000430406.1 GAAGCAGGTTGACAAGGAAATCAGAGAACGTAATTTATAAGAAAGATTGTCATTGCTTTT ******** ******* *********** ***************** ** ***** *** ENST00000399688.3 TTTAGGGGAAAAACTACAAATTTCTAATTTAGCTGAAGGAAAATCAAGCAAGATGAAAAG ENST00000430406.1 TTTAGGGGGGAA-CTACAAAT-----GTTTAGCTGCAGGAAAATCAAGCAAGATGAAAAG ******** ** ******** ******** ************************ ENST00000399688.3 GTAATTTTAAATTAGAGAACACAAATAAAATGTATTAGTGAATAAATGCTTCTCTAGATC ENST00000430406.1 ATGATGCTAAATTAGAGAACACAAATACAATGTATTAGTGAATAAATGCTTTTCCAGATC * ** ******************** *********************** ** ***** ENST00000399688.3 CATAT-----TAATAAACATGAGCAT-----CTAACCCCTCCTTTCTTAGGCTAGACACC ENST00000430406.1 CATAGGTATGTAGAATATCTGTTCATATTTATTAATATCTCCTTA--TGAGC-AGA---G **** ** * * ** *** *** ****** * ** *** ENST00000399688.3 AAGATATTTCAGCCAGCCTTT---ATCATTCCTCT---TACTTTATCCTTTTTCCTTAAG ENST00000430406.1 AAGTTACTATAAGGACATTTTCAAATTACTCTCCTGTCCACTGTATGGTCATTG-TTAGG *** ** * * * *** ** * ** ** *** *** * ** *** * ENST00000399688.3 TATTGGTGGTCACTACTATTGAGTTTCTTCCTTAA-CACTGATTAAATGATCT----TAA ENST00000430406.1 TGATAATA-TAATTA--AAGAAATATCTTTTATAAATGCTAAT--AATGTTCTATTATAA * * * * * ** * * * **** *** ** ** **** *** *** ENST00000399688.3 CTCCCTCAGCTAAAACTGGCATTAC-TGACTCCCAGCTATATTTCTCCAGACTTGCATTT ENST00000430406.1 AGCT-----CTAGAGTT---ATTACCTGACCTTCTG-TATGTCAATCCATAAGT------ * *** * * ***** **** * * *** * **** * * ENST00000399688.3 TTTTTTTTTTTTTTGAGACAGGGTCTCACTGTCGCCCAGGCTGGAGTGCAGTGGCGTGAT ENST00000430406.1 ----------TTTAGAAAGTAAAACTGGCTATATTTTAGGT--GATAAGAGCAATATAAT *** ** * ** ** * *** ** ** * ** ENST00000399688.3 CTCAGTTCACTGCTGCTTTCCCTCCTGGGCTC-AAG----CAGTTCT-----CCCACCTC ENST00000430406.1 TCTCATTCACT-CTGTGGTCTTCACAAAATTCTAAGGGTATAGTTCTAAATTTTCAA-TT ****** *** ** * ** *** ****** ** * ENST00000399688.3 AGCCTCTCGACTAACAGGGACTATAATCTTGCA-GCACCATGCCGAGCTA-ATTTTA--T ENST00000430406.1 AGTATTTCAG---AAAGTGATTTCTAT-TTACATGTAT-ATCTATAGATACGTTTTGATT ** * ** * ** ** * ** ** ** * * ** ** ** **** * ENST00000399688.3 TTTTTGTAGAGATGAGCTCTCACTATGTC--ACCCAGGTTCGTCTCAAACTCCTGAACCC ENST00000430406.1 TTCTTTTAAGGAAAAGTTGAGATTGGGTAGAAAACAAGGTAGAGGAACACTGTTGGACCC ** ** ** ** ** * * * ** * ** * * * * *** ** **** ENST00000399688.3 TAGTAA-------TTCTC-----CTATCTCAGCC---TCCCAAAGTG-----CTAGGGTT ENST00000430406.1 ACGGAAAGGGGACTTTTCTGAGACTTTCTCTGTTGGTTTTTAGAGCAATTTTCCATGGAA * ** ** ** ** **** * * * ** * * ** ENST00000399688.3 