CLUSTAL 2.1 multiple sequence alignment ENST00000422514.2 GTTC---GACCGAGCAAA--TCCTGCTCCAGC--ACTCTAGAACTTAGCTGTA---TCTA ENST00000450011.1 GCACCGAAAGCGAAGGAAGCTCCTGCTCCTCCTAAAGCCGAAGCCAAAGTGAAGGTTTTA * * * *** ** ********* * * * * * * ** * * ** ENST00000422514.2 ACTCCCGAGT---CAATCC--AAATGTGTTCTTTCCTCTTGGCAGC------GTTCC--- ENST00000450011.1 AAGGCCAAGAAGGCAGTGTTGAAAGGTGTCCGCAGCCACACGCAAAAAAGAAGATCCGCA * ** ** ** * *** **** * * *** * *** ENST00000422514.2 TGCCTCCTGGCAT--GGCAATCCTCTTCCCTGAGACT--GGCAGTTGCTCAAGATA---- ENST00000450011.1 TGTCACCCACCTTCAGGCGGCCCAAGACACTGCGACTCCGGAGGCAGCCCA-GATATCCT ** * ** * * *** ** * *** **** ** * ** ** **** ENST00000422514.2 -GGAAG----CTCCCGGGAC---CAGACCCGAGCGCCA-GCCGGC--------TACGCCG ENST00000450011.1 CGGAAGAGCACCCCCAGGAGAAACAAGCTTGGCCACTATGCTATCATCAAGTTTCCGCTG ***** * *** *** ** * * * * * ** * * *** * ENST00000422514.2 TCCGCTG-----GCCTGA-----------GCAAATAA-ACGCGTGTCTTCA--------- ENST00000450011.1 ACCACTGAGTCGGCCGGAAGAAGATAGAAGAAAACAACACGCTTGTGTTCACTGTGGATG ** *** *** ** * *** ** **** *** **** ENST00000422514.2 --AAAAACTACAATCCCCATGGT--GGCACGC---------GC-CTGT---AGT------ ENST00000450011.1 TTAAAGCCAACAAGCACCA-GATCAGACAGGCTGTGAAGAAGCTCTATGACAGTGATGTG *** * **** * *** * * * ** ** ** ** * *** ENST00000422514.2 -CCCAG----CTACTCTGGT--GGCTGAGGCAGGAGAAT--GGCGTAAACCCGGGAGGC- ENST00000450011.1 GCCAAGGTCACCACCCTGATTTGTCCTGATAAAGAGAACAAGGCATATGTTCGACTTGCT ** ** * ** *** * * * * ***** *** ** ** ** ENST00000422514.2 ---------GGAGCTTACAGTG---------AGCCGAGATCGCGCCA-CTGCACTCCAGC ENST00000450011.1 CCTGATTATGATGCTTTCGATGTTGTAACAAAATTGGGATCATCTAAACTG-AGTCCAGC * **** * ** * * **** * *** * ****** ENST00000422514.2 CTGGGCGAC---AGA-----GCGC------TCA--AAAAAAAAACAAAAA-----ACAAA ENST00000450011.1 -TGGCTAACTCTAAATATATGTGTATTTTTTCAGCATAAAAAAATAATGTTTTTCATAAG *** ** * * * * *** * ******* ** * ** ENST00000422514.2 AA--ACAA-------------AAAACTACAACCCCCATGA------AGCTTTAGT----- ENST00000450011.1 AATGACAACTTAATTAGAATCAAATCTATAAGCTTTAAGATTTTACATTTCTAGTAAGTA ** **** *** *** ** * * ** * * **** ENST00000422514.2 --------GCCT--TTGAGGGGAG--------GAGTGG-------CGCATGTTT---GTT ENST00000450011.1 TAATATTAGCTTATTTGACTAGAACTCAAGCAGAATAGGAATTTATGCTTGTTTTATATT ** * **** ** ** * * ** ***** ** ENST00000422514.2 CA---------------------------------CGCACGAAAAAGAA---ATTAAACC ENST00000450011.1 CAATAATGATAATTTTGAAGATATAGTTGTTTTATTACACCAAAAATACTATATTAATCT ** *** ***** * ***** * ENST00000422514.2 TAACTACC---GTTC---CCAGAGGGCGCCGCTCTGCAAATTACCCAATCAGCTC-TAAG ENST00000450011.1 TATTTAACTAAGTTTTATCCAAATCATGTTAACTTAAGAAACATTTGATCAGTTCCTATA ** ** * *** *** * * * ** * ***** ** ** ENST00000422514.2 TAC---AAAGCATCGCGAGTCTTTA-------GTGCTCTTTGGCGCTATAAGCCC-GTGG