CLUSTAL 2.1 multiple sequence alignment ENST00000405805.1 TTTCTGCGGAGGGATTACGCTGACGAAAGAGACCTGCTTGCGCGTCGCTGTTCCGTGGTC ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 CGCGCGAGCGTGGTCGGGAGCCGCTGGTTCCTGGGGTGACCCGCGGAGGTGGGAGAGGGA ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 AGGGCTTCCGAAGCCGGCGGGGGTGCCATGGACCCTCTCCGCCGGCGCGGCCTTCACAGC ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 TGGGCCGCGCCGGGCATCCGTAGTCCGCTCTCCCAAAGCCTCGGTGGAGCTGAAGCTGCC ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 ACAGAGTGCATGTTCACAAAGGGTCATCACACACGGAGCTGCCCCTCCCTGTCTCCCTAG ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 AGCCCATCTTCGAGGCCAGGGGCTTTTCTACCAGGATTCTGGGGTGTTTCTCCTCCTTTC ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 CTCCCTCCCAGATCTTCTCACGGTAAGGGGAGCAGCGAAAGCGCAGGGACTTTGCATTCC ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 ACGACCCGTTCTGACTAGTCAACAGCCGATCTGTCCCTGCTGCTCTAATTCCAGCTGCCC ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 TGCCTTGTTTTAACTTCAGAGAAAGGGGGAGTTCTCATTTGATAAGTTTAAGCCTTTGCT ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 TTCGTAGGAAGGTCATGTGGCTTAAGGGACATCGTGACCGCGTATGCTATTTCTGCCTGT ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 GCATTCTAAATCTTGGGGGCAGCATATTCCAGAAGTCCTTTTGGTCGATTGGTTCTGTGT ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 CCTAGGATAACAATTTGTAGTTTCTGACCATTTCTTTACAGAAAAACCACAATTGGTATT ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 TTGGACTGCGGGGTTTTTTAGTGGTCTCAAACTAAATGATTATATTCTGGAATAATGCTG ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 ACAATTTGGATAGGGTGGTGTGGAGGAAACAAGTCTCGTGTAGAAGAAATTATTTAGTAA ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 AAAGGATTTTAGTTTTTGGTACTTCTGAATGCAAATGGCCAAGGAATCCAGCAGTTTGTT ENST00000435986.1 ------------------------------------------------------------ ENST00000405805.1 GGGGTTTCTCCAGACAAAAATAGGCTGAAAAATAACTAAACATGGGCAAAGGAGATCCTA ENST00000435986.1 -----------------------------------------ATGGGCAAAGGAGATCCTA ******************* ENST00000405805.1 AGAAGCCGAGAGGCAAAATGTCATCATATGCATTTTTTGTGCAAACTTGTCGGGAGGAGC ENST00000435986.1 AGAAGCCAAGAGGCAAAATGTTATCATATGCATTTCTTGTGAAAACTTGTCAGAAGGAGC ******* ************* ************* ***** ********* * ****** ENST00000405805.1 ATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGCTCAG ENST00000435986.1 ATAAGAAG-------------CTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGCTCAG ******** *************************************** ENST00000405805.1 A---------------GAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAG ENST00000435986.1 AAAAAAAGTGCTCAGTGAGGTGGAAGACCATATCTGCTAAACAGAAAGGAAAATCTGAAG * *************** ********* ************ ***** ENST00000405805.1 ATATGGCAAAAGCGGACAAGGCCCGTTATGAAAGAGAAATGAAAACCTATATCCCTCCCA ENST00000435986.1 ATATGGCAAAGGCAAACAAGGCCCGTTATGAAAGAGAAATGAAAATCTATATCCCCCCTA ********** ** ****************************** ********* ** * ENST00000405805.1 AAGGGGAGACAAAAAAGAAGTTCAAGGATCCCAATGCACCCAAGAGGCCTCCTTCGGCCT ENST00000435986.1 AAGGGGAGACAAAAAAGAAGTTCAAG---TCCAATGCACCCAAGTGGCCTCCTGCAGCCT ************************** ************** ******** * **** ENST00000405805.1 TCTTCCTCTTCTGCTCTGAGTATCGCCCAAAAATCAAAGGAGAACATCCTGGCCTGTCCA ENST00000435986.1 GTTTCGTGTTCTGTTCTGAGTGTTGCCCCAAA-TCAAA---GAACATCTTGGCCTGTCCA *** * ***** ******* * **** *** ***** ******* *********** ENST00000405805.1 TTGGTGATGTTGCGAAGAAACTGGGAGAGATGTGGAATAACACTGCTGCAGATGACAAGC ENST00000435986.1 TTGGTGATGTTGCAAAGAAACTGGGAGACATGTGGAATAGCACTGCTGCAGATGACAAGC ************* ************** ********** ******************** ENST00000405805.1 AGCCTTATGAAAAGAAGGCTGCGAAGCTGAAGGAAAAATATGAAAAGGATATTGCTGCAT ENST00000435986.1 AGCCTTATGAAAAGACAGCTGTGAAGCTGAAGGAAAAATACAAAAAGGATCTTGCTGCAT *************** **** ****************** ******** ********* ENST00000405805.1 ATCGAGCTAAAGGAAAGCCTGATGCAGCAAAAAAGGGAGTTGTCAAGGCTGAAAAAAGCA ENST00000435986.1 ATTGAACTAAAGGAAAGCCTGATGCAGCAAAAAAGGGAGTCATCAAGGCTGAAAAAAGCA ** ** ********************************** ****************** ENST00000405805.1 AGAAAAAGAAGGAAGAGGAGGAAGATGAGGAAGATGAAGAGGATGAGGAGGAGGAGGAAG ENST00000435986.1 AGAAGAAGAAGGAAGGGGAGGAAGATGA---------AGAGGATCAGGAGGAGGAGGAAG **** ********** ************ ******* *************** ENST00000405805.1 ATGAAGAAGATGAAGATGAAGAAGAAGATGATGATGATGAATAAGTTGGTTCTAGCGCAG ENST00000435986.1 ATG---------AAGGTGAAGAA------AATGATGATGAATAAGTTGATTCTAGTGCAG *** *** ******* ****************** ****** **** ENST00000405805.1 TTTTTTTTTTCTTGTCTATAAAGCATTTAACCCCCCTGTACACAACTCACTCCTTTTAAA ENST00000435986.1 TTTTTTTTT-CTTGTCTAAAAAGCATTTAACCCCCCTGTACAAAACTCACTCATTTTAAA ********* ******** *********************** ********* ******* ENST00000405805.1 GAAAAAAA--TTGAAATGTAAGGCT---GTGTAAGATTTGTTTTTAAACTGTACAGTGTC ENST00000435986.1 GAAAAAAAAATTGAAATATAAGACTTTAATGTAAGGTTT-----TAA------------- ******** ******* **** ** ****** *** *** ENST00000405805.1 TTTTTTTGTATAGTTAACACACTACCGAATGTGTCTTTAGATAGCCCTGTCCTGGTGGTA ENST00000435986.1 -TTATCTTTAAAGTTTTTATGTT--------TTCCTTT--------TTATCCTG----TA ** * * ** **** * * * **** * ***** ** ENST00000405805.1 TTTTCAATAGCCACTAACCTTGCCTGGTACAGTATGGGGGTTGTAAATTGGCATGGAAAT ENST00000435986.1 ATTTTTAT-----TTAATATTATTTTATGTCATAC-----TTATA------CATACAGAT *** ** *** ** * * ** ** ** *** * ** ENST00000405805.1 TTAAAGCAGGTTCTTGTTGGTGCACAGCACAAATTAGTTATATATGGGGATGGTAGTTTT