Welcome to psiCube, the site for comparative analysis of pseudogene annotation, activity and evolution across human, worm and fly.
In this analysis, we find the pseudogene complement has a strong lineage specificity which reflects each organims's evolution. However, we also find notable similarities in pseudogene activity among species. A majority of pseudogenes in each organism exhibit varying degree of partial activity, and in particular, a consistent fraction of pseudogenes are transcribed across all organisms.
- Reference: Sisu et al. Comparative analysis of pseudogenes across three phyla. PNAS, 111(37):13361-6, 2014.
Note: A detailed description of the analysis on human pseudogenes from an earlier GENCODE version (version 7) can be seen in psiDr.