CLUSTAL 2.1 multiple sequence alignment ENST00000409711.1 CCTGCATTTAGATGGCTCCCGCAAAGAAGGGTGGCGAGAAGAAAAAGGGCCGTTCTGCCA ENST00000449897.1 -----------ATGGCTCCCACAAAGAAG---------------AAGGGTCATTCTCCCA ********* ******** ***** * **** *** ENST00000409711.1 TCAACGAAGTGGTAACCCGAGAATACACCATCAACATTCACAAGCGCATCCATGGAGTGG ENST00000449897.1 TCAATGAGGTGGTGACCTGAGCATACA--ATCAACATTCACAAGTGCATCCATGGAGTGG **** ** ***** *** *** ***** *************** *************** ENST00000409711.1 GCTTCAAGAAGCGTGCACCTCGGGCACTCAAAGAGATTCGGAAATTTGCCATGAAGGAGA ENST00000449897.1 GCTTCAAGAAGCATGCCCATCAGGCACTCAAAGAGATCTGGAAATCTGTCATGAGGGAGA ************ *** * ** *************** ****** ** ***** ***** ENST00000409711.1 TGGGAACTCCAGATGTGCGCATTGACACCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAA ENST00000449897.1 GGGGAACTCCAGAACTGTGCACTGATAGCAGGCTCAACAAAGCTGTCTGGGCCAAAGGAA ************ ** *** *** * ******************************** ENST00000409711.1 TAAGGTGCTAAAGTTAT-CTGTATTCGAAGGTGAACTTTTGCAATGACACCAGCTTCACT ENST00000449897.1 TAAGGAAT--GTGCCATACCATATCCATGTGTGG-CTGTCGAGAAAACATAA-------- ***** * ** * *** * *** ** * * * *** * ENST00000409711.1 TAACCCTGCAAGAGC--CCATATCAGTTCAGTAATTTGGTTA---ATGCATGTGGAAGTA ENST00000449897.1 TAAGGATG-AAGATCTACCAAATGAGTTCTACACTTTGGTTACCTATGCACCTGT---TA *** ** **** * *** ** ***** * ******** ***** ** ** ENST00000409711.1 TAAAAAAAAAAAATACTGT-GACCGTGACTTAGGGTGTGTAGTATCTGCAGGGAAGCCCC ENST00000449897.1 CCACTTTCAAAAAT-CTACAGACAGTCATTGTGGATGAGAACTAACTGCTGATCATCAAA * ****** ** *** ** * * ** ** * * ** **** * * * ENST00000409711.1 TTAATTTAGTGGC-TTATGAACTGAGACCCAAGGGAAGGAGCCAGCAGTGTAGGGTGGGA ENST00000449897.1 TACATCAAATAAAGTTATAAAATCA---CCAAA------AATAAACATAAAAAAATAAGA * ** * * **** ** * * **** * * ** * * ** ENST00000409711.1 AAGAGCATTGCAG----AGAGAGGAAGCTTGGCAGGATCTGGGAGCGGGGTGGTGAACGC ENST00000449897.1 AATCACACCTCATCCTCAGAAAGAAAACT-----GACTCCTTCAACTT--CCACAAACAC ** ** ** *** ** ** ** * ** * * *** * ENST00000409711.1 AGGTAAAGTGGAAT--AAATCACT-GTGAGCCCAGTGGAGGAGGGAGGGGTGAGGGTCGC ENST00000449897.1 ATACACACTTCTTTTCAACTTATTTATACACTTTATAAATGTGAATAAAGTGATACTTCC * * * * * ** * * * * * * * * * **** * * ENST00000409711.1 TCTAGACATCATGGCAAGTCCACCAGGAGAGAAGTG--GTTCT-----TGGCCTGCGGCA ENST00000449897.1 T------GCTGTTGCAAA-----CAGGGTATATGTGCTGTTCTCCAAATAGTTCA-AATG * * **** **** * * *** ***** * * ENST00000409711.1 GTTTTACCTGTC-CTTCCCGGGGT-TGTGGCGGGG-GTGGGGGGCAGTGTTTTTTGTCAC ENST00000449897.1 GTTTTAT-TATCACAACCTGAGAAATATTTCAAGAAGCAATGGATCCTGTTGTCTA--AC ****** * ** * ** * * * * * * * ** **** * * ** ENST00000409711.1 TACTGAGGGATACTGTGGGCCAGGGACTACTAAACATCCTACAACTCA--------TGG- ENST00000449897.1 TAGTAAGAGAAGGAAAAGCTCA----TCATCAAATATATCCAAATTCAAAATTTTTTGGC ** * ** ** * ** * *** ** ** *** *** ENST00000409711.1 GGCTGCTCCCTCA---ACAAAAAAT---TGCCTAGCTCAGATGTTAGTTCTCATGTTGGG ENST00000449897.1 AGCTATTTTCTAGTTTACACAAGGTAAATACCAAAC---AAAGTCAGTTCA---GCAGGG *** * ** *** ** * * ** * * * ** ***** * *** ENST00000409711.1 GGACCCTGCTCTAAAGTGGAACCAGAAAGCAGGGGAGGC-TTGTGCTG----TAA-AGGA ENST00000449897.1 CAATTC----CTGGAG--GAACATATTTTTACCCAATTCCTTCTGCTAGGCCCAATAGGA * * ** ** **** * * * ** **** ** **** ENST00000409711.1 CGTCATGAGGTGCCAGAACAGAAGTGGAGTGAGGGG--CAGCTAG---AGGAATGAT--- ENST00000449897.1 CATGATATTATTTC--AACTCAACTATTGTGAAGAATTCAGTCACCTTAGAATTGATATG * * ** * * *** ** * **** * *** * ** * **** ENST00000409711.1 GACAGT--GTGG-ACTAGTTG-ATTCTGGAAACGGGTTGGGGGAGGACTGTCTGC-ATCT ENST00000449897.1 GACAACTGGTGGCACTTTCCACATTTT-----CCTGTTAC---AGGGATCCCTGCCATCT **** **** *** *** * * *** *** * **** **** ENST00000409711.1 -GTGTGGTATTTAAACCTTAGG--ATTAAGTGAG---------ATGAACA-AGACAGGGA ENST00000449897.1 TGCGTGGCATG-AAATTCTAGGGTATCAACAGAGTACTTACTCAGGAACGTAGACTGTTT * **** ** *** **** ** ** *** * **** **** * ENST00000409711.1 CCTGAGACCTAGCTCTTCTGTGGGTGGACATTGAAGGGTGCAGCAGGAGAGGTGTCCTCC ENST00000449897.1 CTTGAAAAATATTTTGCCTCTGCCTAGA--------GATACCGCTATAGTCACACCCATG * *** * ** * ** ** * ** * * * ** ** ** ENST00000409711.1 GATGCCTGCCTTGGGATAAGAG---GAATGGG-ATTACAGGA-GCCAAGA-GAAGTCCTG ENST00000449897.1 GAAGAACACATCCCAGTAAGAATATAAGTCAGTATTTTGGTATGTCATGATGAAATGCTA ** * * * ***** * * * *** * * * ** ** *** * ** ENST00000409711.1 --AGTTTATAGGAATCGGGGC-----CTAGAACAATACCCGGCATCGATAGAGGAAA--- ENST00000449897.1 CTGCCTTGACATAACCGTTTTACTAGCTAAAATATGAATCAGCTCTATTAGTAAAAATTT ** ** ** *** ** * * * ** *** *** ENST00000409711.1 ---GAGAATCAGCTGTGATGCTACGGAGAGGGTAAGAC------------AGGACAAGGG ENST00000449897.1 AGTGAGCTTCTGCTATGTGCCTAGATGAAATGCACAGCCTCTGCTTTCAAAGAAAAAAAT *** ** *** ** *** * * * * ** * ** ENST00000409711.1 GATTGCATGTGGAAGATAGAGAA-----ATAGAGTATGCGCCTGTGGCAGAGTTTTTAAC ENST00000449897.1 ATTTAGATA-GGAAAATAGATGAGTAACATAAAGGGTATCTATACAACAAGTTCCTCAAC ** ** **** ***** * *** ** * * ** * * *** ENST00000409711.1 --ACTGTTTTTT-GTTCGTTTTGAGATGGAGTTAATGTTGCCCAGGCTGGAG----CGCA ENST00000449897.1 TGAGAGCTGTATAGCTTGTCTCAGGC---AGTTAAGACAGCCAATGTGTAAGAAGACACA * * * * * * * ** * * ****** *** * * ** * ** ENST00000409711.1 ---ATGGCGTAGTCTCAGCTCACT-GCAACC--TCCACCTC-----CTGGGTTCCAGCTA ENST00000449897.1 TCTAAAGCAATGTTTAGGCACACTTACAATTATTTCATGTCTATTTCTCTTTTCTACTTA * ** ** * ** **** *** * ** ** ** *** * ** ENST00000409711.1 TTT--TCCTGCCTCAGCCTC---CCAAGTAGCTG--GGATTACAGGCAGCCGCCACCACG ENST00000449897.1 CTTATTTCCTCTTTTCCCTCACTCCATGAAACTGATGGACTTTAGGCAAT-------ATA ** * * * * **** *** * * *** *** * ***** * ENST00000409711.1 CCTGGCTCTTAGTTTTGCATTTTTAGTAGAGAGGGGTTTTACCATGTTGGCCAGGGTGAT ENST00000449897.1 T-TAGTTCCCAGTAT---AATTTGGGTTGGGAGATACTTATCCA--ATAGATAGGCTGGC * * ** *** * * *** ** * *** ** *** * * *** ** ENST00000409711.1 CTCGAACTCCTGACCTCAGATGATGCACCCACCTCAGCCTCCCAAAGTGCTGGGGTTACA ENST00000449897.1 TGTAATTTCCT--TTAAGGATTCTTTTTTTTTCTCTTCATGTCAAGTTA----GACCACT * **** *** * *** * * *** * * ** ENST00000409711.1 