ENST00000450011.1 TTTCTAGGAGTTTGGTGAATATTTATTTATAAATGCTTATTTTT-TTCCAAGCCAAGTTA * ** * * ** * **** **** ** * ***** ** ENST00000422514.2 GAAC-GAGCA---TTGGAGACCCT----------TTTCACAAGA-----TGGCGCCGA-- ENST00000450011.1 GAATAGAGCACTTTTAGAGGATTTCATAAATGAATTTTGCAATGCTCTCTGGAGTTAAGA *** ***** ** *** * *** *** *** * * ENST00000422514.2 --------------------------------------AAGCGAAGAAGGAAGCTCC--- ENST00000450011.1 AAATATCACATATACATAACATACATTAATAGATATACAAACACAAATAGAGATTTCATA ** * * * ** * * ENST00000422514.2 -TGCCCCTCCTAAAGCTGAAGCCA------AAGCG--AAGGCTTTAAAGGCCAAGA--AG ENST00000450011.1 GCTTTCATCCTGAAATTTCAGCCATGAATCAGGCATAAATATTCTGATGGTTAATTTCAG * **** ** * ***** * ** ** * * * ** ** ** ENST00000422514.2 GCAGT-----------GTTGAAAGGTGTCCACAGCCA--CAAAAAGAAGAAGATCCGCAC ENST00000450011.1 ACATCTACTTGATCCGATTGAGAGACACACATAGCTGGTCAAACACGATTTCAGCCATGA ** **** ** ** *** **** * * * ** ENST00000422514.2 GTCACCCACC----TTCCGGCGGCCGA----AGACA-CTGC--GACT------------- ENST00000450011.1 ATCAGGCATAAATATTCTGATGGTTAATTGTAGACATCTACTTGACTGGATTAAGAGACA *** ** *** * ** * ***** ** * **** ENST00000422514.2 -------CCGG-------AGA---CAGCC------------CAAATATCCTCG------- ENST00000450011.1 CACATAGCTGGTCAAACAAGATTTCAGCCATGAATCAGGCATAAATATTCTGATGGTTAA * ** *** ***** ****** ** ENST00000422514.2 --GAAGAGCGCTCCC----------AGGAGAAACA---AGCTTGACCACTATGCTATCA- ENST00000450011.1 TTGTAGACATCTACTTGACTGGATTAAGAGACACACATAGCTGGTCTAACACGATTTCAG * *** ** * * **** *** **** * * * * * * *** ENST00000422514.2 -------TCAAGT-------TTCCGCTGACCA--CTGAG---TCTGCC-------ATGAA ENST00000450011.1 CCATGAATCAGGCATAAATATTCTGATGGTTAACTTTAGGCATCTACTTGATTGGATTGA *** * *** * ** * * ** *** * ** * ENST00000422514.2 GAAG-----ATAG-------AAGACAA--------------CAACACACTTGT------- ENST00000450011.1 GAGACACACATAGCTGGTCAAACACGATTTCAGCCATGAATCAGCATAAATATTCTGATG ** **** ** ** * ** ** * * * ENST00000422514.2 GTTCATTGTGGATGTT---------------AAAGCCAA-----------CAAGCAC--- ENST00000450011.1 GTTAATTGTAGACATCTACTTGACTGGATTGAGAGACACACATAGCTGGCCAAACACGAT *** ***** ** * * ** ** *** *** ENST00000422514.2 --CAG--ATTAAACAGGC--------TGTGA-----------AGA-AGCTGTATGAC--- ENST00000450011.1 TTCAGCCATGAATCAGGCATAAATATTCTGATGGTTAATTTTAGACATCTACTTGACTGG *** ** ** ***** * *** *** * ** **** ENST00000422514.2 ATTGATG------------TGGCCAAGGTCAAC----ACCCTGATTCGG----------C ENST00000450011.1 ATTAAGGGACACACACAGCTGGTCAAACACAATTTCAGCCATGAATCAGGCATAAATATT *** * * *** *** *** ** *** ** * ENST00000422514.2 CTGATGGAGAGAAGAAGGCATATGTTCGACTGGCTCCTGAT---TACGATGCT--TTGGA ENST00000450011.1 CTGACAGTTAATTTTAGACATCTACTTGACTGGATTAAGAGACACACATAGCTGGTCAAA **** * * ** *** * * ****** * ** ** *** * * ENST00000422514.2 TGT--TGCCAAC---AAAATTGGGATCA----TCTAA--ACTGAGTCCAGCTGCCTAATT