Comprehensive Survey of Processed Pseudogenes in the
Human Genome
We have identified ~8000 processed pseudogenes plus ~4000 duplicated
pseudogenes in the latest GoldenPath human draft genome.
You can either interatively search an online database (coming soon), or download the
relevant data and texts from this page.
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Analysis of Ribosomal Protein Pseudogenes
We have identified over 2000 ribosomal protein (RP) pseudogenes in the August
2001 freeze of the human genome draft. An interactive database holding all the
results is being constructed. Meanwhile, the relevant data and texts can be
found here.
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Patterns of nucleotide substitution, insertion and deletion in the human genome
Using the recently identified human ribosomal protein (RP) pseudogene sequences, we have thoroughly
studied DNA mutation patterns in the human genome. Overall, we found that nucleotide transitions are
more common than transversions, by roughly a factor of two. Moreover, the substitution rates amongst
the 12 possible nucleotide pairs are not homogeneous as they are affected by the type of immediately
neighboring nucleotides and the overall local G+C content. We also found that deletions are about
three times more common than insertions.
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Analysis of Human Mitochondrial Ribosomal Protein
(MRP) Pseudogenes
We have identified over 120 MRP pseudogenes in the August 2001 freeze of the
human genome draft.
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Analysis of Human Cytochrome c (cyc) Pseudogenes
We have identified over 49 cytochrome c (cyc) pseudogenes in the August 2001
freeze of the human genome draft.
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21/22 Annotations
Specific pseudogene annotations for chromosomes 21 and 22
(Harrison et al.
Genome Res (2002)):
- pseudogenes whose primary match is a Swiss-Prot protein - chr21, chr22
- pseudogenes whose primary match is an Ensembl protein - chr21, chr22
- pseudogenes which are primarily Riken Centre or Sanger Centre
annotations but are also detected by our procedures - chr21, chr22
- a parseable table summarizing the above information - chr21, chr22.
Please read the legend
for this data.
- SNPs - Analysis of
single-nucleotide polymorphisms in human chromosomes 21 and 22.
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Database (Under Construction)
Click here for the interactive database
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