CLUSTAL 2.1 multiple sequence alignment ENST00000422466.2 AGCCAGTGCTAAGTTCGCTTGCGGCTGACCTTTCTTTGGAATGTCGTGAGTTCCATTTGT ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 CCCAGAATACGGTCCGCTACCGCTGTGACATGAGTGTTAGGGAAGGCGGGTTGTCACGTT ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 TCTACAAGCCTTCCAGTCAAAAGGGAAACCTTGCCTAAGTCCTTGTAGTTGAGAAATCTC ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 TAAGAGGTGGAAGCAAATACTGCACATGCGTGTTGGTCCTGTGAGGGAAACCAGCTAGTG ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 GAGAGGGAGAGGTTGAAGGAACAGAAAAATGAGAAGACAACTCACTGGAGGCTGAAGTGG ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 GAGGATCGCTTGAGTCTGGAAGCTTGAGACTGCAGCAAGCTGTGATCGTGACACTGCACT ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 CCAGCCTGGGCAACAAAGTAAGATCCTGTCTCAAAAGAAAAAAAAAAAAAGGTGAAGCTG ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 AACCCAGATCTACACATACAGCTAATCTTACCAAAATGTGTGGAAGTAAAGCAATCTGAA ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 GGAAATTCAGTACCATACAATTTACTGACTGAAATACATCATATTGCTCATACTAAGAAT ENST00000533503.1 ------------------------------------------------------------ ENST00000422466.2 AAGAGTGGAGAAGAATCATTTTTTTCCTGCTAAAATGATAGAGGCAGAAGAGCAACAGCC ENST00000533503.1 ---------------------------------TATAATGGAGGCAGAAGAGCATCAGCC ** ** ************** ***** ENST00000422466.2 TTGCAAGACAGACTTCTATTCTGAATTGCCAAAAGTGGAACTTCATGCCCACTTGAATGG ENST00000533503.1 ATGGAAGGTAAGCTTTTACTCTGAATTGCCAAA-GTGGAACTTCATGCCCACTTGAATTG ** *** * *** ** ************** ************************ * ENST00000422466.2 ATCCATTAGTTCTCATACCATGAAGAAATTAATAGCCCAGAAGCCAGATCTTAAAATCCA ENST00000533503.1 ATCCATTAG-----------------AACTAATGG------ATCCAGA-------ATCCA ********* ** **** * * ***** ***** ENST00000422466.2 CGATCAGATGA--CTGTGATTGACAAGGGAAAGAAAAGAACTTTGGAAGAATGTTTCCAG ENST00000533503.1 CGATCAGACAAAACTGTGATTGACAAGGGAAAAAAACAAACTTTAGAAGAATGTTTCCAG ******** * ******************* *** ****** *************** ENST00000422466.2 ATGTTTCAAACTATTCATCAGCTTACTAGTAGCCCTGAAGATATTCTAATGGTCACAAAA ENST00000533503.1 ATGTTCAAAATGATTCATCAGCTTACTAGTAGTTGGGAAGGTATTCTAATGGTCACAAGA ***** *** ******************** **** ***************** * ENST00000422466.2 GATGTCATAAAAGAATTTGCAGATGACGGCGTCAAGTACCTGGAACTAAGGAGCACACCC ENST00000533503.1 GATATCATTAAAGAATTTGCAGA-------GT---------------------------- *** **** ************** ** ENST00000422466.2 AGAAGAGAAAATGCTACTGGAATGACTAAAAAGACTTATGTGGAATCTATACTTGAAGGT ENST00000533503.1 ------------------------------------------GAATCTATACTTGAAAGT *************** ** ENST00000422466.2 ATAAAACAGTCCAAACAAGAAAACTTGGACATTGATGTTAGGTATTTGATAGCAGTTGAC ENST00000533503.1 ATAAAACGGTCCAAACAAGAAAACTTAGACACTGACGTTAGGTA---------------- ******* ****************** **** *** ******** ENST00000422466.2 AGAAGAGGTGGCCCTTTAGTAGCCAAGGAGACTGTAAAACTTGCCGAG---GAGTTCTTC ENST00000533503.1 --AGGACATTGTACCTTAGTAGTTA---ACATTTTAAAAAAAACAGAATGTGAATTTTTA * ** * * * ******* * * * * ***** * ** ** ** ** ENST00000422466.2 CTTTCT--ACTGAGGGTACAGT------TCTTGGCCTTGACCTCAGTGGAGACCCTACTG ENST00000533503.1 CTGTTTTGATTGTGGGTGTAATGGATTTTTTTAAATTAGCTATTAATTGAT-TTCTAAAA ** * * * ** **** * * * ** * * * * * ** *** ENST00000422466.2 TAGGACAAGCAAAAGACTTCTTGGAACCT-CTTTTAGAAGCTAAGAAAGCAGGTCTGAAG ENST00000533503.1 TAGAA--AATAAAA----TCAAGAACCCTACTGTTTAAAG-TGAGAATACAATTCTGAAT *** * * **** ** * * *** ** ** *** * **** ** ****** ENST00000422466.2 TTAGCATTGCATCTTTCAGAGATTCCAAACCAAAAAAAAGAAACACAAATACTCCTGGAT ENST00000533503.1 TTA-----------TTCA-------TATGGCAATAAAA--------------TTCTGAGT *** **** * *** **** * *** * ENST00000422466.2 CTGCTT-CCTGACAGAATCGGGCATGGAACATTTCTCAACTCCGGTGAGGGAGGATCCCT ENST00000533503.1 ATTTTTACTTGAGTAAACAAAAGAC--AACATTTC---------------AAGGAATTTG * ** * *** ** * ******** **** ENST00000422466.2 GGATCTGGTGGACTTTGTGAGGCAACATCGGATACCACTGGAACTCTGTTTGACCTCAAA ENST00000533503.1 GAATAAAGTAGAG-----AAGGCAG----GGAAATGAAC--AACTGTGTGTGAC---AAG * ** ** ** ***** *** * * **** *** **** ** ENST00000422466.2 CGTCAAAAGTCAGACAGTTCCATCTTATGACCAGCACCATTTCGGATTCTGGTACAGCAT ENST00000533503.1 GGACACAAAGCAA--AGTTAAA------AGCCAGAGACAAT------------------- * ** ** ** **** * **** ** * ENST00000422466.2 TGCCCATCCTTCTGTGATCTGTACTGATGATAAGGGTGTTTTTGCAACACACCTTTCTCA ENST00000533503.1 ----------------AACTTTACTGTT--TGAGG-------------ACATCTTAC--- * ** ***** * * *** *** *** * ENST00000422466.2 AGAGTACCAGCTGGCAGCTGAAACATTTAATTTGACCCAGTCTCAGGTGTGGGATCTGTC ENST00000533503.1 ---GAATCAACAGGAAA--GAGAC---TAATATCA-----TAACAGG-GAAAAATATGT- * * ** * ** * ** ** **** * * * **** * ** *** ENST00000422466.2 TTATGAATCCATCAACTACATCTTTGCTTCTGACAGCACCAGATCTGAACTGAGGAAGAA ENST00000533503.1 --GTAAG-----CAA-TATAT--------------ACAC-------AAATTAAGAAAGAA * * *** ** ** *** ** * ** ***** ENST00000422466.2 ATGG-AATCACCTGAAGCCCAGAGTGTTACATATTTAAGCTATAATGAGGTGAACTACTT ENST00000533503.1 ATCATAACTTTCTAAAT----AACTGTTA------------ATATTGATATAAATTATT- ** ** ** ** * ***** *** *** * ** ** * ENST00000422466.2 CTGAGTAT--GTGTTTCAATCAAGTTCCTGCCATATCCCACTTAGTAAAACAGTCCACCA ENST00000533503.1 ---AATATTCATATTGGAATCAAA-----AAGAGATTC---------AAACAATACAG-A * *** * ** ****** * ** * ***** * ** * ENST00000422466.2 CTCCTTTGAAGCATAGCAACCAAGTTCCTTGGGCTCTATCACCAGCACCTTACACATGGC ENST00000533503.1 CGCTAGTAGGGC--AACGATCAA----CATGACCTCTAT-GCTGGCAAA--ACATATAAA * * * ** * * * *** * ** ****** * *** *** ** ENST00000422466.2 AGGTACTCAGTAAATACGTGTCTTCAACTGACTCACAAGCTCTCAGGTGCTTACTGGGTG ENST00000533503.1 AAGCTTTCA--AAAT--GTGTCAT------ATTCCCAG----TCAAGTCATCGCAAAAAA * * *** **** ***** * * ** ** *** ** * * ENST00000422466.2 GGACTTGACTGTTGTTGCTAATTAAATCCCCATTCCACCAGTGA-----TTATTGTGACT ENST00000533503.1 AGAA--AACTGCAA--ACCAAT--ATCCCTCACAACAACAGAAAGATCCTTAACGAAAAT ** **** * *** * ** ** ** *** * *** * * * ENST00000422466.2 --CAGCAG------TCCTTCCCTATTAGTGATCATAAAATTTCAGGGAAATCGAAGTTTC ENST00000533503.1 ATTAGCAAATAGAATCCTATAATATAAAT-ATAAAGAAATCTTGCTTAAAT-GGAGTTTT **** **** *** * * ** * **** * **** * ***** ENST00000422466.2 TCATCAGGAAATGTTTTGGAATTACTAGTATAAAGT-TAGGAAAGTGGGGAAATTAGGTT ENST00000533503.1 TCA--AAGGAA----TTTAAATT--TGATTCAACATGTAGCAG---GGGGAAATCAA--T *** * * ** ** **** * * ** * *** * ******** * * ENST00000422466.2 ACTGCCGAGACCTTTAAGCCTTCTAAACAGCTTTATATTTTATTGTGCATACTTTAATCA ENST00000533503.1 AC-ACCATAATCAACAGGC----TAAAAACCACCACGTCAT--------CACCTTAAT-- ** ** * * * ** **** * * * * * ** ***** ENST00000422466.2 GACTCCCTTCACTCGCTTTAAGTTTTTAAAAGTATTCCCCAGCCGGATGTGATGGCTCAT ENST00000533503.1 --------------GTTTACAGA----AAAAGCATCT----GACACAAGTCACAATTCAT * ** ** ***** ** * * * ** * **** ENST00000422466.2 GCCTGTAATCCCAGCACTTTGGGAAGCCAAAGTGGGCAGATTGCTTGATCCTAGGAGTTC ENST00000533503.1 -TTTATCATAAAAACACT-----AAGCCAG--------------------CTAGGAATA- * * ** * **** ****** ****** * ENST00000422466.2 AGTAGCAGCCTAGGCAACATGGAGAAACCCTGTCTCTACAAAAACAAAAAAACAAAAAAC ENST00000533503.1 GATGGAAGCTTCTCAAACTCATAGGCA-------TTTACAAAAA-----AAACTTACAGC * * *** * *** ** * * ******** **** * * * ENST00000422466.2 CGGAAATTAGTCAGGCACGGTGGTACACACCTGTAGTCCCAGCCACCAGGGAGGCTAAGG ENST00000533503.1 TAACA-----TCAGATGTAATGGTAAAAGACTGAATGCTTCCCCCTCAG------TAAGA * **** ***** * *** * * ** *** **** ENST00000422466.2 TGGGAGGAGACCTGATCCCAGGGATGTTTGAGGCTGCAGTGAGCTGTGATGCTACAGCAC ENST00000533503.1 T--CAGGA-AC---AACACAGCAATATCTA---CTCTCACCA-CTTCTATTCCACAG-AT * **** ** * * *** ** * * ** * ** ** * **** * ENST00000422466.2 TCCAGCCTGGGCAACAGAGTGAAACCCTGTTTCAAGAAAAAGAAAAGTATTCTCCA-AGA ENST00000533503.1 CCTACTCGGTAAAATCAAGCAAAAGAAAAAGAAAGAAAAAAGAAATATATGGTCCACAGA * * * * ** ** *** * ********* *** **** *** ENST00000422466.2 TCCCAAG---ACCATTGACACCAGGCCACATT-GTATACCAGGGATTTATG-TGAATGCC ENST00000533503.1 TGAAAAAGGAAGAAATGAAACCAT-CCTCATTCACAAACC------TCATAATCAGTTAC * ** * * *** **** ** **** * *** * ** * * * * ENST00000422466.2 TAGGGATGACCGTAGTGA---CAGATAAAGCTAGGTGCTGAGATCTGGTTTTGCCCTCTT ENST00000533503.1 AAAAGAAAATCCCAAGAAACTCCCAAAAAGCCA-----CAAGAACTAAC--AGGTCAGTT * ** * * * * * * ***** * *** ** * * ** ENST00000422466.2 TATGATTGTCCCATCGGTACTAGAAAGTGAAGTCATTGCTCCAATTTTGGAAGAGGAGAG ENST00000533503.1 TA-GAATGATCAGTC--TACAAAAAA--CAAACTATTTCTATATACTGGCAACA------ ** ** ** * ** *** * *** ** *** ** * * * ** * ENST00000422466.2 AATAACTGGCTGAGGGGTGAGAAAGACAGAAATAGCTGCAGCTCTCTTTTTTTTTTTTTT ENST00000533503.1 AATAATTGG-----AAATTGAAATTTTAAAAATACCA-------------TTTATGATAG ***** *** * ** * ***** * *** * * ENST00000422466.2 CAACAAAGGCTCTCACTCTGTTCCCCAGGCTGGAGTGCAGTGACATGATCACAGATCAC- ENST00000533503.1 CATTAAAAAATATCAAATAGTA----AGAGATGACTCTAACAAAATATGTGCACATTACA ** *** * *** ** ** ** * * * ** ** ** ** ENST00000422466.2 TGCAGCTTTCAGTTTTAAAACAGCTTTTATTACATTTTCTTTGTGGAAGCTGTATTTCTA ENST00000533503.1 