ACAGACATGAGCCAC-TGTGCC-TGTCTA-----GACTTGT--ACTTTCAACTGTCCATT ENST00000430406.1 ACAG-TA-GAGTTACCTTTGCCATGCCAAATGAAGATTTAGCGAATCTTACTTGGCTATG **** * *** ** * **** ** * * ** ** * * * * ** * ** ENST00000399688.3 TCTCCCTGTCTGTCCCATGGGCACTCA----TGAAA-AAACAG------------AATGC ENST00000430406.1 TAACAACAACAACAACAACAACACTCAATCATAAAATGAACAATTTGATTTTTAAGATGT * * * ** ****** * *** **** *** ENST00000399688.3 TCCCAAC--TTTATT---CATCTTCC--AAGCCTGTA-GCTCTTGGTATACTCACTGTTG ENST00000430406.1 TCAAAATATTTTATTAGACATTCTACCAAAGAAGATATGCAGATGGCAAATAAAC----A ** ** ****** *** * * *** ** ** *** * * ** ENST00000399688.3 CAAGTCAGAAG--CTTGATTTCATCATTGA-------TGTTTTTCTCACGTTT---CACA ENST00000430406.1 CAGG-CAGAAATACTCAATATCATTTGTGGGAAAAGCTGTCTTCTTTATATTTTCCCATA ** * ***** ** ** **** ** *** ** * * *** ** * ENST00000399688.3 TCTCACTCATCACCA-----AGTCATGTTG-GTGTTAATT---TCTGAT-----TAACCC ENST00000430406.1 TTTAATTTTTTTCTACTATTAGTAATATTGTATATTACTTCTATCAGAAAAAAATAATTT * * * * * * * *** ** *** * *** ** ** ** *** ENST00000399688.3 TTGAATT------TACCGTCTTCTCATCCT--CTGTACAAAAGCCTCAAGTGAGGGTCAA ENST00000430406.1 TAGAATTAGTATGTTCAATTTTATAATCATGCTTGTAT---TTTTTTAAATCATGA--AG * ***** * * * ** * *** * **** * ** * * * * ENST00000399688.3 ATTCAACATTATCCTGATCTAGACAGCCCCCATTCTCA---AT--CCACCCTTTTCCAAG ENST00000430406.1 AGCAAACATTGCTGAGA---AAATGACACCTATTCTTATGGATGATGGTTTTTTTTTCAT * ****** ** * * * ** ***** * ** **** * ENST00000399688.3 TTGATTGC-CCAAGGACTTCTAAC-AATAAAC-----TCTCTTTT-GCACCACAGACTTC ENST00000430406.1 TTTTTCACATTTTCAACTTTCATTTAGTGAACATATGTCACTTTTTATCCTAAAAAATTT ** * * **** * * * *** ** ***** * * * * ** ENST00000399688.3 TTTGAAA--------ATATACATGCTGTTG----ACCCTCTCT-GTAGAAAACCGCACAC ENST00000430406.1 TTTAAAATCAATTTTACAAGCATGGGATAGGAAAACTCTGTCTTGTTAATAAATGAAGTG *** *** * * **** * * ** ** *** ** * ** * * ENST00000399688.3 ATAAAACT---TACCAACAGAT-TTCATTGGTT------------CTTGGGTTCTCCCGA ENST00000430406.1 AAAAATCTCTGTACCTTTAGTTGTTCATAAGTTGAAAATGAGTAACGTGATATATCTTTA * *** ** **** ** * ***** *** * ** * ** * ENST00000399688.3 AGCCTA----TCCATGGTTTATAGATTAAGAAT---------TGATGAGGTAG------C ENST00000430406.1 AACACAAACTTCCATGTTAGCTACATTAGTAATGCTTCTTTCCCAGGAACTAATAATCCC * * * ****** * ** **** *** * ** ** * ENST00000399688.3 TGGGCACAGTGGCT---CA---CACCTACGA------TCACAGCACTTCGGGAGGC--TG ENST00000430406.1 CAAGCATATTCCCTTTTCATATCATCTCTGAAATAATCCATGCTATTCTGGGCACCATTT *** * * ** ** ** ** ** ** * * *** * * ENST00000399688.3 