GGGGCAAGCCACC---------ATGCCGTTTCTTCATATTTTAATG---TAACA------ ENST00000449897.1 AGA-CAAGACATTCCTATAAATATAAAGAGTCCTTG-ATTTTACTGGCTTAACACCTTAT * **** ** ** * ** * ****** ** ***** ENST00000409711.1 --GAAAAATCACGTAACAAAGTTTCTGGTGATA--GACAAAAGACTAACACATTTGGACC ENST00000449897.1 ATGCAAAATTACTTTTT----TTTTTAGTAATTATGTCTTTAGATTGTTTTATTTTTATC * ***** ** * *** * ** ** * * *** * **** * * ENST00000409711.1 ATTTG-GACCCAGATA-TCTGCTT-----AGGATTAACCGGTTG-----GGTATCAATGG ENST00000449897.1 AAACGTGACTCAAGTAGTCCATCTTCAACAGGAATATTAAGTTACTAAAAAAATCAGGAT * * *** ** ** ** * **** ** *** **** ENST00000409711.1 TGGCTACCTTAACATGTCTTCAAACAAGCATCCCTCCTGTGGTAACAGCATTTAATGTTC ENST00000449897.1 TGGAAACTTTATCACA--ATTAAATTTAAAAGTTTATAATAAAAACAGGAT--GAAAATA *** ** *** ** * *** * * * ***** ** * * ENST00000409711.1 ACCTGGGG-GTTATGTTTCATTTTCCAGGGAACTGTAAGT-TCTAGGTTGGTCAGAGTAG ENST00000449897.1 ATTTGGGAAGTGAAATTTGA------AAGCCCCAATAAATATTTAGTATTTTC----TAA * **** ** * *** * * * * *** * * *** * ** ** ENST00000409711.1 AGCAAAGGA-CAGCATTAGAAGC--AGGCATATGAGATATGTGAATACAGCTAGTGGCTG ENST00000449897.1 AATAAAGGAATAATACTAAAAATGAAAACATACAAAGTATTCACCTTTAATTATTAA--- * ****** * * ** ** * **** * *** * * ** * ENST00000409711.1 CTTGGTTGAAAGGAGGCATTGACTTCAGCAACACAATTATGTTTTTATTAGGAATGTGCC ENST00000449897.1 --TAGTGGGTATGACA-ACTGATTTCTACGTC-TACTCTTATTTTT-TCAGAAACCCGTC * ** * * ** * *** *** * * * * * ***** * ** ** * * ENST00000409711.1 ATACCGAATCCGTGTGCGGCTGTCCAGAAAACGTAATGAGGATGAA------GATTCACC ENST00000449897.1 AA---GAGTTCTC------CTCCCCAATATTTTTCATAATTATAAATGTTTTGTTTTACT * ** * * ** *** * * ** * ** ** * ** ** ENST00000409711.1 A--AATAAGCTATATACTTTGGTTACCTATGTACCTGTTACCACT-TTCAAAAGTAAGTT ENST00000449897.1 ATAGATAAAATGTACACT------AAACATGT-TCTGTTGCTACCATTCTAGGTCTGATC * **** * ** *** * **** ***** * ** *** * * ENST00000409711.1 CTCCATCCCAT-----AAAGCCATT-TAAATTCATTAGA-AAAATGTCCTTACCTCTTAA ENST00000449897.1 CTTCATCCCATTTTTCAGTGCCTTTCTGATTTTATCAAGCAGAATGC---TAACTATTAA ** ******** * *** ** * * ** ** * * **** ** ** **** ENST00000409711.1 --------AATGTGAATTCA---TCTGTTAAGCTAGGGGTGACACACGTCATTGT-ACCC ENST00000449897.1 GTCCACCTAATTAGGGCCCAGCTTCTGCCAGACCTTCTTTTTTTTTTTTTTTTTTGATCT *** * ** **** * * * * ** * * * ENST00000409711.1 TTTTTAAATTGTTGGTGTGGGAAGATGCTAAAGAATGCAAAACTGATCCATATCTGGGAT ENST00000449897.1 TTTTTTTATTATT--TTTACTATTATACTTTAAGTTTTAG----GGTACATGTGCACAAC ***** *** ** * * * ** ** * * * * * *** * * ENST00000409711.1 GTAAAAAGGTTGTGGAAAATAGAATGCCCAGACCCGTCTACAAAAGGTTTTTAG-AGTTG ENST00000449897.1 GTGCA--GGTT-TGTTACATATGTTTCTTA--CCCATTTGCAACACCTAGGAAGCAGTTC ** * **** ** * *** * * * *** * * *** * * ** **** ENST00000409711.1 AAATATG-AAATGTGATGTGGGTATGGAAATTGACTGT-------------TACTTCCTT ENST00000449897.1 CAAGGTCCAGGTTCAATCTAGACCTTAAAATACCCTGTATGCCTCCTGTTCTTCTTCCTC ** * * * ** * * * **** **** * ****** ENST00000409711.1 TACAGATCTACAGACAGTCAATG--------- ENST00000449897.1 TTTTTGGCTACAAGTGTCCAAAGACACAGACA * ***** *** *