TGT-GCTTAAAGTTATAAAGCAA----TGCTAAAAAGACACTAAAGAAG----------G ** **** **** **** ** * ** * * * **** ENST00000422466.2 CCTTAGTACTCACTTTCTGCTTGGTCTGAAAGATACCTCTAGTAGTGGCAACATTGTGTT ENST00000533503.1 CCTAAATA-------------------AAAAGGTATTGTTA-TGATGTCA--ATTCTCTC *** * ** **** ** ** * ** ** *** * * ENST00000422466.2 AAGTAGAGTTCATTGGGTCTCTTGTAACCCTACCCCTACATAATGGACCACTGGTGCAGG ENST00000533503.1 CAGTTAGATTTAC-AGATTCAATGCAACCTCA-------ATGAAG--TCATCG--GCAAG *** ** * * * ** **** * ** * * ** * *** * ENST00000422466.2 CTTACATAAACACACATACTGTGGCCACTTCAGCTGAAGACAAGGGACAAACTAAGATAG ENST00000533503.1 CTTTT---------TATAC-GAAGTAACT--AGCTGATTCAAAACCTTACATGAAAATGC *** **** * * *** ****** ** * * ** ** ENST00000422466.2 TTCTGAAAGGTAAAAAAACAAACAAACAAACAAAAAACAAAAACAAAATTATTAGATACC ENST00000533503.1 C-----ATGGTCCAAAAATAACCAAAGCAATTTTAAGAAAATATA----TATCAGTTGAC * *** ***** ** **** ** ** *** * * *** ** * * ENST00000422466.2 AAGTTATGCTTGAATTGCTTTGCTCTTTAGAATGTGTGTTTTTCCCTGGTATCAGAAGAA ENST00000533503.1 AGA-----CTCAAA--GATCTGA--TTTAAGA------------CTTAGTAT-------- * ** ** * * ** **** * * * **** ENST00000422466.2 GTTAAGGCTGATGACACCCCTAATTTAAATTACTAAGGATTTCTGATAGGTTTTCTGTCT ENST00000533503.1 ---AAAGCT----ACAC---TAATCAAGATTGGTGTT-ATTGGTGAAAGGACAGACGTAT ** *** **** **** * *** * *** *** *** ** * ENST00000422466.2 TTCTGTGATATCGTAAAGTATTTATTTGGTCTTTGACCCTGTTTCCTGGCATACTGCTCC ENST00000533503.1 CTTTG---------AAAG---TCAACTGACTTTCAA---AGAGTCAAGGTA--------- * ** **** * * ** ** * * ** ** * ENST00000422466.2 TAAAATCCTTAGAGTCTCCAGAGTGATGGCTTTTTGTATCTAATGAGTTGACTGCTGGCT ENST00000533503.1 ---ATTCAATGGAA-----AAAGC-ATAGTTTTTTCCA---AACAAATGG--TACTGGAT * ** * ** * ** ** * ***** * ** * * * * **** * ENST00000422466.2 GGCAGCCCCTAGGGGCTGGTCACTGGAAAGACAAATGCATGATTAGAGTTGGGACTTTCA ENST00000533503.1 --CA-----------------ACTGGATACCCATATGCAAAAA-AAAGT--GTACCTTGA ** ****** * ** ***** * * *** * ** ** * ENST00000422466.2 GTCCTCCCCCAAACTCTTGGGAGAAGGGCTGAAGGTTAAGTTGATCACCAGTGACCAGTG ENST00000533503.1 CCCTTACTTAGCATTATATACAAAAA---TTAAGGTGAAGAGGATC-CTAGCC-CAAATT * * * * * * * ** * ***** *** **** * ** * * * ENST00000422466.2 GTAATCATACCTTCATAATGAAGCCTCC--ATAAAACTCCAGAAGAACA-----GATTTT ENST00000533503.1 GTAA--GTGCTAAAACTATAAAACCTCTGGACGAGAACATAGGAGAAAATCTGTGACTTT **** * * * ** ** **** * * * ** **** * ** *** ENST00000422466.2 GGAGCATTTCCAGGT--AACTGA------ACATATGGAGGTC-CCTAGAGGGTGCTGTAC ENST00000533503.1 GGGTCAATCACAGATTTATCAGATACGACACATATATAAATTACCTAAAA-----TGTGA ** ** * *** * * * ** ****** * * **** * *** ENST00000422466.2 CTGAAG--AGGGTAGAGGGTATAGGAGCTCCCTGTCCCTTCCCACATGCCTTGCTCTATC ENST00000533503.1 TTGAAATCAGACTTCAAAATTTAAGA--TACCTGCTCTTTGCCAGACAC----------- **** ** * * * ** ** * **** * ** *** * * ENST00000422466.2 CATTTCTTCATCTCTATCCTTTGTACTGTCCTTTATAATAAACCAGTGAACCT ENST00000533503.1 --------------------------------TCAAAATAAA--AACAAGC-- * * ****** * * *