ENST00000450011.1 CATGATTTCAGCCGTGAAGCAGGCATAAATATTCTGATGGTTAATTGTAGACATCTACTT * * ** * ** ** ** * *** * * * * ** *** ** ENST00000422514.2 --CTGAATATATATATATATATATCT------------TTTCA-CCATATA-CATGC--- ENST00000450011.1 GACTGGATTGAGAGACACACATAGCTGGTCAAACACAATTTCAGCCATGAATCAGGCGTA *** ** * * * * * *** ** ***** **** * ** ** ENST00000422514.2 ------CTGTCTGTCAATT-------TCTGGTTGGGCTGGGAGGCCACACACACACA-CT ENST00000450011.1 AATATTCTGATGGTTAATTGTAGACATCTACTTGAG-TGGATTGAGAGACACACATAGCT *** ** **** *** *** * *** * * ******* * ** ENST00000422514.2 G-----ACATGA-------CAGGGCTTGGGCA-AGAC-TCCTG--------TTCTA--CT ENST00000450011.1 GGTCAAACACGATTTCAGCCATGAATCAGGCATAAATATTCTGATGGTTAATTTTAGACA * *** ** ** * * **** * * * *** ** ** * ENST00000422514.2 TATCCTT-------TTGAAATAC---CTCACCCTGCCA--------CTCCACCATG---- ENST00000450011.1 TGTACTTGACTGGATTAAGAGACACACATAGCTGGTCAAACACGATTTCAGCCATGAAGC * * *** ** * * ** * * * * ** ** ***** ENST00000422514.2 ---TATGATCATTCC-------------AGAGATCTTTGTGACTAGAGTTAGTGTC---- ENST00000450011.1 AGGCATAAATATTCTGATGGTTAATTGTAGACATCTACTTGACTGGATTAAGAGACACAC ** * **** *** **** ***** ** * ** * * ENST00000422514.2 ----CTAGGAAAACCAGAACTCAG-------------------------------AACTT ENST00000450011.1 ATAGCTGGTCAAACACGATTTCAGCCATGAATCAGGCATAAATATTCTGATGGTTAACTT ** * **** ** **** ***** ENST00000422514.2 ---GCCTCCAT-------GGTTGAGTAACA-----AGCTG------TACAA--------- ENST00000450011.1 TAGGCATCTACTTGATTGGATTGAGAGACACACATAGCTGATCAAACACAATTTCAGCCA ** ** * * ***** *** ***** **** ENST00000422514.2 -GAACC------------CCT---------TTT-----ATCC------CTGGA--AGAGG ENST00000450011.1 TGAATCAGGCATAAATATTCTGACGGTTAATTTTAGACATCTACTTGACTGGATTAAGGG *** * ** *** *** ***** * ** ENST00000422514.2 CTGTGTATGA------AACCAAT----GCC------CAGGG--------TTTGAAGGGTG ENST00000450011.1 ACACACACAGCTGGTCAAACAATTTCAGCCATGAATCAGGCATAAATATTCTGACAGTTA * ** **** *** **** * *** * * ENST00000422514.2 ---TTAG-CATCCATTTCAGGGGAGTGTG-GAT-----TGGCTGGC---------TCTCT ENST00000450011.1 ATTTTAGACATCTACTTGAGTGGATTAAGAGACACACATAGCTGGTCAAACACGATTTCT **** **** * ** ** *** * * ** * ***** * *** ENST00000422514.2 GGTAGCATTT-------TGTCCTC---ACACACCCATCTA-CTATG-TCCAAC------- ENST00000450011.1 GGGCATATCTATGAGGGTGTTTCTGGAAGACACTGAGATAACCATGACCCAATGTGGATG ** ** * *** * **** * ** * *** **** ENST00000422514.2 ----------CGGTCTGTCTGCTTCCCTCACCC---------CTTG---------CCC-- ENST00000450011.1 GGCACTGATATGGTTTGGCTGTGTCCC-CACCCAGATCTCATCTTGAATTGTAGTTCCTG *** ** *** **** ***** **** ** ENST00000422514.2 -AATA---------------AAGGAC-------AAGG--ACT---TCAGAGGAGTA---- ENST00000450011.1 TAATACCTACATGTCGTGGGAGGGACCCAGTGGGAGGTGACTGAATCATGGTGGTGGTTA **** * **** *** *** *** * ** ENST00000422514.2 - ENST00000450011.1 C