CLUSTAL 2.1 multiple sequence alignment ENST00000412624.1 ----TCCCTGGCCCCACCTCTTCTGCCACAAACGTCAGCATGGTGGTATCAGCCGGCCCT ENST00000445758.2 CCAGTCCCTGGCTCCACCTCTTCTGCCACAAACGTCACCATGGTGGTATCTGCCGGCCCC ******** ************************ ************ ******** ENST00000412624.1 TTGTCCAGCGAGAAGGCAGAGATGAACATTCTAGAAATCAATGAGAAATTGCACCCCCAG ENST00000445758.2 TGGTCCAGTGAGAAAGCAGAGATGAACATTCTAGAAATCAATGAGAAATTGCGCCCCCAG * ****** ***** ************************************* ******* ENST00000412624.1 CTGGCAGAGAAGAAACAGCAGTTCAGAAACCTCAAAGAGAGATGTTTTGTAACTCAACTG ENST00000445758.2 CTGGCAGAGAACAAACAACAGTTCAGAAACATGAAGCAGAAATTTCTTGTAACTCAAATG *********** ***** ************ * ** *** ** * *********** ** ENST00000412624.1 GCCGGCTTCCTGGCCAACCAGCAGAAGAAATACAAATATGAAGAGTGCAAAGACCTCATA ENST00000445758.2 GCCGGCTTCCTGGCCAACCAGCAGAACAAATACAAGTATGAGGAGTGCAAAGACCTCATA ************************** ******** ***** ****************** ENST00000412624.1 AAATCTATGCTGAGGAATGAGCGACAGTTCAAGGAGGAGAAGCTTGCAGAGCAGCTCAAG ENST00000445758.2 AAATCTATGCTGAGGGAAGAGCTGCAGTTCAAGGAGGAGAAGCTTGCAGAGCAGCTCAAG *************** * **** ************************************ ENST00000412624.1 CAAGCTGAGGAGCTCAGGCAATATAAAGTCCTGGTTCACGCTCAGGAACGAGAGCTGACC ENST00000445758.2 CAAGCTGAGGAGCTCAGGCAATATAAAGTCCTGGTTCACTCTCAGGAACGAGAGCTGATC *************************************** ****************** * ENST00000412624.1 CAGTTAAGGGAGAAGTTGCGGGAAGGGAGAGATGCCTCCCGCTCATTGAATGAGCATCTC ENST00000445758.2 CAGTTAAGGGAGAAGTTACGGGAAGGGAGAGATGCCTCCCACTCACTGAATCAGCATCTC ***************** ********************** **** ***** ******** ENST00000412624.1 CAGGCCCTCCTTACTCCGGATGAGCCGGACAAGTCCCAGGGGCAGGACCTCCAAGAACAG ENST00000445758.2 CAGGCTCTTCTCACTCCGGATAAGCATGACAACTCCCAGGGGCAGGACTTCCGAGAACAG ***** ** ** ********* *** ***** *************** *** ******* ENST00000412624.1 CTGGCTGAGGGGTGTAGACTGGCACAGCACCTTGTCCAAAAGCTCAGCCCAGAAAATGAC ENST00000445758.2 CTGGCTGAGGGGTGTAGGCTGGCACGGCACCTTGTCCACAAGCTCAGCCCAGAAAATGAC ***************** ******* ************ ********************* ENST00000412624.1 AACGATGACGATGAAGATGTTCAAGTTGAGTTGGCTGAGAAAGTGCAGAAATCGTCTGCC ENST00000445758.2 ACAGATGAGGATGAAAATGATAAAACCAAGGAGCTTGATAAAGTACAGGAATCACCTGCT * ***** ****** *** * ** ** * *** ***** *** **** **** ENST00000412624.1 CCCAGGGAGATGCAGAAGGCTGAAGAAAAGGAAGTCCCTGAGGACTCACAGGAGGAATGT ENST00000445758.2 CCCAGGGAGGAGCAGAAGGCTGAAGAAAAGGAAGTCCCTGAGGACTCACTGGAGGAATGT ********* ************************************** ********** ENST00000412624.1 GCCATCACTTATTCAAATAGCCATGGCCCTTATGACTCCAACCAGCCACATAGGAAAACC ENST00000445758.2 GCCATCACTTATTCAAATAGCCATGGCCCTTCTGACTCCAACCCGCCTCACAAGAACATC ******************************* *********** *** ** * *** * * ENST00000412624.1 