ENST00000435986.1 TTCAACAAAAGAACTGT-----CACTGTCTGCATTTCTTTTCTAT-------GTAATTTT ** ** * *** *** * *** ** * *** *** **** ENST00000405805.1 TTCATCTTCAGTTGTCTCTGATGCAGCTTATACGAAATAATTGTTGTTCTGTTAACTGAA ENST00000435986.1 TCCCACTACTTTCATTTC-----------ATA----ATAATT-------TATGAACCTAA * * ** * * * ** *** ****** * * *** ** ENST00000405805.1 TACCACTCTGTAATTGCAAAAAAAAAAAAA-AAGTTGCAGCTGTTTTGT-----TGACAT ENST00000435986.1 T-----TTTTCA--TATAGAGAAAGGGACTTAAATTGCAA-TGCCCCACAGGTGTGAAAT * * * * * * * *** * ** ***** ** *** ** ENST00000405805.1 -TCTGAATGCTTCTA--AGTAAAT-ACAATTTTTTTTATTAGTATTGTTGTCCTTTTCAT ENST00000435986.1 ATTTGAGGCCCACCACAGGTAAAAGACAGCTTTCCCTGTT--TACCACAGGCC----CA- * *** * * * ***** *** *** * ** ** * ** ** ENST00000405805.1 AGGTCTGAAATTTTTCTTCTTGAGGGGAAGCTAGTCTTTTGCTTTTGCCCATTTTGAATC ENST00000435986.1 AAGTGCCAAATTAACACACCCAAGG----ACCAGTTCTCTACAAATTACTTTTGTGAGTC * ** ***** * *** * *** * * * * * ** *** ** ENST00000405805.1 A---CATGAATTATTACAG-TGTTTATCCTTTCATATAGTTAGCTAATAAAAAGCTTTTG ENST00000435986.1 AGTGTATAAAT-ACTTCAGCTGCCTTGCCCTTTGTG-AAT---CTGGTG------TTTTG * ** *** * * *** ** * ** ** * * * ** * ***** ENST00000405805.1 TCTACACACCCTGCATATCATAATGGGGGTAAAGTTAAGTTGAGATAGTTTTCATCCATA ENST00000435986.1 TGT---CACTGTGAGTTTC-TCCTGGGATTGAGGTCCGGCTG--CTCATTGTGGTGGCCA * * *** ** * ** * **** * * ** * ** * ** * * * ENST00000405805.1 ACTGAACATCCAAAATCTTGATCAGTTAAGAAATTTCACATAGCCCACTTAC--ATTTAC ENST00000435986.1 GCTCAACAAC-AAACCCATCATGGACTCTCTTCTTTTTC-TGTTTCACTGCCTGACTTCT ** **** * *** * * ** * *** * * **** * * ** ENST00000405805.1 AAACTGAAGAGTAATCAATCTACTCAAAGCATGGGATTATTAGAATCAAACATTTTGAAA ENST00000435986.1 CTACTG--GTATCTCTAGTACCTCCCAAATA---AACT--TGGATCCATGTATC---AGG **** * * * * * ** * * * * ** ** ** * ENST00000405805.1 GTCTGTCCTTGAAGGACTAATAGAAAAGTATGTTCTAACCTTTACATGAGGACTCTATTC ENST00000435986.1 GTCTGCTCCTGGAGGA-------ACCAGTATCATTTAACCC-------AGAAC---AGTC ***** * ** **** * ***** * ***** ** ** * ** ENST00000405805.1 TTTAACTCCCATTACCATGTAATGGCAGTTATATTTTGCAGTTCCCACATTAAAGAAGAC ENST00000435986.1 CCCAACTTTTCTTT-------------GTTTTGTTTTGT--TTTTGAGAT----GGAGTC **** ** *** * ***** ** * ** * ** * ENST00000405805.1 CTGAGAATGTATCCCCAAAAGCGTGAGCTTAAAATACAAGACTGCCATATTAAATTTTTT ENST00000435986.1 TTGC---TCTGTCACC--------CAGGCTGGAGTGCAGTGGCGCGATCTCGG------- ** * * ** ** ** * * * ** ** ** * ENST00000405805.1 GTTGACATTAGTCTCAGTGAAGACTATGAAAATGCTGGCTATAGATGTCTTTTCCCATTT ENST00000435986.1 ------------CTCACTGCAAGCTCCGCC--TCCTGGGTTC--ACGCCATTCTCC---T **** ** * ** * * **** * * * * ** ** * ENST00000405805.1 ATCTAAATATGGACTGCTCAGGAAACGAGACTTT---CCATTACAAGTATTTTTAATTAA ENST00000435986.1 