AAGCAAGCA----GATCACTTGAGG-TCA---GGAGTTTGAGACCAGCCTGGCCAACATG ENST00000430406.1 CAACAAGCATGTTGACCAGTTCAAGCTCACCCAGAGGAAAAGACC--CAAGGCGAATATT * ****** ** ** ** * * *** *** ***** * *** ** ** ENST00000399688.3 -GTGAAACCCTGTCTCTACTAAAAATACAAAAAGTAGCCAGCCGTGATGACAGGCACCTG ENST00000430406.1 CAGGAAAGAATGTGA-TATCAGAAACTCTAAG-GCATCAAAGTCTGAGGAAAAATATGAA **** *** ** * *** * ** * * * * *** ** * * ENST00000399688.3 --TAATCCC-AGCTACTCGGGAGGCTG--------AGGCATGAGAATTGCTT----GAAC ENST00000430406.1 GATATTCTCTAAATACTTTCGAGGCTGGCATTTAAAAGAAAGAGAATGTCTTCTCTGAAT ** ** * * **** ******* * * * ****** *** *** ENST00000399688.3 C--CGGGAGGCGGAGGTTGCAGTGAGCCTAGATCATGCCACTGCACTCCAACCTGGGCAG ENST00000430406.1 TATCAGAAAACGGAC-TTCTATCAATTGTTAAGAATATCGTTGC---CAAATATACATTC * * * **** ** * * * * ** * *** * ** * ENST00000399688.3 CAGAGC-AAGACTCTGTC--TCAAAAGGGGAAAAAAAAAATTGCTGATGTGACCCAT--- ENST00000430406.1 AAGAACCAGGAGAATGACAACCATATGGGTTCAGGGAA-----CTG-TTTGACCTATTTT *** * * ** ** * ** * *** * ** *** * ***** ** ENST00000399688.3 GAAGGGAACT---CATTTTCC---TCGTAATTTTGGACTGCCACACATTGGTACCTTTAG ENST00000430406.1 GAGGCAAACTGGACAGGATCCAATTTGT--TTCTTGAGTCTCA------GGAGCCCTT-- ** * **** ** *** * ** ** * ** * ** ** ** ** ENST00000399688.3 TTCTCTGA-AGGCCCACGTTTTTATCATTAAGACCTATTTGTTAGCTAGTAGAGCTTTA- ENST00000430406.1 -TCTCTGATAGGGGGAAGCAGTGGTAATTG-GTCATCCTCGGGAAATAGTATTTCCTCAG ******* *** * * * * *** * * * * * * ***** * * * ENST00000399688.3 ------TGTTCGCT-GTCCATGAAA-----------CCTTCTGTAACCACAGTGACTA-- ENST00000430406.1 AGGCAGCATCCAGTAGTTCCTGAAAGTCTGGGGCATTTTTTCACAGCTATTTAAACCAAG * * * ** * ***** ** * * * ** * ENST00000399688.3 CAAGTAGTTCT----TTCTCTATTGAATTATTAGGTCCAGAATAGAAGATGTCATTGTAC ENST00000430406.1 TAAGTAGTACTAGAACCCTTTGGCGA------AGGCTTGGAA--GAAGGT----TCATGT ******* ** ** * ** *** *** **** * * * ENST00000399688.3 ACTTTATTT----CCCTCACA-CTGTGTTATGCTCTGATGTG--CTATGCTTAGCTATCT ENST00000430406.1 ACCTCATTTGTGGTTATTATAGCAGTATTTATCCCTGAAGTAACCTAGTCTCCTTCATTG ** * **** * * * * ** ** * **** ** *** ** ** ENST00000399688.3 GTCAGAGATTAGTAAATTATAAAAC---TCATGTGTACTACTTAA--GTTTATA----TC ENST00000430406.1 G--AGGGATCTGGGTCTAATGGAACCATTTCTGGGAATTAGGTAAAGGACCATAATTCTG * ** *** * * ** *** * ** * * ** *** * *** * ENST00000399688.3 TTATGCTAGTTTATAAGAAC---AATTAAAAGGACTTAGAAGATTAA ENST00000430406.1 TCGTTGTGGCTCAACAGACCTCTGTTCATTGGGACTCGTA------- * * * * * * *** * * * ***** *