AAAATCACATTTGAGGAAGACAAAGTCGACTCAACTCTGATTG------GCTCATCCTCT ENST00000445758.2 AAAATCACATCTGAGGAAGACAAAGTCAACTCAATTCTGGTTGTAGACAGTGAATCTTCT ********** **************** ****** **** *** * *** *** ENST00000412624.1 CATGTTGAATGGGAGGATGCTGTACACATTATTCCAGAAAATGAAAGTGATGATGAGGAA ENST00000445758.2 CAAGATGAATGGCAGGATGCTCTAAACATTCTTCTGGAAAATCAAAATGATGATGAGGAA ** * ******* ******** ** ***** *** ****** *** ************* ENST00000412624.1 GAGGAAGAAAAAGGGCCAGTGTCTCCC-AGGAATCTGCAGGAGTCTGAAGAGGAGGAAGT ENST00000445758.2 GAGGAAGGGAAAGCGCCAGTGCCCCCCCAGGAAGCTGCAGGAGTCTGAAGAGAAGGAAGT ******* **** ******* * *** ***** ****************** ******* ENST00000412624.1 CCCCCAGGAGTCCTGGGATGAA--GGTTA----TTC-------GAC-------TCTCTCA ENST00000445758.2 CCTGCAGGACTCCCCGGAGGAAAGGGTTACGACTTCTTGTAGTGACCATGATGTGTCCCA ** ***** *** *** *** ***** *** *** * ** ** ENST00000412624.1 ATT-------CCTCCTGAAA------TGTTGGC-CTCGT--ACCAG---------TCT-- ENST00000445758.2 ATCTTACCAACCTTGTGAAGGCACTTTCTTGGCACTAGTTGAACAGAAAGTTTGCTCTGC ** *** **** * ***** ** ** * *** *** ENST00000412624.1 ------TACAGC-----AGCAC---------------------ATTTCACTCA------- ENST00000445758.2 TCAGGATGTAGCCAGCGAACACTCCAATTCCAAAGGGGAAGAAACTCCACTTGGCTTCCC * *** * *** * * **** ENST00000412624.1 ----------TTAGAG--------------GAA----------CAGC---AAG------- ENST00000445758.2 AGAGCTGGGTTTAGAGCCTTCCCTTGCAATGAAGATCCCTCCCCAGCTGGAAGGTGATGC ****** *** **** *** ENST00000412624.1 TCTGCATGGCT--GTTGACA-------TAGGCA----GACATCGGTGGGAT--------C ENST00000445758.2 TCTTGAAGGTTCAGCTGACAACACACATGGGCATCAAGTCATTGGCCACATTCACGCCTC *** * ** * * ***** * **** * *** ** ** * ENST00000412624.1 AAGTG----AAAA---AGGAGGACCAAGAG--------------GCAA------------ ENST00000445758.2 AAGTGTCCTAAAACCAAAAATGATCAAAAGAAAACTGCCGTTCAGCAAGTGGAGACTGGC ***** **** * * ** *** ** **** ENST00000412624.1 ---CAGGTCC---------CAGGCTCAGCAGGGA------GCTGCTGGA----TGA---- ENST00000445758.2 ATGCAGATTCTCTGGCCTGCAAGCTTAGCAGATACCAAATACTGCTGGAAGGATGAAAAG *** * * ** *** ***** * ******** *** ENST00000412624.1 ---GAAAGG-----------------------GCCTGA---------------------- ENST00000445758.2 GATGAAAGGATGTCACAAAAAGTAGCTTTTCTGCTCGATGAAAAAAACTACAACAGCAAA ****** ** ** ENST00000412624.1 ---AGTCT-----------------TGCAGGACTC-----------ACTGGAT------- ENST00000445758.2 CCAAGTTCAATTCCAAACACAACACTGCAGGGCTCCTTCACTGAGGATTGAATTTTAGAC *** ****** *** * ** ** ENST00000412624.1 ---AGATGTTATT--------CAA---------CTCCTTCAGGTTGT------------- ENST00000445758.2 ACAGAATGCTCTTGATGATTGCAAACCACTAGGCTCCTTTGATTTGAGAAACCACAATTC *** * ** *** ****** *** ENST00000412624.1 ------------CTTGAACTGACT---------GACTCATGCC----------------- ENST00000445758.2 ATCCTATTTCCACTTGAGATGAATACCCAAGGAGACCAATTCCCAGATGGACAAACAGCA ***** *** * *** ** ** ENST00000412624.1 ------------AGCCCT---------------------------ACAGAAGT------- ENST00000445758.2 TTGAGAGGCCTTAGCCCTGCTCCTCTCAATTCCATCCTGTAGAGAACAGGAGTCAGGAGC ****** **** *** ENST00000412624.1 ---------------GCCTTTTAC-------------------GTATTGGAGCAACAGCG ENST00000445758.2 CGCTGGCAGGAGACAGCATGTCACCCGGGACTCTGCCAGTGCAGAATATGAACAATGCCA ** * * ** * ** ** *** * ENST00000412624.1 TGTT-----GG------CTTGGCT---GTT-------------------GACA------- ENST00000445758.2 TATTCTTGCGGAAAACACTTAGCCTGAGTTTCATAGGAAGTAATCAGCAGACAACTGCAG * ** ** *** ** *** **** ENST00000412624.1 ----TGGA----TGA-------AATTGA-------------------------------A ENST00000445758.2 AATGTAGAACACTGAGCAGGACAACTGACCGCTCTCCTTCACACAATCCATGTCACCACA * ** *** ** *** * ENST00000412624.1 AAGTAC----CAAGAAG-------------TGG----AAGAAGACCAAGA---------- ENST00000445758.2 AATCACACAACAAAAAGAGAAGAGACATTTTGGGTTCAAAAGGATTGAAAAGATAATGTA ** ** *** *** *** ** * ** * * ENST00000412624.1 -CCCA---------TCAT-----GCCCCAGG------CTCA------------------- ENST00000445758.2 GCTCACTTCTTTAGTCACTTTGAACCCAAAGTATCTCCTCATCTTTTTGTTGTTGTCATT * ** *** *** * * **** ENST00000412624.1 ------------------------GCAGGG------AGCTG-CTGG-------------- ENST00000445758.2 GATGGTGGTGACATGGATTTGTTTGTAGAGGACGTCAGCTGTCTGGCTCAATTTTCTTCA * ** * ***** **** ENST00000412624.1 ----------ATGAGAAAG-------------------AGCCTGAA-GTCTTGCAGGACT ENST00000445758.2 TTCTGAAGTTGTCAGAAAATTTCCTTATGATTAAATTCAGCCTAAATGTTTTGCCAGGAA * ***** ***** ** ** **** * ENST00000412624.1 CACTGGATAG---ATGTTAT------TCGACTCC-----------------------TTC ENST00000445758.2 CACTGCAAAGTCAATGCTGTGAGTTTCCAACCTCAGTCCATCTGCGGGCAGAGAAGGTCC ***** * ** *** * * * ** * * * ENST00000412624.1 AGGTTATCT-------------TGA-------ACTG----CCTGACTTAGG------CCA ENST00000445758.2 AGTTTGTCCATCACCATTATTGTGATATCAGGACTGGTTACCTGGTTAAGGAGGGGTCTA ** ** ** *** **** **** * *** * * ENST00000412624.1 G---------CCCT-------ACAGC---------------------AGTG--------- ENST00000445758.2 GGAGATCTGTCCCTTGTAAAGACACCTGATTTATAATTAATTTGAAAAGTGGTTTGAAAA * **** *** * **** ENST00000412624.1 -----------CTGTTTACT-----------------CATTGGAGGAACA---------- ENST00000445758.2 AGTACAAATACCTGTATTCTAACAATCTTCCTCTGAGCATTTTATCATCAATTAATCACC **** * ** **** * * ** ENST00000412624.1 -------------------------------GTACCTTGG----------CTTGGCTCTT ENST00000445758.2 CCTGGCTGTGTCAGTTATTATATTTATGTTTGTACGTTGGAAATTTTTATCTCAGTCCTT **** **** ** * *** ENST00000412624.1 GACGTGGAC-----------AGAACT--------AAAAAGGA------------------ ENST00000445758.2 AGTATGAACTTGTTTCTGCTGGCATTCTGTTGTGAAAAAGAATATTCCCTGCCCAAATTT ** ** * * * ****** * ENST00000412624.1 ----------CCAAGA----------------AGAGGAAGAA------------------ ENST00000445758.2 TAACTTTCATCCAAGATTAATTTTAGTCTATTAAAATTAAAATGTTTATGTTTTAAATCT ****** * * * ** ENST00000412624.1 --------------------------------GACCAAGG-----------CCCACCATG ENST00000445758.2 GTTTAATTAAAATATTCTTGCCTATTACTCTGGACTAGTGAATTTTTTTTACACACAATG *** * * * *** *** ENST00000412624.1 CCCCAGGCTC------------------------AGCAGGGA-----GCTGCTGGAG--- ENST00000445758.2 TTTTAAGCTTTTATTATTATGATTGTTTTTGGTGGGTAAGGATACAGATTAATAAAAACA * *** * * *** * * * ENST00000412624.1 ------------------------------------------------------------ ENST00000445758.2 TTCTTATTTCCCTGTTTACATTCCAAACTCTTCCATATTTTAGTCTACATTTATCATATG ENST00000412624.1 --GTAGTAGA--------------------------------------GCCT-------- ENST00000445758.2 TAGTAGTAGATGGTATTTACTACATTTCTTTGTCAATGTTATTTTGTTGTCTTTGTTTGT ******** * ** ENST00000412624.1 --------------------------GAAGTCTTGCAGGACTCA--------------CT ENST00000445758.2 GTGTGTGTCTTTTGTTTGTTATTTAGGAAGGGTTGTGTAGCTCATGTTTGAAAGTGCACT **** *** **** ** ENST00000412624.1 GGATAGATGTTA----------------------TTCAACTC------CTTCCAGT---- ENST00000445758.2 AAACATGTTTTGGCATCATGTTTAAAAGTCCCCTTTTAACTTGACACACTTCTAATATTT * * * ** ** **** **** * * ENST00000412624.1 ----------------------TGTCTTGAA---------------------CAGCC--- ENST00000445758.2 GGTTTATACATTTTTAATCTTCTCTTTTGAATTTAAATTTTTACCACTATGACAACCAAA * * ***** ** ** ENST00000412624.1 --------------------TGACT------CCTGCCAGCCCT-ATGGA---AGTTC--- ENST00000445758.2 GATATTATTTTCCTCTTCTCTGACCTCTTAACCTGCCATTTCTTATGGTGTTAGTTCAAC **** ******* ** **** ***** ENST00000412624.1 ---------------------------------------------------CTTTT---- ENST00000445758.2 CCAAGCATATACCAGTGACCGCCTGTGTTTCCCACCTTGTCTCCACCTTGGCTTTTGGTT ***** ENST00000412624.1 ---ATGCA---TTG--------GAGG--------------AAAA---------------- ENST00000445758.2 CAGATCCACAATTAAATATGCTGAGGCTCATGAACTATTCAAAAGTGAGTGTCCTGGGCA ** ** ** **** **** ENST00000412624.1 --ACATGTTGGC-----TTTTCTCTCGACG---------TGGGAGAA------------- ENST00000445758.2 TCACTTGTTGAAAGGAATTTATTCTTGACAGAGTCCTCATGGGGGAATAGGGGCTCGCTG ** ***** *** *** *** **** *** ENST00000412624.1 -----------------------------------------------------ATTGAAA ENST00000445758.2 AGTTTAGCATGCTTAATAACCTTTTCCCACTGCCTTGGTACATGGCGCACATCACTAGAT * * * ENST00000412624.1 AGAAGGGG-------AAGGGGA----------------AGAAAAGA------------AG ENST00000445758.2 AAAAGGTACTTGCCAAAAAAGATTTTTCTTGAGTTTTTAGAAAATATTGTCTTGCTTTAG * **** ** ** ****** * ** ENST00000412624.1 GGGAAGAAGAT--------------------------------------CAAA------- ENST00000445758.2 AGGACAAGGATGGTGTTTGTTCTCATTCTGGGATTCTATTTTGTTCTACCAGGACCACTA *** * *** ** ENST00000412624.1 -------------------------- ENST00000445758.2 ATTTCTGCCAGTTACTTCATTCATTG