Welcome to psiCube, the site for comparative analysis of pseudogene annotation, activity and evolution across human, worm and fly.
In this analysis, we find the pseudogene complement has a strong lineage specificity which reflects each organims's evolution. However, we also find notable similarities in pseudogene activity among species. A majority of pseudogenes in each organism exhibit varying degree of partial activity, and in particular, a consistent fraction of pseudogenes are transcribed across all organisms.
- Reference: Sisu et al. Comparative analysis of pseudogenes across three phyla. PNAS, 111(37):13361-6, 2014.
Note: A detailed description of the analysis on human pseudogenes from an earlier GENCODE version (version 7) can be seen in psiDr.
- Pseudogene annotation in human, worm and fly
- Recombination rate at pseudogene loci of human, worm and fly
- Pseudogene families in multiple organisms including human, macaque, mouse, zebrafish, worm and fly
- Pseudogene parents in human, worm and fly
- Pseudogene activity resource for human, worm and fly
- Mouse orthologs of human pseudogenes and 1-1-1 orthologous pseudogenes in human, worm and fly
- Upstream activity of pseudogenes in human, worm and fly
- Translation evidence for pseudogenes in human