GCCTCA-----GCCTCCCGAGTAACTGGGACTACAGGCGGCCGCCACCATGTCTGGCTAA ** * * ** * ** ** * **** * * * ** * * *** ENST00000405805.1 TTGGGCCAGCTTTTCAAACAAAGATG--------CCACATT---CAAAATAGGGTATATT ENST00000435986.1 TTT--TTTGTATTTTTAACAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATC ** * *** **** ***** ** ** ** ** * * ** ENST00000405805.1 TTCCTATATTACGGTTTGCCC-CTTTATAAATCCAAGTAGATAGGAAGAAAGAAGACAAA ENST00000435986.1 TCCTGTCCTCGTGATTTGCCCGCCTTGGCCTTCCAAAGTGCTGGGATTACAGGTGTGAGC * * * * ******* * ** ***** * * *** * ** * * ENST00000405805.1 CTTTGCATCTCAGTATGAATTATTCAATTTATTTGAATGATTTTTCTTTACAAAACAAAC ENST00000435986.1 CACCGCGCCAGACCCTCAACTGTT---TTTTTTTAAATGCCAGTGATTTACGAAGGA--- * ** * * * ** * ** *** *** **** * ***** ** * ENST00000405805.1 TCATTCATTAGTCATGTTTATCTGCTTAGGAGTTTAGGGAACAATTTGGCAATTTTGTGG ENST00000435986.1 -CATAGA---GGCA-GCTT-TCCACT-----------AGAATGACC---CATCTTCAGGA *** * * ** * ** ** ** *** * ** ** * ENST00000405805.1 TTTTCGAGATTATCGTTTTCTTAAAGTGCCAGTATTTTAAAATAGCGTTCTTGTAATTTT ENST00000435986.1 TTTGTCTGATT---GTTTCTTCATGGTATCA----TTTAAC------TTTTTCTACTCTT *** **** **** * * ** ** ***** ** ** ** * ** ENST00000405805.1 ACACGCTTTTGTGATGGAGTGCTGTTTTGTTATATAATTTAGACTTGGATTCTTTCCATT ENST00000435986.1 CCCTGTATTTCTGGTAAACTG--------------AA---AGACCCAAAAGGTTGC--TT * * *** ** * * ** ** **** * ** * ** ENST00000405805.1 TGCATTTGTTTATGTAATTTCAGGAGGAATACTGAACATCTGAGTCCTGGATGATACTAA ENST00000435986.1 AAAGTAAAATAAAGCTTTCTTGGTAAGACTATT-----------TCATGGGCAATGTTAT * * * * * * * * ** ** * ** *** ** ** ENST00000405805.1 TAA-ACTA-ATAATTGCAGAGGTTTTAAATACTA-GTTAAATGGCTTTCACTTAAGAACT ENST00000435986.1 TTATATTACATAACATTAGAA----TGCATGCCATGTTTGATGG-TTCCACCT-----CT * * * ** **** *** * ** * * *** **** ** *** * ** ENST00000405805.1 TAAGATTTTGTTACATATTTTTAAATCTTGTTTCTAATAAT---ACCTCTTAGCAGTACC ENST00000435986.1 AGAGATGTTAAGATCTACCAGTGGGTTCAGGTGGGGATAGTCTGACTCCTT--CATTG-- **** ** * ** * * * * *** * ** *** ** * ENST00000405805.1 TTTTAAATAAGTATAAGGGATGGCAAAGTTTTTCCCTTTAAAAATACTCACTTTATGCTT ENST00000435986.1 --TTAAA---GTGT-------------GTTTTCCACCTTATAACCA----------ACCT ***** ** * ***** * * *** ** * * * ENST00000405805.1 ATAAATAGGTTAATGGGCTGATAAAAGGTTTTGTCAAACATTGCAAGTATTCGGTGCTAT ENST00000435986.1 CTAA-----TCTGTGAGTTGGTAA-----CTTGACA--CCTCATAAGTCTCCAGTTCCCC *** * ** * ** *** *** ** * * **** * * ** * ENST00000405805.1 ATATAAAGGAGGAAAAACTAGTTTTACTTTCAGA-ATGATTTAAACAAGATTTTTAAAAA ENST00000435986.1 AT-TGTGGCAGACAAAATAATGCCCTCTCCTAGATATGGTTATGCCCTAATCTCCAGAAC ** * * ** **** * ** *** *** ** * ** * * ** ENST00000405805.1 CAAGATACATGCAAGCGAACAGCAG-GGTTAGTGATAGGCTGCAATTGTGTCGAACATCA ENST00000435986.1 CTGTGAATATGTTGTTACATGGCAATAGAAAATAA-AGGTTGCAGATG----GAA--TTA * * *** * *** * * * * *** **** ** *** * * ENST00000405805.1 GATTTTTTGTTAAGAGGAGCAAATGAC-TCAATCTGATTTAGATGGAAGTTTCTACTGTA ENST00000435986.1 AAGTTCCTAAT--------CAGCTGACCTTAAAAGGATTATCATGGGCGTATC------A * ** * * ** **** * ** **** **** ** ** * ENST00000405805.1 TAGAAATCACCATTAATCACCAACATTAATAATTCTGATCCATTTAAAATGAATTCTGGC ENST00000435986.1 TGGATAACGCAGGTGAAC-CCA--ATTAATCACAA-GGTCC-TTTAAAGTGGA------- * ** * * * * * * *** ****** * * *** ****** ** * ENST00000405805.1 TCAAGGAGAATTTGTAACTTTAGTAGGTACGTCATGACAACTACCATTTTTTTAAGATGT ENST00000435986.1 --AAAGGGAGGC-------TTAG--AGCGGGTCA-GA-----GTCA-------------- ** * ** **** * **** ** ** ENST00000405805.1 TGAGAATGGGAACAGTTTTTTTAGGGTTTATTCTTGACCACAGATCTT-AAGAAAATGGA ENST00000435986.1 -GAGAGAGG----------TTTGAAGCT-GTTCC--ACTGCTGGTGTTGAAGAAAGAGGA **** ** *** * * *** ** * * * ** ****** *** ENST00000405805.1 CAAAACCCCTCTTCAATCTGAAGATTAGTATGGTTTGGTGTTCTAACAGTATCCCCTAGA ENST00000435986.1 AGGGGCAACT-----AGCCAAGGA-----ATG----------CAGGCAG---CTTCTAGA * ** * * * ** *** * *** * ***** ENST00000405805.1 AGTTGGATGTCTAAAACTCAAGTAAATGGAAGTGGGAGGCAATTTAGATAAGTGTAAAGC ENST00000435986.1 ACCTGGA------AAAGGCAAATAATTTGATTC---------TTT-------CCTAGGGC * **** *** *** *** * ** *** ** ** ENST00000405805.1 CTTGTAACTGAAGATGATTTTTTTTAGAAAGTGTATAGAAACTATTTTAATGCCAAGATA ENST00000435986.1 C---TGACT----ATGGTTT--------GAATCT-------TTATCTT--CCCCAAGAC- * * *** *** *** * * * *** ** ****** ENST00000405805.1 GTTACAGTGCTGTGGGGTTTAAAGACTTTGTTGACATCAAGAAAAGACTAAATCTATAAT ENST00000435986.1 -TCA---TGTTG----------AAATTTAATTGCCATTGTAA-----TTAAATC-ACCTT * * ** ** * * ** *** *** * ****** * * ENST00000405805.1 TAATTGGGCCAACTTTTAAA--ATGAAGATGCTTTTTAAAACTAATGAACTAAGATGTAT ENST00000435986.1 TAA--GGGGTGA---TTAGACCATGAGGACTCTGCC-----CTAATGGG-TGAGAT---- *** *** * *** * **** ** ** ****** * **** ENST00000405805.1 AAATCTTAGTTTTTTTGTATTTTAAAGATAGGCATATGGCATATTGATTAACGAGTCAAA ENST00000435986.1 ------TAATGCCATTATAA---AAGGGCAAG--TTTGGCCCTCT----------TC--- ** * ** ** ** * * * * **** * ** ENST00000405805.1 TTTCCTAACTTTGCTGTGCAAAGGT-TGAGAGCTATTGCTGATTAGTTACCACAGTTCTG ENST00000435986.1 -TGCCTCTCTTTGCCCTTCCACCATGTGATGCCTTCTGCCA------TGCCA------TG * *** ****** * * * * *** ** *** * *** ** ENST00000405805.1 ATGATCGTCCCATCACAGTGTTGTTAATGTTTGCTGTATTTATTAATTTTCTTAAAGTGA ENST00000435986.1 ATG-------CAGCA-AG-------AAGGCCC-------TTACCAGGT-------ACTGG *** ** ** ** ** * *** * * * ** ENST00000405805.1 AATCTGAAAAATGAAATTTGTGTGTCCTGTGTACCCGAGGGGTAATGATTAAATGATAAA ENST00000435986.1 CACCTTGATATTGGACTT-------CCCA-GCCTCCA----------------------- * ** * * ** * ** ** * ** ENST00000405805.1 GAT ENST00000435986.1 ---